KEGG   Mus musculus (mouse): 18796Help
Entry
18796             CDS       T01002                                 

Gene name
Plcb2, AI550384, B230205M18Rik, B230399N12
Definition
(RefSeq) phospholipase C, beta 2
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu00562  Inositol phosphate metabolism
mmu01100  Metabolic pathways
mmu04015  Rap1 signaling pathway
mmu04020  Calcium signaling pathway
mmu04022  cGMP-PKG signaling pathway
mmu04062  Chemokine signaling pathway
mmu04070  Phosphatidylinositol signaling system
mmu04071  Sphingolipid signaling pathway
mmu04072  Phospholipase D signaling pathway
mmu04261  Adrenergic signaling in cardiomyocytes
mmu04270  Vascular smooth muscle contraction
mmu04310  Wnt signaling pathway
mmu04371  Apelin signaling pathway
mmu04540  Gap junction
mmu04611  Platelet activation
mmu04621  NOD-like receptor signaling pathway
mmu04713  Circadian entrainment
mmu04720  Long-term potentiation
mmu04723  Retrograde endocannabinoid signaling
mmu04724  Glutamatergic synapse
mmu04725  Cholinergic synapse
mmu04726  Serotonergic synapse
mmu04728  Dopaminergic synapse
mmu04730  Long-term depression
mmu04750  Inflammatory mediator regulation of TRP channels
mmu04911  Insulin secretion
mmu04912  GnRH signaling pathway
mmu04915  Estrogen signaling pathway
mmu04916  Melanogenesis
mmu04918  Thyroid hormone synthesis
mmu04919  Thyroid hormone signaling pathway
mmu04921  Oxytocin signaling pathway
mmu04922  Glucagon signaling pathway
mmu04924  Renin secretion
mmu04925  Aldosterone synthesis and secretion
mmu04926  Relaxin signaling pathway
mmu04927  Cortisol synthesis and secretion
mmu04928  Parathyroid hormone synthesis, secretion and action
mmu04933  AGE-RAGE signaling pathway in diabetic complications
mmu04934  Cushing's syndrome
mmu04961  Endocrine and other factor-regulated calcium reabsorption
mmu04970  Salivary secretion
mmu04971  Gastric acid secretion
mmu04972  Pancreatic secretion
mmu04973  Carbohydrate digestion and absorption
mmu05010  Alzheimer's disease
mmu05016  Huntington's disease
mmu05142  Chagas disease (American trypanosomiasis)
mmu05143  African trypanosomiasis
mmu05146  Amoebiasis
mmu05200  Pathways in cancer
Module
mmu_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    18796 (Plcb2)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    18796 (Plcb2)
   04310 Wnt signaling pathway
    18796 (Plcb2)
   04371 Apelin signaling pathway
    18796 (Plcb2)
   04020 Calcium signaling pathway
    18796 (Plcb2)
   04070 Phosphatidylinositol signaling system
    18796 (Plcb2)
   04072 Phospholipase D signaling pathway
    18796 (Plcb2)
   04071 Sphingolipid signaling pathway
    18796 (Plcb2)
   04022 cGMP - PKG signaling pathway
    18796 (Plcb2)
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    18796 (Plcb2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    18796 (Plcb2)
   04621 NOD-like receptor signaling pathway
    18796 (Plcb2)
   04062 Chemokine signaling pathway
    18796 (Plcb2)
  Endocrine system
   04911 Insulin secretion
    18796 (Plcb2)
   04922 Glucagon signaling pathway
    18796 (Plcb2)
   04912 GnRH signaling pathway
    18796 (Plcb2)
   04915 Estrogen signaling pathway
    18796 (Plcb2)
   04921 Oxytocin signaling pathway
    18796 (Plcb2)
   04926 Relaxin signaling pathway
    18796 (Plcb2)
   04918 Thyroid hormone synthesis
    18796 (Plcb2)
   04919 Thyroid hormone signaling pathway
    18796 (Plcb2)
   04928 Parathyroid hormone synthesis, secretion and action
