KEGG ORTHOLOGY: K15759

ORTHOLOGY: K15759

Entry

K15759                      KO

Symbol

IMPAD1, IMPA3

Name

Golgi-resident PAP phosphatase [EC:3.1.3.7]

Pathway

map00920

Sulfur metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01120

Microbial metabolism in diverse environments

map04070

Phosphatidylinositol signaling system

Reaction

R00188

adenosine-3',5'-bisphosphate 3'-phosphohydrolase

R00508

3'-phospho-5'-adenylyl sulfate 3'-phosphohydrolase

Disease

H02306

Chondrodysplasia with joint dislocations, GPAPP type

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09102 Energy metabolism
   00920 Sulfur metabolism
    K15759  IMPAD1, IMPA3; Golgi-resident PAP phosphatase
09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K15759  IMPAD1, IMPA3; Golgi-resident PAP phosphatase
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.7  3'(2'),5'-bisphosphate nucleotidase
     K15759  IMPAD1, IMPA3; Golgi-resident PAP phosphatase

Other DBs

GO:

0008441

Genes

HSA:	54928(BPNT2)

PTR:	464188(IMPAD1)

PPS:	100991995(BPNT2)

GGO:	101126664(IMPAD1)

PON:	100453710(IMPAD1)

NLE:	100602566(IMPAD1)

HMH:	116813273(BPNT2)

MCC:	696893(IMPAD1)

MCF:	102127188(BPNT2)

MTHB:

126961726

MNI:	105482263(IMPAD1)

CSAB:

103236835(IMPAD1)

CATY:

105600606(IMPAD1)

PANU:

101000052(IMPAD1)

TGE:	112629978(IMPAD1)

MLEU:

105552071(IMPAD1)

RRO:	104661769(IMPAD1)

RBB:	108538385(IMPAD1)

TFN:	117078737(BPNT2)

PTEH:

111524860(IMPAD1)

CANG:

105508667(IMPAD1)

CJC:	100395037(BPNT2)

SBQ:	101040387(IMPAD1)

CIMI:

108297621(BPNT2)

CSYR:

103249415(IMPAD1)

MMUR:

105876409(IMPAD1)

LCAT:

123644597(BPNT2)

PCOQ:

105824105(IMPAD1)

OGA:	100949679(IMPAD1)

MMU:	242291(Bpnt2)

MCAL:

110292765(Impad1)

MPAH:

110338776(Impad1)

RNO:	312952(Bpnt2)

MCOC:

116088112(Impad1)

ANU:	117698569(Bpnt2)

MUN:	110561675(Bpnt2)

CGE:	100756245(Bpnt2)

MAUA:

101823882(Bpnt2)

PROB:

127231757(Bpnt2)

PLEU:

114710212(Bpnt2)

MORG:

121441984 121451462(Bpnt2)

MFOT:

126515557

AAMP:

119826526(Bpnt2)

NGI:	103734175(Impad1)

HGL:	101722322(Impad1)

CPOC:

100715393(Impad1)

CCAN:

109699899(Impad1)

DORD:

105980532(Impad1)

DSP:	122095670(Bpnt2)

PLOP:

125360504(Bpnt2)

NCAR:

124985638

MMMA:

107142258(Bpnt2)

OCU:	100343037(BPNT2)

OPI:	101529428(BPNT2)

TUP:	102471602(IMPAD1)

GVR:	103604050(IMPAD1)

CFA:	477890(BPNT2)

CLUD:

112678478(BPNT2)

VVP:	112932290(IMPAD1)

VLG:	121498806(BPNT2)

NPO:	129505326(BPNT2)

AML:	100465239(BPNT2)

UMR:	103677505(BPNT2)

UAH:	113268082(IMPAD1)

UAR:	123786716(BPNT2)

ELK:

111155448

LLV:

125097834

MPUF:

101689001(IMPAD1)

MNP:	132014026(BPNT2)

