KEGG   Mus musculus (mouse): 234779Help
Entry
234779            CDS       T01002                                 

Gene name
Plcg2, PLCgamma2, Plcg-2
Definition
phospholipase C, gamma 2 (EC:3.1.4.11)
Orthology
K05859  
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
mmu  Mus musculus (mouse)
Pathway
Inositol phosphate metabolism
Metabolic pathways
ErbB signaling pathway
Ras signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
VEGF signaling pathway
Osteoclast differentiation
Platelet activation
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    234779 (Plcg2)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    234779 (Plcg2)
   04012 ErbB signaling pathway
    234779 (Plcg2)
   04370 VEGF signaling pathway
    234779 (Plcg2)
   04064 NF-kappa B signaling pathway
    234779 (Plcg2)
   04066 HIF-1 signaling pathway
    234779 (Plcg2)
   04020 Calcium signaling pathway
    234779 (Plcg2)
   04070 Phosphatidylinositol signaling system
    234779 (Plcg2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    234779 (Plcg2)
   04650 Natural killer cell mediated cytotoxicity
    234779 (Plcg2)
   04662 B cell receptor signaling pathway
    234779 (Plcg2)
   04664 Fc epsilon RI signaling pathway
    234779 (Plcg2)
   04666 Fc gamma R-mediated phagocytosis
    234779 (Plcg2)
   04670 Leukocyte transendothelial migration
    234779 (Plcg2)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    234779 (Plcg2)
  Nervous system
   04722 Neurotrophin signaling pathway
    234779 (Plcg2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    234779 (Plcg2)
  Development
   04380 Osteoclast differentiation
    234779 (Plcg2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    234779 (Plcg2)
   05206 MicroRNAs in cancer
    234779 (Plcg2)
   05205 Proteoglycans in cancer
    234779 (Plcg2)
   05214 Glioma
    234779 (Plcg2)
   05223 Non-small cell lung cancer
    234779 (Plcg2)
  Infectious diseases
   05169 Epstein-Barr virus infection
    234779 (Plcg2)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     234779 (Plcg2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
Ensembl: 
UniProt: 
Structure
PDB: 

