KEGG   Myotis davidii (David's myotis): 102770006
Entry
102770006         CDS       T02992                                 
Symbol
LRRK2
Name
(RefSeq) leucine rich repeat kinase 2
  KO
K08844  leucine-rich repeat kinase 2 [EC:2.7.11.1]
Organism
myd  Myotis davidii (David's myotis)
Pathway
myd05012  Parkinson disease
myd05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:myd00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    102770006 (LRRK2)
   05022 Pathways of neurodegeneration - multiple diseases
    102770006 (LRRK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:myd01001]
    102770006 (LRRK2)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:myd04131]
    102770006 (LRRK2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:myd04147]
    102770006 (LRRK2)
Enzymes [BR:myd01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     102770006 (LRRK2)
Protein kinases [BR:myd01001]
 Serine/threonine kinases: TKL group
  LRRK family
   102770006 (LRRK2)
Membrane trafficking [BR:myd04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    102770006 (LRRK2)
Exosome [BR:myd04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   102770006 (LRRK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Roc LRR_8 COR LRR_4 Ras LRR_9 Arf Ank_2 AAA_22 nSTAND3 LRR_6 T2SSE TrwB_AAD_bind AAA_7 Septin MMR_HSR1 GTP_EFTU PduV-EutP ABC_tran AAA_16 SRPRB Kdo TsaE TniB cobW G-alpha Arm NACHT MobB AAA_29 FtsK_SpoIIIE Viral_helicase1 ResIII AAA_23 AAA_14
Other DBs
NCBI-GeneID: 102770006
NCBI-ProteinID: XP_015422108
Position
Un
AA seq 2464 aa
MASGSCQGCEEEDEETLKKLIVRLNNLQEGKQIETLVQILEDMQVFTYADHAAKLFQGKN
VHVPLLIVLDSYVRVACVQQVGWSLLCKLIEICPDIMQSLTGPQDIGCDWEVLGIHQLII
KMLTVHNASMNLSMVGLKALDLLLTSGKITLLILDEDSDIFLLIFDAMKKFSANDEVQKL
GCKALHVLFERVSEEQLTEFVENKDYMILLTALKNFKDEEEIVLYVLRCLHSLASPCNNV
EVLMSGNVRCYNIVVEAMKAFPVHEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVEAV
QRYSKNATLQIAGLSCLALLTETIFLNQDLEVKNENEENEDDEEEDKLFWLEACYKALTW
HRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASA
NALCTLLEQNVNFRKILLSKGIYLNVLELMKRHLHSPEVAESGCKMLNHLFEGSNVSLDV
MAAVAPKIITVMKSHGASLSVQLEALRAILHFLLPGMPEEVTEDTEYKHKLKIVTNQCFR
NDIHKLVLGSLNRFIGNPGIQKCGLKVISSIARFPDALEVLSLEGAIESVLQTLKMYPDD
QEIQRLGLSLIGCLITKKNLILGIENPLAKILVSSLQRFKDITELQTKGFQTVLTVLECS
ESFSKLLVHYSFDLVIFHQMSSSLMEQKDQQFLSLCCKCFAKLAMDDELKGVMLERACDQ
NNSIMVECLLLLGADANRAKEGTSLICQVCEKASSPKLVELLLNSGSHEQDVRKALAISI
GKGDSQIISLLLKRLALDLANNSICLGGFCIGKIEPSWLGPLFPDKTCNSRKEINIGSTL
ARMVLRYQTKSSVAEGAASGSNGDFSEQVLDKFDQWTFIPESYVDSVFGQSDDLDSEGSE
GSFLVKKKSSSISVGEFYRDPALQRCSPNLQSHSSSLITICPAKLSTYISIVCLLLTKGS
SKLPSHMRHSDSTSSLASEREYITSLDLSANELRDIDALSQKCCISGHLEHLARLELHQN
ALTGFPQRLCEVLKCLTHLDLHSNKFTAFPSYLLKMNCIANLDVSRNDIGPSIVLDPAVK
CPTLKQFNLSYNQLSSVPENLGDVAEKLEQLTLEGNKISGMCSPLSLKELKILNLSKNNI
SSLSEDFLEACPKVESFSARMNSLAAMPFLPSSMTNIKLSQNRFTCVPEAILNLPHLRSL
DMSSNEIKYLPSPAHWKSLNLRELLFSHNQISILDLSEKAHAWSRVEKLHLSHNKLKEIP
PEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIRF
LQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDAEMQSATVGIDVKDWPIQIR
GKRKKDLILNVWDFAGREEFYSTHPHFMTPRSLYLAVYDLSKGQAEVDAMKPWLFNIKAR
ASSSPVILVGTHLDVSDEKQRKACISKINKELLNKRGFPAIRDYHFVNATEESDALAKLR
KTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVKENQ
LQLDENELPHAVHFLNESGVLLHFQDPALQLSNLYFVEPKWLCKVMAQILTEKVEGGPKY
PKGIISRRSVEKFLSKKKRFPKNYTQQYFKLLEKFQIALPIGEEHLLVPSSLSDHRPVIE
LPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLN
WSPEAYCLVESEVLDNHPESFLKITVPSCRKGCIILGQVVDHIDSLMEEWFPGLLEIDIC
GEGETLLKKWALYSFNDGEEHEKILLDDLMKKAEEGDLLVNPDQPRLTLPISQIAPDLIL
ADLPRNIMLNSEKLEFEQAPEFLLGDGSFGSVYRATYEGDEVAVKIFNKHTSLRLLRQEL
VVLCHHRHPSLVFLLAAGIRPRMLVMELAPKGSLDRLLQQDTASLTRTLQHRIALHVADG
LRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAP
EVARGNVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYGC
APWPMVEKLIKSCLKENPQERPTSAQVFDILNSAELICLMRHIPIPKSFTVECMVAANQS
CKNASIWLGCGPRDRGQLSLLDLTTERLTSEEVTNSRILCLTLVHLPVEKESWIVSGTQS
GELLVINSEDGKKMHTLEKMTDSVTCLHCNSISKQRYTSKFDHWDRRKMNSSDLLFSPPR
FSYAAVSDSNIIAVVADRVLYIAKKNSPFVEVWDKKTEKLCELIDCAHFLKEEMVEVNKE
SKHNMSYSGRVKTLCLQKNSALWIGTGGGYMLLLDLSTLRLIRIIHDFCDSVRVMMTAQI
GNLKNAMLVLGYTWKNTEDMQHQKELQSCLSIWDINLPHEVQNLEKHIEVRKELAERMRR
ITVE
NT seq 7395 nt   +upstreamnt  +downstreamnt
atggccagtggcagctgtcaggggtgcgaggaggaggacgaggaaactttgaagaagttg
atagtcaggctgaacaatctccaggaaggaaagcagatagagacgctggtccaaattctg
gaggatatgcaggtgttcacctacgctgaccacgccgccaagttatttcaaggcaaaaat
gtccacgtgcctctgttgatcgtcttggactcctatgtgagagtggcctgcgtgcagcag
gtgggttggtcacttctatgcaaattaatagaaatctgtccagatataatgcaaagctta
acgggaccccaggacattggatgcgattgggaagtccttggtattcaccagctgattatt
aaaatgcttacagttcataatgccagtatgaacctgtcaatggttggactgaaggcctta
gatctccttctaacttcaggtaaaatcactttgctgatattggatgaagacagcgatatt
ttcttattaatttttgatgccatgaaaaagttttcagccaatgacgaggtccagaaactt
ggatgcaaagctttacatgtgctatttgagagagtttcagaggagcaactgactgaattt
gtcgagaataaagattatatgatattgctaactgcgttaaaaaactttaaagatgaggag
gaaattgtgctttacgtactgcgctgtttacattccctagcaagtccttgcaacaatgtt
gaagtcctcatgagtggcaacgtcaggtgttacaacattgtggtagaagccatgaaagca
ttccctgtccatgaaaaaattcaagaagtgagttgctgcttgctccatagacttacgtta
ggtaatttttttaatatcctggtattaaacgaggtgcatgagtttgtggtggaagctgtg
cagcggtactcaaagaacgcaacgttgcaaatcgcagggctcagctgtttagcgctcctc
actgagaccatttttttaaatcaagacttagaggtaaagaatgaaaacgaggagaatgaa
gatgatgaggaagaagataaattgttttggctagaagcctgttacaaagccctaacttgg
catagaaagaacaagcatgtgcaggaggctgcctgctgggccttaaacaatctccttatg
taccagaacagtttgcacgagaagatcggagatgaagatggccagttcccagctcatcgg
gaagtgatgctctccatgctgatgcattcttcatcaaaagaagtctttcaggcatctgcg
aacgctttgtgcacccttctagaacaaaatgttaatttcagaaaaatcctgttgtcaaaa
ggaatctacctgaacgtgctggagttgatgaagaggcatctacactcccctgaagtggct
gaaagtggctgcaaaatgctgaaccatctttttgaaggaagtaacgtttccctggatgta
atggcagcagtggcccccaaaataataacagttatgaaaagtcacggggcatcattgtca
gtgcagctggaggctcttcgagccattttacatttcctgcttccaggcatgccagaggaa
gtcacagaagataccgaatataaacacaagctaaaaattgttacaaatcagtgtttcagg
aatgatattcacaaactggtcctgggatctttaaacaggttcattggaaatcctgggatt
caaaaatgtggattaaaagtaatttcttctatagcacgttttcctgatgccttagaggtg
