KEGG ORTHOLOGY: K15335

ORTHOLOGY: K15335

Entry

K15335                      KO

Symbol

NSUN2, TRM4

Name

tRNA (cytosine34-C5)-methyltransferase [EC:2.1.1.203]

Disease

H00768

Autosomal recessive intellectual developmental disorder

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis
    K15335  NSUN2, TRM4; tRNA (cytosine34-C5)-methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.203  tRNA (cytosine34-C5)-methyltransferase
     K15335  NSUN2, TRM4; tRNA (cytosine34-C5)-methyltransferase
Transfer RNA biogenesis [BR:ko03016]
Eukaryotic type
  tRNA modification factors
   Methyltransferases
    K15335  NSUN2, TRM4; tRNA (cytosine34-C5)-methyltransferase

Other DBs

GO:

0016428

Genes

HSA:	54888(NSUN2)

PTR:	461711(NSUN2)

PPS:	100978191(NSUN2)

GGO:	101144331(NSUN2)

PON:	100443369(NSUN2)

NLE:	100606775(NSUN2)

HMH:	116456578(NSUN2)

MCC:	694987(NSUN2)

MCF:	102125748(NSUN2)

MTHB:

126956056

MNI:	105489466(NSUN2)

CSAB:

103214972(NSUN2)

CATY:

105585975(NSUN2)

PANU:

101004079(NSUN2)

TGE:	112625947(NSUN2)

MLEU:

105531491(NSUN2)

RRO:	104672269(NSUN2)

RBB:	108522883(NSUN2)

TFN:	117064732(NSUN2)

PTEH:

111546740(NSUN2)

CANG:

105510958(NSUN2)

CJC:	100391414(NSUN2)

SBQ:	101044631(NSUN2)

CIMI:

108297968 108316245(NSUN2)

CSYR:

103257158(NSUN2)

MMUR:

105859938(NSUN2)

LCAT:

123648093(NSUN2)

PCOQ:

105816440(NSUN2)

OGA:	100943399(NSUN2)

MMU:	28114(Nsun2)

MCAL:

110307569(Nsun2)

MPAH:

110328757(Nsun2)

RNO:	361191(Nsun2)

MCOC:

116083163(Nsun2)

ANU:	117723946(Nsun2)

MUN:	110550387(Nsun2)

CGE:	100760286(Nsun2)

MAUA:

101835211(Nsun2)

PROB:

127220714(Nsun2) 127225602

PLEU:

114696117(Nsun2)

MORG:

121433711(Nsun2)

MFOT:

126503184

AAMP:

119809134(Nsun2)

NGI:	103735347(Nsun2)

HGL:	101714363(Nsun2)

CPOC:

100713426(Nsun2)

CCAN:

109693822(Nsun2)

DORD:

105983800(Nsun2)

DSP:	122121006(Nsun2)

PLOP:

125367664(Nsun2)

NCAR:

124987313

MMMA:

107146312(Nsun2)

OCU:

100350862

OPI:	101534510(NSUN2)

TUP:	102500776(NSUN2)

GVR:	103605708(NSUN2)

CFA:	478625(NSUN2)

CLUD:

112662863(NSUN2)

VVP:	112934270(NSUN2)

VLG:	121477364(NSUN2)

NPO:	129498495(NSUN2)

AML:	100472688(NSUN2)

UMR:	103679252(NSUN2)

UAH:	113260708(NSUN2)

UAR:	123791261(NSUN2)

ELK:

111153408

LLV:

125101325

MPUF:

101675788(NSUN2)

MNP:	132028197(NSUN2)

MLK:	131831565(NSUN2)

NVS:	122896089(NSUN2)

ORO:	101363016(NSUN2)

EJU:	114223664(NSUN2)

ZCA:	113928775(NSUN2)

MLX:	118006298(NSUN2)

NSU:	110591572(NSUN2)

LWW:	102730956(NSUN2)

FCA:	101099103(NSUN2)

PYU:	121042383(NSUN2)

PCOO:

112860203(NSUN2)

PBG:	122495564(NSUN2)

PVIV:

125162449(NSUN2)

LRUF:

124522644

PTG:	102952778(NSUN2)

PPAD:

109267837(NSUN2)

PUC:

125934729

AJU:

