Entry |
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Symbol |
PDE10
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Name |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 [EC: 3.1.4.17 3.1.4.35]
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Pathway |
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Reaction |
R00191 | adenosine 3',5'-phosphate 5'-nucleotidohydrolase |
R01234 | guanosine 3',5'-cyclic phosphate 5'-nucleotidohydrolase |
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Disease |
H01570 | Autosomal dominant striatal degeneration |
H02388 | Infantile-onset limb and orofacial dyskinesia |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
K18438 PDE10; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10
09130 Environmental Information Processing
09132 Signal transduction
04024 cAMP signaling pathway
K18438 PDE10; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
K18438 PDE10; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10
Enzymes [BR:ko01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase
K18438 PDE10; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10
3.1.4.35 3',5'-cyclic-GMP phosphodiesterase
K18438 PDE10; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10
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Other DBs |
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Genes |
» show all
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Reference |
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Authors |
Omori K, Kotera J |
Title |
Overview of PDEs and their regulation. |
Journal |
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Reference |
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Authors |
Fujishige K, Kotera J, Michibata H, Yuasa K, Takebayashi S, Okumura K, Omori K |
Title |
Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). |
Journal |
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Sequence |
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