MLK:	131826812(BPNT2)

NVS:	122904581(BPNT2)

ORO:	101380943(IMPAD1)

EJU:	114220891(IMPAD1)

ZCA:	113930843(BPNT2)

MLX:	118014840(BPNT2)

NSU:	110579049(BPNT2)

LWW:

102731802

FCA:	101098356(BPNT2)

PYU:	121038303(BPNT2)

PCOO:

112859357(IMPAD1)

PBG:	122495431(BPNT2)

PVIV:

125156233(BPNT2)

LRUF:

124507660

PTG:	102950783(IMPAD1)

PPAD:

109250293(IMPAD1)

PUC:

125924681

AJU:	106984165(BPNT2)

HHV:	120246953(BPNT2)

BTA:	532797(BPNT2)

BOM:	102278852(IMPAD1)

BBUB:

102413096(BPNT2)

BBIS:

104987884(IMPAD1)

CHX:	102187243(IMPAD1)

OAS:	101109546(BPNT2)

BTAX:

128059153(BPNT2)

ODA:	120878595(BPNT2)

CCAD:

122450912(BPNT2)

MBEZ:

129560094(BPNT2)

SSC:	100156925(IMPAD1)

CFR:	102505980(BPNT2)

CBAI:

105081476(IMPAD1)

CDK:	105100438(IMPAD1)

VPC:	102525781(IMPAD1)

BACU:

103016546(IMPAD1)

BMUS:

118883318(BPNT2)

LVE:	103077117(IMPAD1)

OOR:	101278415(BPNT2)

DLE:	111165811(IMPAD1)

PCAD:

102981401(BPNT2)

PSIU:

116742349(BPNT2)

NASI:

112398173(IMPAD1)

ECB:	100067414(IMPAD1)

EPZ:	103541558(IMPAD1)

EAI:	106841664(BPNT2)

MYB:	102240640(IMPAD1)

MYD:	102752696(IMPAD1)

MMYO:

118670860(BPNT2)

MLF:	102442941(IMPAD1)

PKL:	118718283(BPNT2)

EFUS:

103287621(BPNT2)

MNA:	107533117(IMPAD1)

DRO:	112315639(IMPAD1)

SHON:

118974992(BPNT2)

AJM:	119065567(BPNT2)

PDIC:

114514466(BPNT2)

PHAS:

123833039(BPNT2)

MMF:	118631496(BPNT2)

PPAM:

129084147(BPNT2)

HAI:	109394456(IMPAD1)

RFQ:	117033822(BPNT2)

PALE:

102884282(IMPAD1)

PGIG:

120607226(BPNT2)

PVP:	105291432(IMPAD1)

RAY:	107500729(IMPAD1)

MJV:	108408436(BPNT2)

TOD:	119241248(BPNT2)

SARA:

101545552(IMPAD1)

SETR:

126020449(BPNT2)

LAV:	100677588(IMPAD1)

TMU:

101351574

ETF:	101647479(BPNT2)

DNM:	101446580(IMPAD1)

MDO:	100022402(IMPAD1) 100024961

GAS:	123231701(BPNT2) 123235115

SHR:	100915643 100927137(IMPAD1)

AFZ:	127543846 127552473

PCW:	110205207 110221359(IMPAD1)

OAA:	100083240(BPNT2)

GGA:	421132(IMPAD1)

PCOC:

116242164(IMPAD1)

MGP:	100551300(IMPAD1)

CJO:	107310195(BPNT2)

TPAI:

128091421(BPNT2)

LMUT:

125691041(BPNT2)

NMEL:

110393861(IMPAD1)

APLA:

101792028(BPNT2)

ACYG:

106039053(BPNT2)

CATA:

118251225(BPNT2)

AFUL:

116485876(BPNT2)

TGU:	100223091(BPNT2)

LSR:	110484755(IMPAD1)

SCAN:

103812414(IMPAD1)

