KEGG   ORTHOLOGY: K16172Help
Entry
K16172                      KO                                     
Name
IRS1
Definition
insulin receptor substrate 1
Pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04150 mTOR signaling pathway
    K16172  IRS1; insulin receptor substrate 1
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K16172  IRS1; insulin receptor substrate 1
   04920 Adipocytokine signaling pathway
    K16172  IRS1; insulin receptor substrate 1
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K16172  IRS1; insulin receptor substrate 1
  Nervous system
   04722 Neurotrophin signaling pathway
    K16172  IRS1; insulin receptor substrate 1
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K16172  IRS1; insulin receptor substrate 1
BRITE hierarchy
Genes
HSA: 
3667(IRS1)
PTR: 
459985(IRS1)
PPS: 
100971596(IRS1)
GGO: 
101132740(IRS1)
PON: 
100442255(IRS1)
MCC: 
707870(IRS4)
MMU: 
16367(Irs1)
RNO: 
25467(Irs1)
CFA: 
486148(IRS1)
FCA: 
101087257(IRS1)
BTA: 
538598(IRS1)
SSC: 
100512686(IRS1)
ECB: 
100061987
MDO: 
100021838
SHR: 
100918116(IRS1)
OAA: 
100073710
GGA: 
429262(IRS1)
MGP: 
100539255
TGU: 
100220553(IRS1)
ACS: 
100565100
XLA: 
399299(irs1)
XTR: 
100495320
DRE: 
559281(irs1)
BFO: 
BRAFLDRAFT_124878
CIN: 
100185541
SPU: 
100890677
DME: 
Dmel_CG5686(chico)
DPO: 
Dpse_GA19056
DAN: 
Dana_GF14127
DER: 
Dere_GG23965
DPE: 
Dper_GL18973
DSE: 
Dsec_GM11923
DSI: 
Dsim_GD22290
DWI: 
Dwil_GK10422
DYA: 
Dyak_GE26285
DGR: 
Dgri_GH25312
DMO: 
Dmoj_GI10661 Dmoj_GI10672
DVI: 
Dvir_GJ14922
AME: 
408438(IRS)
NVI: 
100119908(NV12182)
API: 
100569479
PHU: 
Phum_PHUM441290
CEL: 
CELE_C54D1.3(ist-1)
CBR: 
CBG10979(Cbr-ist-1)
BMY: 
Bm1_00475
TSP: 
Tsp_03690
NVE: 
NEMVE_v1g92099
TPS: 
THAPSDRAFT_2942
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Sisci D, Morelli C, Cascio S, Lanzino M, Garofalo C, Reiss K, Garcia M, Russo A, Ando S, Surmacz E
  Title
The estrogen receptor alpha:insulin receptor substrate 1 complex in breast cancer: structure-function relationships.
  Journal
Ann Oncol 18 Suppl 6:vi81-5 (2007)
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