KEGG ORTHOLOGY: K16859

ORTHOLOGY: K16859

Entry

K16859                      KO

Symbol

PGF

Name

placenta growth factor

Pathway

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04151

PI3K-Akt signaling pathway

map04510

Focal adhesion

map05200

Pathways in cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K16859  PGF; placenta growth factor
   04014 Ras signaling pathway
    K16859  PGF; placenta growth factor
   04015 Rap1 signaling pathway
    K16859  PGF; placenta growth factor
   04151 PI3K-Akt signaling pathway
    K16859  PGF; placenta growth factor
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K16859  PGF; placenta growth factor
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K16859  PGF; placenta growth factor
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K16859  PGF; placenta growth factor
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Growth factors (RTK binding)
   K16859  PGF; placenta growth factor

Genes

HSA:

5228(PGF)

PTR:	741830(PGF)

PPS:	100984147(PGF)

GGO:	101125053(PGF)

PON:	100440872(PGF)

NLE:	100600228(PGF)

HMH:	116485057(PGF)

MCC:	701219(PGF)

MCF:	102134620(PGF)

MTHB:

126959573

MNI:	105495787(PGF)

CSAB:

103229341(PGF)

CATY:

105590861(PGF)

PANU:

101018226(PGF)

TGE:	112629345(PGF)

MLEU:

105540798(PGF)

RRO:	104677582(PGF)

RBB:	108534920(PGF)

TFN:	117069324(PGF)

PTEH:

111520971(PGF)

CANG:

105517147(PGF)

CJC:	100386568(PGF)

SBQ:	101042551(PGF)

CIMI:

108304451(PGF)

CSYR:

103266534(PGF)

MMUR:

105858761(PGF)

LCAT:

123646604(PGF)

PCOQ:

105819783(PGF)

MMU:	18654(Pgf)

MCAL:

110307029(Pgf)

MPAH:

110324731(Pgf)

RNO:	94203(Pgf)

MCOC:

116079820(Pgf)

ANU:	117697288(Pgf)

MUN:	110546968(Pgf)

CGE:	100754799(Pgf)

MAUA:

101833210(Pgf)

PROB:

127230983(Pgf)

PLEU:

114698087(Pgf)

MORG:

121452413(Pgf)

MFOT:

126515159

AAMP:

119819672(Pgf)

NGI:	103747350(Pgf)

HGL:	101725085(Pgf)

CPOC:

100734450(Pgf)

CCAN:

109694002(Pgf)

DORD:

105984248(Pgf)

DSP:	122118724(Pgf)

PLOP:

125363322(Pgf)

NCAR:

124977223

MMMA:

107149280(Pgf)

OCU:

100339515

OPI:	101527710(PGF)

TUP:	102480300(PGF)

GVR:	103586269(PGF)

CFA:	100855780(PGF)

CLUD:

112657742(PGF)

VVP:	112927283(PGF)

VLG:	121493888(PGF)

NPO:	129496428(PGF)

AML:	100480980(PGF)

UMR:	103671076(PGF)

UAH:	113270324(PGF)

UAR:	123798976(PGF)

ELK:

111148570

LLV:

125105448

MPUF:

101689165(PGF)

MNP:	132000164(PGF)

MLK:	131836866(PGF)

NVS:	122893035(PGF)

ORO:	101369724(PGF)

EJU:	114205060(PGF)

ZCA:	113909873(PGF)

MLX:	118002257(PGF)

NSU:	110571448(PGF)

LWW:	102730380(PGF)

FCA:	101095904(PGF)

PYU:	121032059(PGF)

PCOO:

112856270(PGF)

PBG:	122469337(PGF)

PVIV:

125168901(PGF)

LRUF:

124512131

PTG:	102960599(PGF)

PPAD:

109253846(PGF)

PUC:

125909344

AJU:

106974417

BTA:	280894(PGF)

BOM:	102273440(PGF)

BIU:	109565356(PGF)

BBUB:

102389960(PGF)

BBIS:

105000064(PGF)

CHX:	102169297(PGF)

OAS:	443245(PGF)

BTAX:

128054318(PGF)

ODA:	120852712(PGF)

CCAD:

122443865(PGF)

MBEZ:

129563157(PGF)