106971247

HHV:	120224479(NSUN2)

BTA:	516044(NSUN2)

BOM:	102272859(NSUN2)

BIU:	109574872(NSUN2)

BBUB:

102396321(NSUN2)

BBIS:

105001030(NSUN2)

CHX:	102180428(NSUN2)

OAS:	101106968(NSUN2)

BTAX:

128065938(NSUN2)

ODA:	120879380(NSUN2)

CCAD:

122454565(NSUN2)

MBEZ:

129553382(NSUN2)

SSC:	100518405(NSUN2)

CFR:	102513890(NSUN2)

CBAI:

105081254(NSUN2)

CDK:	105094036(NSUN2)

VPC:	102541845(NSUN2)

BACU:

102998396(NSUN2)

BMUS:

118892115(NSUN2)

LVE:	103071447(NSUN2)

OOR:	101275527(NSUN2)

DLE:	111178553(NSUN2)

PCAD:

102980393 102980553(NSUN2)

PSIU:

116751298(NSUN2)

NASI:

112404519(NSUN2)

ECB:	100071458(NSUN2)

EPZ:	103550089(NSUN2)

EAI:	106822986(NSUN2)

MYB:	102260943(NSUN2)

MYD:	102762450(NSUN2)

MMYO:

118655772(NSUN2)

MLF:	102428418(NSUN2)

PKL:	118702873(NSUN2)

EFUS:

103305303(NSUN2)

MNA:	107540527(NSUN2)

DRO:	112320946(NSUN2)

SHON:

118998671(NSUN2)

AJM:	119056049(NSUN2)

PDIC:

114502627(NSUN2)

PHAS:

123824611(NSUN2)

MMF:	118642617(NSUN2)

PPAM:

129074545(NSUN2)

HAI:	109376003(NSUN2)

RFQ:	117025146(NSUN2)

PALE:

102893514(NSUN2)

PGIG:

120586290(NSUN2)

RAY:	107518892(NSUN2)

MJV:	108401277(NSUN2) 118973607

TOD:	119260647(NSUN2)

SARA:

101558312(NSUN2)

SETR:

126000775(NSUN2)

LAV:	100673463(NSUN2)

TMU:

101347263

ETF:	101638420(NSUN2)

DNM:	101422598(NSUN2)

MDO:	100018054(NSUN2)

GAS:	123231585(NSUN2)

SHR:	100920695(NSUN2)

AFZ:

127543611

PCW:	110220444(NSUN2)

OAA:	100092642(NSUN2)

GGA:	420938(NSUN2)

PCOC:

116226341(NSUN2)

MGP:	100541040(NSUN2)

CJO:	107309500(NSUN2)

TPAI:

128090834(NSUN2)

LMUT:

125691410(NSUN2)

NMEL:

110393801(NSUN2)

APLA:

101792480(NSUN2)

ACYG:

106036579(NSUN2)

CATA:

118250970(NSUN2)

AFUL:

116485611(NSUN2)

TGU:	100223811(NSUN2)

LSR:	110479508(NSUN2)

SCAN:

103815426(NSUN2)

PMOA:

120504882(NSUN2)

OTC:	121339699(NSUN2)

PRUF:

121358104(NSUN2)

GFR:	102039201(NSUN2)

FAB:	101814592(NSUN2)

OMA:	130249720(NSUN2)

PHI:	102110302(NSUN2)

PMAJ:

107200160(NSUN2)

CCAE:

111925368(NSUN2)

CCW:	104685923(NSUN2)

CBRC:

103618792(NSUN2)

ETL:	114055138(NSUN2)

ZAB:	102072178(NSUN2)

ACHL:

103811350

SVG:	106850749(NSUN2)

MMEA:

130576268(NSUN2)

HRT:	120759483(NSUN2)

FPG:	101910766(NSUN2)

FCH:	102049337(NSUN2)

CLV:	102086935(NSUN2)

EGZ:	104126189(NSUN2)

NNI:	104018890(NSUN2)

PCRI:

104024195(NSUN2)

PLET:

104619143(NSUN2)

EHS:	104503015(NSUN2)

PCAO:

104050978(NSUN2)

ACUN:

113476068(NSUN2)

TALA:

104363767 122153950(NSUN2)

PADL:

103915156(NSUN2)

