KEGG   Mus musculus (mouse): 18795Help
Entry
18795             CDS       T01002                                 

Gene name
Plcb1, 3110043I21Rik, AI132408, Plcb, mKIAA0581
Definition
phospholipase C, beta 1 (EC:3.1.4.11)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mmu  Mus musculus (mouse)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    18795 (Plcb1)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    18795 (Plcb1)
   04310 Wnt signaling pathway
    18795 (Plcb1)
   04020 Calcium signaling pathway
    18795 (Plcb1)
   04070 Phosphatidylinositol signaling system
    18795 (Plcb1)
   04022 cGMP - PKG signaling pathway
    18795 (Plcb1)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    18795 (Plcb1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    18795 (Plcb1)
   04062 Chemokine signaling pathway
    18795 (Plcb1)
  Endocrine system
   04911 Insulin secretion
    18795 (Plcb1)
   04912 GnRH signaling pathway
    18795 (Plcb1)
   04915 Estrogen signaling pathway
    18795 (Plcb1)
   04921 Oxytocin signaling pathway
    18795 (Plcb1)
   04918 Thyroid hormone synthesis
    18795 (Plcb1)
   04919 Thyroid hormone signaling pathway
    18795 (Plcb1)
   04916 Melanogenesis
    18795 (Plcb1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    18795 (Plcb1)
   04270 Vascular smooth muscle contraction
    18795 (Plcb1)
  Digestive system
   04970 Salivary secretion
    18795 (Plcb1)
   04971 Gastric acid secretion
    18795 (Plcb1)
   04972 Pancreatic secretion
    18795 (Plcb1)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    18795 (Plcb1)
  Nervous system
   04724 Glutamatergic synapse
    18795 (Plcb1)
   04725 Cholinergic synapse
    18795 (Plcb1)
   04728 Dopaminergic synapse
    18795 (Plcb1)
   04726 Serotonergic synapse
    18795 (Plcb1)
   04720 Long-term potentiation
    18795 (Plcb1)
   04730 Long-term depression
    18795 (Plcb1)
   04723 Retrograde endocannabinoid signaling
    18795 (Plcb1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    18795 (Plcb1)
  Environmental adaptation
   04713 Circadian entrainment
    18795 (Plcb1)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    18795 (Plcb1)
   05016 Huntington's disease
    18795 (Plcb1)
  Infectious diseases
   05146 Amoebiasis
    18795 (Plcb1)
   05142 Chagas disease (American trypanosomiasis)
    18795 (Plcb1)
   05143 African trypanosomiasis
    18795 (Plcb1)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     18795 (Plcb1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Position
2 F3; 2 65.66 cM
AA seq 1216 aa AA seqDB search
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETSSEAPSETRTTPAENGVNHTASLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYL
RRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHNEIRQQILDEKP
KLQTELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPPSLASDAAKVNLKSPSS
EEIERENPGREFDTPL
NT seq 3651 nt NT seq  +upstreamnt  +downstreamnt
atggctggggctcagcccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactattgttactcca
attattttgaggactgatcctcagggatttttcttttactggacagaccagaataaggag
acggagctgttagatctcagccttgtcaaggatgccaggtgtgggaagcacgccaaagct
cccaaggaccccaagttgcgtgaacttctggatgttgggaacatcggacacttggaacag
cgcatgataactgtggtgtatggaccagacctggtgaacatttcccacttgaatcttgtg
gcttttcaagaggaagtagccaaggaatggacaaatgaggttttcagcttggcaacaaac
