KEGG   Mus musculus (mouse): 18803Help
Entry
18803             CDS       T01002                                 

Gene name
Plcg1, AI894140, Cded, Plc-1, Plc-gamma1, Plcg-1
Definition
phospholipase C, gamma 1 (EC:3.1.4.11)
Orthology
K01116  
phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
mmu  Mus musculus (mouse)
Pathway
Inositol phosphate metabolism
Metabolic pathways
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
VEGF signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    18803 (Plcg1)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    18803 (Plcg1)
   04015 Rap1 signaling pathway
    18803 (Plcg1)
   04012 ErbB signaling pathway
    18803 (Plcg1)
   04370 VEGF signaling pathway
    18803 (Plcg1)
   04064 NF-kappa B signaling pathway
    18803 (Plcg1)
   04066 HIF-1 signaling pathway
    18803 (Plcg1)
   04020 Calcium signaling pathway
    18803 (Plcg1)
   04070 Phosphatidylinositol signaling system
    18803 (Plcg1)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    18803 (Plcg1)
   04660 T cell receptor signaling pathway
    18803 (Plcg1)
   04664 Fc epsilon RI signaling pathway
    18803 (Plcg1)
   04666 Fc gamma R-mediated phagocytosis
    18803 (Plcg1)
   04670 Leukocyte transendothelial migration
    18803 (Plcg1)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    18803 (Plcg1)
  Nervous system
   04722 Neurotrophin signaling pathway
    18803 (Plcg1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    18803 (Plcg1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    18803 (Plcg1)
   05206 MicroRNAs in cancer
    18803 (Plcg1)
   05205 Proteoglycans in cancer
    18803 (Plcg1)
   05214 Glioma
    18803 (Plcg1)
   05223 Non-small cell lung cancer
    18803 (Plcg1)
  Infectious diseases
   05169 Epstein-Barr virus infection
    18803 (Plcg1)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     18803 (Plcg1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Position
2 H2; 2 80.97 cM
AA seq 1302 aa AA seqDB search
MAGVATPCANGCGPGAPSEAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLETNALRT
GERPEHCQVSLSEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDELVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQHFRKVLGDTLLTKPVDIAADGLPSPNQLRRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASS
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLW
FPSNYVEEMINPAVLEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MPSVAQWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCVICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKENGDLSPFSGISLRERASDASSQLFHVRAREGSFEARYQQPFEDF
RISQEHLADHFDSRERSTSDGPSSATNLIEDPLHDKLWKCSL
NT seq 3909 nt NT seq  +upstreamnt  +downstreamnt
atggcgggcgtcgcgaccccctgcgccaacggctgcgggcctggcgcaccctccgaagcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggccagaacggaagaccttccaggtcaagttggagacgcgccagatc
acatggagccgcggcgcggacaaaatcgaggggtccattgatatccgagaaatcaaggag
atccgtccagggaagacttctcgggactttgaccgctaccaagaagaccctgccttccgg
ccagatcaatcacactgctttgtcatcctctatggaatggaattccgcttgaagaccctg
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggcta
atggaggatacactgcaggcagccacacccctgcaaattgagaggtggctccggaagcag
ttctactcagtggatcgtaaccgagaggatcgtatatcagccaaggacttgaagaacatg
ctgtctcaggtcaactaccgagtccccaatatgcgcttcctccgagagcggctgacggac
cttgaacagcgcagcggggacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggaccttcccttcttggaaaccaacgctttgaggact
