KEGG   ORTHOLOGY: K15588Help
Entry
K15588                      KO                                     

Name
NSD1
Definition
histone-lysine N-methyltransferase NSD1 [EC:2.1.1.43]
Pathway
Lysine degradation
Disease
H00713  
Beckwith-Wiedemann syndrome
H00718  
Sotos syndrome and Weaver syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Amino acid metabolism
   00310 Lysine degradation
    K15588  NSD1; histone-lysine N-methyltransferase NSD1
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     K15588  NSD1; histone-lysine N-methyltransferase NSD1
Chromosome [BR:ko03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K15588  NSD1; histone-lysine N-methyltransferase NSD1
BRITE hierarchy
Other DBs
Genes
HSA: 
64324(NSD1)
PTR: 
471754(NSD1)
PPS: 
100991882(NSD1)
PON: 
100461473(NSD1)
MCC: 
706131(NSD1)
MCF: 
102120529(NSD1)
MMU: 
18193(Nsd1)
RNO: 
306764(Nsd1)
CGE: 
100773206(Nsd1)
HGL: 
101698401(Nsd1)
TUP: 
102476810(NSD1)
CFA: 
489094(NSD1)
AML: 
100477428(NSD1)
FCA: 
101100618(NSD1)
PTG: 
102967043(NSD1)
BTA: 
540197(NSD1)
BOM: 
102268569(NSD1)
PHD: 
102315799(NSD1)
CHX: 
102184804(NSD1)
SSC: 
100524976(NSD1)
CFR: 
102509336(NSD1)
BACU: 
103015430(NSD1)
LVE: 
103079235(NSD1)
ECB: 
100058570(NSD1)
MYB: 
MYD: 
PALE: 
102879695(NSD1)
MDO: 
100031881(NSD1)
SHR: 
100913201(NSD1)
OAA: 
100085446(NSD1)
GGA: 
416214(NSD1)
MGP: 
100538695(NSD1)
TGU: 
100219515(NSD1)
FAB: 
101815424(NSD1)
PHI: 
102101098(NSD1)
APLA: 
101789499(NSD1)
FPG: 
101914789(NSD1)
FCH: 
102055251(NSD1)
CLV: 
102084521(NSD1)
ASN: 
102368735(NSD1)
AMJ: 
102567385(NSD1)
PSS: 
102461475(NSD1)
CMY: 
102930063(NSD1)
ACS: 
PBI: 
103052448(NSD1)
XTR: 
100145675(nsd1)
DRE: 
556086(nsd1a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102346523(NSD1)
CMK: 
103189717(nsd1)
BMOR: 
CSL: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Schneider R, Bannister AJ, Kouzarides T
  Title
Unsafe SETs: histone lysine methyltransferases and cancer.
  Journal
Trends Biochem Sci 27:396-402 (2002)
Reference
  Authors
Qiao Q, Li Y, Chen Z, Wang M, Reinberg D, Xu RM
  Title
The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation.
  Journal
J Biol Chem 286:8361-8 (2011)
  Sequence
[hsa:64324]

DBGET integrated database retrieval system