KEGG ORTHOLOGY: K13855

ORTHOLOGY: K13855

Entry

K13855                      KO

Symbol

SLC4A2, AE2

Name

solute carrier family 4 (anion exchanger), member 2

Pathway

map04970

Salivary secretion

map04971

Gastric acid secretion

map04972

Pancreatic secretion

map04976

Bile secretion

Disease

H00436

Osteopetrosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09154 Digestive system
   04970 Salivary secretion
    K13855  SLC4A2, AE2; solute carrier family 4 (anion exchanger), member 2
   04971 Gastric acid secretion
    K13855  SLC4A2, AE2; solute carrier family 4 (anion exchanger), member 2
   04972 Pancreatic secretion
    K13855  SLC4A2, AE2; solute carrier family 4 (anion exchanger), member 2
   04976 Bile secretion
    K13855  SLC4A2, AE2; solute carrier family 4 (anion exchanger), member 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K13855  SLC4A2, AE2; solute carrier family 4 (anion exchanger), member 2
Transporters [BR:ko02000]
Solute carrier family (SLC)
  SLC4: Bicarbonate transporter
   K13855  SLC4A2, AE2; solute carrier family 4 (anion exchanger), member 2

Other DBs

GO:

0005452

TC:	2.A.31.1.2

Genes

HSA:	6522(SLC4A2)

PTR:	463890(SLC4A2)

PPS:	100976776(SLC4A2)

GGO:	101128372(SLC4A2)

PON:	100172030(SLC4A2)

NLE:	100599599(SLC4A2)

HMH:	116814537(SLC4A2)

MCC:	713966(SLC4A2)

MCF:	102117461(SLC4A2)

MTHB:

126951569

MNI:	105474906(SLC4A2)

CSAB:

103227241(SLC4A2)

CATY:

105584740(SLC4A2)

PANU:

100997428(SLC4A2)

TGE:	112620080(SLC4A2)

MLEU:

105542704(SLC4A2)

RRO:	104675399(SLC4A2)

RBB:	108532528(SLC4A2)

TFN:	117072834(SLC4A2)

PTEH:

111551517(SLC4A2)

CANG:

105511335(SLC4A2)

CJC:	100410591(SLC4A2)

SBQ:	101035155(SLC4A2)

CIMI:

108297662(SLC4A2)

CSYR:

103275286(SLC4A2)

MMUR:

105883167(SLC4A2)

LCAT:

123647512(SLC4A2)

PCOQ:

105824604(SLC4A2)

OGA:	100954313(SLC4A2)

MMU:	20535(Slc4a2)

MCAL:

110293883(Slc4a2)

MPAH:

110315987(Slc4a2)

RNO:	24780(Slc4a2)

MCOC:

116097547(Slc4a2)

ANU:	117721023(Slc4a2)

MUN:	110562560(Slc4a2)

CGE:	100762427(Slc4a2)

MAUA:

101836419(Slc4a2)

PROB:

127235667(Slc4a2)

PLEU:

114700080(Slc4a2)

MORG:

121439962(Slc4a2)

MFOT:

126489452

AAMP:

119806639(Slc4a2)

NGI:	103745308(Slc4a2)

HGL:	101708028(Slc4a2)

CPOC:

100135618(Slc4a2)

CCAN:

109694451(Slc4a2)

DORD:

105993869(Slc4a2)

DSP:	122105880(Slc4a2)

PLOP:

125347317(Slc4a2)

NCAR:

124991203

MMMA:

107148933(Slc4a2)

OCU:	100009159(SLC4A2)

OPI:	101519388(SLC4A2)

TUP:	102497672(SLC4A2)

GVR:	103585102(SLC4A2)

CFA:	475538(SLC4A2)

CLUD:

112663722(SLC4A2)

VVP:	112916213(SLC4A2)

VLG:	121489293(SLC4A2)

NPO:	129516032(SLC4A2)

AML:	100483077(SLC4A2)

UMR:	103660994(SLC4A2)

