KEGG   ORTHOLOGY: K11987Help
Entry
K11987                      KO                                     
Name
PTGS2, COX2
Definition
prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
Pathway
Arachidonic acid metabolism
NF-kappa B signaling pathway
VEGF signaling pathway
Retrograde endocannabinoid signaling
Serotonergic synapse
Ovarian steroidogenesis
Leishmaniasis
Pathways in cancer
Chemical carcinogenesis
Small cell lung cancer
Disease
H00017  
Esophageal cancer
H00025  
Penile cancer
H00046  
Cholangiocarcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00590 Arachidonic acid metabolism
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
 Environmental Information Processing
  Signal transduction
   04370 VEGF signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04064 NF-kappa B signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
 Organismal Systems
  Endocrine system
   04913 Ovarian Steroidogenesis
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  Nervous system
   04726 Serotonergic synapse
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04723 Retrograde endocannabinoid signaling
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05204 Chemical carcinogenesis
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05222 Small cell lung cancer
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  Infectious diseases
   05140 Leishmaniasis
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors with incorporation of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.1  prostaglandin-endoperoxide synthase
     K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
BRITE hierarchy
Other DBs
Genes
HSA: 
5743(PTGS2)
PTR: 
469616(PTGS2)
PPS: 
100985650(PTGS2)
GGO: 
101146681(PTGS2)
PON: 
100436566(PTGS2)
MCC: 
716671(PTGS2)
MMU: 
19225(Ptgs2)
RNO: 
29527(Ptgs2)
CFA: 
442942(PTGS2)
AML: 
FCA: 
100126581(PTGS2)
BTA: 
282023(PTGS2)
SSC: 
397590(PTGS2)
ECB: 
791253(PTGS2)
MDO: 
100024802
SHR: 
100926756(PTGS2)
OAA: 
100086096
GGA: 
396451(PTGS2)
MGP: 
100550092
TGU: 
100221909(PTGS2)
ACS: 
100560130
XLA: 
446781(ptgs2)
XTR: 
595089(ptgs2)
DRE: 
559020(ptgs2b)
TRU: 
101064817
OLA: 
100359365(ptgs2)
BFO: 
BRAFLDRAFT_129952
CIN: 
100183010 100183175
API: 
100568622
SMP: 
SMAC_09193
PAN: 
PODANSg1229
MTM: 
MYCTH_2094824
FGR: 
FG10960.1
NHE: 
NECHADRAFT_40259
VAL: 
VDBG_03337
SSL: 
SS1G_10705
BFU: 
BC1G_04254
ANI: 
AN5028.2
NFI: 
NFIA_045480 NFIA_065200
AFM: 
AFUA_3G12120
AOR: 
AOR_1_1372154(AO090003000772)
ANG: 
ANI_1_1118024(An02g07930)
AFV: 
AFLA_030430 AFLA_120760
ACT: 
ACLA_039980
PCS: 
Pc18g00240
CIM: 
CIMG_00042
CPW: 
CPC735_060720
PBL: 
PAAG_03986
URE: 
UREG_00168
ABE: 
ARB_07881
AJE: 
HCAG_01100
TML: 
GSTUM_00000322001
PPL: 
POSPLDRAFT_98495
LBC: 
LACBIDRAFT_305274 LACBIDRAFT_315146
CCI: 
CC1G_00844 CC1G_09914
SCM: 
SCHCODRAFT_11038 SCHCODRAFT_114799
NEU: 
NE1240(Ptgs1)
MET: 
M446_1624
MNO: 
Mnod_6498
RSH: 
Rsph17029_3626
RSK: 
RSKD131_4262
RDE: 
RD1_1072
RLI: 
RLO149_c002730
MVA: 
Mvan_3099
MCB: 
Mycch_2784
SRO: 
Sros_8745
GOB: 
Gobs_1219
GLP: 
Glo7428_2177
NPU: 
Npun_R5469
NOS: 
Nos7107_2301
CSG: 
Cylst_1559
ONI: 
Osc7112_4273
MIC: 
Mic7113_3623
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Rouzer CA, Marnett LJ
  Title
Cyclooxygenases: structural and functional insights.
  Journal
J Lipid Res 50 Suppl:S29-34 (2009)
Reference
  Authors
Kim SF, Huri DA, Snyder SH
  Title
Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.
  Journal
Science 310:1966-70 (2005)
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