KEGG ORTHOLOGY: K23332

ORTHOLOGY: K23332

Entry

K23332                      KO

Symbol

RSPRY1

Name

RING finger and SPRY domain-containing protein 1

Disease

H02187

Spondyloepimetaphyseal dysplasia

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K23332  RSPRY1; RING finger and SPRY domain-containing protein 1
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   Cul5 complex
    Target recognizing subunit
     K23332  RSPRY1; RING finger and SPRY domain-containing protein 1

Genes

HSA:	89970(RSPRY1)

PTR:	454113(RSPRY1)

PPS:	100980683(RSPRY1)

GGO:	101136240(RSPRY1)

PON:	100173142(RSPRY1)

NLE:	100580495(RSPRY1)

HMH:	116471292(RSPRY1)

MCC:	703783(RSPRY1)

MCF:	102121113(RSPRY1)

MTHB:

126943832

MNI:	105494035(RSPRY1)

CSAB:

103233053(RSPRY1)

CATY:

105588177(RSPRY1)

PANU:

101002704(RSPRY1)

TGE:	112613806(RSPRY1)

MLEU:

105533402(RSPRY1)

RRO:	104664047(RSPRY1)

RBB:	108533871(RSPRY1)

TFN:	117087839(RSPRY1)

PTEH:

111541280(RSPRY1)

CANG:

105509577(RSPRY1)

CJC:	100411619(RSPRY1)

SBQ:	101029764(RSPRY1)

CIMI:

108285442(RSPRY1)

CSYR:

103270510(RSPRY1)

MMUR:

105863889(RSPRY1)

LCAT:

123625291(RSPRY1)

PCOQ:

105820849(RSPRY1)

OGA:	100964158(RSPRY1)

MMU:	67610(Rspry1)

MCAL:

110299677(Rspry1)

MPAH:

110337424(Rspry1)

RNO:	689249(Rspry1)

MCOC:

116069904(Rspry1)

ANU:	117723287(Rspry1)

MUN:	110559522(Rspry1)

CGE:	100759716(Rspry1)

MAUA:

101826551(Rspry1)

PROB:

127234886(Rspry1)

PLEU:

114694501(Rspry1)

MORG:

121447124(Rspry1)

MFOT:

126502585

AAMP:

119801868(Rspry1)

NGI:	103735590(Rspry1)

HGL:	101698434(Rspry1)

CPOC:

100724764(Rspry1)

CCAN:

109687003(Rspry1)

DORD:

105994413(Rspry1)

DSP:	122116279(Rspry1)

PLOP:

125358408(Rspry1)

NCAR:

124966599

MMMA:

107144834(Rspry1)

OCU:

100345413

OPI:	101528462(RSPRY1)

TUP:	102492120(RSPRY1)

GVR:	103592084(RSPRY1)

CFA:	478112(RSPRY1)

CLUD:

112660605(RSPRY1)

VVP:	112929641(RSPRY1)

VLG:	121497083(RSPRY1)

NPO:	129513848(RSPRY1)

AML:	100469723(RSPRY1)

UMR:	103673767(RSPRY1)

UAH:	113252276(RSPRY1)

UAR:	123798437(RSPRY1)

ELK:

111157370

LLV:

125089916

MPUF:

101685750(RSPRY1)

MNP:	132005424(RSPRY1)

MLK:	131818718(RSPRY1)

NVS:	122911420(RSPRY1)

ORO:	101370872(RSPRY1)

EJU:	114201452(RSPRY1)

ZCA:	113935737(RSPRY1)

MLX:	118023753(RSPRY1)

NSU:	110594266(RSPRY1)

LWW:	102731222(RSPRY1)

FCA:	101083894(RSPRY1)

PYU:	121045342(RSPRY1)

PCOO:

112857402(RSPRY1)

PBG:	122494243(RSPRY1)

PVIV:

125152800(RSPRY1)

LRUF:

124511335

PTG:	102965045(RSPRY1)

PPAD:

109270878(RSPRY1)

PUC:

125916031

AJU:

106977032

HHV:	120232142(RSPRY1)

BTA:	538571(RSPRY1)

BOM:	102283405(RSPRY1)

BIU:	109572709(RSPRY1)

BBUB:

102394042(RSPRY1)

BBIS:

105004309(RSPRY1)

CHX:	102168379(RSPRY1)

OAS:	101122619(RSPRY1)

BTAX:

128063481(RSPRY1)

ODA:	120873149(RSPRY1)

CCAD:

122421501(RSPRY1)

MBEZ:

129547077(RSPRY1)

SSC:	100515835(RSPRY1)

CFR:	102509361(RSPRY1)

