KEGG   Macaca mulatta (rhesus monkey): 697930
Entry
697930            CDS       T01028                                 
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
  KO
K08844  leucine-rich repeat kinase 2 [EC:2.7.11.1]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc05012  Parkinson disease
mcc05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:mcc00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    697930 (LRRK2)
   05022 Pathways of neurodegeneration - multiple diseases
    697930 (LRRK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcc01001]
    697930 (LRRK2)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mcc04131]
    697930 (LRRK2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mcc04147]
    697930 (LRRK2)
Enzymes [BR:mcc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     697930 (LRRK2)
Protein kinases [BR:mcc01001]
 Serine/threonine kinases: TKL group
  LRRK family
   697930 (LRRK2)
Membrane trafficking [BR:mcc04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    697930 (LRRK2)
Exosome [BR:mcc04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   697930 (LRRK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr LRR_8 Roc COR LRR_4 Ras LRR_9 Arf Ank_2 LRR_6 T2SSE AAA_22 nSTAND3 WD40_like AAA_7 PduV-EutP Septin AAA_16 NACHT ABC_tran Kdo cobW MMR_HSR1 MobB GTP_EFTU TniB TrwB_AAD_bind FtsK_SpoIIIE G-alpha TsaE AAA_29 AAA_33
Other DBs
NCBI-GeneID: 697930
NCBI-ProteinID: XP_015006935
Ensembl: ENSMMUG00000015857
Position
11:39533177..39678644
AA seq 2547 aa
MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI
HVPLLIVLDSYMRVASVQQVGWSLLCKLIEICPGTMQSLMGPQDVGNDWEVLGVHQLILK
MLTVHNASVNLSMIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEIQKLG
CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
VLMSGNVRCYNIVVEAMKAFPISEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
RYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEVKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDTM
AAVLPKIITVMKSHETSLPVQLEALRAILHFIVPGMPEESREDAESHRKLNMVKKQCFKN
DIHKLVLAALNRFIGNPGIQKCGLKVISFIAHFTDALGVLSLEGAVDSVLHTLQMYPDDQ
EIQCLGLSLIGCLITKKNLCIGTGHLLAKILASSLYRFKDVAEVQTEGFQTILAILKLSA
SFSKLLVHHSFDLVIFHQMSSSIMEQKDQQFLNLCCKCFAKVAMDDDLKNMMLERACDQN
NSIMVECLLLLGADANQAKEGTSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
KGDSQIISLLLRRLALDMANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
RMVIRYQMKSAMEEGAASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSSSLGPIFDHEDLLRRKRKILSSDDSLR
SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKSCISGHLEHLEKLELHQ
NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCVANLDVSRNDIGPSVVLDPAV
KCPTLKQFNLSYNQLSSVPENLADGIEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTSLKLSQNKFTCIPEAILNLPHLRS
LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMVVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI
RGKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDERQRKACIGKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDQKRLLQLVREN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK
HPKGIISRRDVEKFLSKKRRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLITKCLKENPQERPTSAQVFDILNSAELVCLTRHILLPKNVIVDCMVATHH
NSRNASIWLGCGHTNRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVQKESWIVSGTQ
SGTLLVINTEDGKKRHTLEKMTDSITCLYCNSFSKQSKQKNFLLVGTADGNLAIFEDKTV
KLEGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRT
SQLFSSDSKVYSRLRYTADCNVLFSYAAFSDSNIVTVVVDTVLYIAKKNSPVVEVWDKKT
EKLCELIDCVHFLREVMVKVNKESKHKMSYSGRVKALCLQKNTALWIGTGGGHILLLDLS
TRRVIRIIYNFCDSVRVMMTAQLGSLKNVMLVLGYNRKSTEGTQQQKEIQSCLTVWDINL
PHEVQNLEKHIEVRKELAEKMRGTSIE
NT seq 7644 nt   +upstreamnt  +downstreamnt
atggctagtggcagctgtcaggggtgcgaggaggacgaggaaactctgaagaagttgata
gtcaggctgaacaatgtccaggaaggtaaacagatagaaacgctggtccaaatcctggag
gatctgctggtgttcacgtactccgagcacgcctccaagttatttcaaggcaaaaatatc
catgtgcctctgttgatcgtcttggactcgtatatgagagtcgcgagtgtgcagcaggtg
ggttggtcacttctgtgcaaattaatagaaatctgcccgggtacaatgcaaagcttaatg
ggaccccaggatgttggaaatgattgggaagtccttggtgttcaccaattgattcttaaa
atgctaacagttcataatgccagtgtaaacttgtcaatgattggactgaagaccttagat
ctcctcctaacttcaggtaaaatcaccttactgatattggatgaagaaagtgatattttc
atgttaatttttgatgccatgcactcatttccagccaatgatgaaatccagaaacttgga
tgcaaagctttacatgtgctgtttgaaagagtctcagaggagcaactaactgaatttgtt
gagaacaaagattatatgatattgttaagtgcgttaacaaattttaaagatgaagaggaa
attgtgcttcatgtactgcattgtttacattccctagcaattccttgcaataatgtggaa
gtcctcatgagtggcaatgtcaggtgttataatattgtggtggaagctatgaaagcattc
cctatcagtgaaaaaattcaagaagtgagttgctgtttgctccataggcttacattaggt
aatttttttaatatcctggtattaaacgaagtccatgaatttgtggtgaaagctgtgcag
cggtacccagagaacgcagcattacagatctcagcgctcagctgtttggccctcctcact
gagaccattttcttaaatcaagatttagaggaaaagaatgagaatcaagagaatgatgat
gagggggaagaagttaaattgttttggctggaagcctgttacaaagcgttaacgtggcat
agaaagaacaagcacgtgcaggaggctgcatgctgggcactaaataatctccttatgtac
caaaacagtttacatgagaagattggagatgaagatggccatttcccagctcatagggaa
gtgatgctgtccatgctgatgcattcatcatcaaaggaagttttccaggcatctgctaat
gcattgtcaactcttttagaacaaaatgttaatttcagaaaaatcctgttatcaaaagga
atatacctgaatgttttggagttaatgcagaagcatatacattctcctgaagtggctgaa
agtggctgtaaaatgctaaatcatctttttgaaggaagcaacacatccctggatacaatg
gcagcagtgctccccaaaataataacagttatgaaaagtcatgagacatcattaccagtg
cagctggaggcgcttcgagctattttacattttatagtgccaggcatgccagaagaatcc
agagaggatgcagaatctcatcgtaagctaaatatggttaaaaaacagtgtttcaagaat
gatattcacaaactggtcctagcagctttgaacaggttcattggaaatcctgggattcag
aaatgtggattaaaagtaatttcttttattgcacattttactgatgcattaggggtgtta
tccctggaaggtgctgtggattcagtgcttcacacactgcagatgtatccagatgaccaa
gaaattcagtgtctgggtttaagtcttataggatgcttgattacaaagaagaatttatgc
ataggaactggacatctgctggcaaaaattctggcttccagcttataccgatttaaggat
gttgctgaagtacagactgaaggatttcagacaatcttagcaatcctcaaattgtcagca
tctttttctaagctgctggtgcatcattcgtttgacttagtaatattccatcaaatgtct
tccagtatcatggaacaaaaggatcaacagtttctaaacctctgttgcaagtgttttgca
aaagtagctatggatgatgacttaaaaaatatgatgctagagagagcgtgtgatcagaat
aacagcatcatggttgaatgcttgcttctattaggagcagatgccaatcaagcaaaggag