SSC:	100156404(PGF)

CFR:	102520919(PGF)

CBAI:

105075181(PGF)

CDK:	105086095(PGF)

VPC:	102531220(PGF)

BACU:

103017555(PGF)

BMUS:

118890418(PGF)

LVE:	103082053(PGF)

OOR:	101284353(PGF)

DLE:	111176246(PGF)

PCAD:

102979244(PGF)

PSIU:

116749646(PGF)

NASI:

112394889(PGF)

ECB:	100051349(PGF)

EAI:	106827733(PGF)

MYB:	102243042(PGF)

MYD:	102761298(PGF)

MMYO:

118658139(PGF)

MLF:	102421300(PGF)

PKL:	118715262(PGF)

EFUS:

103283571(PGF)

MNA:	107533829(PGF)

DRO:	112311551(PGF)

SHON:

118976883(PGF)

AJM:	119035599(PGF)

PDIC:

114492659(PGF)

PHAS:

123808460(PGF)

MMF:	118637179(PGF)

PPAM:

129065733(PGF)

HAI:	109381519(PGF)

RFQ:	117022809(PGF)

PALE:

102889783(PGF)

PGIG:

120619506(PGF)

PVP:	105299223(PGF)

RAY:	107504821(PGF)

MJV:	108399226(PGF)

TOD:	119239359(PGF)

SARA:

101557525(PGF)

SETR:

126004091(PGF)

LAV:	100674895(PGF)

TMU:

101355158

ETF:	101654245(PGF)

DNM:	101426371(PGF)

MDO:	100023623(PGF)

GAS:	123235857(PGF)

SHR:	100925473(PGF)

AFZ:

127549494

PCW:	110208321(PGF)

OAA:	100093060(PGF)

GGA:	771832(PGF)

PCOC:

116229407(PGF)

MGP:	100542999(PGF)

TPAI:

128086972(PGF)

LMUT:

125695248(PGF)

NMEL:

110401232(PGF)

APLA:

101800933(PGF)

ACYG:

106038790(PGF)

CATA:

118244475(PGF)

AFUL:

116490346(PGF)

TGU:	100221017(PGF)

LSR:	110477279(PGF)

SCAN:

103826914(PGF)

PMOA:

120500460(PGF)

OTC:	121331390(PGF)

PRUF:

121356054(PGF)

GFR:	102038207(PGF)

OMA:	130254165(PGF)

PHI:	102099617(PGF)

PMAJ:

107206015(PGF)

CCAE:

111929568(PGF)

CCW:	104688590(PGF)

CBRC:

103621036(PGF)

ETL:	114056008(PGF)

ZAB:	102070098(PGF)

ACHL:

103807687(PGF)

SVG:	106861359(PGF)

MMEA:

130577986(PGF)

HRT:	120754669(PGF)

FPG:	101920675(PGF)

FCH:	102059983(PGF)

CLV:	102097929(PGF)

EGZ:	104133226(PGF)

NNI:	104021035(PGF)

PCRI:

104026493

PLET:

104622774(PGF)

EHS:	104510301(PGF)

PCAO:

104048602(PGF)

TALA:

104366963(PGF)

PADL:

103913044(PGF)

AFOR:

103900261(PGF)

ACHC:

115337354(PGF)

HLE:	104841952(PGF)

AGEN:

126049447

GCL:

127016909

CCRI:

104169009(PGF)

CSTI:

104556630(PGF)

MUI:	104535494(PGF)

BREG:

104631432(PGF)

GSTE:

104261928(PGF)

LDI:	104341850(PGF)

MNB:	103775087(PGF)

OHA:	104334089(PGF)

NNT:	104401121(PGF)

SHAB:

115606010(PGF)

ACAR:

104529283(PGF)

CPEA:

104385492(PGF)

AVIT:

104280187(PGF)

CVF:	104288262(PGF)

RTD:	128909541(PGF)

CUCA:

104061707(PGF)

TEO:	104383423(PGF)

AAM:	106482869 106483053

AROW:

112960520(PGF)

NPD:

112958059

TGT:	104579145(PGF)

DNE:	112995390(PGF)

SCAM:

104141575(PGF)

ASN:	102386060(PGF)

