KEGG ORTHOLOGY: K12172

ORTHOLOGY: K12172

Entry

K12172                      KO

Symbol

RANBP2, NUP358

Name

E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]

Pathway

map03013

Nucleocytoplasmic transport

map03250

Viral life cycle - HIV-1

map05014

Amyotrophic lateral sclerosis

Disease

H02536

Infection-induced acute encephalopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09122 Translation
   03013 Nucleocytoplasmic transport
    K12172  RANBP2, NUP358; E3 SUMO-protein ligase RanBP2
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    K12172  RANBP2, NUP358; E3 SUMO-protein ligase RanBP2
09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K12172  RANBP2, NUP358; E3 SUMO-protein ligase RanBP2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K12172  RANBP2, NUP358; E3 SUMO-protein ligase RanBP2
   03110 Chaperones and folding catalysts
    K12172  RANBP2, NUP358; E3 SUMO-protein ligase RanBP2
   04121 Ubiquitin system
    K12172  RANBP2, NUP358; E3 SUMO-protein ligase RanBP2
Messenger RNA biogenesis [BR:ko03019]
Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    Nuclear pore complex
     K12172  RANBP2, NUP358; E3 SUMO-protein ligase RanBP2
Chaperones and folding catalysts [BR:ko03110]
Protein folding catalysts
  Peptidyl prolyl isomerase
   Cyclophilin
    K12172  RANBP2, NUP358; E3 SUMO-protein ligase RanBP2
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  UBL E3 ligases
   K12172  RANBP2, NUP358; E3 SUMO-protein ligase RanBP2

Other DBs

GO:	0019789 0031267

TC:

1.I.1.1.3

Genes

HSA:	5903(RANBP2)

PTR:	749348(RANBP2)

PPS:

100989340

GGO:	101136692 109025447

PON:

100438733

NLE:

100593752

MCC:

694823

MCF:	102123033(RANBP2)

MNI:

105471838

CSAB:

103241220(RANBP2)

CATY:

105591200(RANBP2)

PANU:

101000556

TGE:

112636969

MLEU:

105540048(RANBP2)

RRO:

104666650

RBB:

108536784

TFN:	117062236(RANBP2)

PTEH:

111525057

CANG:

105525734(RANBP2)

CJC:	100386461(RANBP2)

SBQ:	101042943(RANBP2)

CIMI:

108312957(RANBP2)

CSYR:

103264213

MMUR:

105856129(RGPD4)

LCAT:

123637298(RANBP2)

PCOQ:

105826310(RANBP2)

OGA:

100950429

MMU:	19386(Ranbp2)

MCAL:

110302686

MPAH:

110326481

RNO:	294429(Ranbp2)

MCOC:

116075526

ANU:	117724149(Ranbp2)

MUN:

110560706

CGE:	100762334(Ranbp2)

MAUA:

101826176(Ranbp2)

PROB:

127223979

PLEU:

114708897

MORG:

121450886(Ranbp2)

MFOT:

126498931

AAMP:

119822270(Ranbp2)

NGI:	103745619(Ranbp2)

HGL:	101698338(Ranbp2)

CPOC:

101788077

CCAN:

109698368

DORD:

105999292(Ranbp2)

DSP:	122121203(Ranbp2)

PLOP:

125356141(Rgpd4)

NCAR:

124962933

MMMA:

107154082(Rgpd4)

OCU:

100338469

OPI:	101532730(RANBP2)

TUP:	102484104(RANBP2)

GVR:	103593119(RANBP2)

CFA:	474539(RANBP2)

CLUD:

112669445

VVP:

112929024

VLG:	121490751(RANBP2)

NPO:

129511462

AML:

100484820

UMR:	103670652(RANBP2)

UAH:

113267793

UAR:	123776081(RANBP2)

ELK:

111155833

LLV:

125108400

MPUF:

101679310(RANBP2)

MNP:

132021656

MLK:

131808304

NVS:	122916423(RANBP2)

ORO:	101385181(RANBP2)

EJU:

114199377

ZCA:	113938313(RANBP2)

MLX:	118008296(RANBP2)

NSU:	110572065(RANBP2)

LWW:

102749113

FCA:	101094012(RANBP2)

PYU:	121016484(RANBP2)

