KEGG   ORTHOLOGY: K12407Help
Entry
K12407                      KO                                     

Name
GCK
Definition
glucokinase [EC:2.7.1.2]
Pathway
Glycolysis / Gluconeogenesis
Galactose metabolism
Starch and sucrose metabolism
Amino sugar and nucleotide sugar metabolism
Streptomycin biosynthesis
Butirosin and neomycin biosynthesis
Carbon metabolism
Insulin signaling pathway
Insulin secretion
Prolactin signaling pathway
Type II diabetes mellitus
Maturity onset diabetes of the young
Module
M00001  
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
M00549  
Nucleotide sugar biosynthesis, glucose => UDP-glucose
Disease
H00410  
Maturity onset diabetes of the young (MODY)
H00512  
Permanent neonatal diabetes mellitus (PNDM)
H01267  
Familial hyperinsulinemic hypoglycemia (HHF)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Overview
   01200 Carbon metabolism
    K12407  GCK; glucokinase
  Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K12407  GCK; glucokinase
   00052 Galactose metabolism
    K12407  GCK; glucokinase
   00500 Starch and sucrose metabolism
    K12407  GCK; glucokinase
   00520 Amino sugar and nucleotide sugar metabolism
    K12407  GCK; glucokinase
  Biosynthesis of other secondary metabolites
   00521 Streptomycin biosynthesis
    K12407  GCK; glucokinase
   00524 Butirosin and neomycin biosynthesis
    K12407  GCK; glucokinase
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    K12407  GCK; glucokinase
   04910 Insulin signaling pathway
    K12407  GCK; glucokinase
   04917 Prolactin signaling pathway
    K12407  GCK; glucokinase
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K12407  GCK; glucokinase
   04950 Maturity onset diabetes of the young
    K12407  GCK; glucokinase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Central carbohydrate metabolism
    M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
     K12407  GCK; glucokinase
   Sugar metabolism
    M00549  Nucleotide sugar biosynthesis, glucose => UDP-glucose
     K12407  GCK; glucokinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.2  glucokinase
     K12407  GCK; glucokinase
BRITE hierarchy
Other DBs
Genes
HSA: 
2645(GCK)
PTR: 
737923(GCK)
PPS: 
GGO: 
PON: 
MCC: 
699728(GCK)
MCF: 
MMU: 
103988(Gck)
RNO: 
24385(Gck)
CGE: 
HGL: 
TUP: 
CFA: 
606490(GCK)
AML: 
FCA: 
PTG: 
BTA: 
616576(GCK)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
MDO: 
SHR: 
OAA: 
GGA: 
430370(GCK)
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
378602(gck)
XTR: 
DRE: 
751668(gck)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Iynedjian PB
  Title
Molecular physiology of mammalian glucokinase.
  Journal
Cell Mol Life Sci 66:27-42 (2009)

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