AMJ:	102567693(PGF)

CPOO:

109321430(PGF)

GGN:	109299323(PGF)

PSS:	102451883(PGF)

CMY:	102935251(PGF) 119564394

CCAY:

125629104 125637597(PGF)

DCC:	119847257 119857620(PGF)

CPIC:

101934809(PGF) 101941746

TST:	117876640(PGF) 117888750

CABI:

116835314 116837516(PGF)

MRV:	120388700 120403267(PGF)

ACS:	100552896(pgf)

ASAO:

132764417(PGF)

PVT:	110075606 110079090(PGF)

SUND:

121915919 121919724(PGF)

PBI:	103050803 103067148(PGF)

PMUR:

107293072(PGF)

CTIG:

120311775(PGF)

TSR:	106541647(PGF) 106551621

PGUT:

117665829(PGF)

APRI:

131187765(PGF)

PTEX:

113439386(PGF)

NSS:	113409940(PGF)

VKO:	123026720(PGF)

PMUA:

114591899(PGF) 114603133

PRAF:

128409076(PGF) 128420230

ZVI:	118081879(PGF)

HCG:	128332457 128351521(PGF)

GJA:	107118328(PGF) 107125835

STOW:

125425808(PGF)

EMC:	129324477(PGF) 129343545

MUO:

115480869

GSH:

117366027

DRE:	101883508(pgfa) 557468(pgfb)

SRX:	107712199 107732225 107739261

SANH:

107659813 107664476 107668531 107704385

SGH:	107559882 107564316 107575298 107586903

CCAR:

109107093 109108119 109108136

CAUA:

113060531 113094133 113117082

CGIB:

127938586 127976691 127983410 128031420

PTET:

122324419(pgfa) 122362267(pgfb)

LROH:

127179376(pgfb) 127183387(pgfa)

OMC:	131522970(pgfb) 131526972(pgfa)

PPRM:

120475986(pgfb) 120492043(pgfa)

RKG:	130070087(pgfa) 130080186(pgfb)

MAMB:

125269007(pgfb) 125278795(pgfa)

CIDE:

127498919 127501973

MASI:

127411361 127415568 127454886

TROS:

130560020(pgfb) 130565646(pgfa)

TDW:	130434802(pgfa) 130436883(pgfb)

MANU:

129417766(pgfb) 129429633(pgfa)

IPU:	108258015(pgfa) 108270479(pgfb)

IFU:	128601229(pgfa) 128612936(pgfb)

PHYP:

113538606(pgf)

SMEO:

124377255(pgfa) 124390453(pgfb)

TFD:	113644543(pgfa) 113659293(pgfb)

TVC:	132842327(pgfa) 132852839(pgfb)

AMEX:

107197829

CMAO:

118815583(pgfa) 118824184(pgfb)

EEE:

113587029

CHAR:

116223738

TRU:	101062196 101067669

TFS:	130515727 130540131(pgfb)

TNG:	GSTEN00020306G001

LCO:

104919815

NCC:	104960600 104960941

TBEN:

117478923(pgfb) 117498500(pgfa)

CGOB:

115003575 115026992

PGEO:

117439727 117467727(pgfb)

GACU:

117550215(pgfb) 117554322

EMAC:

134876589 134882072(pgfb)

ELY:	117267586(pgfb) 117270645

EFO:	125897313 125901055(pgfb)

PLEP:

121953602(pgfb) 121955958

SLUC:

116035597(pgfb) 116057929

ECRA:

117935621(pgfb) 117961361(pgfa)

ESP:	116670486 116706644

PFLV:

114547115 114573284

GAT:	120807992 120833332(pgfb)

PPUG:

119194840 119227758(pgfb)

AFB:	129103539(pgfb) 129107431

CLUM:

117751696(pgfb)

PSWI:

130201567(pgfb) 130202566

MSAM:

119908452 119910658(pgfb)

SCHU:

122861980(pgfb) 122863626(pgfa)

CUD:	121521924 121526730(pgfb)

ALAT:

119005031(pgfb) 119012251

MZE:	101474897(pgf) 101480538

ONL:	100695462 100703833(pgf)

OAU:	116332192 116335867(pgfb)

OLA:

101161449

OML:	112148046(pgfb)