ggagagcgtccggagcattgccaggtgtccctttctgagttccagcagttcctccttgaa
taccagggggagctgtgggctgtcgaccggctccaggtgcaggaattcatgctcagcttc
cttcgagaccccttgcgagagattgaggagccatacttcttcttggatgagcttgtcacc
ttcctgttctccaaagagaacagcgtgtggaactcacagctggatgctgtgtgcccggac
accatgaacaacccactctctcactattggatctcctcctcacataatacgtacctgact
ggggaccagttctccagtgagtcctccctggaagcctatgctcgctgcctgaggatgggc
tgtcgctgcattgagttggactgctgggatgggccagatgggatgccagtcatttaccat
gggcacactctcaccaccaagatcaagttctctgacgtcctgcacaccatcaaggagcat
gctttcgtagcctcagagtacccagtcatcctgtccatcgaggaccactgcagcattgcc
cagcagagaaacatggctcagcacttcagaaaggtgcttggcgacacactccttaccaag
cctgtggacattgctgctgatggccttccttctcccaaccagctcaggaggaagatcctt
attaagcacaagaagctggctgagggcagtgcctatgaggaggtgcctacctctgtgatg
tactccgagaatgacatcagtaactccatcaagaatggtatcctctacttggaggacccc
gtgaatcatgagtggtatccccactacttcgttctgactagcagcaagatctactactct
gaggagaccagcagtgaccagggcaatgaggatgaagaggagccgaaggaggccagcagc
agcacagagctgcactcgagtgagaagtggttccacgggaagctcggggctggacgtgac
gggcggcacattgctgagcgcctgctcactgagtactgcatagagactggggctcctgat
ggctccttcctagtgcgagaaagtgagaccttcgtgggtgactacacgctgtctttctgg
cggaatgggaaagtccagcactgccgcatccactcccggcaggatgctgggactcctaag
ttcttcttgacagataaccttgtctttgactctctctatgacctcatcacacattatcag
caagtacccctgcgctgcaatgagtttgagatgcgcctttcagagcctgttccacagacg
aatgcccatgagagcaaagagtggtaccacgcaagcctgactagagctcaggctgaacat
atgctgatgcgagtgccccgggatggggccttcctggtgcggaaacgcaatgagcctaac
tcatatgccatctctttccgggctgagggaaagatcaagcactgccgagtacagcaggaa
ggccagacagtgatgctggggaactctgagtttgacagcctggttgacctcatcagctac
tatgagaagcaccccctgtaccgcaaaatgaagctacgctaccccatcaacgaggaggca
ctggagaagatcgggacagctgaacccgattatggggcactatacgagggccgcaaccct
ggtttctatgtggaggcaaaccctatgccaactttcaagtgtgcagtaaaagccctcttc
gactacaaggcccagagagaggatgagctgaccttcaccaagagtgccatcatccagaat
gtggaaaagcaagatggtggctggtggcgaggggactatggtgggaagaagcagctgtgg
ttcccctcaaactatgtggaagagatgatcaatccagcagtcctagagcctgagagggag
cacctggatgagaacagcccactgggggacttgctgcgaggggtcttagatgtgccagct
tgtcagatcgccatccgtcctgagggcaaaaacaaccggctcttcgtcttctccatcagc
atgccatcagtggctcagtggtccctggatgttgcagctgactcacaggaggagttacag
gactgggtgaaaaagatccgtgaagttgcccagactgcagatgccaggctcactgaggga
aagatgatggagaggaggaagaagatcgccttggagctctccgagcttgtggtctactgc
cggcccgttccctttgatgaagagaagattggcacagaacgtgcttgttaccgggacatg
tcctcctttccggaaaccaaggctgagaagtatgtgaacaaggccaaaggcaagaagttc
ctccagtacaaccggctgcagctctcgcgcatctaccctaagggccagaggctagactcc
tccaattatgaccctctgcccatgtggatctgcggtagccagcttgtagcactcaatttc
cagaccccagacaagcctatgcagatgaaccaggccctcttcatggctggtgggcattgt
ggctatgtgctgcagccaagcaccatgagagacgaagcctttgacccctttgataagagc
agtctccgaggtctggaaccctgtgtcatttgcattgaggtgctgggggccaggcatctg
ccgaagaatggccggggtattgtgtgtccttttgtggagattgaggtggctggggctgag
tacgacagcaccaagcaaaagacggagtttgtagtggacaacggactgaaccctgtgtgg
cctgctaagcccttccacttccagatcagtaacccagagtttgcctttctgcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaacttcttggctcaggctactttcccagta
aaaggcctgaagacaggatatagagcagtgcctttgaagaacaactacagtgaagacctg
gagttggcctccctgctcatcaagattgacattttccctgctaaggagaacggtgacctc
agtcctttcagtggcatatccctaagggaacgggcctcagatgcctccagccagctgttc
catgtccgggcccgggaagggtcctttgaagccagataccagcagccatttgaagatttc
cgcatctcgcaggagcatctagcagaccattttgacagtcgggaacgaagtacttcagat
ggtccttcctcagccactaaccttattgaggatcccttacatgacaagctgtggaagtgc
tctctttaa

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