KEGG   Leishmania major: LMJF_28_2280
Entry
LMJF_28_2280      CDS       T01014                                 
Name
(RefSeq) DNA topoisomerase II
  KO
K03164  DNA topoisomerase II [EC:5.6.2.2]
Organism
lma  Leishmania major
Brite
KEGG Orthology (KO) [BR:lma00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins [BR:lma03032]
    LMJF_28_2280
   03036 Chromosome and associated proteins [BR:lma03036]
    LMJF_28_2280
Enzymes [BR:lma01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.2  DNA topoisomerase (ATP-hydrolysing)
     LMJF_28_2280
DNA replication proteins [BR:lma03032]
 Eukaryotic type
  DNA Topoisomerases
   LMJF_28_2280
Chromosome and associated proteins [BR:lma03036]
 Eukaryotic type
  Chromosome condensation proteins
   Other regulators of chromosome condensation
    LMJF_28_2280
  Centrosome formation proteins
   Centriole proteins
    LMJF_28_2280
SSDB
Motif
Pfam: DNA_topoisoIV TOPRIM_C DNA_gyraseB HATPase_c Toprim DNA_gyraseB_C
Other DBs
NCBI-GeneID: 5653441
NCBI-ProteinID: XP_001684512
UniProt: Q4Q836
Position
28:884562..889055
AA seq 1497 aa
MGKTVEQIYQKKTQHDHILTRPDMYIGTLEPVTDDIWVYDDAENSMKQRKCTWTPGLYKI
FDEILVNAADNKVRDPIGQTVIRVWMTESYVRVYNNGEGIPIQKHREHDLWVPEMIFGHL
LTSSNYDDEEAKVTGGRNGFGAKLTNVFSKQFEVETVHSRSRKKFYMKWTNNMLQHDDPV
IVPCDSADYTMVTFYPDFALFHVDKFTEDMLLMMKRRVYDIAGCTDKTLKCFLNDERIAC
TTFPEYVDLYPTMGEERKAASYSRVNDRWEVCVRVSNIGPQQVSFVNSIATTRGGTHVKY
IMDQITSKVMEQAKKKKKTDVKPHMIRPHIFLFVNCLIENPGFDSQTKETLNTVKSKFGS
TCDLPNSIVDYIMSSGIVERSVEMANSKIAREMASKMRSSDRKQIMGIPKLDDANEAGGK
HSHRCTLILTEGDSAKTLCTAGLAVKDRDYFGVFPLRGKPLNVREASLKKLAACEEIQCV
MKIMGLDIRQTYENSDGLRYGHLMIMSDQDHDGSHIKGLLINFIHCFWPNLLRVPGFLQQ
FITPIVKARPKGRGGAGKAISFFSMPDYFEWKKAIGDNLSNYQIRYYKGLGTSGAEEGRE
YFENIDRHRLNFVEQEQSEEDRIVMAFGKDRVEDRKEWITNFKTNVNVNESMDYNVRQVS
YRDFVDKELILFSIADCERSIPSVIDGFKPGQRKILFSCFKRNLVNSIKVVQLAGYVSEH
SAYHHGEQSLVQTIVGMAQDFVGSNNVPLLRKDGQFGTRLHGGKDHAAGRYIFTRLMQVA
RAIFHPADDFVVEYKDDDGLSVEPFFYIPVIPMVLVNGTTGIGTGFSTSIPNYNPLEIIS
NLERLMRGEEVHKMQPWYFGFTGTMEEKEPGKFISHGRYEIRPDGVVCITELPIGVWTQA
YKKFLEDMREKELVVQYREHTTDVTVDFEVFLHPQVLEQWVAQDVVEERLQLKEYVHATN
IIAFNKEGQITKYSDAESVLKEFYLVRLDYYAKRKQYLLGELRRLTSKLENMVRFVREVV
EGTLVVTKRKKKELLEDLQRRMYLPFPPHTKKKLSSTTVEEGDDEGAPDAQNSEEDVLGV
GNAADSGADDGAAEPPEMRRATRDYDYLLGMKLWSLTAEMIARLEAQMARARRDTAAMEA
RTPKDMWMEDLKVLRTKLESFYADREVEIATIQRKKVKKPFDARRLRVPILSDKARSLLQ
KEAEKSLKANGVGGRRRVGGGDDTLAGGAASAVGEVARPKPKKAAAKKRRKAKDSDDDDD
SDSDEEWMFDNSDNDDEGENIVGMGDAGAPPVPERARVCGSPKKPRAAPKRHAASKPRKK
VRNSDDDDSGDNSNSGSSKPVRRRPKKDAISAAAAAATKTALDDLDLDGFGLDALASASA