    18796 (Plcb2)
   04916 Melanogenesis
    18796 (Plcb2)
   04924 Renin secretion
    18796 (Plcb2)
   04925 Aldosterone synthesis and secretion
    18796 (Plcb2)
   04927 Cortisol synthesis and secretion
    18796 (Plcb2)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    18796 (Plcb2)
   04270 Vascular smooth muscle contraction
    18796 (Plcb2)
  Digestive system
   04970 Salivary secretion
    18796 (Plcb2)
   04971 Gastric acid secretion
    18796 (Plcb2)
   04972 Pancreatic secretion
    18796 (Plcb2)
   04973 Carbohydrate digestion and absorption
    18796 (Plcb2)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    18796 (Plcb2)
  Nervous system
   04724 Glutamatergic synapse
    18796 (Plcb2)
   04725 Cholinergic synapse
    18796 (Plcb2)
   04728 Dopaminergic synapse
    18796 (Plcb2)
   04726 Serotonergic synapse
    18796 (Plcb2)
   04720 Long-term potentiation
    18796 (Plcb2)
   04730 Long-term depression
    18796 (Plcb2)
   04723 Retrograde endocannabinoid signaling
    18796 (Plcb2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    18796 (Plcb2)
  Environmental adaptation
   04713 Circadian entrainment
    18796 (Plcb2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    18796 (Plcb2)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    18796 (Plcb2)
   05016 Huntington's disease
    18796 (Plcb2)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    18796 (Plcb2)
   04934 Cushing's syndrome
    18796 (Plcb2)
  Infectious diseases
   05146 Amoebiasis
    18796 (Plcb2)
   05142 Chagas disease (American trypanosomiasis)
    18796 (Plcb2)
   05143 African trypanosomiasis
    18796 (Plcb2)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     18796 (Plcb2)
Membrane trafficking [BR:mmu04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    18796 (Plcb2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    18796 (Plcb2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PLC-beta_C PI-PLC-X PI-PLC-Y EF-hand_like C2
Motif
Other DBs
NCBI-GeneID: 18796
NCBI-ProteinID: NP_808236
MGI: 107465
Ensembl: ENSMUSG00000040061
Vega: OTTMUSG00000015372
UniProt: A3KGF7
Position
2 E5; 2 59.43 cM
AA seq 1181 aa AA seqDB search
MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQEMEFLD
VTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKE
NVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEH
LTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGV
AEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLE
VTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQ
MSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHE
FMRRLDKQFNPFSVDRIDVVVATTLSITIISGQFLSERSVRTYVEVELFGLPGDPKRRYR
TKLSPTANSINPVWKEEPFIFEKILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHH
LCLRSESNMALTMPALFVFLEMKDYIPDTWADLTVALANPIKYFNAQDKKSVKLKGVTGS
LPEKLFSGTPVASQSNGAPVSAGNGSTAPGTKATGEEATKEVTEPQTASLEELRELKGVV
KLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTQAAGCKLRPGKGSRKKRTLPCEE
TVVAPSEPHDRADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREK
QAAELKTFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVV
QAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRA
YFKDCFPTEAEDKPERSCEASEESCPQEPLVSKADTQESRL
NT seq 3546 nt NT seq  +upstreamnt  +downstreamnt
atgtctttgctcaaccctgttctattgccccctaacgtgaaggcatatctgagccaaggg
gagcgcttcatcaagtgggacgatgaaacttcaatagcctctcctgttatcctccgtgtg
gatcccaagggctattacttatactggacatatcaaaatcaggagatggagttcctggat