ttatctctggaaggtgctattgaatcggtgctgcaaacactgaagatgtatccggatgac
caagaaattcagcgtctgggtttaagtcttataggatgcttgattacaaagaagaattta
atcctaggaattgagaatccgctggcaaaaattctggtttccagtttgcaacgatttaag
gatattactgaattacagactaaaggatttcagacagtcttgaccgtgctggaatgttca
gagtctttttccaagctgttggtgcattattcctttgacttagtaatattccatcagatg
tcctccagtctcatggaacagaaggatcaacagtttctaagcctttgttgcaagtgcttt
gcaaaattagccatggatgatgagttaaaaggtgtgatgctagagagagcatgcgatcag
aataacagcatcatggttgaatgcttgcttctgctgggagcagacgccaatcgagcaaag
gagggaacttctttaatttgtcaggtgtgtgaaaaagcaagcagtcctaaactggtggaa
ctgttactgaatagtgggtcccatgaacaagacgtacggaaagcgctggcaataagcatc
gggaaaggcgacagccagatcatcagtttgctgttaaagagacttgccctggatctggcc
aacaacagcatatgcctcggcggattctgtatcgggaaaatcgaaccttcttggcttggt
cctttatttccagacaagacatgtaattcaagaaaagaaataaatataggatccacacta
gcgagaatggtcctcagataccagacgaaaagttctgtggcagagggagcagcctcaggc
agcaatggggatttttctgagcaagtacttgataaatttgaccaatggaccttcattcct
gagtcctacgtggacagtgtgtttggacaaagtgatgacctagatagcgaaggaagtgaa
ggttcatttcttgtgaaaaagaagtcaagttcgattagtgtaggagaattttaccgagat
cctgccttgcaacgttgttcaccaaatttgcaaagtcattccagttcactgataaccatt
tgcccagctaaattatccacttatatttccattgtttgtctgcttttgacaaaagggtca
tcaaaacttccatcccatatgaggcattcagacagcacttcttccctggcttctgagaga
gaatatattacatccctagatctttcagccaacgaactcagagatattgatgccctaagc
cagaagtgctgcatcagtggtcatctggagcacctggcaaggctggagcttcaccagaac
gcactcacgggcttcccacagcggctatgtgaagtgctgaagtgtttgacgcacttggac
ttgcacagtaataagttcacagcgtttccctcctacttgttgaaaatgaattgtattgcc
aaccttgatgtctctcgaaatgacattgggccctcgatagttttggatcctgcagtgaag
tgtccgaccttgaaacagttcaacctgtcatataaccagctctcttctgttcccgagaac
ttgggcgatgtggcagagaaactggagcagctgactttagaaggaaataaaatatcagga
atgtgttctcccctgagcctgaaggaactgaagattttaaatctgagtaaaaacaacatt
tcatccctgtcagaggactttcttgaggcttgtcctaaagtggagagtttcagcgccaga
atgaactcccttgctgctatgccttttttaccttcttctatgacaaacatcaaattatct
caaaacagatttacgtgtgttccagaagcaattttaaatcttccacacttgcgatcatta
gacatgagcagcaacgaaattaaatacctaccaagtcctgcacactggaaatctttgaac
ttaagggaactcttgtttagtcataatcagatcagcatcttggacttgagcgaaaaagca
catgcatggtctagagtagagaaactacatctttctcataataaactgaaagagattcct
cctgagattggctgtcttgaaaacctgacatctcttgatgttagttacaacttggaactg
agatcctttcccaatgaaatggggaaattgagcaaaatatgggatcttcctttggatgag
ctgcgtcttaattttgattttaagcatataggatgtaaagccaaagacatcataaggttt
cttcaacagcggttaaaaaaggctgtgccctataaccgcatgaaacttatgattgtggga
aacacggggagtggtaaaaccaccttactgcagcaattaatgaaaaccaagaaatcagat
gctgagatgcagagtgccaccgttggcatagacgtgaaggactggcctatccaaataaga
ggcaaaaggaagaaagacctgattctaaatgtgtgggatttcgcaggtcgggaggaattc
tacagcacgcacccgcacttcatgaccccacgatccctgtacctcgccgtctatgacctc
agcaaaggacaggcggaagttgatgctatgaagccttggctattcaatataaaggctaga
gcttcctcttcccctgtgattcttgtgggcacacatttggatgtttctgatgagaagcag
cgcaaagcctgcatcagtaaaatcaacaaggagctcttgaacaagcgggggtttcccgca
atccgcgattaccactttgtgaacgccaccgaggaatccgatgctttggcaaaacttcgg
aaaaccatcataaatgagagcctcaatttcaagatccgagatcagcctgttgttgggcag
ctgattccagactgctatgtagaacttgagaaaatcattttatcggagcgtaaaaatgtg
