KEGG ORTHOLOGY: K13302

ORTHOLOGY: K13302

Entry

K13302                      KO

Symbol

SGK1

Name

serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]

Pathway

map04068

FoxO signaling pathway

map04148

Efferocytosis

map04150

mTOR signaling pathway

map04151

PI3K-Akt signaling pathway

map04928

Parathyroid hormone synthesis, secretion and action

map04960

Aldosterone-regulated sodium reabsorption

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K13302  SGK1; serum/glucocorticoid-regulated kinase 1
   04151 PI3K-Akt signaling pathway
    K13302  SGK1; serum/glucocorticoid-regulated kinase 1
   04150 mTOR signaling pathway
    K13302  SGK1; serum/glucocorticoid-regulated kinase 1
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K13302  SGK1; serum/glucocorticoid-regulated kinase 1
09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K13302  SGK1; serum/glucocorticoid-regulated kinase 1
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K13302  SGK1; serum/glucocorticoid-regulated kinase 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K13302  SGK1; serum/glucocorticoid-regulated kinase 1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K13302  SGK1; serum/glucocorticoid-regulated kinase 1
Protein kinases [BR:ko01001]
Serine/threonine kinases: AGC group
  SGK family [OT]
   K13302  SGK1; serum/glucocorticoid-regulated kinase 1

Genes

HSA:	6446(SGK1)

PTR:	463011(SGK1)

PPS:	100984960(SGK1)

GGO:	101132422(SGK1)

PON:	100447685(SGK1)

NLE:	100586194(SGK1)

HMH:	116472584(SGK1)

MCC:	713082(SGK1)

MCF:	101866184(SGK1)

MTHB:

126952874

MNI:	105465645(SGK1)

CSAB:

103240340(SGK1)

CATY:

105600428

PANU:

101017114(SGK1)

TGE:	112623602(SGK1)

MLEU:

105547766(SGK1)

RRO:

104678238

RBB:	108531834(SGK1)

TFN:

117097504

PTEH:

111554889(SGK1)

CANG:

105526195(SGK1)

CJC:	100389266(SGK1)

SBQ:	101046433(SGK1)

CIMI:

108297394(SGK1)

CSYR:

103276717(SGK1)

MMUR:

105857243(SGK1)

LCAT:

123633293

PCOQ:

105827188(SGK1)

OGA:	100948095(SGK1)

MMU:	20393(Sgk1)

MCAL:

110302862(Sgk1)

MPAH:

110338537(Sgk1)

RNO:	29517(Sgk1)

MCOC:

116097831(Sgk1)

ANU:	117700994(Sgk1) 117701891 117717336

MUN:	110550419(Sgk1)

CGE:	100771433(Sgk1)

MAUA:

101829943(Sgk1)

PROB:

127215060(Sgk1)

MORG:

121449339

MFOT:

126511965

AAMP:

119821263(Sgk1)

NGI:	103724913(Sgk1) 103733926

HGL:	101708117(Sgk1)

CPOC:

100720058(Sgk1)

CCAN:

109697937(Sgk1)

DORD:

105993569(Sgk1)

DSP:	122107005(Sgk1) 122114215

PLOP:

125357304(Sgk1)

NCAR:

124988613

MMMA:

107155549(Sgk1)

OCU:	100008723(SGK1)

OPI:	101526325(SGK1)

TUP:	102499967(SGK1)

GVR:	103596668(SGK1)

CFA:	403647(SGK1)

CLUD:

112644153(SGK1)

VVP:	112919455(SGK1)

VLG:	121484830(SGK1)

NPO:	129509226(SGK1)

AML:	100468926(SGK1)

UMR:	103663385(SGK1)

UAH:	113259468(SGK1)

UAR:	123797568(SGK1)

ELK:

111147659

LLV:

125102732

MPUF:

101678505(SGK1)

MNP:	132018177(SGK1)

MLK:	131833777(SGK1)

NVS:	122906460(SGK1)

ORO:	101378055(SGK1)

EJU:	114206626 114225658

ZCA:	113924665 113927108(SGK1)

MLX:	118000805(SGK1)

NSU:	110583655(SGK1)

LWW:	102735522(SGK1)

FCA:	101098954(SGK1)

PYU:	121013433(SGK1)

PCOO:

112862092(SGK1)

PBG:	122490011(SGK1)

PVIV:

125166306(SGK1)

LRUF:

124528063

PTG:	102966723(SGK1)

PPAD:

109249901(SGK1)

PUC:

125937990

AJU:

106976864

HHV:	120238347(SGK1)