PMOA:

120499264(BPNT2)

OTC:	121340191(BPNT2)

PRUF:

121356844(BPNT2)

GFR:	102044277(IMPAD1)

FAB:	101819036(IMPAD1)

OMA:	130249612(BPNT2)

PHI:	102102546(IMPAD1)

PMAJ:

107200422(BPNT2)

CCAE:

111924800(IMPAD1)

CCW:	104690427(BPNT2)

ETL:	114060203(IMPAD1)

ZAB:	102073964(IMPAD1)

ACHL:

103797773(IMPAD1)

SVG:	106851263(IMPAD1)

MMEA:

130579981(BPNT2)

HRT:	120753843(BPNT2)

FPG:	101913553(IMPAD1)

FCH:	102056114(IMPAD1)

CLV:	102088560(IMPAD1)

EGZ:	104127551(IMPAD1)

NNI:	104019786(IMPAD1)

PCRI:

104029681(IMPAD1)

PLET:

104615230(IMPAD1)

EHS:	104504469(IMPAD1)

PCAO:

104043970(IMPAD1)

ACUN:

113476533(IMPAD1)

TALA:

104356876(BPNT2)

PADL:

103923697(IMPAD1)

AFOR:

103907225(IMPAD1)

ACHC:

115340392(BPNT2)

HALD:

104325316(IMPAD1)

HLE:	104841335(IMPAD1)

AGEN:

126047289

GCL:

127013820

CCRI:

104164493(IMPAD1)

CSTI:

104551146(IMPAD1)

CMAC:

104486075(IMPAD1)

MUI:	104537092(IMPAD1)

BREG:

104636808(IMPAD1)

GSTE:

104252094(IMPAD1)

LDI:	104344711(IMPAD1)

OHA:	104332328(IMPAD1)

NNT:	104404783(IMPAD1)

SHAB:

115613082(BPNT2)

DPUB:

104303517(IMPAD1)

PGUU:

104462714(IMPAD1)

ACAR:

104532920(IMPAD1)

AVIT:

104268851(IMPAD1)

CVF:	104293297(IMPAD1)

RTD:	128905794(BPNT2)

CUCA:

104061354(IMPAD1)

BRHI:

104497646(IMPAD1)

AAM:	106494374(IMPAD1)

AROW:

112977270(IMPAD1)

NPD:	112956575(IMPAD1)

TGT:	104573248(IMPAD1)

DNE:	112984482(IMPAD1)

SCAM:

104143209(IMPAD1)

ASN:	102381501(IMPAD1)

AMJ:	102561192(IMPAD1)

CPOO:

109318886(IMPAD1)

GGN:	109298739(IMPAD1)

PSS:	102447509(IMPAD1)

CMY:	102935218(BPNT2)

CCAY:

125632477(BPNT2)

DCC:	119851514(BPNT2)

CPIC:

101946952(BPNT2)

TST:	117873505(BPNT2)

CABI:

116834642(BPNT2)

MRV:	120396396(BPNT2)

ACS:	100556213(impad1)

ASAO:

132779079(BPNT2)

PVT:	110082566(IMPAD1)

SUND:

121935018(BPNT2)

PBI:	103058901(IMPAD1)

PMUR:

107300554(IMPAD1)

CTIG:

120319684(BPNT2)

TSR:	106549909(IMPAD1)

PGUT:

117673243(BPNT2)

APRI:

131198942(BPNT2)

PTEX:

113451209(IMPAD1)

NSS:	113426639(IMPAD1)

VKO:	123017890(BPNT2)

PMUA:

114607226(IMPAD1)

PRAF:

128423871(BPNT2)

ZVI:	118091742(BPNT2)

HCG:	128324558(BPNT2)

GJA:	107113880(IMPAD1)

STOW:

125439030(BPNT2)

EMC:	129333483(BPNT2)

XLA:	108719261(bpnt2.L) 414458(bpnt2.S)

