KEGG   PATHWAY: map00525
Entry
map00525                    Pathway                                
Name
Acarbose and validamycin biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
map00525  Acarbose and validamycin biosynthesis
map00525

Module
M00814  Acarbose biosynthesis, sedoheptulopyranose-7P => acarbose [PATH:map00525]
M00815  Validamycin A biosynthesis, sedoheptulopyranose-7P => validamycin A [PATH:map00525]
Reference
  Authors
Flatt PM, Mahmud T
  Title
Biosynthesis of aminocyclitol-aminoglycoside antibiotics and related compounds.
  Journal
Nat Prod Rep 24:358-92 (2007)
DOI:10.1039/b603816f
Reference
  Authors
Mahmud T, Flatt PM, Wu X
  Title
Biosynthesis of unusual aminocyclitol-containing natural products.
  Journal
J Nat Prod 70:1384-91 (2007)
DOI:10.1021/np070210q
Reference
  Authors
Wendler S, Hurtgen D, Kalinowski J, Klein A, Niehaus K, Schulte F, Schwientek P, Wehlmann H, Wehmeier UF, Puhler A
  Title
The cytosolic and extracellular proteomes of Actinoplanes sp. SE50/110 led to the identification of gene products involved in acarbose metabolism.
  Journal
J Biotechnol 167:178-89 (2013)
DOI:10.1016/j.jbiotec.2012.08.011
Reference
  Authors
Schwientek P, Szczepanowski R, Ruckert C, Kalinowski J, Klein A, Selber K, Wehmeier UF, Stoye J, Puhler A
  Title
The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110.
  Journal
BMC Genomics 13:112 (2012)
DOI:10.1186/1471-2164-13-112
Reference
  Authors
Deng Z, Bai L
  Title
Antibiotic biosynthetic pathways and pathway engineering--a growing research field in China.
  Journal
Nat Prod Rep 23:811-27 (2006)
DOI:10.1039/b611140h
Reference
  Authors
Asamizu S, Yang J, Almabruk KH, Mahmud T
  Title
Pseudoglycosyltransferase catalyzes nonglycosidic C-N coupling in validamycin a biosynthesis.
  Journal
J Am Chem Soc 133:12124-35 (2011)
DOI:10.1021/ja203574u
Reference
  Authors
Choi WS, Wu X, Choeng YH, Mahmud T, Jeong BC, Lee SH, Chang YK, Kim CJ, Hong SK
  Title
Genetic organization of the putative salbostatin biosynthetic gene cluster including the 2-epi-5-epi-valiolone synthase gene in Streptomyces albus ATCC 21838.
  Journal
Appl Microbiol Biotechnol 80:637-45 (2008)
DOI:10.1007/s00253-008-1591-2
Reference
  Authors
Wu X, Flatt PM, Xu H, Mahmud T
  Title
Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419.
  Journal
Chembiochem 10:304-14 (2009)
DOI:10.1002/cbic.200800527
Related
pathway
map00030  Pentose phosphate pathway
map00520  Amino sugar and nucleotide sugar metabolism
KO pathway
ko00525   

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