KEGG   Mus musculus (mouse): 26419Help
Entry
26419             CDS       T01002                                 

Gene name
Mapk8, AI849689, JNK, JNK1, Prkm8, SAPK1
Definition
mitogen-activated protein kinase 8 (EC:2.7.11.24)
Orthology
K04440  
c-Jun N-terminal kinase [EC:2.7.11.24]
Organism
mmu  Mus musculus (mouse)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
cAMP signaling pathway
FoxO signaling pathway
Protein processing in endoplasmic reticulum
Wnt signaling pathway
Osteoclast differentiation
Focal adhesion
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Salmonella infection
Pertussis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
HTLV-I infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    26419 (Mapk8)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    26419 (Mapk8)
   04010 MAPK signaling pathway
    26419 (Mapk8)
   04012 ErbB signaling pathway
    26419 (Mapk8)
   04310 Wnt signaling pathway
    26419 (Mapk8)
   04668 TNF signaling pathway
    26419 (Mapk8)
   04068 FoxO signaling pathway
    26419 (Mapk8)
   04024 cAMP signaling pathway
    26419 (Mapk8)
 Cellular Processes
  Cell communication
   04510 Focal adhesion
    26419 (Mapk8)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    26419 (Mapk8)
   04621 NOD-like receptor signaling pathway
    26419 (Mapk8)
   04622 RIG-I-like receptor signaling pathway
    26419 (Mapk8)
   04664 Fc epsilon RI signaling pathway
    26419 (Mapk8)
  Endocrine system
   04910 Insulin signaling pathway
    26419 (Mapk8)
   04920 Adipocytokine signaling pathway
    26419 (Mapk8)
   04912 GnRH signaling pathway
    26419 (Mapk8)
   04914 Progesterone-mediated oocyte maturation
    26419 (Mapk8)
   04917 Prolactin signaling pathway
    26419 (Mapk8)
  Nervous system
   04728 Dopaminergic synapse
    26419 (Mapk8)
   04723 Retrograde endocannabinoid signaling
    26419 (Mapk8)
   04722 Neurotrophin signaling pathway
    26419 (Mapk8)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    26419 (Mapk8)
  Development
   04380 Osteoclast differentiation
    26419 (Mapk8)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    26419 (Mapk8)
   05210 Colorectal cancer
    26419 (Mapk8)
   05212 Pancreatic cancer
    26419 (Mapk8)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    26419 (Mapk8)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    26419 (Mapk8)
  Infectious diseases
   05132 Salmonella infection
    26419 (Mapk8)
   05133 Pertussis
    26419 (Mapk8)
   05152 Tuberculosis
    26419 (Mapk8)
   05166 HTLV-I infection
    26419 (Mapk8)
   05164 Influenza A
    26419 (Mapk8)
   05161 Hepatitis B
    26419 (Mapk8)
   05160 Hepatitis C
    26419 (Mapk8)
   05168 Herpes simplex infection
    26419 (Mapk8)
   05169 Epstein-Barr virus infection
    26419 (Mapk8)
   05145 Toxoplasmosis
    26419 (Mapk8)
   05142 Chagas disease (American trypanosomiasis)
    26419 (Mapk8)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     26419 (Mapk8)
Protein kinases [BR:mmu01001]
 Serine/threonine protein kinases: CMGC group
  MAPK family [OT]
   26419 (Mapk8)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
Position
14 B; 14
AA seq 384 aa AA seqDB search
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLAQVQQ
NT seq 1155 nt NT seq  +upstreamnt  +downstreamnt
atgagcagaagcaaacgtgacaacaatttttatagtgtagagattggagattctacattc
acagtcctaaaacgataccagaatttaaagcctataggctcaggagctcaaggaatagtg
tgtgcagcttatgatgccattcttgaaagaaatgttgcaatcaagaagctcagccggcca
tttcagaatcagacccatgctaagcgcgcctaccgagaactagttcttatgaagtgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggagttagatcatgaaagaatgtcctaccttctctatcaaatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacttaaagcctagtaatatagtagtcaaa
tcagactgcactttgaagattcttgattttggactggcgaggactgcaggaacgagtttt
atgatgacgccttatgtggtgactcgctactacagagcaccagaggtcattctcggcatg
ggctacaaggagaacgtggacttatggtctgtggggtgcattatgggagaaatggtttgc
cacaaaatcctctttccaggaagggactatattgatcagtggaataaagttattgaacag
ctcggaacaccttgtcctgaattcatgaagaaactacaaccaacagtaaggacttatgtt
gaaaacaggcctaaatacgctggatatagctttgagaaactgttccccgatgtgcttttc
ccagctgactcagagcataacaaacttaaagccagtcaggcaagagatttgttatccaaa
atgctagtaatagatgcatccaaaaggatctccgtagatgaagctctccagcacccatac
atcaacgtctggtatgatccttcagaagcagaagccccaccaccaaagatcccggacaag
cagttagatgagagggagcacacaatagaggagtggaaagaactgatatacaaggaggta
atggatttggaggaacgaactaagaatggagtcataagagggcagccgtctcctttagca
caggtgcagcaatga

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