KEGG   ORTHOLOGY: K16342Help
Entry
K16342                      KO                                     

Name
PLA2G4, CPLA2
Definition
cytosolic phospholipase A2 [EC:3.1.1.4]
Pathway
ko00564  Glycerophospholipid metabolism
ko00565  Ether lipid metabolism
ko00590  Arachidonic acid metabolism
ko00591  Linoleic acid metabolism
ko00592  alpha-Linolenic acid metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04072  Phospholipase D signaling pathway
ko04217  Necroptosis
ko04270  Vascular smooth muscle contraction
ko04370  VEGF signaling pathway
ko04611  Platelet activation
ko04664  Fc epsilon RI signaling pathway
ko04724  Glutamatergic synapse
ko04726  Serotonergic synapse
ko04730  Long-term depression
ko04750  Inflammatory mediator regulation of TRP channels
ko04912  GnRH signaling pathway
ko04913  Ovarian steroidogenesis
ko04921  Oxytocin signaling pathway
ko05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00564 Glycerophospholipid metabolism
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   00565 Ether lipid metabolism
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   00590 Arachidonic acid metabolism
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   00591 Linoleic acid metabolism
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   00592 alpha-Linolenic acid metabolism
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04010 MAPK signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04370 VEGF signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04072 Phospholipase D signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
 Cellular Processes
  Cell growth and death
   04217 Necroptosis
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
 Organismal Systems
  Immune system
   04611 Platelet activation
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04664 Fc epsilon RI signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
  Endocrine system
   04912 GnRH signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04913 Ovarian Steroidogenesis
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04921 Oxytocin signaling pathway
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
  Circulatory system
   04270 Vascular smooth muscle contraction
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
  Nervous system
   04724 Glutamatergic synapse
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04726 Serotonergic synapse
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
   04730 Long-term depression
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
 Human Diseases
  Cancers
   05231 Choline metabolism in cancer
    K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.4  phospholipase A2
     K16342  PLA2G4, CPLA2; cytosolic phospholipase A2
BRITE hierarchy
Other DBs
RN: R01315 R01317 R02053 R07064 R07379 R07387 R07859
GO: 0004623
Genes
HSA: 100137049(PLA2G4B) 123745(PLA2G4E) 255189(PLA2G4F) 283748(PLA2G4D) 5321(PLA2G4A) 8605(PLA2G4C) 8681(JMJD7-PLA2G4B)
PTR: 100610135(PLA2G4D) 453356(PLA2G4F) 467664(PLA2G4E) 468935(PLA2G4C) 469617(PLA2G4A) 747584
PPS: 100978248(PLA2G4C) 100984773(PLA2G4A) 100986585(PLA2G4F) 100986912(PLA2G4D) 100987249(PLA2G4E)
GGO: 101126764(PLA2G4C) 101130728(PLA2G4B) 101137812(PLA2G4E) 101138793(PLA2G4F) 101142484 101147399(PLA2G4A) 109023434 109025233
PON: 100173125(PLA2G4A) 100434495(PLA2G4C) 100447631(PLA2G4B) 100448616(PLA2G4F) 100454614(PLA2G4E) 100454977(PLA2G4D)
NLE: 100587969(PLA2G4C) 100591421(PLA2G4A) 100591987(JMJD7) 100593220(PLA2G4E) 100593575(PLA2G4D) 100593907(PLA2G4F)