UAH:	113241479(SLC4A2)

UAR:	123788774(SLC4A2)

ELK:

111154322

LLV:

125081325

MPUF:

101678519(SLC4A2)

MNP:	132015565(SLC4A2)

MLK:	131829940(SLC4A2)

NVS:	122897907 122905201(SLC4A2)

ORO:	101383982(SLC4A2)

EJU:	114198000(SLC4A2)

ZCA:	113911330(SLC4A2)

MLX:	118026802(SLC4A2)

NSU:	110582955(SLC4A2)

LWW:	102733341(SLC4A2)

FCA:	101097632(SLC4A2)

PYU:	121022885(SLC4A2)

PCOO:

112866506(SLC4A2)

PBG:	122488532(SLC4A2)

PVIV:

125159279(SLC4A2)

LRUF:

124523524

PTG:	102956966(SLC4A2)

PPAD:

109252375(SLC4A2)

PUC:

125930307

AJU:

106969575

HHV:	120230908(SLC4A2)

BTA:	404084(SLC4A2)

BOM:	102266702(SLC4A2)

BIU:	109557799(SLC4A2)

BBUB:

102416209(SLC4A2)

BBIS:

105001188(SLC4A2)

CHX:	102186459 106502068(SLC4A2)

OAS:	101113325(SLC4A2)

BTAX:

128047049(SLC4A2)

ODA:	120877874(SLC4A2)

CCAD:

122438870(SLC4A2)

MBEZ:

129552785(SLC4A2)

SSC:	397203(SLC4A2)

CFR:	102523025(SLC4A2)

CBAI:

105067014(SLC4A2)

CDK:	105105652(SLC4A2)

VPC:	102529171(SLC4A2)

BACU:

103018324(SLC4A2)

BMUS:

118901141(SLC4A2)

LVE:	103085321(SLC4A2)

OOR:	101282015(SLC4A2)

DLE:	111176796(SLC4A2)

PCAD:

102987296(SLC4A2)

PSIU:

116759263(SLC4A2)

NASI:

112405890(SLC4A2)

ECB:	791243(SLC4A2)

EPZ:	103564177(SLC4A2)

EAI:	106823325(SLC4A2)

MYB:	102254052(SLC4A2)

MYD:	102756219(SLC4A2)

MMYO:

118679403(SLC4A2)

MLF:	102432248(SLC4A2)

PKL:	118704762(SLC4A2)

EFUS:

103301757(SLC4A2)

MNA:	107524905(SLC4A2)

DRO:	112308281(SLC4A2)

SHON:

118975547(SLC4A2)

AJM:	119039238(SLC4A2)

PDIC:

114507579(SLC4A2)

PHAS:

123817937(SLC4A2)

MMF:	118619782(SLC4A2)

PPAM:

129086761(SLC4A2)

HAI:	109389643(SLC4A2)

RFQ:	117018036(SLC4A2)

PALE:

102878766(SLC4A2)

PGIG:

120601498(SLC4A2)

PVP:	105303771(SLC4A2)

RAY:	107520293(SLC4A2)

MJV:	108391843(SLC4A2)

TOD:	119248873(SLC4A2)

SARA:

101548081(SLC4A2)

SETR:

126014299(SLC4A2)

LAV:	100672425(SLC4A2)

TMU:

101358128

ETF:	101661174(SLC4A2)

DNM:	101447961(SLC4A2)

MDO:	100619209(SLC4A2)

GAS:	123250550(SLC4A2)

SHR:	100916401(SLC4A2)

AFZ:

127538820

PCW:	110201933(SLC4A2)

OAA:	103169934(SLC4A2)

GGA:	395809(SLC4A2)

PCOC:

116242825(SLC4A2)

MGP:	104915906(SLC4A2)

CJO:	107308707(SLC4A2)

TPAI:

128087174(SLC4A2)

LMUT:

125696253(SLC4A2)

NMEL:

110390739(SLC4A2)

APLA:

119715726(SLC4A2)

ACYG:

106029587(SLC4A2)