ccaattgaatttcctgtaattgaccggaaacgattattacaactcgtgaaagaaaatcaa
ctgcagttagatgaaaatgagcttcctcatgcagtgcacttcctaaatgaatcaggggtc
cttcttcatttccaagacccagcactgcagttaagtaacttatattttgtggaacccaag
tggctctgtaaagtcatggcacagattttgacagagaaagtagaaggcggtccaaaatat
cctaaaggaattatttcacgtagaagtgtggaaaaatttctttcaaagaaaaagagattt
ccaaagaactacacacaacagtacttcaaactcctagaaaaatttcagattgccttgcca
ataggagaagaacatttgctggttccaagcagtctgtctgaccacaggcctgtgatagag
ctcccccattgtgagaactctgaaattatcattcgactatatgaaatgccttattttcca
atgggattttggtcaagattaatcaatcgattacttgaaatttcaccttacatgctttca
ggtagagaacgagcgcttcgcccaaacagaatgtattggcgacaaggcatctatttgaat
tggtctcctgaagcttactgcctggtagaatctgaagtcttagataatcatccagagagt
ttcctaaaaattacagttccttcttgtagaaaaggctgtattattttgggacaagttgtg
gaccacattgattctctcatggaagaatggtttcctgggttattggagattgatatttgt
ggtgaaggagaaactttgttgaagaaatgggcattatacagttttaatgatggcgaagaa
catgaaaaaatcttacttgatgacttgatgaagaaagcagaagaaggagacctcctagta
aatccagatcaaccaaggctcacccttccaatatcccagattgctcctgacttgattttg
gctgacctgcctagaaatattatgttgaacagtgaaaaattggagtttgaacaagctccc
gaatttctcttaggtgatggcagttttggatcagtttatcgagcaacctacgaaggagat
gaagtggctgtaaagatatttaataaacatacatcacttagactgttaagacaggagctg
gtggtgctttgccaccaccgccaccccagcttggtctttttgctggcggctgggattcgt
ccccggatgctggtgatggagctggcccccaagggctccctggaccgcctgctgcagcag
gacacagccagcctcacgcggactctgcagcataggatcgcgctccatgtggctgacggc
ttgagatacctccactcggccatgattatataccgggatctgaagccccacaatgtactg
ctcttcaccctgtatcccaatgccgccatcattgccaagatcgctgactacgggattgct
cagtactgctgcaggatgggcatcaaaacctcggagggcacaccaggctttcgtgcacct
gaagttgctagaggaaatgtaatttataaccaacaggctgatgtttattcatttggttta
ctactgtatgacattttgacaactggaggtagaatagcagagggtttgaagtttccaaat
gagtttgatgaattggcaatacaaggcaaattaccagatccagttaaagaatatggttgt
gccccgtggcctatggttgagaagttaattaaaagctgtttaaaagaaaatcctcaagaa
aggcctacatctgcccaggtctttgacattttgaactcggcggagttaatctgtctgatg
agacacatacccattcccaaaagcttcactgtggagtgcatggttgctgcaaaccagagc
tgcaagaatgccagcatctggctgggctgcgggcccagggacagaggccaactctccctt
cttgacttaactactgaaagacttacttcggaggaagttaccaatagcagaatactgtgc
ctcaccttggtgcacctgcctgtggaaaaggaaagttggattgtgtctgggacacagtcc
ggcgagctcctcgtcattaattccgaagatgggaaaaagatgcatacccttgaaaagatg
accgattctgttacttgcttgcattgcaattccatttccaaacaaaggtacactagtaaa
tttgaccactgggatagaagaaaaatgaatagtagtgaccttcttttttcccctcctagg
ttttcttatgcagctgtcagtgactccaacatcatagcagtggtggcggacagggttctc
tacattgctaagaaaaatagcccatttgtggaagtgtgggataagaaaacggaaaaactc
tgtgaactaatagactgtgcgcactttttaaaggaggaaatggtggaagtgaacaaggag
tccaaacacaatatgtcttactcggggagagtgaaaactctctgccttcagaagaacagt
gctctctggattggaaccgggggaggctacatgctactccttgacctttcgactctcagg
ctcatccgtataattcacgacttctgtgactctgtccgagtcatgatgacagcgcagata
ggaaaccttaaaaatgccatgttggttttgggatatacctggaaaaatactgaagatatg
caacaccaaaaagaattacaatcttgcttgtctatttgggacatcaatcttccacatgaa
gtgcaaaatttagaaaaacatattgaagtgagaaaagaattagctgaaagaatgagaaga
ataactgttgaataa

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (37)   
   Pfam (37)   
All databases (52)   

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