BTA:	515854(SGK1)

BOM:	102272039(SGK1)

BIU:

109563967

BBUB:

102405402(SGK1)

BBIS:

104991686(SGK1)

CHX:	102176607(SGK1)

OAS:	101107709(SGK1)

BTAX:

128053038(SGK1)

ODA:	120863053(SGK1)

CCAD:

122434060(SGK1)

MBEZ:

129561018(SGK1)

SSC:	100625739(SGK1)

CFR:	102516719(SGK1)

CBAI:

105077247(SGK1)

CDK:	105096363(SGK1)

VPC:	102537028(SGK1) 107033172

BACU:

103016100(SGK1)

BMUS:

118889154 118905080(SGK1)

LVE:	103071928(SGK1)

OOR:	101281043(SGK1)

DLE:	111165956 111177220

PCAD:

102987463(SGK1) 112065033

PSIU:

116759483 116763384

NASI:

112398354 112409111

ECB:	100073151(SGK1)

EPZ:

103556350

EAI:	106837176(SGK1)

MYB:	102250674(SGK1)

MYD:	102766031(SGK1)

MMYO:

118660084(SGK1)

MLF:	102421134(SGK1)

PKL:	118705938(SGK1)

EFUS:

103305472(SGK1)

MNA:	107530994(SGK1)

DRO:	112297072(SGK1)

SHON:

118986683

AJM:	119039939(SGK1)

PDIC:

114494180(SGK1)

PHAS:

123821687(SGK1)

MMF:	118621399(SGK1)

PPAM:

129067792(SGK1)

HAI:	109371924(SGK1)

RFQ:	117019130(SGK1)

PALE:

102891704

PGIG:

120615796

PVP:

105289483

RAY:	107516175(SGK1)

MJV:	108394031(SGK1)

TOD:	119252895(SGK1)

SARA:

101551219(SGK1)

SETR:

126029731(SGK1)

LAV:

100666881

TMU:

101349244

ETF:	101654490(SGK1)

DNM:

101434507

MDO:	100025435(SGK1)

GAS:	123247938(SGK1)

SHR:	100935143(SGK1)

AFZ:

127562233

PCW:	110208905(SGK1)

OAA:	100073891(SGK1)

GGA:	395133(SGK1)

PCOC:

116240381(SGK1)

MGP:	100541500(SGK1)

CJO:	107311699(SGK1)

TPAI:

128080821(SGK1)

LMUT:

125689446(SGK1)

NMEL:

110390596

APLA:

101801765

ACYG:

106032508

CATA:

118243957(SGK1)

AFUL:

116487835(SGK1)

TGU:	100219883(SGK1)

LSR:	110476052(SGK1)

SCAN:

103820550(SGK1)

PMOA:

120501191

OTC:	121346155(SGK1)

PRUF:

121354838(SGK1)

GFR:	102037330(SGK1)

FAB:	101810101(SGK1)

OMA:	130250982(SGK1)

PHI:	102101880(SGK1)

PMAJ:

107202355

CCAE:

111927653(SGK1)

CCW:	104690470(SGK1)

CBRC:

103619327(SGK1)

ETL:	114065221(SGK1)

ZAB:	102075037(SGK1)

ACHL:

103808494(SGK1)

SVG:	106851917(SGK1)

MMEA:

130572604(SGK1)

HRT:	120749959(SGK1)

FPG:	101924246(SGK1)

FCH:

102052186

CLV:	102094792(SGK1)

EGZ:	104131203(SGK1)

NNI:	104008826(SGK1)

PCRI:

104025225(SGK1)

PLET:

104621612(SGK1)

EHS:	104504021(SGK1)

PCAO:

104048992(SGK1)

ACUN:

113478259(SGK1)

TALA:

104356280(SGK1)

PADL:

103912698(SGK1)

AFOR:

103900743(SGK1)

ACHC:

115344814(SGK1)

HALD:

104316787(SGK1)

HLE:	104836223(SGK1)

AGEN:

126038455

GCL:

127013998

CCRI:

104166189(SGK1)

CSTI:

104550554(SGK1)

CMAC:

104477406(SGK1)

MUI:	104540732(SGK1)

BREG:

104636346(SGK1)

FGA:	104084047(SGK1)

GSTE:

104264026(SGK1)

LDI:	104340935(SGK1)

MNB:	103772288(SGK1)

OHA:	104327068(SGK1)

NNT:	104406971(SGK1)

SHAB:

115609508

DPUB:

104306970(SGK1)

PGUU:

104468219(SGK1)