CATA:

118251733(SLC4A2)

AFUL:

116486503(SLC4A2)

TGU:	100224615(SLC4A2)

LSR:	110475104(SLC4A2)

SCAN:

103824486(SLC4A2)

PMOA:

120510568(SLC4A2)

OTC:	121334864(SLC4A2)

PRUF:

121356979(SLC4A2)

GFR:	102034427(SLC4A2)

FAB:	101813800(SLC4A2)

OMA:	130249314(SLC4A2)

PHI:	102111666(SLC4A2)

PMAJ:

107200646(SLC4A2)

CCAE:

111925499(SLC4A2)

CCW:	120409677(SLC4A2)

ETL:	114067996(SLC4A2)

SVG:	106861807(SLC4A2)

MMEA:

130574586(SLC4A2)

HRT:	120757797(SLC4A2)

FPG:	101912308(SLC4A2)

FCH:	102055270(SLC4A2)

CLV:

102090741

NNI:	104011534(SLC4A2)

ACUN:

113477502(SLC4A2)

TALA:

116959677(SLC4A2)

AFOR:

103897134(SLC4A2)

ACHC:

115339073(SLC4A2)

HLE:	104828473(SLC4A2)

AGEN:

126037688

NNT:	104410045(SLC4A2)

SHAB:

115610705(SLC4A2)

DPUB:

104298512(SLC4A2)

RTD:	128904775(SLC4A2)

CUCA:

104061720(SLC4A2)

AAM:

106491562

AROW:

112976167(SLC4A2)

NPD:

112956376

DNE:	112994029(SLC4A2)

ASN:	102382201(SLC4A2)

AMJ:	102568314(SLC4A2)

CPOO:

109307764(SLC4A2)

CMY:	102940195(SLC4A2)

CCAY:

125632954(SLC4A2)

DCC:	119850587(SLC4A2)

CPIC:

101931188(SLC4A2)

MRV:	120397571(SLC4A2)

ACS:	100559030(slc4a2)

ASAO:

132779094(SLC4A2)

PVT:	110082557(SLC4A2)

SUND:

121933021(SLC4A2)

PBI:

103062025

PMUR:

107297800(SLC4A2)

CTIG:

120318308(SLC4A2)

TSR:	106550750(SLC4A2)

PGUT:

117669212(SLC4A2)

APRI:

131196504(SLC4A2)

NSS:

113430402

VKO:	123019564(SLC4A2)

PMUA:

114607266(SLC4A2)

PRAF:

128423986(SLC4A2)

ZVI:	118092262(SLC4A2)

HCG:	128329344(SLC4A2)

GJA:	107108221(SLC4A2)

STOW:

125440675(SLC4A2)

EMC:	129337717(SLC4A2)

XLA:	108704633 108719786(slc4a2.S)

XTR:	101735130(slc4a2)

NPR:

108803803

RTEM:

120941772

BBUF:

121002666(SLC4A2)

MUO:	115461852(SLC4A2)

GSH:	117354778(SLC4A2)

DRE:	566075(slc4a2a) 570716(slc4a2b)

SRX:	107709836 107718031 107731790 107732091

SANH:

107657435 107677145 107690982 107700975

SGH:	107555345 107556941 107599717 107599902

CCAR:

109051276 109096629 109102605

CAUA:

113042610 113045692 113092647 113118420 113118437

CGIB:

127946555 127950707 128013461 128030455

PTET:

122329998(slc4a2b) 122357177(slc4a2a)

LROH:

127155596(slc4a2b) 127178583(slc4a2a)

OMC:	131523550(slc4a2a) 131533484(slc4a2b)

PPRM:

120482154(slc4a2a) 120488180(slc4a2b)

RKG:	130084109(slc4a2b) 130101656(slc4a2a)

MAMB:

125250174(slc4a2a) 125257802(slc4a2b)

CIDE:

127506315 127525094

MASI:

127431798 127434635 127441419 127442119

TROS:

130547022(slc4a2b) 130554603(slc4a2a)