PBG:	122497563(RANBP2)

PVIV:

125161834

LRUF:

124504377

PTG:	102949686(RANBP2)

PPAD:

109258054

PUC:

125936184

AJU:

106977302

HHV:	120223969(RANBP2)

BTA:	785768(RANBP2)

BOM:	102285692(RANBP2)

BIU:

109566113

BBUB:

102390517(RANBP2)

BBIS:

105005116(RANBP2)

CHX:

102172632

OAS:

101116816

BTAX:

128056237

ODA:	120851433(RANBP2)

CCAD:

122441715(RANBP2)

MBEZ:

129540048

SSC:

100511376

CFR:

102514604

CBAI:

105072245(RANBP2)

CDK:	105099086(RGPD4)

VPC:	102530506(RGPD4)

BACU:

102998734(RANBP2)

BMUS:

118905994

LVE:	103071752(RANBP2)

OOR:	101272377(RGPD4)

DLE:	111187540(RGPD4)

PCAD:

PSIU:

NASI:

ECB:

EPZ:	103543735(RANBP2)

EAI:	106823941(RANBP2)

MYB:	102261459(RANBP2)

MYD:	102774681(RANBP2)

MMYO:

118676720(RANBP2)

MLF:

102437255

PKL:	118724566(RANBP2)

EFUS:

103297413

MNA:	107528725(RANBP2)

DRO:

112297574

SHON:

119003934(RANBP2)

AJM:	119044132(RANBP2)

PDIC:

114496000(RANBP2)

PHAS:

123816327(RANBP2)

MMF:	118627029(RANBP2)

PPAM:

129085608

HAI:

109394058

RFQ:	117033443(RANBP2)

PALE:

102896535

PGIG:

120594537(RANBP2)

PVP:

105302318

RAY:	107519863(RANBP2)

MJV:	108409721(RANBP2)

TOD:

119258948

SARA:

101540874(RANBP2)

SETR:

126019114

LAV:

100662857

TMU:

101354044

ETF:	101647733(RANBP2)

DNM:

101429037

MDO:	100020173(RANBP2)

GAS:	123241776(RANBP2)

SHR:

100934513

AFZ:

127553514

PCW:

110193387

OAA:	100090614(RANBP2)

GGA:

776067

PCOC:

116236505(RGPD4)

MGP:	100545924(RGPD4)

CJO:

TPAI:

LMUT:

NMEL:

ACYG:

CATA:

118253620(RGPD4)

AFUL:

116489741

TGU:

100221862

LSR:

110478774

SCAN:

103812650(RGPD4)

PMOA:

120504542

OTC:

121343225

PRUF:

121354046

GFR:	102032878(RANBP2)

FAB:	101807167(RANBP2)

OMA:	130248886(RGPD4)

PHI:	102110372(RANBP2)

PMAJ:

107207366

CCAE:

111944706

CCW:	104686095(RANBP2)

CBRC:

103617545(RGPD4)

ETL:

114060285

ZAB:	102073813(RGPD4)

ACHL:

103806705(RANBP2)

SVG:	106858444(RANBP2)

MMEA:

130572258

HRT:	120749630(RGPD4)

FPG:	101910441(RANBP2)

FCH:

102050104

CLV:

102086702

EGZ:

104126393

NNI:	104019404(RANBP2)

PCRI:

104036813(RANBP2)

EHS:	104509010(RANBP2)

ACUN:

113491410(RGPD4)

TALA:

104363684

PADL:

103918847

AFOR:

103896272(RGPD4)

ACHC:

115334574

HALD:

104312800(RANBP2)

HLE:

104836899

AGEN:

126052867

GCL:

127029393

CSTI:

104553932(RANBP2)

MUI:	104535839(RANBP2)

FGA:	104079310(RANBP2)

MNB:	103778807(RANBP2)

OHA:	104326933(RANBP2)

NNT:	104405394(RANBP2)

SHAB:

115601272

PGUU:

104460777(RANBP2)

ACAR:

104524616

CPEA:

104389009

CVF:

104284741

RTD:	128906792(RGPD4)

CUCA:

104056679

TEO:

104379739

BRHI:

104489647(RANBP2)

AROW:

112960875

NPD:	112943325(RGPD4)

