KEGG   Mus musculus (mouse): 18796Help
Entry
18796             CDS       T01002                                 

Gene name
Plcb2, AI550384, B230205M18Rik, B230399N12
Definition
(RefSeq) phospholipase C, beta 2 (EC:3.1.4.11)
  KO
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mmu  Mus musculus (mouse)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Renin secretion
Aldosterone synthesis and secretion
AGE-RAGE signaling pathway in diabetic complications
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Carbohydrate digestion and absorption
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    18796 (Plcb2)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    18796 (Plcb2)
   04310 Wnt signaling pathway
    18796 (Plcb2)
   04020 Calcium signaling pathway
    18796 (Plcb2)
   04070 Phosphatidylinositol signaling system
    18796 (Plcb2)
   04072 Phospholipase D signaling pathway
    18796 (Plcb2)
   04071 Sphingolipid signaling pathway
    18796 (Plcb2)
   04022 cGMP - PKG signaling pathway
    18796 (Plcb2)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    18796 (Plcb2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    18796 (Plcb2)
   04062 Chemokine signaling pathway
    18796 (Plcb2)
  Endocrine system
   04911 Insulin secretion
    18796 (Plcb2)
   04922 Glucagon signaling pathway
    18796 (Plcb2)
   04912 GnRH signaling pathway
    18796 (Plcb2)
   04915 Estrogen signaling pathway
    18796 (Plcb2)
   04921 Oxytocin signaling pathway
    18796 (Plcb2)
   04918 Thyroid hormone synthesis
    18796 (Plcb2)
   04919 Thyroid hormone signaling pathway
    18796 (Plcb2)
   04916 Melanogenesis
    18796 (Plcb2)
   04924 Renin secretion
    18796 (Plcb2)
   04925 Aldosterone synthesis and secretion
    18796 (Plcb2)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    18796 (Plcb2)
   04270 Vascular smooth muscle contraction
    18796 (Plcb2)
  Digestive system
   04970 Salivary secretion
    18796 (Plcb2)
   04971 Gastric acid secretion
    18796 (Plcb2)
   04972 Pancreatic secretion
    18796 (Plcb2)
   04973 Carbohydrate digestion and absorption
    18796 (Plcb2)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    18796 (Plcb2)
  Nervous system
   04724 Glutamatergic synapse
    18796 (Plcb2)
   04725 Cholinergic synapse
    18796 (Plcb2)
   04728 Dopaminergic synapse
    18796 (Plcb2)
   04726 Serotonergic synapse
    18796 (Plcb2)
   04720 Long-term potentiation
    18796 (Plcb2)
   04730 Long-term depression
    18796 (Plcb2)
   04723 Retrograde endocannabinoid signaling
    18796 (Plcb2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    18796 (Plcb2)
  Environmental adaptation
   04713 Circadian entrainment
    18796 (Plcb2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    18796 (Plcb2)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    18796 (Plcb2)
   05016 Huntington's disease
    18796 (Plcb2)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    18796 (Plcb2)
  Infectious diseases
   05146 Amoebiasis
    18796 (Plcb2)
   05142 Chagas disease (American trypanosomiasis)
    18796 (Plcb2)
   05143 African trypanosomiasis
    18796 (Plcb2)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     18796 (Plcb2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Position
2 E5; 2 59.43 cM
AA seq 1181 aa AA seqDB search
MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQEMEFLD
VTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKE
NVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEH
LTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGV
AEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLE
VTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQ
MSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHE
FMRRLDKQFNPFSVDRIDVVVATTLSITIISGQFLSERSVRTYVEVELFGLPGDPKRRYR
TKLSPTANSINPVWKEEPFIFEKILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHH
LCLRSESNMALTMPALFVFLEMKDYIPDTWADLTVALANPIKYFNAQDKKSVKLKGVTGS
LPEKLFSGTPVASQSNGAPVSAGNGSTAPGTKATGEEATKEVTEPQTASLEELRELKGVV
KLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTQAAGCKLRPGKGSRKKRTLPCEE
TVVAPSEPHDRADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREK
QAAELKTFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVV
QAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRA
YFKDCFPTEAEDKPERSCEASEESCPQEPLVSKADTQESRL
NT seq 3546 nt NT seq  +upstreamnt  +downstreamnt
atgtctttgctcaaccctgttctattgccccctaacgtgaaggcatatctgagccaaggg
gagcgcttcatcaagtgggacgatgaaacttcaatagcctctcctgttatcctccgtgtg
gatcccaagggctattacttatactggacatatcaaaatcaggagatggagttcctggat
gtcacgagtatccgagatactcgctttgggaagtttgcaaagatacccaagagccagaaa
ctccgggaggtcttcaacatggactttccagacaaccacttcctgctgaaaacactcaca
gtggtgtccggccctgacatggtggacctcaccttctacaactttgtctcttacaaggag
aacgtaggcaaggactgggctgaggacgtgctagctctcgccaaacacccgatgacagtc
aatgctcctcgaagcacattcctggacaagatcctggtgaagcttaagatgcagctcaac
cctgaagggaagattcccgtgaagaattttttccagatgtttcctgctgatcgaaaacgg
gtggaagctgccctcggtgcttgtcaccttgcaaaaggcaaaaatgatgctatcaaccca
gaggacttcccagaatccgtgtacaagagcttcctcatgagcctctgtcctcggccagaa
atcgacgagatcttcacttcctaccactctaaagctaagccctacatgaccaaggaacac
ctgaccaaattcatcaatcagaagcagcgagaccctcgactcaactccttgctgttccca
ccagcccggcctgagcaagttcaagtgctcattgacaagtacgaacccagcggcatcaat
gtgcagaggggccagctgtcaccagaggggatggtctggtttctctgtggaccagagaac
agtgtgctggcccacgatacactgctgatccaccaagacatgacacaaccactgaatcac
tatttcatcaactcctcacacaacacctacctgacagccggccagttctcaggcctttcc
tcggctgagatgtaccgccaggtgctgctgtctggctgccggtgtgtagagttagactgt
tggaagggcaagccccctgacgaagagcccattatcacccacggcttcaccatgaccaca
gatatcttgttcaaggaagcaattgaagccattgcagaaagtgcctttaagacctccccg
tatcctgtcatcctatcatttgaaaaccatgtagactcaccccggcaacaggctaagatg
gctgagtactgcaggagcatgtttggagagaccttgctcacagatcccctggaaaatttc
cctctgaaacctggcatccctctgcccagccccgaggacctccggggcaagatcctcatt
aagaataagaagaaccagttttctgggccagcatcccccagcaagaagcctggtggggtg
gctgagggcagcctcccgtctagtgtccctgtagaagaggacacggggtggactgctgag
gaccggactgaggtggaggaggaggaggtggtggaagaggaggaagaggaggagtcagga
aacctggatgaagaagaaattaagaagatgcagtcggatgagggcacagcaggcctggag
gtgacagcttatgaggaaatgtccagccttgtcaattatatccagcccaccaagtttatc
tccttcgagttctctgcacagaagaacagaagttacgttgtctcttccttcacggagctc
aaggcctacgagctgctctccaaggcctccatgcagtttgtggactataataaacgccag
atgagccgtgtgtaccccaagggcacacgcatggactcttccaactacatgccccagatg
ttctggaatgctggatgtcagatggttgccctcaatttccagacaatggacctgcccatg
cagcagaacatggcactgtttgagttcaacgggcagagtggctacctcctaaagcacgag
ttcatgcgcagactggacaagcagttcaaccccttctcagtggaccgcattgatgtggtg
gtagccaccaccctttccattacgatcatctctgggcagttcctgtcagagcgcagtgta
cgcacctatgtggaagtggaactgtttggcctcccaggggaccccaagaggcggtatcga
accaagctgtcacctactgctaactccatcaatcctgtctggaaagaggaaccctttatc
tttgagaagatcttgatgcctgagctggcctccctcaggatagctgtgatggaagaaggc
agcaaatttcttggacaccgcatcatccccatcaatgccttacattctggataccaccat
ctgtgcctgcgcagtgagagcaacatggcccttaccatgccagctctctttgtcttcctg
gagatgaaggactacatacctgacacctgggcagatcttacagtagcccttgccaacccc
atcaagtacttcaatgcccaggataagaagtccgtgaagctcaaaggagtgacaggaagt
ctgcccgagaaactcttctctgggacacctgttgccagtcagtccaatggggcgccagtc
tcggcaggcaatgggtcaacagcgcctgggaccaaggccacgggggaagaagctacgaaa
gaagtgacagagccacagaccgccagcttggaagagttgcgggaactgaagggcgtggtg
aaactgcagcgaagacatgagaaggagcttcgagagttggagcgccgtggagcccggcgc
tgggaggaactgctgcagcgtggcgccgcacagctggcggagctccagacccaggcagca
ggctgcaagctccgcccaggcaagggctcccgcaagaagaggaccctgccctgtgaggag
accgtcgtggcgcctagcgagccccacgaccgggcggacccgcgcgtgcaggagctgaag
gacaggctggagcaggagctgcagcagcaaggcgaggagcagtaccgctccgtcctcaag
cgcaaggagcagcacgtgaccgagcaaatcgccaagatgatggagctggccagagagaaa
caggctgctgaactcaagaccttcaaggagacctcagaaactgacaccaaagaaatgaag
aaaaaactggaggccaagaggctggaacggatccaagccatgaccaaggtcaccacagac
aaggtggcccaggagaggctcaagagagaaattaacaactcccacatccaggaagtggtc
caggctgtcaagcagatgacagagaccctggagcgtcaccaggagaagctggaagagagg
cagacagcctgcctggagcagatccaggcaatggaaaagcagttccaggagaaggcgctg
gcagagtatgaggccaagatgaagggcctggaggctgaagtaaaggagtcggtgcgggcc
tacttcaaggactgcttccccaccgaagcagaagacaagcctgagaggtcctgtgaggcc
tctgaggagtcgtgtccacaggaaccacttgtgagcaaggcagacactcaggagagccgc
ctctga

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