KEGG ORTHOLOGY: K24369

ORTHOLOGY: K24369

Entry

K24369                      KO

Symbol

ZC4H2

Name

zinc finger C4H2 domain-contaning protein

Disease

H02268

Wieacker-Wolff syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K24369  ZC4H2; zinc finger C4H2 domain-contaning protein
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   Other zinc fingers
    K24369  ZC4H2; zinc finger C4H2 domain-contaning protein

Genes

HSA:	55906(ZC4H2)

PTR:	465671(ZC4H2)

PPS:	100982751(ZC4H2)

GGO:	101132447(ZC4H2)

PON:	100457329(ZC4H2)

NLE:	100598715(ZC4H2)

HMH:	116811740(ZC4H2)

MCC:	708764(ZC4H2)

MCF:	102139117(ZC4H2)

MTHB:

126946561

MNI:	105476702(ZC4H2)

CSAB:

103232088(ZC4H2)

CATY:

105586173(ZC4H2)

PANU:

101010478 116271966 116272440

TGE:	112616103(ZC4H2)

MLEU:

105537031(ZC4H2)

RBB:	108520865(ZC4H2)

TFN:	117077216(ZC4H2)

PTEH:

111531206(ZC4H2)

CANG:

105501475(ZC4H2)

CJC:	100394952(ZC4H2)

SBQ:	101035117(ZC4H2)

CIMI:

108291698(ZC4H2)

CSYR:

103270922(ZC4H2)

MMUR:

105863193(ZC4H2)

LCAT:

123628305(ZC4H2)

PCOQ:

105809280(ZC4H2)

OGA:	100947547(ZC4H2)

MMU:	245522(Zc4h2)

MCAL:

110287222(Zc4h2)

MPAH:

110313572(Zc4h2)

RNO:	367838(Zc4h2)

MCOC:

116086929(Zc4h2)

ANU:	117695543(Zc4h2)

MUN:	110539430(Zc4h2)

CGE:	100756582(Zc4h2)

MAUA:

101837005(Zc4h2)

PROB:

127217855(Zc4h2)

PLEU:

114706488(Zc4h2)

MORG:

121443136 121445072

MFOT:

126493135

AAMP:

119805005(Zc4h2)

NGI:	103743132(Zc4h2)

HGL:	101716058(Zc4h2)

CPOC:

100734959(Zc4h2)

CCAN:

109682376(Zc4h2)

DORD:

105999315(Zc4h2)

DSP:	122096372(Zc4h2)

PLOP:

125343503(Zc4h2)

NCAR:

124972057

MMMA:

107155698(Zc4h2)

OCU:

100357865

OPI:	101528505(ZC4H2)

TUP:	102480392(ZC4H2)

GVR:	103607817(ZC4H2)

CFA:	491920(ZC4H2)

CLUD:

112671774(ZC4H2)

VVP:	112911213(ZC4H2)

VLG:	121483546(ZC4H2)

NPO:	129518238(ZC4H2)

AML:	100463874(ZC4H2)

UMR:	103681155(ZC4H2)

UAH:	113246900(ZC4H2)

UAR:	123787937(ZC4H2)

ELK:

111139324

MPUF:

101681632(ZC4H2)

MNP:	132007808(ZC4H2)

MLK:	131821593(ZC4H2)

NVS:	122897140(ZC4H2)

ORO:	101372805(ZC4H2)

EJU:	114226469(ZC4H2)

MLX:	118013970(ZC4H2)

NSU:	110571683(ZC4H2)

LWW:	102726510(ZC4H2)

FCA:	101101621(ZC4H2)

PYU:	121024992(ZC4H2)

PCOO:

112871181(ZC4H2)

PBG:	122476896(ZC4H2)

PVIV:

125157857(ZC4H2)

LRUF:

124521586

PTG:	102969287(ZC4H2)

PPAD:

109260574(ZC4H2)

PUC:

125931710

AJU:

106979072

HHV:	120224072(ZC4H2)

BTA:	768236(ZC4H2)

BOM:	102269527(ZC4H2)

BIU:	109555465(ZC4H2)

BBUB:

102402278(ZC4H2)

BBIS:

104988371(ZC4H2)

CHX:	102175668(ZC4H2)

OAS:	101111604(ZC4H2)

BTAX:

128070211(ZC4H2)

ODA:	120882210(ZC4H2)

CCAD:

122435264(ZC4H2)

MBEZ:

129534992(ZC4H2)

SSC:	100151781(ZC4H2)

CBAI:

105083723(ZC4H2)

CDK:	105107142(ZC4H2)

VPC:	102539401(ZC4H2)

BACU:

103005959

BMUS:

118888636(ZC4H2)

LVE:

103074956

OOR:	101282964 125960263

DLE:	111169705(ZC4H2)

