| Entry |
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| Name |
Secondary bile acid biosynthesis
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| Description |
The secondary bile acids are derived from the primary bile acids by the enzymatic action of intestinal bacteria through the process of deconjugation and dehydroxylation. The secondary bile acids in humans include deoxycholic acid and lithocholic acid, formed from the 7alpha-dehydroxylation of cholic acid and chenodeoxycholic acid, respectively.
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| Class |
Metabolism; Lipid metabolism
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| Pathway map |
| Secondary bile acid biosynthesis |
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| Reference |
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| Authors |
Hofmann AF, Hagey LR |
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| Title |
Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. |
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| Journal |
Cell Mol Life Sci 65:2461-83 (2008) |
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| Reference |
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| Authors |
Ridlon JM, Kang DJ, Hylemon PB |
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| Title |
Bile salt biotransformations by human intestinal bacteria. |
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| Journal |
J Lipid Res 47:241-59 (2006) |
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| Reference |
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| Authors |
Ridlon JM, Kang DJ, Hylemon PB |
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| Title |
Isolation and characterization of a bile acid inducible 7alpha-dehydroxylating operon in Clostridium hylemonae TN271. |
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| Journal |
Anaerobe (2009) |
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| Reference |
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| Authors |
Kang DJ, Ridlon JM, Moore DR 2nd, Barnes S, Hylemon PB |
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| Title |
Clostridium scindens baiCD and baiH genes encode stereo-specific 7alpha/7beta-hydroxy-3-oxo-delta4-cholenoic acid oxidoreductases. |
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| Journal |
Biochim Biophys Acta 1781:16-25 (2008) |
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| Reference |
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| Authors |
Moschetta A, Xu F, Hagey LR, van Berge-Henegouwen GP, van Erpecum KJ, Brouwers JF, Cohen JC, Bierman M, Hobbs HH, Steinbach JH, Hofmann AF |
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| Title |
A phylogenetic survey of biliary lipids in vertebrates. |
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| Journal |
J Lipid Res 46:2221-32 (2005) |
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| KO pathway |
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