CBAI:

105078693(RSPRY1)

CDK:	105106167(RSPRY1)

VPC:	102527349(RSPRY1)

BACU:

103006816(RSPRY1)

BMUS:

118884915(RSPRY1)

LVE:	103069058(RSPRY1)

OOR:	101279026(RSPRY1)

DLE:	111165323(RSPRY1)

PCAD:

102994241(RSPRY1)

PSIU:

116744276(RSPRY1)

NASI:

112401278(RSPRY1)

ECB:	100052133(RSPRY1)

EPZ:	103556090(RSPRY1)

EAI:	106822204(RSPRY1)

MYB:	102242668(RSPRY1)

MYD:	102765909(RSPRY1)

MMYO:

118674028(RSPRY1)

MLF:	102428146(RSPRY1)

PKL:	118720416(RSPRY1)

EFUS:

103295833(RSPRY1)

MNA:	107532229(RSPRY1)

DRO:	112296661(RSPRY1)

SHON:

118983946(RSPRY1)

AJM:	119046423(RSPRY1)

PDIC:

114488250(RSPRY1)

PHAS:

123806087(RSPRY1)

MMF:	118639156(RSPRY1)

PPAM:

129068231(RSPRY1)

HAI:	109395657(RSPRY1)

RFQ:	117035012(RSPRY1)

PALE:

102888810(RSPRY1)

PGIG:

120617318(RSPRY1)

PVP:	105292034(RSPRY1)

RAY:	107501911(RSPRY1)

MJV:	108399515(RSPRY1)

TOD:	119249216(RSPRY1)

SARA:

101543173(RSPRY1)

SETR:

126027147(RSPRY1)

LAV:	100653770(RSPRY1)

TMU:

101361326

ETF:	101650342(RSPRY1)

DNM:	101428915(RSPRY1)

MDO:	100015903(RSPRY1)

GAS:	123237297(RSPRY1)

SHR:	100917636(RSPRY1)

AFZ:

127550743

PCW:	110193710(RSPRY1)

OAA:	100080289(RSPRY1)

GGA:	415648(RSPRY1)

PCOC:

116243798(RSPRY1)

MGP:	100549279(RSPRY1)

CJO:	107319100(RSPRY1)

TPAI:

128082214(RSPRY1)

LMUT:

125699099(RSPRY1)

NMEL:

110404100(RSPRY1)

APLA:

101795973(RSPRY1)

ACYG:

106033195(RSPRY1)

CATA:

118246614(RSPRY1)

AFUL:

116493977(RSPRY1)

TGU:	100222247(RSPRY1)

LSR:	110476329(RSPRY1)

SCAN:

103816705(RSPRY1)

PMOA:

120508075(RSPRY1)

OTC:	121333769(RSPRY1)

PRUF:

121348901(RSPRY1)

GFR:	102033550(RSPRY1)

FAB:	101821993(RSPRY1)

OMA:	130257883(RSPRY1)

PHI:	102106997(RSPRY1)

PMAJ:

107209685(RSPRY1)

CCAE:

111934498(RSPRY1)

CCW:	104691792(RSPRY1)

CBRC:

103620131(RSPRY1)

ETL:	114062490(RSPRY1)

ZAB:	102073760(RSPRY1)

ACHL:

103810161(RSPRY1)

SVG:	106860922(RSPRY1)

MMEA:

130579509(RSPRY1)

HRT:	120757927(RSPRY1)

FPG:	101921773(RSPRY1)

FCH:	102059323(RSPRY1)

CLV:	102097057(RSPRY1)

EGZ:	104130255(RSPRY1)

NNI:	104017421(RSPRY1)

PCRI:

104033187(RSPRY1)

PLET:

104621305(RSPRY1)

EHS:	104511527(RSPRY1)

PCAO:

104042297(RSPRY1)

ACUN:

113484398(RSPRY1)

TALA:

104355966(RSPRY1)

PADL:

103913347(RSPRY1)

AFOR:

103908386(RSPRY1)

ACHC:

115346007(RSPRY1)

HALD:

104321462(RSPRY1)

HLE:	104841602(RSPRY1)

AGEN:

126040525

GCL:

127020912

CCRI:

104154459(RSPRY1)

CSTI:

104549342(RSPRY1)

CMAC:

104473938(RSPRY1)

MUI:	104539698(RSPRY1)

BREG:

104638517(RSPRY1)

FGA:	104083804(RSPRY1)

GSTE:

104260389(RSPRY1)

LDI:	104346677(RSPRY1)

MNB:	103772089(RSPRY1)

OHA:	104328579(RSPRY1)