Jmol
Position
8 E1; 8 64.26 cM
AA seq 1265 aa AA seqDB search
MTTMVNVDTLPEYEKSQIKRALELGTVMTVFNARKSTPERRTVQMIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRHKAECCFTILYGTQFVLSTLSLATDSKEDAV
KWLSGLKILHQEAMSASTPTMIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSGI
KFLKDKLVEIGAQKDELSFEQFHLFYKKLMFDQQKSILDEFKKDSSVFILGNTDRPDASA
VYLQDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCSVEQQRHMAKV
FKEVLGDMLLTKPTEASADQLPSPSQLREKIIIKHKKLGPKGDVDVNVEDKKDEHKPQGE
LYMWDSIDQKWTRHYCAIADAKLSFGDDIEQAVEEEPVQDTPPTELHFGEKWFHKKVESR
TSAEKLLQEYCAETGAKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMENGVMKYY
LTDNLTFNSIYALIQHYREAHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML
MRIPRDGAFLIRKREGTNSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELTFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISAGDAEEMEKQII
EDNPLGSLCKGILDLNTYNVVKAPQGKNQKAFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKMDTKENNMKYWERNQSIAIELSDLVVYCKPTSKTKDHLENPDFREIRSFVE
TKADSIVRQKPVDLLRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY
MQMNHALFSLNGRTGYVLQPESMRSEKYDPMPLESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDSNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRGANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSN
SRFYS
NT seq 3798 nt NT seq  +upstreamnt  +downstreamnt
atgaccaccatggtcaacgtggacacccttccagaatatgagaagagtcagatcaagaga
gcgctggagttagggacggtgatgaccgtgttcaacgcccgcaaatccaccccagagcgg
aggacagtacagatgatcatggagactcggcaggtggcatggagcaagaccgcagacaag
attgaaggcttcctggacatcatggagataaaggaaatccgtccggggaagaactccaag
gactttgagcgagccaaggctgtccgccacaaggcagaatgttgcttcaccatcctctac
ggcacccagtttgtcctcagcacgctcagtttggcaacggactcaaaggaggatgcggtg
aagtggctctctggtttgaagatcctacaccaggaagcgatgagtgcatccacccccaca
atgattgagagttggctgagaaaacagatttattcagtagatcaaacccgaagaaacagc
atcagcctccgggagctgaagaccatcttgcccctggtcaacttcaaagtgagcggcatc
aagtttctcaaggacaagctggtggaaatcggcgcacagaaagatgagctcagctttgaa
cagttccatctcttctataagaaactcatgtttgaccagcaaaaatcgatacttgacgaa
ttcaaaaaagactcctccgtgttcatcctaggaaacacagaccggccggatgcctcggct
gtctacctgcaggacttccaaaggtttcttttacatgaacagcaggagctatgggctcag
gatctgaacaaagtccgggagcggatgaccaagtttatcgacgacacaatgagagagacc
gcagagcccttcttatttgtggatgagttcctcacgtatctgttctcccgggagaacagc
atctgggacgagaagtacgatgcagtggacatgcaggacatgaacaaccccttgtcccac
tactggatctcctcttcccacaacacgtacctcactggggaccagctgcgtagtgagtcc
tccacggaagcgtatatccgctgtctgcgcgctggttgccgctgcattgagctggactgc
tgggacgggcctgatgggaagcccattatctaccacggctggacacggaccaccaagatc
aagtttgatgatgttgttcaggccatccgagaccacgcctttgttacctccagcttcccc
gtcatcttgtctatcgaggagcactgcagtgtggagcagcaacgtcacatggccaaggtg
ttcaaggaagtgttaggagacatgctgttgacgaagcccacagaggccagtgctgaccag
ctgccctcgcccagtcagcttcgtgagaagatcattatcaagcataagaagctgggtccc
aagggtgatgtcgacgtcaacgtggaggacaagaaagatgagcacaagccccagggcgag
ctgtatatgtgggactccatcgaccagaaatggacgcgccactactgtgccattgctgac
gccaagctgtccttcggtgatgacattgaacaggctgtggaggaggagccggtccaggac
actccccccacggagctgcattttggggagaaatggttccacaagaaggtggagagtagg
accagtgcggagaagctgctgcaagagtactgtgctgagaccggggccaaggacggcacc
ttcctggtgcgggagagcgagaccttccccaatgactacacactctccttctggcggtct
ggccgggtgcagcactgccggatccggtctactatggagaatggggtcatgaagtactac
ctgaccgacaacctcacgttcaacagcatctacgccctcatccagcactaccgtgaggca
cacctgcgctgcgcggagttcgagctgcggctcacagacccggtgcccaaccccaaccca
cacgagtccaagccgtggtactatgacagtctgagcaggggggaagcggaggacatgctg
atgcggatcccccgagatggagccttcctcatccggaagagggaggggaccaactcctac
gccatcaccttcagggccaggggcaaggtgaaacattgtcgcatcaaccgggacggacgc
cacttcgtgctgggcacctctgcctactttgagagcctagtggagcttgtcagctactac
gagaagcacgcgctctatcgcaagatgaggcttcgataccccgtgaccccggagctcctg
gagcgatataatatggaaagagacatcaactctctttatgacgtcagcaggatgtatgtg
gacccaagtgagatcaacccttccatgcctcagaggaccgtgaaagcgctctatgactac
aaagccaagcgcagcgacgagctgaccttctgccgcggtgccctcatccacaatgtctcc
aaggagcccgggggatggtggaaaggggactacgggacccggatccagcagtacttcccg
tccaactatgtcgaggatatctcggcaggcgatgctgaggagatggaaaagcagattatt
gaagacaatcccctcgggtctctctgcaaaggcatattggatcttaatacctacaacgtt
gtgaaggccccccaggggaaaaaccagaaagccttcgtctttatcctggagcctaagaaa
cagggagatcctcccgtggagttcgcgaccgaccgtgtggaggagctgtttgagtggttt
cagagcatacgggagatcacttggaagatggacaccaaggagaacaacatgaagtactgg
gagaggaaccagtccatcgccattgagctctcggacttggttgtatactgcaagccaact
agcaaaaccaaggaccatttggaaaatcccgacttccgagaaatccgctcttttgtggag
acgaaggcagacagcattgtcaggcaaaaacctgtcgatctattgcgatacaatcagaag
ggcctgacccgagtctaccccaagggacagagagttgactcttcgaactatgaccccttc
cgtctgtggctgtgcggctcccagatggtggcactcaatttccagactccagacaaatac
atgcagatgaaccacgcgctgttttcgctcaatgggcgaacaggctacgtcctgcagcct
gagagcatgcgctctgagaagtatgatccgatgcccctggagtcccagaggaagatcctg
atgacactcactgtcaaggttcttggtgcacgccacctccctaaactagggcggagtatt
gcctgtccttttgtggaggtggaaatctgcggggctgagtatgacagcaacaaattcaag
acgacggttgtgaatgacaatggcctcagccctgtctgggctccaactcaggagaaggtg
acatttgagatctatgatccaaaccttgccttcctacgctttgtggtctacgaagaagac
atgttcagtgatcccaacttcctggctcatgccacgtaccccattaaaggcatcaaatcc
gggtttagatcagtccctctgaagaatgggtacagtgaagacatcgagctggcatccctc
ctggttttctgtgagatgaggccagtcctggagagtgaagaggaactctattcctcctgt
cgccaactgcggaggcggcaagaagagctcaacaaccagctcttcctttacgacacgcac
cagaacctgcgcggagccaaccgtgatgccctggtgaaggagttcaatgttaacgagaat
cagctgcagctgtaccaggagaagtgcaaccggaggctgagagagaagagagtaagcaac
agcaggttctactcctag

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