KEGG   Mus musculus (mouse): 18796Help
Entry
18796             CDS       T01002                                 

Gene name
Plcb2, AI550384, B230205M18Rik, B230399N12
Definition
phospholipase C, beta 2 (EC:3.1.4.11)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mmu  Mus musculus (mouse)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Taste transduction
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Carbohydrate digestion and absorption
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    18796 (Plcb2)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    18796 (Plcb2)
   04310 Wnt signaling pathway
    18796 (Plcb2)
   04020 Calcium signaling pathway
    18796 (Plcb2)
   04070 Phosphatidylinositol signaling system
    18796 (Plcb2)
   04022 cGMP - PKG signaling pathway
    18796 (Plcb2)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    18796 (Plcb2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    18796 (Plcb2)
   04062 Chemokine signaling pathway
    18796 (Plcb2)
  Endocrine system
   04911 Insulin secretion
    18796 (Plcb2)
   04912 GnRH signaling pathway
    18796 (Plcb2)
   04915 Estrogen signaling pathway
    18796 (Plcb2)
   04921 Oxytocin signaling pathway
    18796 (Plcb2)
   04918 Thyroid hormone synthesis
    18796 (Plcb2)
   04919 Thyroid hormone signaling pathway
    18796 (Plcb2)
   04916 Melanogenesis
    18796 (Plcb2)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    18796 (Plcb2)
   04270 Vascular smooth muscle contraction
    18796 (Plcb2)
  Digestive system
   04970 Salivary secretion
    18796 (Plcb2)
   04971 Gastric acid secretion
    18796 (Plcb2)
   04972 Pancreatic secretion
    18796 (Plcb2)
   04973 Carbohydrate digestion and absorption
    18796 (Plcb2)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    18796 (Plcb2)
  Nervous system
   04724 Glutamatergic synapse
    18796 (Plcb2)
   04725 Cholinergic synapse
    18796 (Plcb2)
   04728 Dopaminergic synapse
    18796 (Plcb2)
   04726 Serotonergic synapse
    18796 (Plcb2)
   04720 Long-term potentiation
    18796 (Plcb2)
   04730 Long-term depression
    18796 (Plcb2)
   04723 Retrograde endocannabinoid signaling
    18796 (Plcb2)
  Sensory system
   04742 Taste transduction
    18796 (Plcb2)
   04750 Inflammatory mediator regulation of TRP channels
    18796 (Plcb2)
  Environmental adaptation
   04713 Circadian entrainment
    18796 (Plcb2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    18796 (Plcb2)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    18796 (Plcb2)
   05016 Huntington's disease
    18796 (Plcb2)
  Infectious diseases
   05146 Amoebiasis
    18796 (Plcb2)
   05142 Chagas disease (American trypanosomiasis)
    18796 (Plcb2)
   05143 African trypanosomiasis
    18796 (Plcb2)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     18796 (Plcb2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Position
2 E5; 2 59.43 cM
AA seq 1158 aa AA seqDB search
MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQSQKLRE
VFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAP
RSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDF
PESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPAR
PEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFI
NSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIL
FKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLK
PGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRT
EVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFE
FSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWN
AGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVAT
TLSITIISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEK
ILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHHLCLRSESNMALTMPALFVFLEMK
DYIPDTWADLTVALANPIKYFNAQDKKSVKLKGVTGSLPEKLFSGTPVASQSNGAPVSAG
NGSTAPGTKATGEEATKEVTEPQTASLEELRELKGVVKLQRRHEKELRELERRGARRWEE
LLQRGAAQLAELQTQAAGCKLRPGKGSRKKRTLPCEETVVAPSEPHDRADPRVQELKDRL
EQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKTFKETSETDTKEMKKKL
EAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEERQTA
CLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRAYFKDCFPTEAEDKPERSCEASEE
SCPQEPLVSKADTQESRL
NT seq 3477 nt NT seq  +upstreamnt  +downstreamnt
atgtctttgctcaaccctgttctattgccccctaacgtgaaggcatatctgagccaaggg
gagcgcttcatcaagtgggacgatgaaacttcaatagcctctcctgttatcctccgtgtg
gatcccaagggctattacttatactggacatatcaaaatcagagccagaaactccgggag
gtcttcaacatggactttccagacaaccacttcctgctgaaaacactcacagtggtgtcc
ggccctgacatggtggacctcaccttctacaactttgtctcttacaaggagaacgtaggc
aaggactgggctgaggacgtgctagctctcgccaaacacccgatgacagtcaatgctcct
cgaagcacattcctggacaagatcctggtgaagcttaagatgcagctcaaccctgaaggg
aagattcccgtgaagaattttttccagatgtttcctgctgatcgaaaacgggtggaagct
gccctcggtgcttgtcaccttgcaaaaggcaaaaatgatgctatcaacccagaggacttc
ccagaatccgtgtacaagagcttcctcatgagcctctgtcctcggccagaaatcgacgag
atcttcacttcctaccactctaaagctaagccctacatgaccaaggaacacctgaccaaa
ttcatcaatcagaagcagcgagaccctcgactcaactccttgctgttcccaccagcccgg
cctgagcaagttcaagtgctcattgacaagtacgaacccagcggcatcaatgtgcagagg
ggccagctgtcaccagaggggatggtctggtttctctgtggaccagagaacagtgtgctg
gcccacgatacactgctgatccaccaagacatgacacaaccactgaatcactatttcatc
aactcctcacacaacacctacctgacagccggccagttctcaggcctttcctcggctgag
atgtaccgccaggtgctgctgtctggctgccggtgtgtagagttagactgttggaagggc
aagccccctgacgaagagcccattatcacccacggcttcaccatgaccacagatatcttg
ttcaaggaagcaattgaagccattgcagaaagtgcctttaagacctccccgtatcctgtc
atcctatcatttgaaaaccatgtagactcaccccggcaacaggctaagatggctgagtac
tgcaggagcatgtttggagagaccttgctcacagatcccctggaaaatttccctctgaaa
cctggcatccctctgcccagccccgaggacctccggggcaagatcctcattaagaataag
aagaaccagttttctgggccagcatcccccagcaagaagcctggtggggtggctgagggc
agcctcccgtctagtgtccctgtagaagaggacacggggtggactgctgaggaccggact
gaggtggaggaggaggaggtggtggaagaggaggaagaggaggagtcaggaaacctggat
gaagaagaaattaagaagatgcagtcggatgagggcacagcaggcctggaggtgacagct
tatgaggaaatgtccagccttgtcaattatatccagcccaccaagtttatctccttcgag
ttctctgcacagaagaacagaagttacgttgtctcttccttcacggagctcaaggcctac
gagctgctctccaaggcctccatgcagtttgtggactataataaacgccagatgagccgt
gtgtaccccaagggcacacgcatggactcttccaactacatgccccagatgttctggaat
gctggatgtcagatggttgccctcaatttccagacaatggacctgcccatgcagcagaac
atggcactgtttgagttcaacgggcagagtggctacctcctaaagcacgagttcatgcgc
agactggacaagcagttcaaccccttctcagtggaccgcattgatgtggtggtagccacc
accctttccattacgatcatctctgggcagttcctgtcagagcgcagtgtacgcacctat
gtggaagtggaactgtttggcctcccaggggaccccaagaggcggtatcgaaccaagctg
tcacctactgctaactccatcaatcctgtctggaaagaggaaccctttatctttgagaag
atcttgatgcctgagctggcctccctcaggatagctgtgatggaagaaggcagcaaattt
cttggacaccgcatcatccccatcaatgccttacattctggataccaccatctgtgcctg
cgcagtgagagcaacatggcccttaccatgccagctctctttgtcttcctggagatgaag
gactacatacctgacacctgggcagatcttacagtagcccttgccaaccccatcaagtac
ttcaatgcccaggataagaagtccgtgaagctcaaaggagtgacaggaagtctgcccgag
aaactcttctctgggacacctgttgccagtcagtccaatggggcgccagtctcggcaggc
aatgggtcaacagcgcctgggaccaaggccacgggggaagaagctacgaaagaagtgaca
gagccacagaccgccagcttggaagagttgcgggaactgaagggcgtggtgaaactgcag
cgaagacatgagaaggagcttcgagagttggagcgccgtggagcccggcgctgggaggaa
ctgctgcagcgtggcgccgcacagctggcggagctccagacccaggcagcaggctgcaag
ctccgcccaggcaagggctcccgcaagaagaggaccctgccctgtgaggagaccgtcgtg
gcgcctagcgagccccacgaccgggcggacccgcgcgtgcaggagctgaaggacaggctg
gagcaggagctgcagcagcaaggcgaggagcagtaccgctccgtcctcaagcgcaaggag
cagcacgtgaccgagcaaatcgccaagatgatggagctggccagagagaaacaggctgct
gaactcaagaccttcaaggagacctcagaaactgacaccaaagaaatgaagaaaaaactg
gaggccaagaggctggaacggatccaagccatgaccaaggtcaccacagacaaggtggcc
caggagaggctcaagagagaaattaacaactcccacatccaggaagtggtccaggctgtc
aagcagatgacagagaccctggagcgtcaccaggagaagctggaagagaggcagacagcc
tgcctggagcagatccaggcaatggaaaagcagttccaggagaaggcgctggcagagtat
gaggccaagatgaagggcctggaggctgaagtaaaggagtcggtgcgggcctacttcaag
gactgcttccccaccgaagcagaagacaagcctgagaggtcctgtgaggcctctgaggag
tcgtgtccacaggaaccacttgtgagcaaggcagacactcaggagagccgcctctga

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