ACAR:

104529266

CPEA:

104390056(SGK1)

AVIT:

104270997(SGK1)

CVF:	104282104(SGK1)

RTD:	128906765(SGK1)

CUCA:

104058233(SGK1)

TEO:	104374767(SGK1)

BRHI:

104500561(SGK1)

AAM:	106498005(SGK1)

AROW:

112970150(SGK1)

NPD:	112954908(SGK1)

TGT:	104571671(SGK1)

DNE:

112995692

SCAM:

104153137

ASN:	102371183(SGK1)

AMJ:	102576261(SGK1)

CPOO:

109312037(SGK1)

GGN:

109299744

PSS:	102450219(SGK1)

CMY:	102932644(SGK1)

CCAY:

125634151(SGK1)

DCC:	119854098(SGK1)

CPIC:

101936659(SGK1)

TST:

117874915

CABI:

116827542

MRV:	120400868(SGK1)

ACS:	100565714(sgk1)

ASAO:

132760985(SGK1)

PVT:	110071906(SGK1)

SUND:

121928903

PBI:

103054879

PMUR:

107289907(SGK1)

CTIG:

120299136(SGK1)

TSR:	106555854(SGK1)

PGUT:

117666282(SGK1)

APRI:

131192381

PTEX:

113439608(SGK1)

NSS:	113411194(SGK1)

VKO:

123020394

PMUA:

114594162(SGK1)

PRAF:

128410554(SGK1)

ZVI:	118082082(SGK1)

HCG:	128341611(SGK1)

GJA:	107111430(SGK1)

STOW:

125429283(SGK1)

EMC:	129325950(SGK1)

XLA:	399130(sgk1.L) 444618(sgk1.S)

XTR:	594981(sgk1)

NPR:

108794122

RTEM:

120937337(SGK1)

BBUF:

120998512(SGK1)

BGAR:

122934078(SGK1)

MUO:	115466887(SGK1)

GSH:	117357381(SGK1)

DRE:	324140(sgk1) 559050(sgk2b) 768159(si:ch211-195b13.1)

SRX:	107706345 107723736 107731568 107738591 107756394

SANH:

107671861 107672866 107687822 107701736 107702504

SGH:	107549055 107571333 107578381 107578731 107595908

CCAR:

109055590 109064023 109090243 109105363

CAUA:

113041413 113059621 113065600 113076495 113090778 113116653 113119230

CGIB:

127935928 127944578 127974735 127978839(si:ch211-195b13.1) 128011843 128030649

PTET:

122324014(si:ch211-195b13.1) 122328668(sgk1) 122359845(sgk2b)

LROH:

127154517(sgk1) 127178243(sgk2b) 127181632(si:ch211-195b13.1)

OMC:	131521596(sgk2b) 131526179(si:ch211-195b13.1) 131532422(sgk1)

PPRM:

120463096(sgk1) 120484280(sgk2b) 120485289(si:ch211-195b13.1)

RKG:	130075303(sgk1) 130087966(si:ch211-195b13.1) 130101924(sgk2b)

MAMB:

125243134(sgk2b) 125259684(sgk1) 125274706(si:ch211-195b13.1)

CIDE:

127497706 127501252(si:ch211-195b13.1) 127504569

MASI:

127418670 127420563 127421493 127425664 127452876 127453719

TROS:

130557985(sgk2b) 130567197(si:ch211-195b13.1) 130572051(sgk1)

TDW:	130409041(sgk1) 130432895(sgk2b)

MANU:

129430559(sgk1) 129448054(sgk2b) 129455529(si:ch211-195b13.1)

IPU:	108256136(sgk2b) 108273319(si:ch211-195b13.1) 108276211

IFU:	128599976(sgk2b) 128615815(si:ch211-195b13.1) 128619921(sgk1)

PHYP:

113532886 113543898 113545593(sgk1)

SMEO:

124375412(sgk2b) 124382165(si:ch211-195b13.1) 124398971(sgk1)

TFD:	113658296(sgk2b) 113658895(sgk1) 113662830(si:ch211-195b13.1)

TVC:	132840517(sgk2b) 132842683(si:ch211-195b13.1) 132861963(sgk1)

AMEX:

103022302 103036792

CMAO:

118798768(sgk2b) 118805276(si:ch211-195b13.1) 118822004

EEE:	113571961 113582925 113591530(sgk1)

CHAR:

105892152(si:ch211-195b13.1) 105894676(sgk1) 105897889(sgk2b)

