KEGG   ORTHOLOGY: K11987Help
Entry
K11987                      KO                                     

Name
PTGS2, COX2
Definition
prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
Pathway
Arachidonic acid metabolism
NF-kappa B signaling pathway
VEGF signaling pathway
TNF signaling pathway
Retrograde endocannabinoid signaling
Serotonergic synapse
Ovarian steroidogenesis
Oxytocin signaling pathway
Leishmaniasis
Pathways in cancer
Chemical carcinogenesis
MicroRNAs in cancer
Small cell lung cancer
Disease
H00017  
Esophageal cancer
H00025  
Penile cancer
H00046  
Cholangiocarcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00590 Arachidonic acid metabolism
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
 Environmental Information Processing
  Signal transduction
   04370 VEGF signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04064 NF-kappa B signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04668 TNF signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
 Organismal Systems
  Endocrine system
   04913 Ovarian Steroidogenesis
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04921 Oxytocin signaling pathway
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  Nervous system
   04726 Serotonergic synapse
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   04723 Retrograde endocannabinoid signaling
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05206 MicroRNAs in cancer
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05204 Chemical carcinogenesis
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
   05222 Small cell lung cancer
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
  Infectious diseases
   05140 Leishmaniasis
    K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors with incorporation of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.1  prostaglandin-endoperoxide synthase
     K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2
BRITE hierarchy
Other DBs
Genes
HSA: 
5743(PTGS2)
PTR: 
469616(PTGS2)
PPS: 
100985650(PTGS2)
GGO: 
101146681(PTGS2)
PON: 
100436566(PTGS2)
NLE: 
100591090(PTGS2)
MCC: 
716671(PTGS2)
MCF: 
102143028(PTGS2)
CJC: 
100407639(PTGS2)
MMU: 
19225(Ptgs2)
RNO: 
29527(Ptgs2)
CGE: 
100751220(Ptgs2)
HGL: 
101704771(Ptgs2)
TUP: 
102478264(PTGS2)
CFA: 
442942(PTGS2)
AML: 
UMR: 
103668648(PTGS2)
FCA: 
100126581(PTGS2)
PTG: 
102948685(PTGS2)
BTA: 
282023(PTGS2)
BOM: 
102271174(PTGS2)
PHD: 
102326874(PTGS2)
CHX: 
100860905(PTGS2)
OAS: 
443460(PTGS2)
SSC: 
397590(PTGS2)
CFR: 
102509586(PTGS2)
BACU: 
102999195(PTGS2)
LVE: 
103088613(PTGS2)
ECB: 
791253(PTGS2)
MYB: 
102259598(PTGS2)
MYD: 
102774808(PTGS2)
PALE: 
102886561(PTGS2)
MDO: 
100024802(PTGS2)
SHR: 
100926756(PTGS2)
OAA: 
100086096(PTGS2)
GGA: 
396451(PTGS2)
MGP: 
APLA: 
101790135(PTGS2)
TGU: 
100221909(PTGS2)
FAB: 
101816125(PTGS2)
PHI: 
102105209(PTGS2)
FPG: 
101918755(PTGS2)
FCH: 
102050356(PTGS2)
CLV: 
102088650(PTGS2)
ASN: 
102369126(PTGS2)
AMJ: 
102567925(PTGS2)
PSS: 
102459102(PTGS2)
CMY: 
102934690(PTGS2)
ACS: 
100560130(ptgs2)
PBI: 
103063043(PTGS2)
XLA: 
446781(ptgs2)
XTR: 
595089(ptgs2)
DRE: 
246227(ptgs2a) 559020(ptgs2b)
TRU: 
MZE: 
OLA: 
100359365(ptgs2)
XMA: 
LCM: 
102352257(PTGS2)
CMK: 
103179983(ptgs2)
BFO: 
CIN: 
API: 
LGI: 
NCR: 
FGR: 
SSL: 
BFU: 
TML: 
PPL: 
NEU: 
NE1240(Ptgs1)
MET: 
MNO: 
RSH: 
RSK: 
RDE: 
MVA: 
SRO: 
GOB: 
NPU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kim SF, Huri DA, Snyder SH
  Title
Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2.
  Journal
Science 310:1966-70 (2005)
  Sequence
[hsa:5743]

DBGET integrated database retrieval system