KEGG T00047: ML0909

Mycobacterium leprae TN: ML0909

Entry

ML0909            CDS       T00047

Symbol

murE

Name

(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopime ligase (meso-diaminopimelate-adding enzyme).

K01928

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]

Organism

mle Mycobacterium leprae TN

Pathway

mle00300

Lysine biosynthesis

mle00550

Peptidoglycan biosynthesis

mle01100

Metabolic pathways

Brite

KEGG Orthology (KO) [BR:mle00001]
09100 Metabolism
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    ML0909 (murE)
  09107 Glycan biosynthesis and metabolism
   00550 Peptidoglycan biosynthesis
    ML0909 (murE)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01011 Peptidoglycan biosynthesis and degradation proteins [BR:mle01011]
    ML0909 (murE)
Enzymes [BR:mle01000]
6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.13  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase
     ML0909 (murE)
Peptidoglycan biosynthesis and degradation proteins [BR:mle01011]
Precursor biosynthesis
  Amino acid ligase
   ML0909 (murE)

SSDB

Motif

Pfam:

Mur_ligase_M Mur_ligase_C Mur_ligase DUF1611 HEV_ORF1

Other DBs

NCBI-ProteinID:

CAC31290

Pasteur:

ML0909

UniProt:

O69557

Position

1076001..1077593

AA seq 530 aa
MTEVVAVPVRLRPSATAGVRLPELVAQVGAVLADGPGQAATVPDIPVTGVTLRAQEVLSG
DLFAALAGASTHGARYAGVALERGAVAVLTDVAGVAELTAQASSVPILIHPEPRSVLGGL
AAAAYGHPSNRMTVVGITGTSGKTTTTYMVEAGLRAGGRVVGLVGTIGIRIDGADIPSFL
TTPEAPALQAMLAAMVERGVETVVMEVSSHALSLGRVEGTQFAVAGFTNLSRDHLDFHPD
MEEYFEAKAVLFDPHSLLRARTVVVCIDDDAGRATAARAGDAITVSALGQPASWRATDIR
SPGVGAQEFTAVDPAGVQHRVGIRLPGRYNVANCLVALAILDVVGVSPEQASLGFRDIRI
PGRLERIDCGQDFLALVDYAHKPGALHSVLTALLQPDHRLAVVFGAGGERDPGKRAPMGE
IAAELADLVVVTDDNPRGEDPAAIRRDILTGTVAAGGAAQVVEIGDRRAAIQYAVAWAGP
DDVVLVAGKGHETGQRGAAETCPFDDRVELARALQVRDARLLPAPGRACQ

NT seq 1593 nt +upstreamnt +downstreamnt
gtgactgaggtggtggcggtgccggttaggttgcgccccagcgccactgcgggggtgcgg
ctccctgagcttgtggctcaggttggtgctgtgctggccgacggccccgggcaggcggcg
actgtcccagacattccggtgaccggtgtgacgctgcgggcccaggaggtgctgtccggt
gatctgttcgctgcattggctggtgcatccacacacggcgctcggtatgccggcgttgcg
ctcgaacgaggtgctgtcgcggtgcttaccgacgttgcaggggtcgccgagctgacagcc
caggccagcagcgtgccgatactcatacatccggaaccccgcagcgtgctcggcggtctt
gccgccgcggcatatggacatccctccaaccggatgacggttgttgggattactggaaca
tcgggtaagacgactaccacctatatggttgaggctggtttacgggctggtgggcgagtg
gtcgggctagtcggcaccatcggcattcggatcgacggtgccgacatccctagctttctg
accacgccggaggctcctgcgctgcaggcgatgctcgcggcgatggtcgagcgcggtgtg
gaaaccgtggttatggaggtgtctagtcacgcgttgagtctgggtcgggtggaaggcacc
cagttcgcagtggccggtttcaccaatttgtctcgcgaccacctcgattttcaccccgac
atggaggagtatttcgaagccaaggcggtgctgttcgatccgcactcgttgctgcgggct
cgcaccgtcgtggtatgcatcgacgatgacgctgggcgcgcgacggccgcccgggccggt
gacgccatcacagtcagcgccctaggtcaacccgcatcgtggcgcgcgacggacattagg
tcaccgggtgtcggagcccaggagttcaccgccgtagaccccgccggtgtccagcaccgg
gtcggcattcggttacccggccgctacaacgtcgctaattgtcttgtcgccctggcgatt
ctagacgttgttggggtgtctccggagcaggcttccttggggttccgggacatccgaatc
cccggacgactggaacggatcgactgcggccaagattttcttgcactggtcgactatgcg
cacaagccaggagcgttacactcagtgttgaccgccctactgcagccggaccatcggctg
gcagtggtgttcggtgcggggggcgagcgtgacccgggcaagcgggctccgatgggcgag
attgccgctgagctagccgatttggtcgtcgtgaccgatgacaacccgcgtggcgaggat
ccggcggcaattcgtcgtgacattctgaccggcactgtcgcggctggcggtgcggcgcag
gtcgtcgagattggtgaccggcgggctgctatccaatacgcggttgcttgggcgggtcct
gatgacgtggtgttggtggcgggcaaaggtcatgaaaccgggcagcggggcgctgccgag
acctgccccttcgacgaccgggtggagctggctcgggcgctgcaggtccgtgacgcccga
ctgcttcctgcgcctgggcgagcgtgccaatga

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