VSAAPKMAMTAAPPSNGGAARSTKPTADADDDLLLLGLVKAKTETAPPAATAASKRATAA
SARPAKPHAKPAARRRRRGSSSDSSDDDDEDSTDASASSLEESSASSDSDSDYSFSD
NT seq 4494 nt   +upstreamnt  +downstreamnt
atgggcaaaaccgtcgaacagatctaccaaaagaagacgcagcatgatcacattctcacg
cgtcctgacatgtacatcggcacccttgagccggtgacagacgacatctgggtctatgac
gatgcagagaacagtatgaagcagcgcaagtgcacctggacacctgggctgtacaagatc
tttgatgagatactggtcaacgcggcggacaacaaggtacgcgacccgatcggccagacc
gtcattcgggtgtggatgacggagagctatgtgcgagtgtacaacaacggcgagggcatc
ccgatccagaagcatcgcgagcacgacctctgggtgccggaaatgatcttcgggcacctt
ctcacctcctccaactacgacgatgaggaggcgaaggtgacgggcgggcgcaacggcttc
ggcgcgaagctgacgaacgtcttctcgaagcaattcgaggtcgagaccgtgcacagccgc
tctcgcaagaagttctacatgaaatggacgaacaacatgctgcaacacgacgaccccgtt
atcgtgccgtgcgacagcgctgactacaccatggtcaccttctaccccgactttgcactc
ttccacgtcgataagtttaccgaggacatgctgctgatgatgaagcggcgcgtgtacgac
attgcggggtgcaccgacaagacactcaagtgcttcctgaacgatgagcgcatcgcctgc
accaccttcccggagtacgtcgacctctaccccaccatgggcgaggagaggaaggcggcg
agctactcacgcgtgaatgaccgatgggaggtgtgcgtacgggtgtcgaacattgggccg
cagcaggtgagctttgtcaactccatcgccaccacccgcggcggcacacatgtcaagtac
atcatggatcaaatcacctccaaggtgatggagcaggccaagaaaaagaagaagacagac
gtgaagccgcacatgattaggccgcacatttttttattcgtcaactgcctcattgagaac
cccggcttcgactcgcagacgaaggagacgctcaacactgtcaagagcaagtttggcagc
acgtgcgacctgcccaatagtatcgtcgactacattatgagctccggcattgttgagcgc
tcggtcgagatggcgaacagcaagatcgcaagggagatggcgtccaagatgaggtcgtcg
gaccggaaacagatcatgggcatcccgaagctggacgacgccaacgaggcgggcggcaag
cacagccaccgctgcacgctcatcctcacagagggtgactccgccaagacactctgcacg
gccggcctggcggtgaaggatcgggactactttggcgtgtttccgctgcgcggcaagccc
ctcaacgtgcgcgaggcgtcgctgaagaagctagcggcctgcgaggagatccagtgcgtc
atgaagattatggggctcgacattcgccaaacgtacgagaattcagacgggctgcgctac
ggccaccttatgatcatgtccgatcaggaccatgacgggtcgcacatcaaagggcttctc
atcaacttcattcactgcttctggccgaacctgctgcgggtgcctggctttcttcagcag
ttcatcacgccgattgtgaaagcccgaccaaagggccgcggcggggccggcaaggccatc
tccttcttttccatgccggactacttcgagtggaagaaggcgattggcgacaacctgagc
aattaccaaattcggtactacaagggtctcggcacgtccggcgcggaggagggccgcgag
tacttcgagaacatcgaccggcaccgcctcaactttgtggagcaggagcagagcgaggag
gaccgcattgtcatggcctttgggaaggaccgcgtcgaggaccgcaaggagtggatcacg
aacttcaagacgaacgtgaacgtgaatgagtcgatggactacaacgtgcgccaggtgtcg
taccgagactttgtggacaaggagctgattctcttctccatcgccgactgcgagcgcagc
attccgagtgtgattgacggcttcaagcccggccagcgcaagatcctgttctcctgcttc
aagcgcaacttggtgaactctatcaaggtggtgcagcttgctggctacgtctcggagcac
tccgcgtaccaccacggtgagcagtcgctcgtacagacgatcgtcggaatggcgcaggac