gtcacgagtatccgagatactcgctttgggaagtttgcaaagatacccaagagccagaaa
ctccgggaggtcttcaacatggactttccagacaaccacttcctgctgaaaacactcaca
gtggtgtccggccctgacatggtggacctcaccttctacaactttgtctcttacaaggag
aacgtaggcaaggactgggctgaggacgtgctagctctcgccaaacacccgatgacagtc
aatgctcctcgaagcacattcctggacaagatcctggtgaagcttaagatgcagctcaac
cctgaagggaagattcccgtgaagaattttttccagatgtttcctgctgatcgaaaacgg
gtggaagctgccctcggtgcttgtcaccttgcaaaaggcaaaaatgatgctatcaaccca
gaggacttcccagaatccgtgtacaagagcttcctcatgagcctctgtcctcggccagaa
atcgacgagatcttcacttcctaccactctaaagctaagccctacatgaccaaggaacac
ctgaccaaattcatcaatcagaagcagcgagaccctcgactcaactccttgctgttccca
ccagcccggcctgagcaagttcaagtgctcattgacaagtacgaacccagcggcatcaat
gtgcagaggggccagctgtcaccagaggggatggtctggtttctctgtggaccagagaac
agtgtgctggcccacgatacactgctgatccaccaagacatgacacaaccactgaatcac
tatttcatcaactcctcacacaacacctacctgacagccggccagttctcaggcctttcc
tcggctgagatgtaccgccaggtgctgctgtctggctgccggtgtgtagagttagactgt
tggaagggcaagccccctgacgaagagcccattatcacccacggcttcaccatgaccaca
gatatcttgttcaaggaagcaattgaagccattgcagaaagtgcctttaagacctccccg
tatcctgtcatcctatcatttgaaaaccatgtagactcaccccggcaacaggctaagatg
gctgagtactgcaggagcatgtttggagagaccttgctcacagatcccctggaaaatttc
cctctgaaacctggcatccctctgcccagccccgaggacctccggggcaagatcctcatt
aagaataagaagaaccagttttctgggccagcatcccccagcaagaagcctggtggggtg
gctgagggcagcctcccgtctagtgtccctgtagaagaggacacggggtggactgctgag
gaccggactgaggtggaggaggaggaggtggtggaagaggaggaagaggaggagtcagga
aacctggatgaagaagaaattaagaagatgcagtcggatgagggcacagcaggcctggag
gtgacagcttatgaggaaatgtccagccttgtcaattatatccagcccaccaagtttatc
tccttcgagttctctgcacagaagaacagaagttacgttgtctcttccttcacggagctc
aaggcctacgagctgctctccaaggcctccatgcagtttgtggactataataaacgccag
atgagccgtgtgtaccccaagggcacacgcatggactcttccaactacatgccccagatg
ttctggaatgctggatgtcagatggttgccctcaatttccagacaatggacctgcccatg
cagcagaacatggcactgtttgagttcaacgggcagagtggctacctcctaaagcacgag
ttcatgcgcagactggacaagcagttcaaccccttctcagtggaccgcattgatgtggtg
gtagccaccaccctttccattacgatcatctctgggcagttcctgtcagagcgcagtgta
cgcacctatgtggaagtggaactgtttggcctcccaggggaccccaagaggcggtatcga
accaagctgtcacctactgctaactccatcaatcctgtctggaaagaggaaccctttatc
tttgagaagatcttgatgcctgagctggcctccctcaggatagctgtgatggaagaaggc
agcaaatttcttggacaccgcatcatccccatcaatgccttacattctggataccaccat
ctgtgcctgcgcagtgagagcaacatggcccttaccatgccagctctctttgtcttcctg
gagatgaaggactacatacctgacacctgggcagatcttacagtagcccttgccaacccc
atcaagtacttcaatgcccaggataagaagtccgtgaagctcaaaggagtgacaggaagt
ctgcccgagaaactcttctctgggacacctgttgccagtcagtccaatggggcgccagtc
tcggcaggcaatgggtcaacagcgcctgggaccaaggccacgggggaagaagctacgaaa
gaagtgacagagccacagaccgccagcttggaagagttgcgggaactgaagggcgtggtg
aaactgcagcgaagacatgagaaggagcttcgagagttggagcgccgtggagcccggcgc
tgggaggaactgctgcagcgtggcgccgcacagctggcggagctccagacccaggcagca
ggctgcaagctccgcccaggcaagggctcccgcaagaagaggaccctgccctgtgaggag
accgtcgtggcgcctagcgagccccacgaccgggcggacccgcgcgtgcaggagctgaag
gacaggctggagcaggagctgcagcagcaaggcgaggagcagtaccgctccgtcctcaag
cgcaaggagcagcacgtgaccgagcaaatcgccaagatgatggagctggccagagagaaa
caggctgctgaactcaagaccttcaaggagacctcagaaactgacaccaaagaaatgaag
aaaaaactggaggccaagaggctggaacggatccaagccatgaccaaggtcaccacagac
aaggtggcccaggagaggctcaagagagaaattaacaactcccacatccaggaagtggtc
caggctgtcaagcagatgacagagaccctggagcgtcaccaggagaagctggaagagagg
cagacagcctgcctggagcagatccaggcaatggaaaagcagttccaggagaaggcgctg
gcagagtatgaggccaagatgaagggcctggaggctgaagtaaaggagtcggtgcgggcc
tacttcaaggactgcttccccaccgaagcagaagacaagcctgagaggtcctgtgaggcc
tctgaggagtcgtgtccacaggaaccacttgtgagcaaggcagacactcaggagagccgc
ctctga

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