PCAD:

102977230(ZC4H2)

PSIU:

116746953(ZC4H2) 116746966

NASI:

112404063(ZC4H2)

ECB:	100065318(ZC4H2)

EPZ:	103541792(ZC4H2)

EAI:	106825913(ZC4H2)

MYB:	102254554(ZC4H2)

MYD:	102774482(ZC4H2)

MMYO:

118654603(ZC4H2)

MLF:	102424147(ZC4H2)

PKL:	118720008(ZC4H2)

EFUS:

103304592(ZC4H2)

MNA:	107534895(ZC4H2)

DRO:	112300068(ZC4H2)

SHON:

118986924(ZC4H2)

AJM:	119041781(ZC4H2)

PDIC:

114505194(ZC4H2) 118500107

PHAS:

123824320(ZC4H2)

MMF:	118636226(ZC4H2)

PPAM:

129071054(ZC4H2)

HAI:	109390062(ZC4H2)

RFQ:	117021306(ZC4H2)

PALE:

102895349(ZC4H2)

PGIG:

120592525(ZC4H2)

PVP:	105307767(ZC4H2)

RAY:	107499330(ZC4H2)

MJV:	108393964(ZC4H2)

TOD:	119246118(ZC4H2)

SARA:

101545339 101553367 101558214

SETR:

125999268(ZC4H2)

LAV:	100673964(ZC4H2)

TMU:

101360772

ETF:	101645475(ZC4H2)

DNM:	101430388(ZC4H2)

MDO:	100029043(ZC4H2)

GAS:	123253534(ZC4H2)

SHR:	100929108(ZC4H2)

AFZ:

127542610

PCW:	110203820(ZC4H2)

OAA:	100088019(ZC4H2)

GGA:	422176(ZC4H2)

PCOC:

116229468(ZC4H2)

MGP:	100549065(ZC4H2)

CJO:	107312617(ZC4H2)

TPAI:

128075784(ZC4H2)

LMUT:

125699548(ZC4H2)

NMEL:

110403288(ZC4H2)

APLA:

101799562(ZC4H2)

ACYG:

106045562(ZC4H2)

CATA:

118245295(ZC4H2)

AFUL:

116494296(ZC4H2)

TGU:	100231302(ZC4H2)

LSR:	110480491(ZC4H2)

SCAN:

103816414(ZC4H2)

PMOA:

120508678(ZC4H2)

OTC:	121331930(ZC4H2)

PRUF:

121363139(ZC4H2)

GFR:	102034967(ZC4H2)

FAB:	101808213(ZC4H2)

OMA:	130253285(ZC4H2)

PHI:	102103437(ZC4H2)

PMAJ:

107203878(ZC4H2)

CCAE:

111945227(ZC4H2)

CCW:	104691266(ZC4H2)

CBRC:

103622777(ZC4H2)

ETL:	114067645(ZC4H2)

ZAB:	102064927(ZC4H2)

ACHL:

103802653(ZC4H2)

SVG:	106860022(ZC4H2)

MMEA:

130580455(ZC4H2)

HRT:	120747925 120764877(ZC4H2)

FPG:	101914842(ZC4H2)

FCH:	102056439(ZC4H2)

CLV:	102098724(ZC4H2)

EGZ:	104122402(ZC4H2)

NNI:	104012826(ZC4H2)

PCRI:

104025956(ZC4H2)

PLET:

104615487(ZC4H2)

EHS:	104504752(ZC4H2)

PCAO:

104045176(ZC4H2)

ACUN:

113479971(ZC4H2)

TALA:

104356420(ZC4H2)

PADL:

103925548(ZC4H2)

AFOR:

103906143(ZC4H2)

ACHC:

115333466(ZC4H2)

HALD:

104312591(ZC4H2)

HLE:	104834769(ZC4H2)

AGEN:

126050246

GCL:

127019833

CCRI:

104164914(ZC4H2)

CSTI:

104559860(ZC4H2)

CMAC:

104485336(ZC4H2)

MUI:	104537416(ZC4H2)

BREG:

104630989(ZC4H2)

FGA:	104071448(ZC4H2)

GSTE:

104252381(ZC4H2)

LDI:	104341500(ZC4H2)

MNB:	103782361(ZC4H2)

OHA:	104336281(ZC4H2)

NNT:	104400450(ZC4H2)

SHAB:

115612961(ZC4H2)

DPUB:

104306366(ZC4H2)

PGUU:

104466294(ZC4H2)

ACAR:

104519478(ZC4H2)

CPEA:

104387810(ZC4H2)

AVIT:

104269105(ZC4H2)

CVF:	104282574(ZC4H2)

RTD:	128914702(ZC4H2)

CUCA:

104054310(ZC4H2)

