KEGG   Mus musculus (house mouse): 226153
Entry
226153            CDS       T01002                                 
Symbol
Twnk, D19Ertd626e, PEO, Peo1, Twinl
Name
(RefSeq) twinkle mtDNA helicase
  KO
K17680  twinkle protein [EC:5.6.2.3]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu05017  Spinocerebellar ataxia
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    226153 (Twnk)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:mmu03029]
    226153 (Twnk)
Enzymes [BR:mmu01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.3  DNA 5'-3' helicase
     226153 (Twnk)
Mitochondrial biogenesis [BR:mmu03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA replication factors
   Mitochondrial DNA maintenance factors
    226153 (Twnk)
SSDB
Motif
Pfam: AAA_25 DnaB_C ATPase AAA_22 AAA_16 AAA_29 T2SSE AAA_23 AAA_19 TsaE ABC_tran AAA_33 nSTAND3 cobW
Other DBs
NCBI-GeneID: 226153
NCBI-ProteinID: NP_722491
MGI: 2137410
Ensembl: ENSMUSG00000025209
UniProt: Q8CIW5 Q3V303
Position
19:44994102..45001203
AA seq 685 aa
MWLLLRRAYPLRILLPLRGEWVGRRGLPRSLAPGPPRRRYRKEALPALEMPVSPVTTTEI
RQYLRAHGIPFQDGHSCLRAPSPFVVSSDIKNEKKDAPTSFCLFIDKTTGHFLCMTSLAE
GSWEDLQASVEGRGDGAKEGVLLREGPEAEVREEVLRIWNRAIPLWELPDPEEAQLARVM
FGLTKVTDDTLRRFSVRYLRSARSLVFPWFTPGSSGLRGLKLLGAEGQENGVQYVETTIP
RPGVYHNLFGLPLISRRDTEVVVTSRELDSLALSQSTGLPTLSLPRGTVCLPPALLPYLE
QFRRIVFWLGDDLRSWEAAKLFARKLNPKRCSLVRPGNQQPRPLEALNQGLSLPRILRTA
LPAWHKSIVSFRQLREEVLGELSNVEQAAGVRWSRFPDLNRLLKGHRKGELTVFTGPTGS
GKTTFISEYALDLCTQGVNTLWGSFEISNVRLARVMLTQFAVTRLEEQLDKYEEWADRFE
DLPLYFMTFHGQQSIRSVIDTMQHAVYVYDVCHVVIDNLQFMMGHEQLSSDRIAAQDYIV
GAFRKFATDNSCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPG
KRYLQVSKNRFDGDVGVFPLEFNKNSLTFSIPPKSKARLKKIKDDNGLVAKKSSSGKKGA
AHQNPEICLGQDPSPAQPDTSKSSG
NT seq 2058 nt   +upstreamnt  +downstreamnt
atgtggcttcttctccgacgtgcatatcccctccggatcttgctgccactgcgtggcgag
tgggtgggtaggaggggcctgcccagaagcttggcgccaggccctccccgcagaaggtac
agaaaagaagcgctcccagccttagagatgccagtgtcgccggtgactacgactgaaatc
cgccagtatttacgtgcacatgggatccccttccaggatggccacagctgccttcgagca
ccaagtccctttgtggtgtcctcagacatcaaaaatgagaaaaaggacgctcccacttcc
ttctgcctcttcattgacaagaccacaggacactttctttgcatgaccagcctagcagaa
gggagctgggaagacttgcaggccagtgtggagggacgaggggatggggccaaagagggt
gtcctacttagggaaggcccagaagctgaggttagggaggaggtcttgaggatctggaac
cgagccatacctctttgggagcttccagaccctgaggaagcccagctagctcgtgtgatg
tttggccttaccaaggtgacagatgacacactcaggcgattcagtgtccgctatcttcga
tctgctcgaagtctggtcttcccttggttcacccctgggagctcaggattacgtggcctg
aagctactaggggctgagggtcaggaaaatggagtacagtatgtagagaccaccatcccc
cggcctggtgtctatcacaacctatttggattaccactgatcagccggagagatactgag
gtggttgtgacaagtcgtgaactggacagcctggccttgagccagtcgacggggctgcca
accctttccctaccccgagggacagtctgcttacccccagccttactgccttaccttgaa
cagttccgtcggattgtgttctggttaggagatgaccttcgatcctgggaagctgccaaa
ctgtttgctcgaaaactcaaccccaagcgatgctctctggtgaggcctgggaaccaacag
cctcgtcccctggaggccttaaaccaaggcttaagtcttccccgtattcttcgtaccgcc
ctacctgcctggcacaagtctattgtgtcttttcggcagctccgagaggaggttttagga
gaactgtcaaatgtagagcaagcggctggtgtccgttggagccgcttcccagacctgaat
cgtctgctgaagggacatcggaagggcgagttgacggtctttacagggccaacaggcagt
ggcaagacaacattcatcagtgagtatgccctggacttgtgtacccagggagtgaacaca
ctgtggggtagctttgagatcagcaacgtgagactagcccgggtcatgctgacccagttt
gctgtgacacggctggaagagcaactggacaagtatgaagagtgggcagaccgttttgag
gacctgcctctctacttcatgactttccacggacaacagagcatcaggtccgtcatagac
acaatgcaacatgctgtctacgtctatgacgtctgtcatgtagtcattgacaacttgcag
ttcatgatgggtcacgagcagctctcctctgacaggattgcagctcaagactacattgtt
ggagcctttcggaagtttgctacagacaacagttgccacgtgactctggtcattcaccct
cggaaagaagacgacgacaaggaactgcagacagcatccattttcggctcagccaaagca
agccaagaagcagacaatgttctgatcttacaggataggaaactggtgactgggcctggg
aaacggtatctgcaggtgtccaagaatcgctttgatggagacgtaggtgtcttcccactg
gagttcaacaagaattcccttaccttctccatcccacccaagagcaaagcccgactcaag
aagatcaaggacgacaatggactagtggccaaaaaatcctcttctggcaaaaaaggggct
gcgcaccagaaccctgagatttgcttaggccaggaccccagccccgcccagccagatacc
tccaagtcctcagggtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (25)   
   RefSeq(nuc) (3)   
   GenBank (11)   
   EMBL (11)   
Protein domain (14)   
   Pfam (14)   
All databases (70)   

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