AFOR:

103898443(NSUN2)

ACHC:

115353173(NSUN2)

HALD:

104310539(NSUN2)

HLE:	104834252(NSUN2)

AGEN:

126048733

GCL:

127013251

CCRI:

104154902(NSUN2)

CSTI:

104549800(NSUN2)

CMAC:

104487436(NSUN2)

MUI:	104533608(NSUN2)

BREG:

104629521(NSUN2)

FGA:	104069505(NSUN2)

GSTE:

104250713(NSUN2)

LDI:	104340110(NSUN2)

MNB:	103777759(NSUN2)

OHA:	104336669(NSUN2)

NNT:	104412118(NSUN2)

SHAB:

115617765(NSUN2)

DPUB:

104305685(NSUN2)

PGUU:

104470071(NSUN2)

ACAR:

104530432(NSUN2)

CPEA:

104398278(NSUN2)

AVIT:

104278439(NSUN2)

CVF:	104285352(NSUN2)

RTD:	128905917(NSUN2)

CUCA:

104067552(NSUN2)

TEO:	104382887(NSUN2)

BRHI:

104500725(NSUN2)

AAM:	106492334(NSUN2)

AROW:

112978440(NSUN2)

NPD:	112955277(NSUN2)

TGT:	104574424(NSUN2)

DNE:	112987300(NSUN2)

SCAM:

104137840(NSUN2)

ASN:	102380740(NSUN2)

AMJ:	102565534(NSUN2)

CPOO:

109314232(NSUN2)

GGN:	109300285(NSUN2)

PSS:	102452913(NSUN2)

CMY:	102940691(NSUN2)

CCAY:

125631986(NSUN2)

DCC:	119852207(NSUN2)

CPIC:

101953716(NSUN2)

TST:	117872752(NSUN2)

CABI:

116833514(NSUN2)

MRV:	120397088(NSUN2)

ACS:	100555854(nsun2)

ASAO:

132774197(NSUN2)

PVT:	110080022(NSUN2)

SUND:

121928756(NSUN2)

PBI:	103065582(NSUN2)

PMUR:

107289984(NSUN2)

CTIG:

120301723(NSUN2)

TSR:	106554497(NSUN2)

PGUT:

117662390(NSUN2)

APRI:

131196185(NSUN2)

PTEX:

113436539(NSUN2)

NSS:	113415228(NSUN2)

VKO:	123029693(NSUN2)

PMUA:

114601062(NSUN2)

PRAF:

128417967(NSUN2)

ZVI:

118079331

HCG:	128322434(NSUN2)

GJA:	107123742(NSUN2)

STOW:

125443361(NSUN2)

EMC:	129333243(NSUN2)

XLA:	414460(nsun2.S)

XTR:	548716(nsun2)

NPR:	108795130(NSUN2)

RTEM:

120940577(NSUN2)

BBUF:

121001422(NSUN2)

BGAR:

122938593(NSUN2)

MUO:

115474227

GSH:	117353602(NSUN2)

DRE:	325292(nsun2)

SRX:	107711338 107754797(nsun2)

SANH:

107691499 107694333

SGH:	107584336(nsun2) 107595605

CCAR:

109110846

CAUA:

113090786 113119539(nsun2)

CGIB:

127935711 127979536

PTET:

122324061(nsun2)

LROH:

127181326(nsun2)

OMC:	131526046(nsun2)

PPRM:

120485280(nsun2)

RKG:

130087909

MAMB:

125274769(nsun2)

CIDE:

127500628

MASI:

127421446 127425461

TROS:

130566635(nsun2)

TDW:	130415695(nsun2)

MANU:

129454471(nsun2)

IPU:

108273268

IFU:	128615883(nsun2)

PHYP:

113543748(nsun2)

SMEO:

124382182(nsun2)

TFD:	113634735(nsun2)

TVC:	132842772(nsun2)

AMEX:

103038375(nsun2)

CMAO:

118805422(nsun2)

EEE:	113590336(nsun2)

CHAR:

105892091(nsun2)

TRU:	101074500(nsun2)

TFS:	130517977(nsun2)

TNG:	GSTEN00017585G001

LCO:	104922766(nsun2)

NCC:	104961211(nsun2)

TBEN:

117478191(nsun2)

CGOB:

115015529(nsun2)

PGEO:

117455359(nsun2)

GACU:

117562969(nsun2)

EMAC:

134875062(nsun2)

ELY:	117263989(nsun2)

EFO:	125904546(nsun2)

PLEP:

121957613(nsun2)

SLUC:

116041213(nsun2)

ECRA:

117956552(nsun2)

ESP:	116701413(nsun2)

PFLV:

114567716(nsun2)

GAT:	120826439(nsun2)

PPUG:

119218946(nsun2)

AFB:	129097140(nsun2)

CLUM:

117739257(nsun2)

PSWI:

130192046(nsun2)

MSAM:

119884341 119907446

SCHU:

122863986(nsun2)

CUD:	121523977(nsun2)

ALAT:

119016493(nsun2)

MZE:	101476280(nsun2)

ONL:	100706204(nsun2)

OAU:	116313458(nsun2)

OLA:	101158463(nsun2)

OML:	112136254(nsun2)

CSAI:

133460483(nsun2)

XMA:	102222973(nsun2)

XCO:	114156397(nsun2)

XHE:	116730810(nsun2)

PRET:

103472067(nsun2)

PFOR:

103146022(nsun2)

PLAI:

106961931(nsun2)

PMEI:

106932855(nsun2)

GAF:	122844088(nsun2)

PPRL:

129376401(nsun2)

CVG:	107091822(nsun2)

CTUL:

119792950(nsun2)

GMU:	124879913(nsun2)

NFU:	107383181(nsun2)

KMR:	108238711(nsun2)

ALIM:

106532693(nsun2)

NWH:	119425844(nsun2)

AOCE:

111569837(nsun2)

MCEP:

125019952(nsun2)

CSEM:

103394106(nsun2)

POV:	109631855(nsun2)

SSEN:

122786350(nsun2)

HHIP:

117770488(nsun2)

HSP:	118125011(nsun2)

SMAU:

118310977(nsun2)

LCF:

108900394

SDU:	111233168(nsun2)

SLAL:

111671483(nsun2)

XGL:	120786909(nsun2)

HCQ:	109519206(nsun2)

SSCV:

125986615

SBIA:

133498908(nsun2)

PEE:	133396014(nsun2)

PTAO:

133471212(nsun2)

BPEC:

110167265(nsun2)

MALB:

109971722(nsun2)

BSPL:

114865956(nsun2)

SJO:	128373801(nsun2)

SASA:

106588694

STRU:

115173830(nsun2)

OTW:	112229304 112264511(nsun2)

OMY:

OGO:

ONE:

OKI:

OKE:

SALP:

SNH:	120022713(nsun2)

CCLU:

121586592

ELS:	105012406(nsun2)

SFM:	108919300(nsun2)

PKI:	111852626(nsun2)

AANG:

118234095(nsun2)

LOC:	102694883(nsun2)

PSPA:

121312855 121314785

ARUT:

117394658 117400466

PSEX:

120515601(nsun2)

LCM:	102349429 102352869(NSUN2)

CMK:	103183195(nsun2)

RTP:	109935655(nsun2)

CPLA:

122549724(nsun2)

HOC:	132815956(nsun2)

LERI:

129711497(nsun2)

PMRN:

116954204(NSUN2)

LRJ:	133355791 133355792

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:	102802422 102803327

DME:	Dmel_CG6133(Nsun2)

DER:

6550971

DSE:

6612537

DSI:	Dsimw501_GD16312(Dsim_EG:EG0007.9)

DYA:	Dyak_GE16872(Dyak_EG:EG0007.9)

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI16150

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AAG:

AALB:

CQU:	CpipJ_CPIJ010001

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_212221

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128994265 128995426

PHU:	Phum_PHUM474660

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_329423

DMK:

116916261

DPZ:	124338059 124343079

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:	131887933 131892802

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_Y48G8AL.5(nsun-2)

CBR:

CBG_08493

CRQ:	GCK72_002009

LOA:	LOAG_16801

TSP:

Tsp_00405

HRO:	HELRODRAFT_68497

LGI:	LOTGIDRAFT_122705

PVUL:

126812808

PCAN:

112553222

BGT:

106078723

GAE:	121388401 121392773

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

132719613 132725021 132727781 132757056

DPOL:

127842475 127843701 127844672

OBI:

106883416

OSN:

115221232

LAK:	106159806 106177539

SMM:	Smp_175950

SHX:	MS3_00003735(NSUN2)

OVI:	T265_05975

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

TAD:	TRIADDRAFT_19981

AQU:	100636553 100637475

PSOM:

113312105

CRE:	CHLRE_03g179860v5

VCN:	VOLCADRAFT_54934 VOLCADRAFT_56298

MNG:	MNEG_15166

CSL:	COCSUDRAFT_15359

OLU:	OSTLU_16406

OTA:	OT_ostta08g01420 OT_ostta14g02040

BPG:	Bathy14g01140

MIS:	MICPUN_59711 MICPUN_66831 MICPUN_79216

MPP:	MICPUCDRAFT_15736(JGI:MicpuC2_15736)

CME:	CYME_CMG165C

GSL:	Gasu_11160

ADL:	AURDEDRAFT_158915

ECU:	ECU08_0400

EIN:	Eint_080320

EHE:	EHEL_080320

ERO:	EROM_080320

NCE:	NCER_101435 NCER_101436

MBR:	MONBRDRAFT_36363 MONBRDRAFT_38306

SRE:	PTSG_02162

DDI:	DDB_G0295715

DPP:	DICPUDRAFT_30335

DFA:

DFA_07613

EIV:	EIN_184050

ACAN:

ACA1_071630 ACA1_189790

TAN:

TA19955

TPV:

TP01_0076

TOT:	TOT_010000071

BEQ:	BEWA_033980

BBO:	BBOV_IV000560

BMIC:

BmR1_04g09900

BBIG:

BBBOND_0403430

CPV:	cgd5_3560 cgd7_1630

CHO:	Chro.50016 Chro.70192

TGO:	TGME49_294440

TET:	TTHERM_00028590 TTHERM_00684540

SMIN:

v1.2.013460.t1(symbB.v1.2.013460.t1) v1.2.033994.t1(symbB.v1.2.033994.t1) v1.2.037264.t1(symbB.v1.2.037264.t1)

PTI:	PHATRDRAFT_48154

FCY:	FRACYDRAFT_189551

TPS:	THAPSDRAFT_23686 THAPSDRAFT_24350 THAPSDRAFT_39812

AAF:	AURANDRAFT_68423

PIF:	PITG_00448 PITG_02560 PITG_17253 PITG_17298

PSOJ:

PHYSODRAFT_248298 PHYSODRAFT_447412 PHYSODRAFT_477678 PHYSODRAFT_551899

SPAR:

SPRG_00868 SPRG_04176 SPRG_05360 SPRG_20720 SPRG_21894

EHX:	EMIHUDRAFT_194550 EMIHUDRAFT_452763 EMIHUDRAFT_459528 EMIHUDRAFT_96831

GTT:	GUITHDRAFT_46333 GUITHDRAFT_55503 GUITHDRAFT_62957 GUITHDRAFT_82201 GUITHDRAFT_99887

TBR:	Tb10.70.0080 Tb927.3.3230

TBG:	TbgDal_III3390 TbgDal_X8190

TCR:	506699.3 508153.370 510187.240

LMA:	LMJF_29_2540 LMJF_36_2170

LIF:	LINJ_29_2650 LINJ_36_2300

LDO:	LDBPK_292650 LDBPK_362300

LMI:	LMXM_08_29_2540 LMXM_36_2170

LBZ:	LBRM_29_2510 LBRM_35_2410

LPAN:

LPMP_292550 LPMP_352260

NGR:	NAEGRDRAFT_56581 NAEGRDRAFT_80707

TVA:	TVAG_2v0135880 TVAG_2v1030680

GLA:	GL50803_0017199

» show all

Reference

PMID:17071714

Authors

Brzezicha B, Schmidt M, Makalowska I, Jarmolowski A, Pienkowska J, Szweykowska-Kulinska Z

Title

Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA).

Journal

Nucleic Acids Res 34:6034-43 (2006)
DOI:10.1093/nar/gkl765

Sequence

[hsa:54888]

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Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (6699)   
   KEGG GENES (772)   
   KEGG MGENES (2131)   
   RefGene (3787)   
   OC (9)   
Literature (1)   
   PubMed (1)   
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