TDW:	130413022(slc4a2b) 130417674(slc4a2a)

MANU:

129426538(slc4a2b) 129442062(slc4a2a)

IPU:	108256300 108267675(slc4a2a)

IFU:	128599982 128609554(slc4a2a)

PHYP:

113540139 113541204

SMEO:

124375303 124387126(slc4a2a)

TFD:	113657330(slc4a2a) 113660682

TVC:	132840563 132848377(slc4a2a)

AMEX:

103040576 103041005

CMAO:

118800433(slc4a2b) 118825673(slc4a2a)

EEE:	113588528 113590306

CHAR:

105891323(slc4a2a) 105894782(slc4a2b)

TRU:	101066802(slc4a2)

TFS:	130513653(slc4a2b)

TNG:	GSTEN00007060G001 GSTEN00007179G001 GSTEN00031825G001

LCO:

104929605

NCC:	104954587(slc4a2)

TBEN:

117473949(slc4a1b) 117479785 117495886(slc4a2b)

CGOB:

115025339(slc4a2)

PGEO:

117441679 117465010(slc4a1b) 117465527(slc4a2b)

GACU:

117539388 117544714(slc4a2b) 117544988(slc4a1b)

EMAC:

134866335(slc4a2a) 134871146(slc4a1b) 134884049(slc4a2b)

ELY:	117264663(slc4a2b) 117272548(slc4a2a)

EFO:	125881609(slc4a2b) 125902719(slc4a2a)

PLEP:

121960133 121960431(slc4a2b)

SLUC:

116038082 116040391 116045293(slc4a2b)

ECRA:

117937955(slc4a2b)

ESP:	116672426(slc4a2)

PFLV:

114548936(slc4a2)

GAT:	120811621(slc4a2b) 120816553(slc4a2a)

PPUG:

119198528(slc4a2b) 119209124(slc4a2a)

AFB:	129110985(slc4a2b) 129116148(slc4a2a)

CLUM:

117746221(slc4a2a) 117749353(slc4a2b)

PSWI:

130190904 130205914(slc4a2b)

MSAM:

119902781 119902783 119911616(slc4a2b)

SCHU:

122866343(slc4a2b) 122886831(slc4a2a)

CUD:	121520287(slc4a2a) 121527116(slc4a2b)

ALAT:

119008667(slc4a2b) 119011570(slc4a2a)

MZE:	101468195 101473216 101487268

ONL:	100691172 100692224 100706255(slc4a2)

OAU:	116321298(slc4a2a) 116329606(slc4a1b) 116335951(slc4a2b)

OLA:	101159706 101165429 101167237

OML:	112144254(slc4a2a) 112151272(slc4a2b) 112153876(slc4a1b)

CSAI:

133423464(slc4a2b) 133452958(slc4a2a)

XMA:	102217004(slc4a2) 102223244 102235868

XCO:	114136662(slc4a2) 114146142 114151747

XHE:	116711627 116721442 116726707

PRET:

103456829(slc4a2) 103460481 103481347

PFOR:

103129538 103129935(slc4a2) 103149772

PLAI:

106937333 106937491(slc4a2) 106941977

PMEI:

106907559 106929950(slc4a2) 106933983

GAF:	122823256(slc4a1b) 122824213(slc4a2b) 122841607(slc4a2a)

PPRL:

129352128(slc4a2b) 129356706 129377827(slc4a1b)

CVG:	107085068 107104163(slc4a2) 107104357

CTUL:

119776807(slc4a2a) 119791679(slc4a2b) 119792278(slc4a1b)

GMU:	124857886(slc4a2b) 124869299(slc4a2a) 124874858(slc4a1b)

NFU:	107382551(slc4a2) 107383634

KMR:	108228685 108230478(slc4a2b)

ALIM:

106517473(slc4a2) 106521379 106534223

NWH:	119414343(slc4a2a) 119423621(slc4a1b) 119426336(slc4a2b)

AOCE:

111577603 111578460(slc4a2)

