KEGG   Mycobacterium leprae Br4923: MLBr02324
Entry
MLBr02324         CDS       T00842                                 
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
  KO
K01649  2-isopropylmalate synthase [EC:2.3.3.13]
Organism
mlb  Mycobacterium leprae Br4923
Pathway
mlb00290  Valine, leucine and isoleucine biosynthesis
mlb00620  Pyruvate metabolism
mlb01100  Metabolic pathways
mlb01110  Biosynthesis of secondary metabolites
mlb01210  2-Oxocarboxylic acid metabolism
mlb01230  Biosynthesis of amino acids
Module
mlb_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:mlb00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    MLBr02324 (leuA)
  09105 Amino acid metabolism
   00290 Valine, leucine and isoleucine biosynthesis
    MLBr02324 (leuA)
Enzymes [BR:mlb01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.13  2-isopropylmalate synthase
     MLBr02324 (leuA)
SSDB
Motif
Pfam: HMGL-like LeuA_dimer
Other DBs
NCBI-ProteinID: CAR72422
UniProt: A0A0H3MRV9
Position
2754565..2756388
AA seq 607 aa
MASFSESLSQDPADAYKSAPSITKPMGPPSPGQPQWNPQRATSMPVFRYRPFAKEVEPIR
LVDRTWPDRVIDCAPLWCAVDLRDGNQALIDPMSPICKRRMFDLLVRMGYKEIEVGFPSA
SQTDFDFVREIITDGTIPDDVTIQVLTQCRPELIERTFEACENASRVIVHFYNSTSILQR
RVVFRADQATVKAIATDGARKCVEEAFKYPGTHWRFEYSPESYTGTELEYAKQVCDAVGE
VIQPTPDNPIIFNLPATVEMATPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAA
ELGYHAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNK
LRVHERHPYGGDLVYTAFSGSHQDAINKGLDQMKIDADAADSDVDDILWQVPYLPIDPRD
VGRTYEAVIRVNSQSGKGGVAYIMKADHGLELPRRLQIEFSRAIQKISEGEGGEITPTEM
WDVFFEEYLSPVQPLERIKQRVNAAEEDGGSTSIAATVKINGEETEISGVGNGPLAAFID
ALGHVGLQVAVLDYSEHAMNAGDDAQAAAYVEASVHGHTAWGVGIAPSITTASLRAVVSA
VNRAMPR
NT seq 1824 nt   +upstreamnt  +downstreamnt
gtggccagcttttctgagtctttgagccaggatccagcagatgcctataaatcggcaccc
tccatcaccaaacccatgggcccgcccagtcccggccaaccccagtggaatccccaacga
gctacatcgatgccagtcttccggtaccggccgttcgccaaggaagtcgagcctatccgg
ctagttgaccgcacctggcccgaccgcgtcattgattgcgcgcctctgtggtgtgcggtg
gatctgcgggacggcaaccaagcgctgatcgacccgatgagcccaatctgcaaacgccgc
atgttcgacctgctggttcgcatgggctacaaggagatcgaggtcggattcccgtcggcc
agccagactgacttcgacttcgtccgcgagatcatcaccgacggcactattccggacgac
gtcaccatccaggttctgacccaatgccgaccggaactgattgagcgcaccttcgaagcc
tgcgaaaacgcgtcgcgggttatagtgcacttctacaactcaacgtcaattctgcagcgc
cgcgtggtttttcgcgccgaccaagccacggtaaaggctatcgcgaccgacggtgctcgt
aagtgtgtcgaagaggcgttcaagtacccgggcacgcactggcgattcgagtattcaccg
gaatcctataccgggaccgagctggaatacgccaaacaggtgtgcgacgccgtcggtgaa
gtcattcaaccgacaccggacaacccgatcatctttaacctgcctgccaccgtggagatg
gccacccccaatgtctacgctgactcgatcgagtggatgagccgcaatctggccaaccga
gagtccgtcatcctgagcctgcatccacacaacgaccgcggaaccgctgtcgccgcagcc
gaattgggctatcacgccggtgccgacagaatcgagggctgcctgttcggcaacggggaa
cgcaccggcaacgtgtgcctggtaacgttgggactgaacctgttttcccgcggtgtggat
ccccagatcgacttctccaatatcgatgagatccggcgaacggtggagtactgcaacaag
ctgcgggtgcacgaacgtcacccctacgggggagacctcgtgtacaccgcgttctctggc
agccaccaggatgccatcaacaagggcctggaccagatgaagatcgatgcggacgccgcc
gactccgatgtcgacgacatcctgtggcaagtaccgtacctgccgatcgacccgcgcgac
gtcggccgcacctacgaggcggtgatccgggtcaactcgcagtctggtaagggcggcgtg
gcttacatcatgaaggccgaccacggtcttgaactgccgcgacggctgcagatcgagttt
tctcgagcgatccagaaaatcagtgagggcgaaggaggcgagatcacacccacggagatg
tgggacgtgttcttcgaggagtacctctcaccggtgcagccgctggaacgcataaagcag
cgggtcaatgccgcagaggaagacggcggcagcaccagtattgccgctaccgtcaagatc
aacggtgaagagaccgaaatcagcggagtcggcaacggcccactggccgctttcatcgac
gcactgggccacgtcggcttgcaggtagccgttctggattattccgaacacgcgatgaac
gccggcgacgacgcgcaggctgctgcttacgtcgaggcatcggtacatgggcacacagca
tggggtgtgggcattgcaccgtcgatcaccacagcgtcgctacgtgccgtcgtctcagcg
gtcaacagggcaatgccccgctag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   OC (1)   
Protein sequence (1)   
   UniProt (1)   
Protein domain (2)   
   Pfam (2)   
All databases (23)   

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