KEGG   Mus musculus (mouse): 26395Help
Entry
26395             CDS       T01002                                 

Gene name
Map2k1, MAPKK1, MEKK1, Mek1, Prkmk1
Definition
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)
Orthology
K04368  
mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
mmu  Mus musculus (mouse)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
Dorso-ventral axis formation
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Gap junction
Toll-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Prion diseases
Alcoholism
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    26395 (Map2k1)
   04015 Rap1 signaling pathway
    26395 (Map2k1)
   04010 MAPK signaling pathway
    26395 (Map2k1)
   04012 ErbB signaling pathway
    26395 (Map2k1)
   04370 VEGF signaling pathway
    26395 (Map2k1)
   04668 TNF signaling pathway
    26395 (Map2k1)
   04066 HIF-1 signaling pathway
    26395 (Map2k1)
   04068 FoxO signaling pathway
    26395 (Map2k1)
   04022 cGMP - PKG signaling pathway
    26395 (Map2k1)
   04151 PI3K-Akt signaling pathway
    26395 (Map2k1)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    26395 (Map2k1)
  Cell growth and death
   04114 Oocyte meiosis
    26395 (Map2k1)
  Cell communication
   04510 Focal adhesion
    26395 (Map2k1)
   04540 Gap junction
    26395 (Map2k1)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    26395 (Map2k1)
   04650 Natural killer cell mediated cytotoxicity
    26395 (Map2k1)
   04660 T cell receptor signaling pathway
    26395 (Map2k1)
   04662 B cell receptor signaling pathway
    26395 (Map2k1)
   04664 Fc epsilon RI signaling pathway
    26395 (Map2k1)
   04666 Fc gamma R-mediated phagocytosis
    26395 (Map2k1)
   04062 Chemokine signaling pathway
    26395 (Map2k1)
  Endocrine system
   04910 Insulin signaling pathway
    26395 (Map2k1)
   04912 GnRH signaling pathway
    26395 (Map2k1)
   04915 Estrogen signaling pathway
    26395 (Map2k1)
   04914 Progesterone-mediated oocyte maturation
    26395 (Map2k1)
   04917 Prolactin signaling pathway
    26395 (Map2k1)
   04921 Oxytocin signaling pathway
    26395 (Map2k1)
   04919 Thyroid hormone signaling pathway
    26395 (Map2k1)
   04916 Melanogenesis
    26395 (Map2k1)
  Circulatory system
   04270 Vascular smooth muscle contraction
    26395 (Map2k1)
  Nervous system
   04725 Cholinergic synapse
    26395 (Map2k1)
   04726 Serotonergic synapse
    26395 (Map2k1)
   04720 Long-term potentiation
    26395 (Map2k1)
   04730 Long-term depression
    26395 (Map2k1)
   04722 Neurotrophin signaling pathway
    26395 (Map2k1)
  Development
   04320 Dorso-ventral axis formation
    26395 (Map2k1)
   04380 Osteoclast differentiation
    26395 (Map2k1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    26395 (Map2k1)
   05206 MicroRNAs in cancer
    26395 (Map2k1)
   05205 Proteoglycans in cancer
    26395 (Map2k1)
   05210 Colorectal cancer
    26395 (Map2k1)
   05212 Pancreatic cancer
    26395 (Map2k1)
   05214 Glioma
    26395 (Map2k1)
   05216 Thyroid cancer
    26395 (Map2k1)
   05221 Acute myeloid leukemia
    26395 (Map2k1)
   05220 Chronic myeloid leukemia
    26395 (Map2k1)
   05218 Melanoma
    26395 (Map2k1)
   05211 Renal cell carcinoma
    26395 (Map2k1)
   05219 Bladder cancer
    26395 (Map2k1)
   05215 Prostate cancer
    26395 (Map2k1)
   05213 Endometrial cancer
    26395 (Map2k1)
   05223 Non-small cell lung cancer
    26395 (Map2k1)
  Neurodegenerative diseases
   05020 Prion diseases
    26395 (Map2k1)
  Substance dependence
   05034 Alcoholism
    26395 (Map2k1)
  Infectious diseases
   05164 Influenza A
    26395 (Map2k1)
   05161 Hepatitis B
    26395 (Map2k1)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     26395 (Map2k1)
Protein kinases [BR:mmu01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   26395 (Map2k1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Position
9 C; 9 34.55 cM
AA seq 393 aa AA seqDB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI
NT seq 1182 nt NT seq  +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgatggctcggcggtt
aacgggaccagctcggccgagaccaacctggaggccttgcagaagaagctggaggagctg
gagcttgacgagcagcagcggaagcggctcgaggcctttctgacgcagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagcgaactgggagctggcaacggtgga
gtggtcttcaaggtctcccacaagccatctggcctggttatggctagaaagctgatccac
ctggagatcaaacccgcaatccggaaccagatcatccgggagctgcaggtactgcacgag
tgcaactccccgtacatcgtgggcttctacggggccttctacagcgacggcgagatcagc
atctgcatggagcacatggatggtgggtccttggatcaagttctgaagaaagctggaaga
attcctgagcaaattttaggaaaagttagcattgctgtgataaaaggcctgacctatctt
cgggagaagcacaagattatgcacagagatgtcaagccatccaacattctagtgaactca
cgtggggagatcaaactctgtgattttggggtcagcgggcagctaattgactctatggcc
aactccttcgtgggcacgagatcctacatgtcgcctgagagactccaggggactcactac
tctgtgcagtcggacatctggagcatggggctctctctggtggagatggcagttgggaga
taccccattcctcctcctgatgccaaggagctggagctactgtttggatgccatgtggaa
ggagacgcagccgaaacaccacccaggccaaggacccctgggaggcctctcagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacattgtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggagtttcaggattttgtgaataaa
tgcttaataaagaaccctgcagagagagcagatctgaagcagctcatggtacatgctttc
atcaaaagatctgacgccgaggaggtagacttcgcaggctggctctgctccaccattggg
cttaaccagcccagcacaccaacccacgctgccagcatctga

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