SHAB:

115619201 115619390(RSPRY1)

PGUU:

104461624(RSPRY1)

ACAR:

104524415(RSPRY1)

CPEA:

104398399(RSPRY1)

CVF:	104294807(RSPRY1)

RTD:	128908486(RSPRY1)

CUCA:

104068311(RSPRY1)

TEO:	104371721(RSPRY1)

BRHI:

104492980(RSPRY1)

AAM:	106489463(RSPRY1)

AROW:

112966579(RSPRY1)

NPD:	112943232(RSPRY1)

TGT:	104575239(RSPRY1)

DNE:	112985417(RSPRY1)

SCAM:

104142471(RSPRY1)

ASN:	102376895(RSPRY1)

AMJ:	102572171(RSPRY1)

GGN:	109289695(RSPRY1)

PSS:

102463386

CMY:	102938288(RSPRY1)

CCAY:

125620622(RSPRY1)

DCC:	119841186(RSPRY1)

CPIC:

101945773(RSPRY1)

TST:	117886760(RSPRY1)

CABI:

116821126(RSPRY1)

MRV:	120384752(RSPRY1)

ACS:	100563758(rspry1)

ASAO:

132783210(RSPRY1)

PVT:	110085708(RSPRY1)

SUND:

121937548(RSPRY1)

PBI:	103060084(RSPRY1)

PMUR:

107293760

CTIG:

120312689(RSPRY1)

TSR:	106550656(RSPRY1)

PGUT:

117670404(RSPRY1)

APRI:

131184428(RSPRY1)

PTEX:

113445267(RSPRY1)

NSS:	113420279(RSPRY1)

VKO:	123025383(RSPRY1)

PMUA:

114601775(RSPRY1)

PRAF:

128418992(RSPRY1)

ZVI:	118086183(RSPRY1)

HCG:	128334125(RSPRY1)

GJA:	107111788(RSPRY1)

STOW:

125443481(RSPRY1)

EMC:	129344231(RSPRY1)

XLA:	108714018(rspry1.L) 447422(rspry1.S)

XTR:	548695(rspry1)

NPR:	108786174(RSPRY1)

RTEM:

120917694(RSPRY1)

BBUF:

120980303(RSPRY1)

BGAR:

122920908(RSPRY1)

MUO:	115470507(RSPRY1)

GSH:	117358943(RSPRY1)

DRE:	565154(rspry1)

SRX:	107738742(rspry1) 107740308

SANH:

107672266 107686275(rspry1)

SGH:	107549640(rspry1) 107583786

CCAR:

109109936

CAUA:

113061480 113118335(rspry1)

CGIB:

127934598 127977824

PTET:

122362849(rspry1)

LROH:

127181189(rspry1)

OMC:	131524539(rspry1)

PPRM:

120493989(rspry1)

RKG:	130094719(rspry1)

MAMB:

125253995(rspry1)

CIDE:

127499420

MASI:

127417194 127456172

TROS:

130563230(rspry1)

TDW:	130435265(rspry1)

MANU:

129419407(rspry1)

IPU:

108264379

IFU:	128606675(rspry1)

PHYP:

113534520(rspry1)

SMEO:

124395497(rspry1)

TFD:	113652775(rspry1)

TVC:	132851263(rspry1)

AMEX:

103038974(rspry1)

CMAO:

118817872(rspry1)

EEE:	113589782(rspry1)

CHAR:

105892548(rspry1)

TRU:	101073825(rspry1)

TFS:	130536411(rspry1)

TNG:	GSTEN00016794G001

LCO:	104938427(rspry1)

NCC:	104953709(rspry1)

TBEN:

117491401(rspry1)

CGOB:

115009930(rspry1)

PGEO:

117447947(rspry1)

GACU:

117542813(rspry1)

EMAC:

134880233(rspry1)

ELY:	117262482(rspry1)

EFO:	125887632(rspry1)

PLEP:

121950152(rspry1)

SLUC:

116052991(rspry1)

ECRA:

117948440(rspry1)

ESP:	116693659(rspry1)

PFLV:

114560482(rspry1)

GAT:	120809402(rspry1) 120812494

PPUG:

119195945(rspry1)

AFB:	129108784(rspry1)

CLUM:

117732422(rspry1)

PSWI:

130195701(rspry1)

MSAM:

119887691 119893516(rspry1)

SCHU:

122874336(rspry1)

CUD:	121514602(rspry1)

ALAT:

119023838(rspry1)

MZE:	101479969 112433222

ONL:	100708532(rspry1)

OAU:	116326331(rspry1)

OLA:	101172328(rspry1)

OML:	112151718(rspry1)