CSAI:

133418354 133461987(pgfb)

XMA:	102223366 102225990

XCO:	114134848 114158134

XHE:	116709624 116733613

PRET:

103457897 103461058(pgf)

PFOR:

103138702 103152664

PLAI:

106938785 106954555

PMEI:

106922138 106932887

GAF:	122824984(pgfa) 122846480(pgfb)

PPRL:

129365607(pgfb) 129369060(pgfa)

CVG:	107085608(pgf) 107090862

CTUL:

119784172 119787501(pgfb)

GMU:	124856012(pgfb) 124882351(pgfa)

NFU:

107392368

KMR:	108236961(pgfb)

ALIM:

106520837(pgf) 106535210

NWH:	119417854 119427720(pgfb)

AOCE:

111582499 111583097 111584551

MCEP:

124999177 125023506(pgfB)

CSEM:

103381019 103396668(pgf)

POV:	109627986 109632425

SSEN:

122783343(pgfb)

HHIP:

117755759(pgfb) 117758563(pgfa)

HSP:	118099951(pgfa) 118116899(pgfb)

SMAU:

118286465(pgfb) 118290714

LCF:	108892573(pgfb) 108896919

SDU:	111225931(pgf) 111240400

SLAL:

111663130(pgf) 111672600

XGL:	120789018 120794921(pgfb)

HCQ:

109513204

SSCV:

125981153

SBIA:

133513635(pgfb)

PEE:	133412927(pgfb)

PTAO:

133488236(pgfb)

BPEC:

110155603

MALB:

109955230 109962223

BSPL:

114849008(pgfb)

SJO:	128375694(pgfb) 128377229

SASA:

106571724 106593515 106611025

STRU:

115162304 115172588 115174504

OTW:	112233191 112250555 112256717(pgfb)

OMY:	110497896 110505581(pgfb) 110529858

OGO:	123991688 124001844 124045272

ONE:	115107982 115138528 115146644

OKI:	109894484 109900957 109904071

OKE:	118362518 118368282 118398429

SALP:

111963302 111968709(pgf) 112072029

SNH:	120023725(pgfb) 120023936 120059887

CCLU:

121539301 121544465(pgfb) 121552720

ELS:	105017540 105026447(pgf)

SFM:	108941445(pgf)

PKI:	111852514(pgf)

AANG:

118219958(pgfb) 118229382

LOC:

102693016

PSPA:

121323875 121330283

ARUT:

117416693 117422031

PSEX:

120518393(pgfb)

LCM:	102359260(PGF) 102361405

CMK:

RTP:

CPLA:

HOC:

LERI:

MPHA:

ACEP:

PBAR:

VPS:

HAME:

ABRU:

Reference

PMID:1924389

Authors

Maglione D, Guerriero V, Viglietto G, Delli-Bovi P, Persico MG

Title

Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.

Journal

Proc Natl Acad Sci U S A 88:9267-71 (1991)
DOI:10.1073/pnas.88.20.9267

Sequence

[hsa:5228]

Reference

PMID:22228176

Authors

De Falco S

Title

The discovery of placenta growth factor and its biological activity.

Journal

Exp Mol Med 44:1-9 (2012)
DOI:10.3858/emm.2012.44.1.025

Reference

PMID:21215706

Authors

Rolny C, Mazzone M, Tugues S, Laoui D, Johansson I, Coulon C, Squadrito ML, Segura I, Li X, Knevels E, Costa S, Vinckier S, Dresselaer T, Akerud P, De Mol M, Salomaki H, Phillipson M, Wyns S, Larsson E, Buysschaert I, Botling J, Himmelreich U, Van Ginderachter JA, De Palma M, Dewerchin M, Claesson-Welsh L, Carmeliet P

Title

HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF.

Journal

Cancer Cell 19:31-44 (2011)
DOI:10.1016/j.ccr.2010.11.009

Sequence

[hsa:5228]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (12)   
   KEGG PATHWAY (12)   
Drug (2)   
   KEGG DRUG (2)   
Gene (556)   
   KEGG GENES (509)   
   KEGG MGENES (29)   
   RefGene (14)   
   OC (4)   
Literature (3)   
   PubMed (3)   
All databases (575)   

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