ggaacttctttaatttgtcaggtatgtgagaaagagagcagtcccaaattggtggaactc
ttattgaatagtggatctcgtgaacaagatgtacgaaaagcgctgacaataagcattggg
aaaggcgacagccagatcatcagcttgctcttaaggaggctggccctggacatggccaac
aatagcatttgccttggagggttttgtataggaaaagttgaaccttcttggcttggtcct
ttatttccagataagacttctaatttaaggaaacaaacaaatatagcatctacactagca
agaatggtgatcagatatcagatgaaaagtgccatggaagaaggagcagcctcaggcagt
gatggaaatttttctgaagatgtgctgtctaaatttgatgaatggacctttattcctgac
tcttctatggacagtgtctttgctcaaagtgatgatctagatagtgaaggaagtgaaggc
tcatttcttgtgaaaaagaaatcaaattcaattagtgtaggagaattttaccgagatgcc
gtattacaacgttgctcaccaaatttgcaaaggcattccagttccttggggcccattttt
gatcatgaagatttactgagaagaaaaagaaaaatattatcttcagatgattcactcagg
tcatcaaaacttcaatcccatatgaggcattcagacagcatttcttctctggcttctgag
agagaatatattacatcactagacctttcagcaaatgaactaagagatattgatgcccta
agccagaaatcctgtataagtggtcatttggagcatcttgaaaagctggagcttcaccag
aatgcactcacgagctttccacaacagctatgtgaaactctgaagagtttgacacatttg
gacttgcacagtaataaatttacatcatttccttcttacttgttgaaaatgagttgtgtt
gctaaccttgatgtctctcgaaatgacattggaccctcagtggttttagatcctgcagtg
aaatgtccaactctgaaacagtttaacctgtcatataaccagctgtcttctgttcctgag
aaccttgctgatgggatagagaaactggagcagctcattttagaaggaaataaaatatca
gggatatgctcccccttgagactgaaggaactgaagattttaaaccttagtaaaaaccac
atttcatccctatcagagaactttcttgaggcttgtcctaaagtggagagtttcagtgcc
agaatgaattttcttgctgctatgcctttcttgcctccttccatgacaagcctaaaatta
tctcaaaacaaatttacatgtattccagaagcaattttaaatcttccacacttgcggtct
ttagatatgagcagcaatgatattcaatatctaccaggtcctgcacactggaaatctttg
aacttaagggaactcttatttagccataatcagatcagcatcttggacttgagtgaaaaa
gcgtatttatggtctagagtagagaaactgcatctttctcacaataaactgaaagagatt
cctcctgagattggctgtcttgaaaatctgacatctctggatgtcagttacaacttggaa
ctaagatcctttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttggat
gaactgcgtcttaactttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcagcagcggttaaaaaaggctgtgccctataaccgaatgaaacttatggttgtt
ggaaatactgggagtggtaaaaccaccttgttgcagcaattaatgaaaaccaagaaatca
gatcttggaatgcaaagtgccacagttggcatagatgtgaaagactggcctatccaaata
agaggcaaaagaaagagagatctcgttctgaatgtgtgggattttgcaggtcgtgaggaa
ttctatagcactcatcctcattttatgacgcagcgagcattgtaccttgctgtctatgac
cttagcaaaggacaggctgaagttgatgccatgaagccttggctcttcaatataaaggct
cgcgcttcttcttcccctgtgattctcgttggcacacatttggatgtttctgatgagagg
cagcgcaaagcctgcataggtaaaatcaccaaggaactcctgaataagcgagggttccct
gctatacgagattaccactttgtgaatgccaccgaggaatctgatgctttggcaaaactt
cggaaaaccatcataaacgagagccttaatttcaagatccgagatcagcctgttgttgga
cagctgattccagactgctatgtagaacttgagaaaatcattttatcggagcgtaaaaat
gtgccaattgaatttcctgtaattgaccagaaacgattattacaactagtgagagaaaat
cagttgcagttagatgaaaatgagcttcctcacgcagttcactttctaaatgaatcagga
gtccttcttcattttcaagacccagcactgcagttaagtgacttgtattttgtggaaccc
aagtggctttgtaaaatcatggcacagattttgacagtgaaagtggaaggttgtccaaaa
caccctaagggaattatttcacgtagagatgtggaaaaatttctttcgaagaaaaggaga
tttccaaagaactacatgtcacagtattttaagctcctagaaaaattccagattgctttg
ccaataggagaagaatatttgctggttccaagcagtttgtctgaccacaggcctgtgata
gagcttccccattgtgagaactctgaaattatcatccgactatatgaaatgccttatttt
