KEGG   Mus musculus (mouse): 18798Help
Entry
18798             CDS       T01002                                 

Gene name
Plcb4, A930039J07Rik, AI854601, C230058B11Rik
Definition
phospholipase C, beta 4 (EC:3.1.4.11)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mmu  Mus musculus (mouse)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    18798 (Plcb4)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    18798 (Plcb4)
   04310 Wnt signaling pathway
    18798 (Plcb4)
   04020 Calcium signaling pathway
    18798 (Plcb4)
   04070 Phosphatidylinositol signaling system
    18798 (Plcb4)
   04022 cGMP - PKG signaling pathway
    18798 (Plcb4)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    18798 (Plcb4)
 Organismal Systems
  Immune system
   04611 Platelet activation
    18798 (Plcb4)
   04062 Chemokine signaling pathway
    18798 (Plcb4)
  Endocrine system
   04911 Insulin secretion
    18798 (Plcb4)
   04912 GnRH signaling pathway
    18798 (Plcb4)
   04915 Estrogen signaling pathway
    18798 (Plcb4)
   04921 Oxytocin signaling pathway
    18798 (Plcb4)
   04918 Thyroid hormone synthesis
    18798 (Plcb4)
   04919 Thyroid hormone signaling pathway
    18798 (Plcb4)
   04916 Melanogenesis
    18798 (Plcb4)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    18798 (Plcb4)
   04270 Vascular smooth muscle contraction
    18798 (Plcb4)
  Digestive system
   04970 Salivary secretion
    18798 (Plcb4)
   04971 Gastric acid secretion
    18798 (Plcb4)
   04972 Pancreatic secretion
    18798 (Plcb4)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    18798 (Plcb4)
  Nervous system
   04724 Glutamatergic synapse
    18798 (Plcb4)
   04725 Cholinergic synapse
    18798 (Plcb4)
   04728 Dopaminergic synapse
    18798 (Plcb4)
   04726 Serotonergic synapse
    18798 (Plcb4)
   04720 Long-term potentiation
    18798 (Plcb4)
   04730 Long-term depression
    18798 (Plcb4)
   04723 Retrograde endocannabinoid signaling
    18798 (Plcb4)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    18798 (Plcb4)
  Environmental adaptation
   04713 Circadian entrainment
    18798 (Plcb4)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    18798 (Plcb4)
   05016 Huntington's disease
    18798 (Plcb4)
  Infectious diseases
   05146 Amoebiasis
    18798 (Plcb4)
   05142 Chagas disease (American trypanosomiasis)
    18798 (Plcb4)
   05143 African trypanosomiasis
    18798 (Plcb4)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     18798 (Plcb4)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Position
2 F3; 2 66.64 cM
AA seq 1175 aa AA seqDB search
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRQAAIPKDPKILAALEAVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFLTNTTGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEELKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPASILEDDNEEEIESADQEEEAHPEYKFGNELSADDYSHKEAVANSVKKGLV
TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG
LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL
NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGT
YVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNK
LIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKK
FLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANPAKANVTPQSSSELRPTTTAA
LGSGQEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQ
VDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEIKKETEIKIQTLTTDHKSKVKEIVAQH
TKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKLSHDRESKEMRAHQ
AKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ
LEHLEFLEKQNEQAKEMQQMVKLEAEMDRRPATVV
NT seq 3528 nt NT seq  +upstreamnt  +downstreamnt