MCC: 100424593(PLA2G4E) 100533113(PLA2G4B) 707592(PLA2G4D) 707690(PLA2G4F) 716635(PLA2G4A) 718510(PLA2G4C)
MCF: 102142596(PLA2G4C) 102143026(PLA2G4B) 102143695(PLA2G4A) 102143812(PLA2G4E) 102144463(PLA2G4D) 102146081(PLA2G4F)
CSAB: 103230418(PLA2G4A) 103235528(PLA2G4C) 103245774(PLA2G4F) 103245776(PLA2G4D) 103245777(PLA2G4E) 103246100(PLA2G4B)
RRO: 104664371(PLA2G4A) 104665267(PLA2G4F) 104666910(PLA2G4B) 104666913(PLA2G4E) 104666914(PLA2G4D) 104673480(PLA2G4C)
RBB: 108517617(PLA2G4F) 108523179(PLA2G4A) 108540165(PLA2G4C) 108544325(PLA2G4D) 108544332(PLA2G4E) 108544335(PLA2G4B)
CJC: 100391709(PLA2G4F) 100400789(PLA2G4D) 100401154(PLA2G4E) 100402439(PLA2G4A) 108590272
SBQ: 101036859(PLA2G4F) 101037291(PLA2G4D) 101037621(PLA2G4E) 101038256(PLA2G4B) 101054434(PLA2G4A)
MMU: 18783(Pla2g4a) 211429(Pla2g4b) 232889(Pla2g4c) 271844(Pla2g4f) 329502(Pla2g4e) 78390(Pla2g4d)
RNO: 24653(Pla2g4a) 296091(Pla2g4e) 311341(Pla2g4b) 691810(Pla2g4c) 691813 691905(Pla2g4d) 691907(Pla2g4f)
CGE: 100750927(Pla2g4a) 100754559(Pla2g4c) 100770605(Pla2g4f) 100770894(Pla2g4e) 100771756(Pla2g4b) 103158591(Pla2g4d)
NGI: 103726649(Pla2g4a) 103732429(Pla2g4c) 103744942(Pla2g4b) 103744945(Pla2g4e) 103744946(Pla2g4d) 103744947(Pla2g4f)
HGL: 101703792(Pla2g4b) 101704061(Pla2g4a) 101705849(Pla2g4e) 101706202(Pla2g4f) 101713091(Pla2g4c) 101717491(Pla2g4d)
CCAN: 109678488(Pla2g4d) 109682660(Pla2g4f) 109685136(Pla2g4a) 109693126(Pla2g4e) 109697572 109697577 109697580 109697581
OCU: 100008748(PLA2G4A) 100340517(PLA2G4F) 100340775(PLA2G4D) 100341033(PLA2G4E) 100341237(PLA2G4C) 100533118(PLA2G4B)
TUP: 102470223(PLA2G4E) 102470647(PLA2G4F) 102471767(PLA2G4D) 102472618(JMJD7) 102473333(PLA2G4C) 102477396(PLA2G4A)
CFA: 480048(PLA2G4A) 487512(PLA2G4B) 487514(PLA2G4E) 487515(PLA2G4F) 608811(PLA2G4D)
AML: 100469987(PLA2G4F) 100470240(PLA2G4D) 100470490(PLA2G4E) 100470998(PLA2G4B) 100482619(PLA2G4A)
UMR: 103668635(PLA2G4A) 103673432(PLA2G4E) 103673531(PLA2G4F) 103673532(PLA2G4D) 103673534(PLA2G4B)
ORO: 101362322(PLA2G4B) 101374803(PLA2G4A) 101377203(PLA2G4F) 101377493(PLA2G4D) 101386671(PLA2G4E)
FCA: 101082033(PLA2G4A) 101082574(PLA2G4F) 101082828(PLA2G4E) 101082829(PLA2G4D) 101083342
PTG: 102948969(PLA2G4A) 102959018(PLA2G4B) 102959667(PLA2G4E) 102959937(PLA2G4F) 102964036(PLA2G4D)
AJU: 106968512(PLA2G4E) 106968514 106968562(PLA2G4F) 106968584(PLA2G4D) 106977949(PLA2G4A)
BTA: 505485(PLA2G4B) 522866(PLA2G4F) 525072(PLA2G4A) 526364(PLA2G4E) 531209(PLA2G4D)
BOM: 102271639(PLA2G4A) 102282019(PLA2G4B) 102282579(PLA2G4E) 102282862(PLA2G4D) 102283142(PLA2G4F)
BIU: 109564977(PLA2G4B) 109564980(PLA2G4E) 109564981(PLA2G4D) 109564982(PLA2G4F) 109570204 109570696(PLA2G4A)
PHD: 102326509(PLA2G4A) 102339197(PLA2G4F) 102339558(PLA2G4D) 102339921(PLA2G4E) 102340632(PLA2G4B)
CHX: 102175216(JMJD7) 102178930(PLA2G4A) 102187595(PLA2G4E) 102187867(PLA2G4D) 102188141(PLA2G4F)
OAS: 101111472(PLA2G4A) 101115372(PLA2G4B) 101115878(PLA2G4E) 101116150(PLA2G4D) 101116403(PLA2G4F)
SSC: 100152927(PLA2G4B) 100513834(PLA2G4F) 100514811(PLA2G4E) 100520687(PLA2G4A) 102162529(PLA2G4D)
CFR: 102507142(PLA2G4D) 102509341(PLA2G4A) 102516599(PLA2G4B) 102517096(PLA2G4E) 102517351(PLA2G4F)
CDK: 105096850(PLA2G4B) 105099290(PLA2G4A) 105101745(PLA2G4E) 105101759(PLA2G4F) 105101760(PLA2G4D)
BACU: 102997982 102999275(PLA2G4B) 103008898(PLA2G4F) 103009192(PLA2G4D) 103012091 103012675
LVE: 103083510(PLA2G4D) 103083784(PLA2G4E) 103089071(PLA2G4A) 103090681(PLA2G4F) 103090934(PLA2G4B)
OOR: 101269805(PLA2G4F) 101270052(PLA2G4E) 101270539 101270543(PLA2G4A) 101286206(PLA2G4D)