ccaatgggattttggtcgaggttaatcaatcgattacttgagatttcaccttacatgctt
tcagggagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatctactta
aattggtctcctgaagcttattgtctggtaggatctgaagtcttagacaatcacccagag
agtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttttgggccaagtt
gtggaccacattgattctctcatggaggaatggtttcctgggttgctggagattgatatt
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaa
gagcatcaaaaaatcttacttgatgacttgatgaagaaagcagaggaaggagatctctta
gtaaatccagatcaaccaaggctcaccattccaatatctcagattgcccctgacttgatt
ttggctgacctgcctagaaatattatgttgaataatgatgagctggaatttgaacaagct
ccagagtttctcctaggtgatggcagttttggatcagtttatcgagcagcctatgaagga
gaagaagtggctgtgaagatttttaataaacacacatcacttaggctgttaagacaagag
ctggtggtgctttgccacctccaccaccccagtttgatatctttgctggcagctggtatt
cgtccccggatgttggtgatggagttagcctccaagggttccttggatcgcctgcttcag
caggacaaagccagcctcactagaaccctacagcacaggattgcactccatgtggctgat
ggtttgagatacctccattcagccatgattatataccgagacttgaagccccacaatgtg
ctgcttttcacactgtatcccaatgctgccatcattgcaaagattgctgactacggcatt
gctcagtactgctgtagaatggggataaaaacgtcagagggcacaccagggtttcgtgca
cctgaagttgccagaggaaatgtcatttataatcaacaagctgatgtttattcatttggt
ttgctactctatgacattttgacaactggaggtagaatagtagagggtttgaagtttcca
aatgagtttgatgaattagcaatacaaggaaaattacctgatccagttaaagaatatggt
tgtgccccatggcctatggttgagaaattaattacaaagtgtttgaaagaaaatcctcaa
gaaaggcctacttctgcccaggtctttgacattttgaattcagctgaattagtctgtctg
acgagacacattttattacctaaaaacgtaattgttgactgcatggttgctacacatcac
aacagcaggaatgcaagcatttggctgggctgtgggcacaccaacagaggacagctctca
tttcttgacttaaatactgaaggatacacttctgaggaggttgctgatagtagaatattg
tgcttagccttggtgcatcttcctgttcaaaaagaaagctggattgtgtccgggacacag
tctggtactctcctggtcatcaataccgaagatgggaaaaagagacataccctagaaaag
atgactgattccatcacttgtttgtattgcaattccttttccaagcaaagcaaacaaaaa
aattttcttttggttggaaccgctgatggcaatttagcaatttttgaagataaaactgtt
aagcttgaaggagctgctcctttgaagatactaaatataggaaatgtcagtactccattg
atgtgtttgagtgaatccacaaattcaacagaaagaaatgtaatgtggggaggatgtggc
acaaagattttctccttttctaatgatttcaccattcagaaactcattgagacaagaaca
agccaactgttctcaagtgattctaaagtatattcgaggttaagatatactgcagactgc
aatgtattgttttcttacgcagctttcagtgattccaacatcgtaacagtggtggtagac
actgttctctatattgctaagaaaaatagccctgttgtggaagtgtgggataagaaaact
gaaaaactctgcgaactaatagactgtgtgcattttttaagggaggtaatggtaaaagta
aacaaggaatcaaaacacaaaatgtcttattctgggagagtgaaagctctctgccttcag
aagaacactgctctttggataggaactggaggaggccatattttactcctggatctttca
actcgtcgagttatacgtataatttacaacttttgtgattcggtcagagtcatgatgaca
gcacagctagggagccttaaaaatgtcatgctggtattgggctataaccggaaaagtact
gaaggtacacaacagcagaaagagatacaatcttgcttgactgtttgggacatcaatctt
ccacatgaagtgcaaaatttagaaaaacacattgaagtgagaaaagaattagctgaaaaa
atgagaggaacatctattgaataa

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG ORTHOLOGY (1)   
   RefGene (26)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (7)   
   RefSeq(nuc) (3)   
   GenBank (2)   
   EMBL (2)   
Protein domain (33)   
   Pfam (33)   
All databases (83)   

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