TRU:	101068373 101075473(sgk1) 101079677

TFS:	130515909(sgk1) 130518827(si:ch211-195b13.1) 130533200(sgk2b)

TNG:	GSTEN00030273G001 GSTEN00034014G001

LCO:	104923042 104925665(sgk1) 104937362

NCC:	104955017 104965738(sgk1)

TBEN:

117478021(si:ch211-195b13.1) 117480276(sgk2b) 117492628(sgk1)

CGOB:

115003513(sgk1) 115015956 115021740

PGEO:

117439763(sgk1) 117454924(si:ch211-195b13.1)

GACU:

117553922(sgk2b) 117558085(sgk1) 117559327(si:ch211-195b13.1)

EMAC:

134861693(sgk2b) 134874813(si:ch211-195b13.1) 134876705(sgk1)

ELY:	117263820(si:ch211-195b13.1) 117266180(sgk2b) 117270714(sgk1)

EFO:	125892643(sgk2b) 125896538(sgk1) 125904954(si:ch211-195b13.1)

PLEP:

121945541(sgk2b) 121955154(sgk1) 121957512(si:ch211-195b13.1)

SLUC:

116047187(si:ch211-195b13.1) 116049499(sgk2b) 116066033(sgk1)

ECRA:

117945866(sgk2b) 117956883(si:ch211-195b13.1) 117961438(sgk1)

ESP:	116674520 116702173 116706054(sgk1)

PFLV:

114556999 114567573 114573330(sgk1)

GAT:	120807809(sgk1) 120826054(si:ch211-195b13.1)

PPUG:

119195264(sgk1) 119219595(si:ch211-195b13.1)

AFB:	129097060(si:ch211-195b13.1) 129106837(sgk1) 129109325(sgk2b)

CLUM:

117727084(sgk1) 117738922(si:ch211-195b13.1)

PSWI:

130196062(si:ch211-195b13.1) 130202686(sgk1)

MSAM:

119897652(sgk2b) 119908795(sgk1) 119909745(si:ch211-195b13.1)

SCHU:

122863241(sgk1) 122865010(si:ch211-195b13.1) 122881638(sgk2b)

CUD:	121514278(sgk2b) 121521495 121524097(si:ch211-195b13.1)

ALAT:

119005662(sgk2b) 119012632(sgk1) 119016743(si:ch211-195b13.1)

MZE:	101469250 101475491 101484635(sgk1)

ONL:	100690652 100696638 100698826(sgk1)

OAU:	116309560(sgk1) 116331376(sgk2b) 116333540(si:ch211-195b13.1)

OLA:	101162537 101169880 101173276(sgk1)

OML:	112143993(sgk2b) 112157984(sgk1) 112161612(si:ch211-195b13.1)

CSAI:

133418631(sgk1) 133441004(sgk2b) 133460757 133461363

XMA:	102224351 102230112(sgk1) 102236366

XCO:	114141844 114156054 114158439(sgk1)

XHE:	116716928 116731773 116733841(sgk1)

PRET:

103457665(sgk1) 103473069 103478672

PFOR:

103138668(sgk1) 103140851 103154962

PLAI:

106935479 106945799(sgk1) 106963873

PMEI:

106911072 106926752(sgk1) 106929190

GAF:	122825024(sgk1) 122830830(sgk2b) 122843312(si:ch211-195b13.1)

PPRL:

129351156(sgk1) 129371270(sgk2b) 129375732(si:ch211-195b13.1)

CVG:	107081636 107097378(sgk1) 107102671

CTUL:

119787276(sgk2b) 119788364(sgk1) 119792609(si:ch211-195b13.1)

GMU:	124865951(sgk2b) 124879880(si:ch211-195b13.1) 124882051(sgk1)

NFU:	107372622 107377484(sgk1) 107379638

KMR:	108241115(sgk2b) 108242480(sgk1) 108251730(si:ch211-195b13.1)

ALIM:

106522582 106524886(sgk1) 106529406

NWH:	119410064(sgk2b) 119418529(sgk1) 119425651(si:ch211-195b13.1)

AOCE:

111562467(sgk1) 111562595 111563485

MCEP:

124998970(sgk1) 125016755(sgk2b) 125019992

CSEM:

103388196 103393944 103398704(sgk1)

POV:	109632568(sgk1) 109633033 109642399

SSEN:

122775081(sgk2b) 122784132(sgk1) 122786220(si:ch211-195b13.1)

HHIP:

117757978(sgk1) 117770584(si:ch211-195b13.1) 117776559(sgk2b)

HSP:	118099595(sgk1) 118113768(sgk2b) 118125086(si:ch211-195b13.1)