ECB: 100033889(PLA2G4A) 100071016(PLA2G4F) 100071025(PLA2G4D) 100071038(PLA2G4E) 100071062(PLA2G4B)
EPZ: 103549946(PLA2G4D) 103549947(PLA2G4E) 103549950(PLA2G4B) 103549953(PLA2G4F) 103560072(PLA2G4A)
EAI: 106841342(PLA2G4F) 106841343(PLA2G4D) 106841344(PLA2G4E) 106841348(PLA2G4B) 106846782(PLA2G4A)
MYB: 102241902(PLA2G4D) 102242502(PLA2G4F) 102259120(PLA2G4A) 102260953(PLA2G4E)
MYD: 102754320(PLA2G4D) 102754611(PLA2G4E) 102771796(PLA2G4F) 102772466(JMJD7) 102774327(PLA2G4A)
HAI: 109379089(PLA2G4A) 109383984(PLA2G4E) 109384003(PLA2G4F) 109384004(PLA2G4D) 109384055(PLA2G4B)
RSS: 109444196(PLA2G4F) 109444197(PLA2G4E) 109444199 109444268(PLA2G4D) 109450621(PLA2G4A)
PALE: 102883421(PLA2G4F) 102883684(PLA2G4E) 102886310(PLA2G4A) 102887778(PLA2G4D) 102888274
LAV: 100658490(PLA2G4A) 100667057(PLA2G4E) 100675131(PLA2G4D) 100675410(PLA2G4F) 111753010(PLA2G4B)
MDO: 100009808(PLA2G4E) 100024859(PLA2G4A) 100029983(PLA2G4C) 100029998 100620032(PLA2G4D)
SHR: 100913647(PLA2G4E) 100914602(PLA2G4B) 100917893(PLA2G4D) 100918158(PLA2G4F) 100927005(PLA2G4C) 100927268(PLA2G4A)
OAA: 100085563 100086135(PLA2G4A) 100086190 100086783 100088450(PLA2G4E) 100088466(PLA2G4D) 100089728 100681775(PLA2G4F)
GGA: 101749229(PLA2G4B) 396394(PLA2G4A) 423226(PLA2G4EL7) 423227(PLA2G4EL6) 423229(PLA2G4EL1) 428870(PLA2G4EL3) 428871(PLA2G4F) 771552(PLA2G4EL5) 771560(PLA2G4EL4) 771574(PLA2G4EL2)
FPG: 101915779(PLA2G4C) 101918580(PLA2G4A) 101920043 101922121 101922643(PLA2G4B) 101924845 101925011(PLA2G4E) 101925028(PLA2G4F)
AMJ: 102564564(PLA2G4A) 102568256(PLA2G4B) 102568705(PLA2G4F.1) 102570036(PLA2G4C) 102571167 102571708 102571930 102572385 102572619(PLA2G4E) 102572848(PLA2G4D) 102573092 102573324(PLA2G4F) 106736657
XLA: 108698978(jmjd7-pla2g4b.L) 108699173 108699245(pla2g4f.L) 108699264 108700467 380561(pla2g4a.L)
XTR: 100145731(pla2g4a) 100485430(jmjd7-pla2g4b) 100497525(pla2g4f) 105948093
NPR: 108789293(PLA2G4F) 108789917 108793921 108798704(PLA2G4A)
DRE: 100148818(si:ch73-55i23.1) 30554(pla2g4aa) 559087(pla2g4ab) 565386(pla2g4f.2) 798864(pla2g4f.1)
AMEX: 103030644(pla2g4f) 103034242 103034573
NCC: 104955131(pla2g4a)
OLA: 101156151(pla2g4c) 101172400(pla2g4a)
XMA: 102235312(pla2g4a) 111611546(pla2g4c)
PRET: 103468160(pla2g4c) 103468245(pla2g4a)
NFU: 107391550(pla2g4c) 107392886(pla2g4a)
CSEM: 103393578(pla2g4c) 103395269(pla2g4a)
BPEC: 110162475 110167951(pla2g4a) 110169133
ELS: 105028802 105029083(pla2g4a)
LCM: 102351206 102352898(PLA2G4A) 102356324(PLA2G4F) 102360293
OBI: 106876643
HMG: 100200456
PXB: 103942742
NCR: NCU08298
NTE: NEUTE1DRAFT60205(NEUTE1DRAFT_60205)
MGR: MGG_01523
MAW: MAC_06783
MAJ: MAA_01120
CMT: CCM_02980
MBE: MBM_02873
ANI: AN6211.2
ANG: ANI_1_2450024(An02g04040)
CIM: CIMG_11529(CIMG05408)
PBL: PAAG_11047(PAAG_00099)
PBN: PADG_12248(PADG_07163)
ABE: ARB_00638
TVE: TRV_05103
PTE: PTT_15862
MGL: MGL_1512
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Schaloske RH, Dennis EA
  Title
The phospholipase A2 superfamily and its group numbering system.
  Journal
Biochim Biophys Acta 1761:1246-59 (2006)
DOI:10.1016/j.bbalip.2006.07.011
Reference
  Authors
Ghosh M, Loper R, Gelb MH, Leslie CC
  Title
Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes.
  Journal
J Biol Chem 281:16615-24 (2006)
DOI:10.1074/jbc.M601770200
Reference
  Authors
Song C, Chang XJ, Bean KM, Proia MS, Knopf JL, Kriz RW
  Title
Molecular characterization of cytosolic phospholipase A2-beta.
  Journal
J Biol Chem 274:17063-7 (1999)
DOI:10.1074/jbc.274.24.17063
  Sequence
[hsa:100137049]

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