tttgtgggcagcaacaacgtcccgctgctgcgcaaggatggtcagttcggtacgcgtctg
cacggtggcaaggaccacgccgcgggccgctacatcttcacccggctcatgcaggtcgcc
cgggccatctttcacccggccgacgactttgtggtcgagtacaaggacgacgacggtctc
tcggtggagcctttcttctacattccggtcatcccgatggtgctggtgaacggcacgacg
ggcatcggcaccgggttcagcacaagcatcccgaactacaacccgctggagatcatcagc
aacctcgagcgcctcatgcggggcgaggaggtgcacaagatgcagccgtggtacttcggc
ttcaccggcacgatggaggagaaggagccaggtaagttcatctcccacggcaggtacgag
atacgcccggatggggtagtgtgcatcacggagctgccgatcggcgtgtggacgcaggcg
tacaagaagttcctggaggacatgcgggagaaggagctcgtggtgcagtaccgcgagcac
acgacggatgtgacagtagacttcgaagtgtttctgcatccccaggtgctggaacagtgg
gttgcgcaggatgtcgtggaggagcggctgcagctgaaggagtacgtgcacgcgacgaac
atcatcgccttcaacaaggagggccagatcaccaagtactcggacgcggagtcggtgctc
aaggagttctacctcgtgcgcctcgactactacgcgaagcgcaagcagtacctcttgggt
gagctgcgtcggctgacgagcaagctggagaacatggtccgcttcgtgcgcgaggtggtg
gagggcacgctcgttgtgaccaagcggaaaaagaaggagctgctcgaggacctgcagcgg
cgcatgtatctgcccttcccgccccacacaaagaagaagctatcttcgaccaccgtggag
gagggggacgacgagggggcgcccgacgcgcagaacagcgaggaggacgtgctgggcgtg
gggaacgccgctgacagtggagcagacgacggcgcggcagagccgccggagatgcgtcgt
gccactcgcgactacgactacctgcttggcatgaagctgtggagcctcacggcggagatg
attgcgcgactggaggcgcagatggcccgggcccgccgcgacactgccgcgatggaggcc
cgcacaccgaaagatatgtggatggaagacctcaaggtgctgcgcaccaagctggagagc
ttctacgcggaccgcgaagtggagattgccaccattcaacgcaagaaggtgaagaagccg
ttcgacgctcgacgactgcgcgtgccgatcttatccgacaaggcgcgctctcttctgcag
aaggaggcggagaagtccctgaaggcaaacggcgtcggcggccgccgtcgcgtcggcggt
ggggatgacacgcttgccggcggagccgcctcggccgttggcgaggtcgcgcggccgaag
ccgaagaaggccgcggcgaagaagcgacgcaaggcaaaggacagcgatgacgacgacgac
agcgactcagatgaggagtggatgtttgacaacagcgataatgacgatgaaggcgagaac
atcgtgggtatgggtgatgcgggagcgccaccggtgccggagagggcacgggtgtgcggc
tctccgaagaagccccgcgcagctccgaagcgccacgcagcatcgaagccgcgcaagaag
gtgcgtaacagcgacgacgacgactcaggcgacaacagcaacagcggcagctccaagcca
gtgaggcgcaggcccaagaaggacgcgatatcggcagctgctgctgctgctacgaagact
gcgcttgacgaccttgacctggacggcttcggactcgatgcgctcgcctccgcttcagcg
gtgagcgccgctccgaagatggccatgactgccgcgcccccgtcaaacggcggtgcagcg
cgctccacaaagcccaccgcagacgccgacgatgatctcctcctgctggggctcgtcaag
gcgaagacagagacagctccaccggctgccacagcagccagcaagagggccactgccgcc
tctgcccgccctgcaaagccgcacgcgaagccggctgctcggcggcgacgccgcggcagc
agcagcgactcgagcgacgatgacgacgaagacagcaccgatgcgtcggcgtcgtcattg
gaggagtcctccgcgtcatccgattccgactccgactacagcttcagtgactag

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (6)   
   Pfam (6)   
All databases (19)   

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