TEO:	104380384(ZC4H2)

BRHI:

104499480(ZC4H2)

AAM:	106493804(ZC4H2)

AROW:

112966353(ZC4H2)

NPD:	112960444(ZC4H2)

DNE:	112980841(ZC4H2)

SCAM:

104145664(ZC4H2)

ASN:	102369838(ZC4H2)

AMJ:	102574846(ZC4H2)

CPOO:

109310860(ZC4H2)

GGN:	109300441(ZC4H2)

PSS:	102463606(ZC4H2)

CMY:	102931753(ZC4H2)

CCAY:

125642282(ZC4H2)

DCC:	119861366(ZC4H2)

CPIC:

101943589(ZC4H2)

TST:	117883121(ZC4H2)

CABI:

116816579(ZC4H2)

MRV:	120371332(ZC4H2)

ACS:	100553200(zc4h2)

ASAO:

132762934(ZC4H2)

PVT:	110074345(ZC4H2)

SUND:

121937388(ZC4H2)

PBI:	103049183(ZC4H2)

PMUR:

107291298(ZC4H2)

CTIG:

120314126 120316622(ZC4H2)

TSR:	106554813(ZC4H2)

PGUT:

117675979(ZC4H2)

APRI:

131205195(ZC4H2)

PTEX:

113437926(ZC4H2)

NSS:	113419275(ZC4H2)

VKO:	123022061(ZC4H2)

PMUA:

114589058(ZC4H2)

PRAF:

128406367(ZC4H2)

ZVI:	118084524(ZC4H2)

HCG:	128335412(ZC4H2)

STOW:

125442917 125442918

EMC:	129341333(ZC4H2)

XLA:	444382(zc4h2.L) 494779(zc4h2.S)

XTR:	549429(zc4h2)

NPR:	108789933(ZC4H2)

RTEM:

120913759(ZC4H2)

BBUF:

121009496(ZC4H2)

BGAR:

122946780(ZC4H2)

MUO:	115474151(ZC4H2)

GSH:	117361643(ZC4H2)

DRE:	323487(zc4h2)

SRX:	107741194(zc4h2) 107746238

SANH:

107663226 107672730

SGH:	107557113 107597258

CCAR:

109090390 109090391(zc4h2)

CAUA:

113048856(zc4h2) 113091411

CGIB:

127957591 128012011

PTET:

122345085(zc4h2)

LROH:

127165297(zc4h2)

OMC:	131541297(zc4h2)

PPRM:

120470270(zc4h2)

RKG:	130091929(zc4h2)

MAMB:

125266482(zc4h2)

CIDE:

127513665

MASI:

127419860 127438901

TROS:

130570520(zc4h2)

TDW:	130419190(zc4h2)

MANU:

129439917(zc4h2)

IPU:	108259842 108269407

IFU:	128603871(zc4h2) 128611489

PHYP:

113542810(zc4h2)

SMEO:

124379129(zc4h2) 124386571

TFD:	113635626 113658396(zc4h2)

TVC:	132841284(zc4h2) 132856318

AMEX:

103036162 103036407(zc4h2)

CMAO:

118807256 118814626(zc4h2)

EEE:	113574204 113590073(zc4h2)

CHAR:

105893203(zc4h2) 105906304

TRU:	101077424(zc4h2)

TFS:	130531909(zc4h2)

TNG:	GSTEN00029347G001

LCO:	104925169(zc4h2)

NCC:

104949428

TBEN:

117475216(zc4h2)

CGOB:

115014388(zc4h2)

PGEO:

117454012(zc4h2)

GACU:

117550761(zc4h2)

EMAC:

134859918(zc4h2)

ELY:	117260926(zc4h2)

EFO:	125894884(zc4h2)

PLEP:

121948528(zc4h2)

SLUC:

116036595(zc4h2)

ECRA:

117952229(zc4h2)

ESP:	116696800(zc4h2)

PFLV:

114562510(zc4h2)

GAT:	120818484(zc4h2)

PPUG:

119210325(zc4h2)

AFB:	129090055(zc4h2)

CLUM:

117737332(zc4h2)

PSWI:

130209917(zc4h2)

MSAM:

119888161(zc4h2)

SCHU:

122879783(zc4h2)

CUD:	121516284(zc4h2)

ALAT:

119007812(zc4h2)

MZE:	101465025(zc4h2)

ONL:	100701550(zc4h2)

OAU:	116315175(zc4h2)

OLA:	101167375(zc4h2)

OML:	112153341(zc4h2)

CSAI:

133447216(zc4h2)

XMA:	102236440(zc4h2)

XCO:	114138943(zc4h2)

XHE:	116714258(zc4h2)

PRET:

103470911(zc4h2)

PFOR:

103139928(zc4h2)