CSAI:

133443940(rspry1)

XMA:	102236117(rspry1)

XCO:	114137231(rspry1)

XHE:	116708510(rspry1)

PRET:

103466830(rspry1)

PFOR:

103129267(rspry1)

PLAI:

106936618(rspry1)

PMEI:

106907573(rspry1)

GAF:	122835088(rspry1)

PPRL:

129356225

CVG:	107084311(rspry1)

CTUL:

119789165(rspry1)

GMU:	124856685(rspry1)

NFU:	107389308(rspry1)

KMR:	108237570(rspry1)

ALIM:

106536694(rspry1)

NWH:	119415543(rspry1)

AOCE:

111576307(rspry1)

MCEP:

125015118(rspry1)

CSEM:

103379567(rspry1)

POV:	109624464(rspry1)

SSEN:

122775749(rspry1)

HHIP:

117763761(rspry1)

HSP:	118109879(rspry1)

SMAU:

118315504(rspry1)

LCF:

108901903

SDU:	111225245(rspry1)

SLAL:

111666052(rspry1)

XGL:	120793399(rspry1)

HCQ:	109526774(rspry1)

SSCV:

125970170

SBIA:

133502530(rspry1)

PEE:	133402483(rspry1)

PTAO:

133478645(rspry1)

BPEC:

110169545(rspry1)

MALB:

109962526(rspry1)

BSPL:

114857405(rspry1)

SJO:	128359011(rspry1)

SASA:

106560854 106573715(rspry1)

STRU:

115151930(rspry1) 115196829

OTW:	112218515(rspry1) 112252330

OMY:	110494657(rspry1) 110520144

OGO:	124000308 124037468(rspry1)

ONE:	115109361 115134305

OKI:	109867117 109889313

OKE:	118396654(rspry1) 118401288

SALP:

111952530 111962344

SNH:	120066233(rspry1)

CCLU:

121531850 121576662

ELS:	105018501(rspry1)

SFM:	108918936(rspry1)

PKI:	111851869(rspry1)

AANG:

118228356(rspry1)

LOC:	102690641(rspry1)

PSPA:

121296388(rspry1) 121325828

ARUT:

117424110 117425142

PSEX:

120535255(rspry1)

LCM:	102346296(RSPRY1)

CMK:	103183189 103187878(rspry1)

RTP:	109914300(rspry1)

CPLA:

122558494(rspry1)

HOC:	132823988(rspry1)

LERI:

129705123(rspry1)

PMRN:

116954213(RSPRY1)

LRJ:	133355803(RSPRY1)

BFO:

118417970

BBEL:

109480550

CIN:	778888(zf(ring)-26)

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

ECOE:

CLON:

HIS:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ004873

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_203937

MJU:

NIQ:

VCD:

MCIX:

PMAC:

106719902 106719934 106720044

PPOT:

106103281 106110086

PXU:	106113806 106126441 106126454

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PGW:

CFEL:

CCRN:

API:	100165675(Rspry1)

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM581500

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_62402

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_F16A11.1(F16A11.1)

CBR:

CBG_22191

CRQ:	GCK72_000003

NAI:	NECAME_13405

BMY:	BM_BM3401(Bm3401)

LOA:	LOAG_06326

TSP:

Tsp_09551

HRO:	HELRODRAFT_91560

LGI:	LOTGIDRAFT_130506

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:	106153154 106175079 106181396 106181397

NVE:	5500689 5505890

EPA:

110242340

ATEN:

116293095

ADF:	107329817 107348962

AMIL:

114970813

PDAM:

113673935

SPIS:

111329578

DGT:	114516951 114542611

XEN:

124437536

TAD:	TRIADDRAFT_64223

ACAN:

ACA1_043660 ACA1_377320

SMIN:

v1.2.014914.t1(symbB.v1.2.014914.t1)

AAF:	AURANDRAFT_36550

» show all

Reference

PMID:26365341

Authors

Faden M, AlZahrani F, Mendoza-Londono R, Dupuis L, Hartley T, Kannu P, Raiman JA, Howard A, Qin W, Tetreault M, Xi JQ, Al-Thamer I, Maas RL, Boycott K, Alkuraya FS

Title

Identification of a Recognizable Progressive Skeletal Dysplasia Caused by RSPRY1 Mutations.

Journal

Am J Hum Genet 97:608-15 (2015)
DOI:10.1016/j.ajhg.2015.08.007

Sequence

[hsa:89970]

All links

Ontology (2)   
   KEGG BRITE (2)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (1040)   
   KEGG GENES (644)   
   KEGG MGENES (396)   
All databases (1043)   

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