XTR:	548969(impad1)

NPR:	108800347(IMPAD1)

RTEM:

120941015(BPNT2)

BBUF:

121001584(BPNT2)

BGAR:

122938787(BPNT2)

MUO:	115477635(IMPAD1)

GSH:	117355642(BPNT2)

DRE:	641570(bpnt2)

SRX:	107719309(impad1) 107741594

SANH:

107663252 107675678(impad1)

SGH:	107562424(impad1)

CCAR:

109081559 109089100(impad1)

CAUA:

113068435 113115275(impad1)

CGIB:

127934892 128021551

PTET:

122360006(bpnt2)

LROH:

127160818(bpnt2)

OMC:	131520365(bpnt2)

PPRM:

120482834(bpnt2)

RKG:	130094507(bpnt2)

MAMB:

125250917(bpnt2)

CIDE:

127524516

MASI:

127441253 127442805

TROS:

130554865(bpnt2)

TDW:	130418363(bpnt2)

MANU:

129442527 129442529

IPU:	108280718(bpnt2)

IFU:	128624193(bpnt2)

PHYP:

113546442(impad1)

SMEO:

124403185(bpnt2)

TFD:	113650154(bpnt2)

TVC:	132844285(bpnt2)

AMEX:

103046746(impad1)

CMAO:

118797129(bpnt2)

EEE:	113591392(impad1)

CHAR:

105893831(bpnt2)

TRU:	101065705(impad1)

TFS:	130539469(bpnt2)

TNG:	GSTEN00006004G001 GSTEN00006005G001 GSTEN00007240G001 GSTEN00007241G001

LCO:	104935388(impad1)

TBEN:

117473872(bpnt2)

CGOB:

115022724(impad1)

PGEO:

117462501(bpnt2)

GACU:

117548584(bpnt2)

EMAC:

134865532(bpnt2)

ELY:	117272109(bpnt2)

EFO:	125901560(bpnt2)

PLEP:

121951432(bpnt2)

SLUC:

116041555(bpnt2)

ECRA:

117954874(bpnt2)

ESP:	116699336 116700278(bpnt2)

PFLV:

114565646(impad1)

GAT:	120815733(bpnt2)

PPUG:

119209283(bpnt2)

AFB:	129094108(bpnt2)

CLUM:

117746600(bpnt2)

PSWI:

130198076(bpnt2)

MSAM:

119898429 119902579(bpnt2)

SCHU:

122887664(bpnt2)

CUD:	121520792(bpnt2)

ALAT:

119011360(bpnt2)

MZE:	101483138(impad1)

ONL:	100710795(impad1)

OAU:	116313223(bpnt2)

OLA:	101174377(impad1)

OML:	112147134(bpnt2)

CSAI:

133452570(bpnt2)

XMA:	102233478(impad1)

XCO:	114146717(impad1)

XHE:	116721785(bpnt2)

PRET:

103479296(impad1)

PFOR:

103146978(impad1)

PLAI:

106965057(impad1)

PMEI:

106931409(impad1)

GAF:	122841168(bpnt2)

PPRL:

129362190(bpnt2)

CVG:	107088617(impad1)

CTUL:

119774220(bpnt2)

GMU:	124869830(bpnt2)

NFU:	107384185(impad1)

KMR:	108239551(bpnt2)

ALIM:

106514899(impad1)

NWH:	119414459(bpnt2)

AOCE:

111583308(impad1)

MCEP:

125010548(bpnt2)

CSEM:

103396546(impad1)

POV:	109645685(impad1)

SSEN:

122771778(bpnt2)

HHIP:

117777916(bpnt2)

HSP:	118117908(bpnt2)

SMAU:

118310490(bpnt2)

LCF:	108896676(bpnt2)

SDU:	111233886(impad1)

SLAL:

111648396(impad1)

XGL:	120799473(bpnt2)