MCEP:

125010374(slc4a2a) 125024440(slc4a2b)

CSEM:

103377405(slc4a2) 103398755

POV:	109642528 109644457

SSEN:

122762085 122769654 122771304(slc4a2b) 122782244

HHIP:

117754117(slc4a2b) 117777827(slc4a2a)

HSP:	118098867(slc4a2b) 118117447(slc4a2a)

SMAU:

118287178(slc4a2b) 118311220(slc4a2a)

LCF:	108884931(slc4a2a) 108899977(slc4a2b)

SDU:	111237338 111237919

SLAL:

111656581 111659179

XGL:	120789588(slc4a2b) 120800229(slc4a2a)

HCQ:

109529967

SSCV:

125986057

SBIA:

133492531(slc4a2b) 133495562(slc4a1b)

PEE:	133396218(slc4a2b) 133418141(slc4a1b)

PTAO:

133469586(slc4a1b) 133470537(slc4a2b)

BPEC:

110170095(slc4a2)

MALB:

109971491(slc4a2) 109974845

BSPL:

114844235(slc4a2a) 114853337(slc4a2b)

SJO:	128369846(slc4a2a) 128382696(slc4a2b)

SASA:

106568665 106578671 106590174 106597086 106606856

STRU:

115154822 115156571 115170159 115195749

OTW:	112215689 112227245 112227935 112260153

OMY:	110489906 110509101 110529974 110535651

OGO:	123991061 124009532 124039757 124042153(slc4a2a)

ONE:	115103355 115105186 115114089 115130341

OKI:	109871953 109875279 109899456 109908810

OKE:	118361477 118373166 118394384 118401645

SALP:

111953440 111956791 111973200 111979765

SNH:	120019936 120028132 120051131 120056183

CCLU:

121534918 121550044 121569911 121580595

ELS:	105019375 105025010

SFM:	108937693(slc4a2) 108942360

PKI:	111837195(slc4a2) 111841574

AANG:

118224825(slc4a2b) 118233599

LOC:	102694554(slc4a2)

PSPA:

121313454 121314397

ARUT:

117394343(slc4a2b) 117400207

PSEX:

120529431(slc4a2a)

LCM:

102345863

CMK:	103183827 103190096

CPLA:

122539953 122548789

HOC:	132815145 132830817

LERI:

129696099 129710365

PMRN:

116940906 116946982 116954669

LRJ:	133344671 133345143

BFO:	118405237 118405285 118406013

BBEL:

CIN:

LPIC:

SKO:

DGR:

CCAT:

BOD:

AOQ:

TDA:	119671723 119671725 119672170

SCAC:

GFS:

CLON:

HIS:

AGA:

ACOZ:

AAG:

CPII:

CNS:

AME:

ACER:

ALAB:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:	114876542 114876553

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

AGRG:

ATD:

AGB:

LDC:

NVL:

PPYR:

OTU:

MSEX:

DPL:	KGM_200084

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

SLIU:

OFU:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM582450

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:	110858343 110858507 110862467 110862677

PVM:

PJA:

PCHN:

PMOO:

PCLA:

123746716 123746721 123746730

CQD:	128702372 128702373

PTRU:

123503376

ESN:

127002923

MNZ:	135209245 135209247

HAZT:

108664921 108664925 108664930

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

CSCU:

PTEP:

ABRU:

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PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111122801 111125577

CANU:

OED:

MYI:

PMAX:

MMER:

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OBI:

OSN:

ATEN:

DGT:

HSY:

TAD:	TRIADDRAFT_54168

AQU:

100633898

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Reference

PMID:17890222

Authors

Gonzalez-Begne M, Nakamoto T, Nguyen HV, Stewart AK, Alper SL, Melvin JE

Title

Enhanced formation of a HCO3- transport metabolon in exocrine cells of Nhe1-/- mice.

Journal

J Biol Chem 282:35125-32 (2007)
DOI:10.1074/jbc.M707266200

Sequence

[mmu:20535]

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