KEGG ORTHOLOGY: K23790

ORTHOLOGY: K23790

Entry

K23790                      KO

Symbol

GSTP

Name

glutathione S-transferase P [EC:2.5.1.18]

Pathway

map00480

Glutathione metabolism

map00980

Metabolism of xenobiotics by cytochrome P450

map00982

Drug metabolism - cytochrome P450

map00983

Drug metabolism - other enzymes

map01100

Metabolic pathways

map01524

Platinum drug resistance

map05200

Pathways in cancer

map05204

Chemical carcinogenesis - DNA adducts

map05215

Prostate cancer

map05225

Hepatocellular carcinoma

map05418

Fluid shear stress and atherosclerosis

Reaction

R03522

RX:glutathione R-transferase

R07002

(1R)-hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene glutathione-lyase (epoxide-forming)

R07003

(1R)-glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene glutathione-lyase (epoxide-forming)

R07004

(1S)-hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene glutathione-lyase (epoxide-forming)

R07023

1-nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene glutathione-lyase (epoxide-forming)

R07024

1-nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene glutathione-lyase (epoxide-forming)

R07025

1-nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene glutathione-lyase (epoxide-forming)

R07026

1-nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene glutathione-lyase (epoxide-forming)

R07069

3,4-dihydro-3-hydroxy-4-S-glutathionyl bromobenzene glutathione-lyase (epoxide-forming)

R07070

2,3-dihydro-2-S-glutathionyl-3-hydroxy bromobenzene glutathione-lyase (epoxide-forming)

R07083

4,5-dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene glutathione-lyase (epoxide-forming)

R07084

7,8-dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene hydrolase

R07091

S-(2,2-dichloro-1-hydroxy)ethyl-glutathione 2,2-dichloroacetaldehyde-lyase (glutathione-forming)

R07092

1,1-dichloroethylene-epoxide:glutathione S-(chloroepoxyethyl)transferase [2-(S-glutathionyl)acetyl-chloride-forming]

R07093

chloroacetyl-chloride:glutathione S-chloroacetyltransferase

R07094

2-(S-glutathionyl)acetyl-chloride:glutathione 2-(S-glutathionyl)acetyltransferase

R07100

trichloroethene:glutathione S-(1,2-dichlorovinyl)transferase

R07113

1,2-dibromoethane:glutathione ethylenetransferase (episulfonium-forming)

R07116

2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

R08280

4-glutathionyl cyclophosphamide hydrolase

R09409

glutathione-S-transferase

R11905

Disease

H00024

Prostate cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K23790  GSTP; glutathione S-transferase P
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K23790  GSTP; glutathione S-transferase P
   00982 Drug metabolism - cytochrome P450
    K23790  GSTP; glutathione S-transferase P
   00983 Drug metabolism - other enzymes
    K23790  GSTP; glutathione S-transferase P
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K23790  GSTP; glutathione S-transferase P
   05204 Chemical carcinogenesis - DNA adducts
    K23790  GSTP; glutathione S-transferase P
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K23790  GSTP; glutathione S-transferase P
   05215 Prostate cancer
    K23790  GSTP; glutathione S-transferase P
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K23790  GSTP; glutathione S-transferase P
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K23790  GSTP; glutathione S-transferase P
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K23790  GSTP; glutathione S-transferase P
Enzymes [BR:ko01000]
2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.18  glutathione transferase
     K23790  GSTP; glutathione S-transferase P
Transporters [BR:ko02000]
Other transporters
  Pores ion channels
   K23790  GSTP; glutathione S-transferase P

Other DBs

GO:

0004364

Genes

HSA:	2950(GSTP1)

PTR:	745954(GSTP1)

PPS:	100990234(GSTP1)

GGO:	101141693(GSTP1)

PON:	100174544(GSTP1)

NLE:

100580544

HMH:	116469088(GSTP1)

MCC:	721704(GSTP1)

MCF:	102127415(GSTP1)

MNI:	105469690(GSTP1)

CSAB:

103216679(GSTP1)

CATY:

105577345(GSTP1)

PANU:

101008213(GSTP1)

TGE:	112606114(GSTP1)

MLEU:

105544479(GSTP1)

RRO:	104664729(GSTP1) 104680184 104682897

RBB:	108518709(GSTP1)

TFN:	117081010(GSTP1)

PTEH:

111522339(GSTP1)

CANG:

105512082(GSTP1)

CJC:	100398632(GSTP1)

SBQ:	101029537(GSTP1)

CIMI:

108310189(GSTP1)

CSYR:

103252256(GSTP1)

MMUR:

105867418 105867419

LCAT:

123642835 123642836

PCOQ:

105826847 105827398

OGA:	100965976 100966292

MMU:	100042625(Gstp-ps) 14869(Gstp2) 14870(Gstp1) 225884(Gstp3)

MCAL:

110285868

MPAH:

110328983 110332920 110335587

RNO:	100911464 24426(Gstp1) 293656(Gstp3)

MCOC:

116100999 116101000

ANU:	117698262 117698288 117722448

MUN:	110560369 110560370

CGE:	100689311(Gstp1) 100757534

MAUA:

101840758 101841030(Gstp1)

PROB:

127228622

PLEU:

114694764 114694770

MFOT:

126488776 126498812 126498898 126500077 126515453

AAMP:

119817596 119821268 119823311

NGI:

103725597

HGL:	101696396 101712988(Gstp1)

CPOC:

100734245(Gstp1)

CCAN:

109692070(Gstp1)

DORD:

105989131 105989276

DSP:	122105104 122105105

PLOP:

125361333

NCAR:

124958870

MMMA:

107157012(Gstp1)

OCU:

100342268

OPI:	101536139(GSTP1)

TUP:	102468765 102470193

GVR:	103597997(GSTP1)

CFA:	119867218 476005(GSTP1) 476006 611366

CLUD:

112650671 112653087 112659403 112659438 112664896 112675097 112677108 118353087

VVP:	112924174 112924175 112932685

VLG:	121472289 121474755 121489250 121492960 121493582 121497865 121498757 121501330

NPO:	129503208 129503209 129507966 129520093 129521167

AML:	100466250(GSTP1) 100466491

UMR:	103672175 103679521 103679616

UAH:	113244018 113244019

UAR:	123778509 123778513 123791569

ELK:	111149481 111149482

LLV:	125110256 125110257

MPUF:

101673784 101676916(GSTP1)

MNP:	132017791 132017797

MLK:	131816596(GSTP1) 131816599

NVS:	122913193 122914571(GSTP1)

ORO:	101363382 101363675

EJU:	114220476 114220477

ZCA:	113913994 113914159(GSTP1) 113914398 113920419 113924221 113937552

MLX:	118008609 118016136(GSTP1) 118016139

NSU:	110570615 110571000 110576049 110576050 110582361

LWW:	102730785 102736804

FCA:	101082184(GSTP1)

PYU:	121023699 121023737(GSTP1)

PCOO:

112860551(GSTP1)

PBG:	122484066(GSTP1)

PVIV:

125147216(GSTP1)

LRUF:

124505671

PTG:	102964863(GSTP1)

PPAD:

109246865 109246991

PUC:

125930454

AJU:

106971176

HHV:	120233931(GSTP1) 120233937

BTA:	281806(GSTP1) 525938(GSTP1)

BOM:	102271929 102272205

BIU:	109554614(GSTP1) 109554615

BBUB:

102391835(GSTP1) 102395607

BBIS:

104986954 104987066(GSTP1)

CHX:	100861197 102184041

OAS:	101120874 105607169

BTAX:

128068782 128068894(GSTP1)

ODA:	120874784(GSTP1) 120874785

CCAD:

122431193 122431348

MBEZ:

129548686(GSTP1)

SSC:	100739163 100739508

CFR:	102521850(GSTP1) 102522092

CBAI:

105070345 105070346

CDK:	105104415 105104416(GSTP1)

VPC:	102537998(GSTP1) 102538267 102541613

BACU:

103003254 103009177

BMUS:

118899700(GSTP1) 118900275

LVE:	103070610 103079831

OOR:	101269985 101270233

DLE:	111183661 111183662

PCAD:

102973461 102980638(GSTP1)

PSIU:

116758573(GSTP1) 116758576

NASI:

112402342 112402344

ECB:	100053249 100059533

EPZ:	103543521 103560039

EAI:	106833486 106833487

MYB:	102246313(GSTP1)

MYD:	102763245(GSTP1)

MMYO:

118665212(GSTP1)

MLF:	102426861(GSTP1)

PKL:	118706960(GSTP1)

EFUS:

103291067(GSTP1)

MNA:	107537398(GSTP1) 107537399

DRO:	112317130 112317408(GSTP1)

SHON:

118991827(GSTP1)

AJM:	119041910 119041911

PDIC:

114499161 114499463

PHAS:

123829384 123829387

MMF:	118628907(GSTP1) 118628908

PPAM:

129068348 129068349

HAI:	109384157 109384161

RFQ:	117030858 117030859

PALE:

102889068 102896271

PGIG:

120583786 120584749 120584750 120619747

PVP:	105306557 105306558

RAY:	107499218 107503575 107503958

TOD:	119249897 119249900

SARA:

101553461 101553725

SETR:

126002884(GSTP1)

LAV:	100669606(GSTP1)

TMU:

101356570

ETF:	101649025 101649339 101652001

DNM:	101436889 101437314

MDO:	100618766(GSTP1)

GAS:	123255467(GSTP1)

SHR:	100917755(GSTP1)

AFZ:	127539723 127539724 127539725

PCW:	110195579(GSTP1)

OAA:	100075326(GSTP1)

ASN:	102380698(GSTP1)

AMJ:	102561359(GSTP1)

PSS:	102461019(GSTP1)

CMY:	102946499(GSTP1)

CCAY:

125638233(GSTP1)

DCC:	119857356(GSTP1)

CPIC:

101950002(GSTP1)

TST:	117873101(GSTP1)

CABI:

116822219(GSTP1)

MRV:	120402787(GSTP1)

ACS:	100562923 100565219

ASAO:

132763176 132772487(GSTP1)

PVT:	110078372(GSTP1)

SUND:

121919457(GSTP1)

PBI:	103052321(GSTP1)

PMUR:

107290800(GSTP1)

CTIG:

120308303(GSTP1)

TSR:

106546456

PGUT:

117667082(GSTP1)

APRI:

131183944(GSTP1)

PTEX:

113450209(GSTP1)

NSS:	113423821(GSTP1)

VKO:	123019721(GSTP1)

PMUA:

114600945(GSTP1)

PRAF:

128418208(GSTP1)

ZVI:	118089497(GSTP1)

HCG:	128340896(GSTP1)

GJA:	107112617(GSTP1)

STOW:

125425851(GSTP1)

EMC:	129325124(GSTP1)

XLA:	121397248 398321(gstp1.L)

XTR:	100490385 101730710 549395(gstp1)

NPR:	108796232 108796240 108803819 108804036

RTEM:

120909156 120909159 120909162

BGAR:

122940742 122940804 122940968 122941147 122941285 122941320 122941536 122941806 122941870 122942121 122942122 122942123 122942312 122942405

MUO:	115456742(GSTP1) 115456748 115456755 115456763 115456768 115460575

GSH:	117348114 117348351(GSTP1) 117348632 117348633 117348634 117348635 117348695

DRE:	553169(gstp1.1) 79381(gstp1.2)

SRX:	107710458 107715170

SANH:

107676164 107676166 107678620

SGH:	107556847 107589127

CCAR:

109090485 109090487

CAUA:

113047821 113114480

CGIB:

127971698 128027703

PTET:

122358282(gstp1)

LROH:

127175787(gstp1.2)

OMC:	131553102(gstp1.2)

PPRM:

120465393(gstp1)

RKG:	130077977(gstp1.2)

MAMB:

125266893(gstp1.2) 125266894

CIDE:

127494157 127494158

MASI:

127413352 127413353 127418176

TROS:

130563768 130563962

TDW:	130437847 130437867(gstp1.2) 130437868 130437869

MANU:

129422429 129422430

IPU:

108275325

IFU:

128618547

PHYP:

113530137(gstp1)

SMEO:

124392962

TFD:

113654973

TVC:

132856913

AMEX:

103038276(gstp1)

CMAO:

118812161

EEE:	113588610(gstp1)

CHAR:

105893541 105893620

SASA:

100136484(GSTP1) 106611534(GSTP1) 106611535(GSTP1)

STRU:

115170171 115205084 115205085

OTW:	112221077 112256361 112256363

OMY:	110488957 110505157 110505158

OGO:	123993532 124010995 124011086

ONE:	115129573 115129946 115130839

OKI:	109864869 109905299 109906033

OKE:	118363614 118363615 118380048

SALP:

111965855 111967603 111967604

SNH:	120046954 120047410 120061980 120062233

CCLU:

121535268 121540478

ELS:	105006792(gstp1) 105006793(gstp1)

SFM:	108920991 108938722(gstp1)

PKI:	111832815 111835465

AANG:

118228221

LOC:	102694737 102694931

PSPA:

121294719 121323500(gstp1)

ARUT:

117408499 117421255

PSEX:

120532343

LCM:	102363583(GSTP1)

CPLA:

122546256 122547755

HOC:	132808834 132808840

LERI:

129705462

SPU:	115918957 580662

LPIC:

129260511 129271529

APLC:

110973104 110977486 110989966

AJC:	117113073 117113171

SKO:	100373058 102807751

CEL:	CELE_F37F2.3(gst-25) CELE_R107.7(gst-1) CELE_R13D7.7(gst-41) CELE_T28A11.11(gst-23) CELE_Y45G12C.2(gst-10)

CBR:	CBG_01286(Cbr-gst-10.2) CBG_01287(Cbr-gst-10.1) CBG_01288 CBG_06825(Cbr-gst-1)

CRQ:	GCK72_009251 GCK72_020025 GCK72_020026 GCK72_020027

BMY:	BM_BM5414(Bma-gst-1)

LOA:	LOAG_01321

TSP:

Tsp_05430

HRO:	HELRODRAFT_168544 HELRODRAFT_168545

LGI:	LOTGIDRAFT_237303

PVUL:

126810973

BGT:

106078662

GAE:

121370754

CRG:	105320049 105323725

CVN:	111103987 111104156 111105347 111105513

CANU:

128185651 128186251

OED:	125675291 130053397

MYI:

PMAX:

MCAF:

MMER:

RPHI:

132720216 132720217 132739157 132760502

DPOL:

127852352 127852353 127852354 127853433 127854132

LAK:	106152304 106169389

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:	124441838 124446217 124446847

HMG:

100207134

TAD:	TRIADDRAFT_64179

CRE:	CHLRE_17g721350v5 CHLRE_17g742300v5 CHLRE_17g742450v5

VCN:	VOLCADRAFT_107623 VOLCADRAFT_92063 VOLCADRAFT_94521

MNG:	MNEG_5012 MNEG_9750

CVR:	CHLNCDRAFT_142000 CHLNCDRAFT_57035

GSL:	Gasu_24110 Gasu_27200 Gasu_28590 Gasu_44900 Gasu_44970

ACAN:

ACA1_028180 ACA1_054650 ACA1_144840 ACA1_174170 ACA1_215720 ACA1_217200 ACA1_235060 ACA1_364370

» show all

Reference

PMID:3664469

Authors

Kano T, Sakai M, Muramatsu M

Title

Structure and expression of a human class pi glutathione S-transferase messenger RNA.

Journal

Cancer Res 47:5626-30 (1987)

Sequence

[hsa:2950]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (22)   
   KEGG PATHWAY (22)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (42)   
   KEGG ENZYME (1)   
   KEGG REACTION (22)   
   KEGG RCLASS (19)   
Gene (615)   
   KEGG GENES (591)   
   KEGG MGENES (24)   
All databases (684)   

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