HCQ:	109515484(impad1)

SSCV:

125985316

SBIA:

133511274(bpnt2)

PEE:	133411566(bpnt2)

PTAO:

133489264(bpnt2)

BPEC:

110170409(impad1)

MALB:

109963703 109967651

BSPL:

114844276(bpnt2)

SJO:	128369141(bpnt2)

SASA:

106568878(impad1)

STRU:

115156826(impad1)

OTW:	112260379(bpnt2)

OMY:	110530202(bpnt2)

OGO:	124009584(bpnt2)

ONE:	115114309(impad1)

OKI:	109874830(impad1)

OKE:	118402214(bpnt2)

SALP:

111956527(impad1) 111956528 111979813

SNH:	120055840(bpnt2)

CCLU:

121535119

ELS:	105006788(impad1)

SFM:	108929609(impad1) 108937512

PKI:	111852571(impad1)

AANG:

118226230 118233032

LOC:	102695274(impad1)

PSPA:

121314385(bpnt2)

ARUT:

117395015(bpnt2)

PSEX:

120530236(bpnt2)

LCM:	102346788(IMPAD1) 102349503

CMK:	103180765(bpnt2) 103190839

RTP:	109932983(bpnt2)

CPLA:

122560077(bpnt2)

HOC:	132822730(bpnt2)

LERI:

129696278(bpnt2)

PMRN:

116942578(BPNT2)

LRJ:	133349180(BPNT2)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG15743(CG15743)

DER:

6551071

DSE:

6618652

DSI:	Dsimw501_GD27264(Dsim_GD27264)

DYA:	Dyak_GE17055

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21462

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:	110677190 5565072

AALB:

109412116 109430970

CQU:	CpipJ_CPIJ003326

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	103312349 663675

DPA:

SOY:

AGRG:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_210374

BANY:

112051351

MJU:

123868375

NIQ:	126774329 126777803

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105385316 105396700

PGW:

CFEL:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:	129002390 129003993

PHU:	Phum_PHUM521040

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_303854 DAPPUDRAFT_303919 DAPPUDRAFT_340569

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:	111705738 111707780

LSM:

TCF:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

ABRU:

129971816 129972287 129973052

UDV:	129233173 129233272

SDM:

118192470

LPOL:

106471795 106471872

PMEO:

129585239 129587319 129597464

CEL:	CELE_Y6B3B.5(gpap-1)

CBR:

CBG_13639

CRQ:	GCK72_001789

NAI:	NECAME_03391

BMY:	BM_BM6286(Bma-gpap-1)

LOA:	LOAG_08887

TSP:

Tsp_08849

HRO:	HELRODRAFT_185657

LGI:	LOTGIDRAFT_103282

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111118897 111118981

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

OBI:

OSN:

LAK:

SMM:	Smp_173550

OVI:	T265_10261

EGL:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_57924

AQU:

100635317

» show all

Reference

PMID:21549340

Authors

Vissers LE, Lausch E, Unger S, Campos-Xavier AB, Gilissen C, Rossi A, Del Rosario M, Venselaar H, Knoll U, Nampoothiri S, Nair M, Spranger J, Brunner HG, Bonafe L, Veltman JA, Zabel B, Superti-Furga A

Title

Chondrodysplasia and abnormal joint development associated with mutations in IMPAD1, encoding the Golgi-resident nucleotide phosphatase, gPAPP.

Journal

Am J Hum Genet 88:608-15 (2011)
DOI:10.1016/j.ajhg.2011.04.002

Sequence

[hsa:54928]

Reference

PMID:16445858

Authors

Caldwell KK, Sosa M, Buckley CT

Title

Identification of mitogen-activated protein kinase docking sites in enzymes that metabolize phosphatidylinositols and inositol phosphates.

Journal

Cell Commun Signal 4:2 (2006)
DOI:10.1186/1478-811X-4-2

DBGET integrated database retrieval system