| Entry |
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| Name |
Lysine biosynthesis
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| Class |
Metabolism; Amino acid metabolism
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| Pathway map |
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| Module |
| Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH: map00300] | | Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine [PATH: map00300] | | Lysine biosynthesis, 2-aminoadipate => lysine [PATH: map00300] | | Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate [PATH: map00300] | | Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine [PATH: map00300] | | Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine [PATH: map00300] | | Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine [PATH: map00300] |
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| Disease |
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| Other DBs |
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| Reference |
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| Authors |
Ledwidge R, Blanchard JS. |
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| Title |
The dual biosynthetic capability of N-acetylornithine aminotransferase in arginine and lysine biosynthesis. |
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| Journal |
Biochemistry 38:3019-3024 (1999) |
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| Reference |
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| Authors |
Fuchs TM, Schneider B, Krumbach K, Eggeling L, Gross R. |
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| Title |
Characterization of a bordetella pertussis diaminopimelate (DAP) biosynthesis locus identifies dapC, a novel gene coding for an N-succinyl-L,L-DAP aminotransferase. |
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| Journal |
J Bacteriol 182:3626-3631 (2000) |
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| Reference |
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| Authors |
Zabriskie TM, Jackson MD. |
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| Title |
Lysine biosynthesis and metabolism in fungi. |
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| Journal |
Nat Prod Rep 17:85-97 (2000) |
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| Reference |
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| Authors |
Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS. |
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| Title |
Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch? |
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| Journal |
Nucleic Acids Res 31:6748-57 (2003) |
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| Reference |
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| Authors |
Velasco AM, Leguina JI, Lazcano A. |
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| Title |
Molecular evolution of the lysine biosynthetic pathways. |
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| Journal |
J Mol Evol 55:445-59 (2002) |
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| Reference |
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| Authors |
Miyazaki T, Miyazaki J, Yamane H, Nishiyama M. |
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| Title |
alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus. |
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| Journal |
Microbiology 150:2327-34 (2004) |
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| Reference |
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| Authors |
Goh DL, Patel A, Thomas GH, Salomons GS, Schor DS, Jakobs C, Geraghty MT. |
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| Title |
Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT). |
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| Journal |
Mol Genet Metab 76:172-80 (2002) |
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| Reference |
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| Authors |
Nishiyama M. |
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| Title |
[Novel lysine biosynthesis: a key to elucidate evolution of metabolic and biosynthetic pathways] |
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| Journal |
Tanpakushitsu Kakusan Koso 49:758-63 (2004) |
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| Reference |
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| Authors |
Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H. |
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| Title |
A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis. |
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| Journal |
Genome Res 9:1175-83 (1999) |
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| Reference |
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| Authors |
Sakai H, Vassylyeva MN, Matsuura T, Sekine S, Gotoh K, Nishiyama M, Terada T, Shirouzu M, Kuramitsu S, Vassylyev DG, Yokoyama S. |
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| Title |
Crystal structure of a lysine biosynthesis enzyme, LysX, from Thermus thermophilus HB8. |
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| Journal |
J Mol Biol 332:729-40 (2003) |
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| Reference |
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| Authors |
Hudson AO, Singh BK, Leustek T, Gilvarg C. |
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| Title |
An LL-diaminopimelate aminotransferase defines a novel variant of the lysine biosynthesis pathway in plants. |
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| Journal |
Plant Physiol 140:292-301 (2006) |
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| Reference |
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| Authors |
Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M |
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| Title |
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus. |
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| Journal |
Nat Chem Biol 5:673-9 (2009) |
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| Reference |
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| Authors |
Dairi T, Kuzuyama T, Nishiyama M, Fujii I |
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| Title |
Convergent strategies in biosynthesis. |
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| Journal |
Nat Prod Rep 28:1054-86 (2011) |
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| Reference |
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| Authors |
Gaston MA, Jiang R, Krzycki JA |
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| Title |
Functional context, biosynthesis, and genetic encoding of pyrrolysine. |
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| Journal |
Curr Opin Microbiol 14:342-9 (2011) |
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| KO pathway |
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