PLAI:

106939333(zc4h2)

PMEI:

106928837(zc4h2)

GAF:	122837304(zc4h2)

PPRL:

129362683(zc4h2)

CVG:	107102044(zc4h2)

CTUL:

119790479(zc4h2)

GMU:	124860541(zc4h2)

NFU:	107386844(zc4h2)

KMR:	108237974(zc4h2)

ALIM:

106525225(zc4h2)

NWH:	119409120(zc4h2)

AOCE:

111568067(zc4h2)

MCEP:

125007750(zc4h2)

CSEM:

103391228(zc4h2)

POV:	109647431(zc4h2)

SSEN:

122778355(zc4h2)

HHIP:

117769650(zc4h2)

HSP:	118112233(zc4h2)

SMAU:

118319507(zc4h2)

LCF:

108882769

SDU:	111226797(zc4h2)

SLAL:

111646488(zc4h2)

XGL:	120784950(zc4h2)

HCQ:	109524456(zc4h2)

SSCV:

125983538

SBIA:

133509192(zc4h2)

PEE:	133407648(zc4h2)

PTAO:

133485273(zc4h2)

BPEC:

110158123(zc4h2)

MALB:

109957486(zc4h2)

BSPL:

114864640(zc4h2)

SJO:	128363246(zc4h2)

SASA:

100195859(hc127) 106612177

STRU:

115167954 115205654

OTW:	112238716 112239334

OMY:	110489133 110504289

OGO:	123993666 124010766

ONE:	115129219 115130975

OKI:	109876089 109883119

OKE:	118372982 118373008(zc4h2)

SALP:

112071004 112073527

SNH:	120035150 120042375

CCLU:

121531541 121539591

ELS:

105024399

SFM:	108920020(zc4h2) 108925210

PKI:	111855221(zc4h2) 111859766

AANG:

118222172 118234887(zc4h2)

LOC:	102686345(zc4h2)

PSPA:

121295251 121318922

ARUT:

117411977 117963290

PSEX:

120537414(zc4h2)

LCM:	102347439(ZC4H2)

CMK:	103178619(zc4h2)

RTP:	109917638(zc4h2)

CPLA:

122557295(zc4h2)

HOC:	132820170(zc4h2)

PMRN:

116954423(ZC4H2)

LRJ:	133347831(ZC4H2)

BFO:

BBEL:

CIN:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG13001(CG13001)

DER:

6550049

DSE:

6618016

DSI:	Dsimw501_GD29570(Dsim_GD29570)

DYA:	Dyak_GE15631

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI15222

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:	110678839 5574176

AALB:

109403168

CQU:	CpipJ_CPIJ006008

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_209947

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:	113499850 113506379

SLIU:

OFU:

PXY:

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM479630

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_308736

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:	107359513 107367274

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:	129220531 129233919

SDM:

118205160

LPOL:

106469202

PMEO:

129581020

CEL:	CELE_ZK930.2(ZK930.2) CELE_ZK930.3(vab-23)

CBR:	CBG_02748 CBG_02749(Cbr-vab-23)

CRQ:	GCK72_005218

NAI:	NECAME_17055 NECAME_17056

BMY:	BM_BM7591(Bm7591) BM_BM7592(Bma-vab-23)

LOA:	LOAG_06872 LOAG_11495

TSP:

Tsp_05458

HRO:	HELRODRAFT_101782

LGI:	LOTGIDRAFT_235711

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_012150

OVI:	T265_01390

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:	130641440 130644433

TAD:	TRIADDRAFT_56721

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Reference

PMID:23623388

Authors

Hirata H, Nanda I, van Riesen A, McMichael G, Hu H, Hambrock M, Papon MA, Fischer U, Marouillat S, Ding C, Alirol S, Bienek M, Preisler-Adams S, Grimme A, Seelow D, Webster R, Haan E, MacLennan A, Stenzel W, Yap TY, Gardner A, Nguyen LS, Shaw M, Lebrun N, Haas SA, Kress W, Haaf T, Schellenberger E, Chelly J, Viot G, Shaffer LG, Rosenfeld JA, Kramer N, Falk R, El-Khechen D, Escobar LF, Hennekam R, Wieacker P, Hubner C, Ropers HH, Gecz J, Schuelke M, Laumonnier F, Kalscheuer VM

Title

ZC4H2 mutations are associated with arthrogryposis multiplex congenita and intellectual disability through impairment of central and peripheral synaptic plasticity.

Journal

Am J Hum Genet 92:681-95 (2013)
DOI:10.1016/j.ajhg.2013.03.021

Sequence

[hsa:55906]

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Disease (1)   
   KEGG DISEASE (1)   
Gene (821)   
   KEGG GENES (689)   
   KEGG MGENES (132)   
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