atggccaaaccttacgaatttaactggcagaaggaagtgccctctttcttgcaagaagga
gcagtttttgacagatacgaagaggaatcttttgtgtttgagcccaactgcctcttcaaa
gtagatgaattcggcttcttcctgacgtggaagagtgaaggcaaggaaggacaagtgcta
gaatgttccctcatcaacagtattcgccaagcagccataccaaaggatcccaaaatcctg
gctgctctcgaagctgttggaaaatctgaaaatgatctggaagggcggatattgtgtgtc
tgcagcggcacggatctggtgaatatcggcttcacttacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggcctgagatcgatcattcacaacttcagggcaaacaac
gtcagtccgatgacatgcctcaagaaacactggatgaaactggcctttctgaccaacaca
actggtaaaatcccagtgaggagtatcactagaaccttcgcatcagggaaaacagaaaag
gtgatctttcaagccctcaaggaactaggtcttcccagtggaaagaatgatgaaattgaa
cctgctgcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaagatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaacgaacatcagcgagatcctcggctgaatgaaattttattc
ccattttatgatgctaaaagagcaatgcagatcattgaaatgtatgagcctgatgaagag
ctgaagaaaaaaggcctcatatccagtgatggattctgcagatatctgatgtcagatgaa
aatgcccctgtcttcttagatcgcttagaactttaccaggagatggaccacccgctggct
cattacttcatcagttcctcccacaacacctatctcactggccggcaatttggaggaaag
tcttcagtggaaatgtacagacaagttctcctggctggttgcaggtgtgttgaacttgac
tgttgggatggaaaaggtgaagatcaggaaccgataataactcacggaaaagcaatgtgt
acagacatcctttttaaggatgtaatccaggccatcaaggaaacggcgtttgtcacatca
gaataccctgtcattctctccttcgaaaaccactgcagcaaatatcaacagtacaagatg
tccaagtattgtgaagatctatttggggatctcctgttgaaacaagcacttgagtcgcat
ccacttgaaccaggaaggcccttgccgtctcctaatgacctcaaaagaaaaatactcatc
aagaataagaggctgaagcctgaagttgaaaagaaacagcttgaagctttgaaaagcatg
atggaagctggagagtcagccgccccagctagcatcttggaagacgacaatgaagaggaa
atagaaagtgctgatcaagaggaagaagcccaccctgaatacaaatttggaaatgaactt
tctgccgatgactacagtcacaaggaagcggttgcaaacagcgtcaagaagggcctggtc
accgtagaggatgagcaagcatggatggcatcttataaatacgtaggtgctaccacgaac
atccatccgtacttgtccacgatgatcaactatgcccagcccgtgaagtttcaaggtttc
cacgtggctgaagagcgcaatattcactataacatgtcttcttttaacgagtcggttggc
cttggctacttgaagacgcacgcgattgagtttgtaaattacaataagcgacaaatgagc
cgcatttaccccaagggaggccgagttgattccagtaattacatgcctcagattttctgg
aacgctggttgccagatggtttcactgaactatcaaaccccagatttagcgatgcaattg
aatcaaggaaaatttgagtataatggatcatgcgggtaccttctcaagccagatttcatg
aggcggcctgatcggacatttgaccccttctctgaaacccctgtggacggggttattgca
gccacgtgctcagtgcaggttatatcagggcagttcctctcagataagaagatcgggaca
tacgtggaagtcgatatgtacgggctgcccaccgacaccatacggaaagagttccgaacc
cgcatggttatgaacaatggactcaacccagtgtataatgaagaatcgtttgtgtttcga
aaggtgatcctgcctgacctagctgtcctgagaatcgcagtctacgatgacaacaacaag
ctaattggccagaggatccttcctttggatggtctccaagcaggctaccgacacatctcc
ctgagaaacgagggaaacaaaccattatcactgccaacaattttctgcaatattgttctt
aaaacatacgtgcctgatggatttggagatattgtggatgctttatccgatccaaagaaa
tttctttcaatcacagagaagagagcagaccaaatgagagcaatgggcattgaaactagt
gacatagcagatgtgcccagtgacacttccaaaaatgacaagaaaggcaaggccaaccca
gccaaagcgaacgtgacccctcagagcagctctgagctcagaccaaccaccacagccgcc
ctgggctctggccaggaagccaagaaaggtattgaacttatccctcaagtgaggatagaa
gatttaaagcaaatgaaggcttacttgaagcatttaaagaaacaacagaaggagttaaac
tctttaaagaagaaacatgcaaaggagcacagtaccatgcagaagttacactgcacacaa
gttgacaaaatcgtggcccagtatgacaaagagaagtcgactcatgagaaaatcctagag
aaggcgatgaagaagaaggggggaagtaattgtcttgaaataaaaaaagaaacagaaatt
aaaattcagaccctgacaacggatcacaaatctaaggtcaaagagattgtggcccagcac
acaaaggagtggtcagaaatgatcaacactcacagtgcggaggagcaggaaatccgggat
ctgcacctgagccagcagtgtgagctgctgagaaagctgctcatcaatgctcatgagcag
cagacccagcagctgaaactctcccatgacagggaaagcaaggagatgagagcccatcag
gctaagatttctatggaaaatagcaaggccatcagtcaagataaatctatcaagaacaag
gcagaacgggaaaggcgagtcagggagttgaacagcagcaacactaagaagttcctagaa
gaaagaaagagactggcgatgaagcagtcaaaagaaatggatcagttgaaaaaagtccag
ctggagcacctagaattcctagagaaacagaacgagcaggcgaaggagatgcagcagatg
gtgaaattggaagccgagatggaccgcagaccagcaacagtagtatga

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