SMAU:

118290214(sgk1) 118292146(si:ch211-195b13.1) 118311122(sgk2b)

LCF:	108889640 108896848 108899469(si:ch211-195b13.1)

SDU:	111230498 111235898(sgk1) 111237181

SLAL:

111650865 111651204(sgk1) 111655039

XGL:	120784699(sgk2b) 120786385(si:ch211-195b13.1) 120789094(sgk1)

HCQ:	109513527 109529014 109531787(sgk1)

SSCV:

125975406 125987351(si:ch211-195b13.1) 125990418

SBIA:

133490834(si:ch211-195b13.1) 133496596 133501198(sgk2b)

PEE:	133395970(si:ch211-195b13.1) 133416757(sgk1)

PTAO:

133468689(sgk1) 133470766(si:ch211-195b13.1)

BPEC:

110153756(sgk1) 110162628 110171528

MALB:

109956374(sgk1) 109958789 109964129

BSPL:

114842425(sgk2b) 114849464(sgk1) 114865228(si:ch211-195b13.1)

SJO:	128365918(sgk2b) 128373764(si:ch211-195b13.1) 128376717(sgk1)

SASA:

106570356(SGK1) 106589037 106591125(SGK1) 106592818 106593510 106593595 106594083

STRU:

115174101 115175621 115187313

OTW:	112229574 112237373(sgk1) 112264320 121846459

OMY:	110488097 110496705 110522663(sgk1) 110529254

OGO:	123990459 123995746(sgk1) 124012717 124028732 124043318(si:ch211-195b13.1)

ONE:	115115172 115131388

OKI:	109903454 109907143 116356201(sgk1)

OKE:	118371394 118373881 118382187 118397995 127931536(sgk1)

SALP:

111955269 111955417

SNH:	120022563 120027205 120030978 120048857

CCLU:

121542333 121542422 121548479 121555444 121571875 121586798

ELS:	105012349 105018004(sgk1) 105018926

SFM:	108921050(sgk1) 108931874 108937441

PKI:	111839665 111841179(sgk1) 111844555

AANG:

118219923(sgk2b) 118229771(sgk1) 118234227(si:ch211-195b13.1)

LOC:	102691934 102695315(sgk1)

PSPA:

121308260(si:ch211-195b13.1) 121315862 121316985

ARUT:

117403374 117411073 117412906 117413751

PSEX:

120517426(si:ch211-195b13.1) 120525443(sgk1)

LCM:	102356269 102364173

CMK:	103179483(si:ch211-195b13.1) 103185144(s-sgk1)

RTP:	109926745 109934538(sgk1)

CPLA:

122547699(sgk1) 122563524(si:ch211-195b13.1)

HOC:	132829853(si:ch211-195b13.1) 132832089(sgk1)

LERI:

129697428(sgk1) 129709895(si:ch211-195b13.1)

PMRN:

116945231 116951040

LRJ:	133347440 133353336

BROR:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

ESN:

MNZ:

HAZT:

PPOI:

TUT:

CEL:	CELE_W10G6.2(sgk-1)

CBR:	CBG_16386(Cbr-sgk-1)

CRQ:	GCK72_023166

NAI:	NECAME_00087 NECAME_00088

ADF:

107329566

PSTR:

Pst134EA_011875

MLR:	MELLADRAFT_90441

TET:	TTHERM_001504069 TTHERM_01388160

PTM:	GSPATT00001504001 GSPATT00002191001 GSPATT00003883001 GSPATT00015946001

SPAR:

SPRG_09607

TVA:	TVAG_2v0770340 TVAG_2v1049140

» show all

Reference

PMID:12649599

Authors

Verrey F, Loffing J, Zecevic M, Heitzmann D, Staub O

Title

SGK1: aldosterone-induced relay of Na+ transport regulation in distal kidney nephron cells.

Journal

Cell Physiol Biochem 13:21-8 (2003)
DOI:10.1159/000070246

Reference

PMID:9114008

Authors

Waldegger S, Barth P, Raber G, Lang F

Title

Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.

Journal

Proc Natl Acad Sci U S A 94:4440-5 (1997)
DOI:10.1073/pnas.94.9.4440

Sequence

[hsa:6446]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (12)   
   KEGG PATHWAY (12)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1424)   
   KEGG GENES (690)   
   KEGG MGENES (180)   
   RefGene (539)   
   OC (15)   
Literature (2)   
   PubMed (2)   
All databases (1442)   

Download RDF

DBGET integrated database retrieval system