ctgctggctcagaacatgtccagggacgcatttctggagaaagcatatactaagctcaag
ctccaggtcaccccagaaggccgcattcctcttaaaaacatctatcgattgttctcagca
gaccggaagcgcgttgaaactgcactagaggcttgtagtcttccatcttcgaggaatgac
tccattccccaagaggacttcactccagatgtatacagagttttcctgaacaatctctgt
ccccgacctgaaattgataacatcttttctgaatttggtgccaaaagcaaaccgtacctg
acggttgatcagatgatggattttatcaaccttaagcagagagatccccggctcaatgaa
atcctttacccacctctgaagcaggagcaggtccaagtgttgattgagaaatatgagccc
aacagcagcctcgccaagaaagggcagatgtcagtggatggattcatgcgctacctgagc
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaacgaagacatgtctcag
cccctgtctcactatttcatcaattcctcgcacaacacctacctcacagctggccagttg
gctgggaactcgtctgtagagatgtatcgccaggtgcttctgtctggatgtcgctgtgtg
gagctggactgctggaagggaaggaccgctgaggaagagcctgtcattacccatggattc
accatgacaacagaaatatccttcaaggaagtcatagaagccatcgcagagtgtgcgttc
aagacgtctcctttccccatcctcctttcctttgagaaccacgtggattccccgaagcaa
caagccaagatggccgagtattgccgattaatctttggtgatgccctcctgatggaacca
ctggaaaaatacccactggaatctggggtacctcttccaagccctatggatttaatgtat
aaaatcttggtgaaaaacaagaagaagtcgcacaagtcgtcagagggaagtggtaagaag
aagctttcagagcaagcttccaacacctacagcgactcctccagtgtgttcgagccttcg
tctccaggagctggggaagcagatacggagagtgatgacgatgacgacgacgatgactgt
aaaaagtcttccatggatgaggggacagctggcagcgaagccatggccacagaagagatg
tctaacctggtgaactatattcagcctgtcaagtttgagtcctttgaaatttcaaaaaaa
agaaataaaagctttgaaatgtcttccttcgtggaaaccaaaggacttgaacaacttaca
aagtctccggtggaatttgtagaatacaacaagatgcaacttagcaggatatatcccaag
ggaacacgtgtggattcatccaactacatgcctcaactcttctggaatgctggctgtcag
atggtggcgctcaacttccagacagtggatctagctatgcagataaacatgggcatgtat
gagtacaatgggaagagcggctataggctgaagccagagttcatgaggaggccggacaag
cattttgatccatttactgaaggaatcgtagatgggatagtggccaacactctatctgtt
aagattatttcaggtcagttcctctctgataagaaagttgggacttatgtggaagtggat
atgtttggcttgcctgtggacacaaggaggaaggcatttaaaaccaagacatcccaagga
aatgctgtaaaccctgtctgggaagaagaacctattgtattcaaaaaggtagttctacct
tctctggcctgtttgaggatagcagcatatgaagagggaggcaaatttattggccaccgg
atattgcctgtgcaggctattcggccaggctatcactacatctgcctgcggaatgagagg
aaccagcccctgacgctgccagctgtctttgtctacatagaagtcaaagattatgtgcca
gacacgtatgcagatgtaatcgaagctctatcaaacccaatccgatatgtcaatctgatg
gaacagagagctaagcagctggctgcgttgaccctggaggatgaagaggaagtaaagaag
gaggctgaccctggagaaacatcttccgaggctccaagcgaaaccaggacaacgccagca
gagaatggggtgaatcacaccgcatcccttgcacccaagccgccttcccaggctccacac
agccagcctgctccagggtctgtgaaggcacctgccaaaacagaagatctgatccagagc
gtgttaacagaagtagaggcgcaaaccatcgaagagctcaagcaacagaaatcgttcgtg
aaacttcaaaagaaacactacaaagaaatgaaagacctggtgaagagacaccacaagaaa
accacggagctcattaaggagcacacgaccaagtacaacgagattcagaatgactacctg
agaaggagggcagccttggagaagtccgccaaaaaggacagcaagaagaaatctgaaccc
agcagccctgaccacggctcatcagccattgagcaagacctcgctgccctggatgcagaa
atgactcagaagttgatagacttgaaagacaagcaacaacagcagctgcttaatcttcgg
caagagcagtattacagcgagaagtaccaaaagcgagaacacattaaactgcttattcag
aagttgacagatgttgcagaagagtgtcagaacaatcagttaaagaagctgaaggaaatc
tgcgagaaagagaagaaggaattaaagaagaaaatggataagaagaggcaagagaagata
acagaagccaagtccaaagacaaaagccagatggaagaggagaagacagagatgatccga
tcgtacatccaggaggtggttcagtacatcaagaggttagaggaagcacaaagtaaaaga
caagaaaaactcgtggagaaacacaatgagatccgccagcagatcctcgatgagaagccc
aagctgcagacggagctggagcaagaataccaagacaagttcaaaaggctgcccctggag
attctggagtttgtacaggaagccatgaaagggaagatcagcgaggacagcaatcacggc
tctgcccctccctctctggcctcagatgctgcaaaggtgaacctcaagtctccctccagt
gaggagatagaaagagagaacccaggaagagagtttgatactcctctgtga

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