TGT:	104565363(RANBP2)

DNE:

112981363

SCAM:

104138059(RANBP2)

ASN:

106721793

AMJ:

102558542

CPOO:

109306272

PSS:	102450376(RGPD4)

CMY:

102945770

CCAY:

125639418(RGPD4)

DCC:

119846366

CPIC:

101947983

TST:

117870750

CABI:

116819891(RANBP2)

MRV:

120408173

ACS:

100562216

ASAO:

132771543(RGPD4)

PVT:	110074119(RGPD4)

SUND:

121926936

PBI:

103050703

PMUR:

107290886

CTIG:

120302839(RANBP2)

TSR:	106542195(RANBP2)

PGUT:

117666627

APRI:

131200209(RGPD4)

PTEX:

113440756(RGPD4)

NSS:

113411610

VKO:

123022496

PMUA:

114596429(RGPD4)

PRAF:

128411829

ZVI:

118084821

HCG:

128348978

GJA:	107117568(RANBP2)

STOW:

125431532

EMC:

129325419

XLA:	100126652(ranbp2.S) 100127327(ranbp2.L)

XTR:	100134999(ranbp2)

NPR:

RTEM:

BBUF:

BGAR:

MUO:	115469133(RGPD4)

GSH:

117362460

DRE:	100317326(si:ch1073-55a19.2)

SRX:	107709150 107733035

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

LROH:

127171170(ranbp2) 127171171

OMC:	131546894(ranbp2) 131547208

PPRM:

120480580 120480581(ranbp2)

RKG:	130068942 130068968 130068969

MAMB:

125269573(ranbp2) 125269575

CIDE:

127519025

MASI:

127447742

TROS:

130556179(ranbp2)

TDW:	130427556(ranbp2)

MANU:

129452570(ranbp2) 129452573

IPU:	108261082(ranbp2)

IFU:	128608532(ranbp2)

PHYP:

113547086

SMEO:

124382873(ranbp2)

TFD:	113647338(ranbp2)

TVC:	132849884(ranbp2)

AMEX:

103044567

CMAO:

118801612(ranbp2)

EEE:

113574619

TRU:

101077614

TFS:	130521567(ranbp2)

TNG:	GSTEN00007599G001

LCO:

104918663

NCC:

104956040

TBEN:

117485684(ranbp2)

CGOB:

115026835

PGEO:

117467103(ranbp2)

GACU:

117560071(ranbp2)

EMAC:

134867177(ranbp2)

ELY:	117251656(ranbp2)

EFO:	125899388(ranbp2)

PLEP:

121948975(ranbp2)

SLUC:

116037763(ranbp2)

ECRA:

117952354(ranbp2)

ESP:

116697557

PFLV:

114563670

GAT:	120833713(ranbp2)

PPUG:

119228452(ranbp2)

AFB:	129104316(ranbp2)

CLUM:

117750912(ranbp2)

PSWI:

130199812(ranbp2)

MSAM:

119903929(ranbp2)

SCHU:

122885192(ranbp2)

CUD:	121522784(ranbp2)

ALAT:

119025413(ranbp2)

MZE:

101470621

ONL:

100692890

OAU:	116311995(ranbp2)

OLA:

101160447

OML:	112154894(ranbp2)

CSAI:

133445598(ranbp2)

XMA:

XCO:

XHE:

PRET:

PFOR:

103141491(ranbp2)

PLAI:

106950289(ranbp2)

PMEI:

106908820(ranbp2)

GAF:	122839321(ranbp2)

PPRL:

129361034(ranbp2)

CVG:	107083567(ranbp2)

CTUL:

119777489(ranbp2)

GMU:	124871135(ranbp2)

NFU:	107395587(ranbp2)

KMR:	108240408(ranbp2)

ALIM:

106519709(ranbp2)

NWH:	119419548(ranbp2)

AOCE:

111575388

MCEP:

125017220(ranbp2)

CSEM:

103392282(ranbp2)

POV:

109631275

SSEN:

122774425(ranbp2)

HHIP:

117754671(ranbp2)

HSP:	118120438(ranbp2)

SMAU:

118320564(ranbp2)

LCF:

108900555

SDU:

111218510

SLAL:

111662719

XGL:	120801211(ranbp2)

HCQ:

109523313

SSCV:

125973647

SBIA:

133512688(ranbp2)

PEE:	133410298(ranbp2)

PTAO:

133486348(ranbp2)

BPEC:

110156144

MALB:

109968299

BSPL:

114846828(ranbp2)

SJO:	128368430(ranbp2)

SASA:

106582182 106582213 106586530

STRU:

115155731 115155732 115161061

OTW:	112224848 112240017 121840986

OMY:	110501703 110520375 118943584

OGO:	124044069 124046360(ranbp2)

ONE:	115108102 115111817

OKI:	109868922 109877772 109887797

OKE:	118366816(ranbp2) 118379950 118380535

SALP:

111959283 111978138

SNH:	120058074 120063954 120063956

CCLU:

121536923 121571721 121571722

ELS:

105016384

SFM:

108920546

PKI:	111846866(ranbp2) 111849066

AANG:

118214474(ranbp2)

LOC:	102689546(ranbp2)

PSPA:

121320680 121327463

ARUT:

117405945 117407243

PSEX:

120522840(ranbp2)

LCM:	102367622(RANBP2)

CMK:	103185758(ranbp2)

RTP:	109932599(ranbp2)

CPLA:

122550679(ranbp2)

HOC:	132816443(ranbp2)

LERI:

129698157(ranbp2)

PMRN:

116952562(RANBP2)

LRJ:

BFO:

BBEL:

CIN:

SCLV:

120339070 120339072 120339075

APLC:

110977836

SKO:

100371313

DME:	Dmel_CG11856(Nup358)

DER:

6555272

DSE:

6619688

DSI:	Dsimw501_GD21193(Dsim_GD21193)

DYA:	Dyak_GE23579

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23639

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

AOQ:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ007518

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:	100120774 100678056

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:	108913782 108913783 108916572

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_204234

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM477850

FOC:

TPAL:

ZNE:

CSEC:

FCD:

DPX:	DAPPUDRAFT_304059

DMK:

116922589

DPZ:

124342541

PVM:	113807607 113807609

PJA:

PCHN:

PMOO:

HAME:

PCLA:

HAZT:

EAF:

PPOI:

DSV:	119440619 119442311

RSAN:

RMP:

VDE:

VJA:

CSCU:

PTEP:

SDM:

CEL:	CELE_F59A2.1(npp-9)

CRQ:	GCK72_009674

TSP:

Tsp_00378

LGI:	LOTGIDRAFT_231853

PCAN:

112572436

GAE:	121370592 121371363

HRF:	124120606 124120609 124120610

HRJ:	124268611 124277977

CRG:

105323093

CVN:	111124696 111124701

MYI:

PMAX:

MMER:

LAK:

SMM:	Smp_016410

OVI:	T265_00163

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

SPIS:

DGT:

XEN:

HMG:

AQU:

SRE:	PTSG_03188

» show all

Reference

PMID:14729961

Authors

Forler D, Rabut G, Ciccarelli FD, Herold A, Kocher T, Niggeweg R, Bork P, Ellenberg J, Izaurralde E

Title

RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export.

Journal

Mol Cell Biol 24:1155-67 (2004)
DOI:10.1128/MCB.24.3.1155-1167.2004

Sequence

[dme:Dmel_CG11856]

Reference

PMID:12032081

Authors

Kirsh O, Seeler JS, Pichler A, Gast A, Muller S, Miska E, Mathieu M, Harel-Bellan A, Kouzarides T, Melchior F, Dejean A

Title

The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.

Journal

EMBO J 21:2682-91 (2002)
DOI:10.1093/emboj/21.11.2682

Sequence

[hsa:5903]

Reference

PMID:7775481

Authors

Wu J, Matunis MJ, Kraemer D, Blobel G, Coutavas E

Title

Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region.

Journal

J Biol Chem 270:14209-13 (1995)
DOI:10.1074/jbc.270.23.14209

Sequence

[hsa:5903]

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Ontology (7)   
   KEGG BRITE (4)   
   GO (2)   
   TC (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (4500)   
   KEGG GENES (602)   
   KEGG MGENES (758)   
   RefGene (3133)   
   OC (7)   
Literature (3)   
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