KEGG   Pteropus alecto (black flying fox): 102880438
Entry
102880438         CDS       T02993                                 
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
  KO
K08844  leucine-rich repeat kinase 2 [EC:2.7.11.1]
Organism
pale  Pteropus alecto (black flying fox)
Pathway
pale05012  Parkinson disease
pale05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:pale00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    102880438 (LRRK2)
   05022 Pathways of neurodegeneration - multiple diseases
    102880438 (LRRK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:pale01001]
    102880438 (LRRK2)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:pale04131]
    102880438 (LRRK2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:pale04147]
    102880438 (LRRK2)
Enzymes [BR:pale01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     102880438 (LRRK2)
Protein kinases [BR:pale01001]
 Serine/threonine kinases: TKL group
  LRRK family
   102880438 (LRRK2)
Membrane trafficking [BR:pale04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    102880438 (LRRK2)
Exosome [BR:pale04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   102880438 (LRRK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr LRR_8 Roc LRR_4 COR Ras LRR_9 Arf WD40_2 nSTAND3 Ank_2 AAA_22 T2SSE TrwB_AAD_bind PduV-EutP GTP_EFTU ABC_tran AAA_7 MMR_HSR1 G-alpha cobW Septin LRR_6 AAA_16 MobB SRPRB TniB NACHT AAA_29 FtsK_SpoIIIE TsaE ResIII Arm AAA_23
Other DBs
NCBI-GeneID: 102880438
NCBI-ProteinID: XP_024907078
Position
Unknown
AA seq 2521 aa
MASGSCQGCEDKDEETLKKLIVRLNNVQEGKQIETLVQILEDMLVFTYADHASKLFQGKN
VHVPLLIVLDSYMRVASVQQVGWSLLCKLIEICPDTMQSLMGPEDIGHDWEVLGVHQLII
KMLTVHNASVNLSTIGLKALDLLLTSGKITLLILDEESDIFLLIFDAMSTFSANDEVQKL
GCKALHVLFERVSEEQLTEFVENKDYMILLNAFKKFKDEEEIALYVLHCLYSLATPCNNI
EVLMSGNVRCYNIVVEAMKAFPINEKIQEVSCRLLHRLTLGNFFNILVLNEVHEFVVKAV
QRYSENAALQIAALSCLALLTETIFLNQDLEEKNENQENDDEEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDTM
AAVAPKIITVMKSHETSLSVQLEALRAILHFIVPGMPGESKEDTEYQHKLNMVTEQCFRN
DIHKLVLVSLNRFIGNPGIQKCGLKVISSIARFPDALAVLSLEGAIDSVLQTLQMYPHDQ
EIQCLGLSLIGCLITKKNLFIGTGRLLAKILVSSLQRFKDMAEIQIKGFQTILTMLELSE
SFSKLLVHYYFDSIIFHQMSSSLMEHKDQQFLNLCCKCFAKLAMDDELKSVMLERACDQN
NSIMVECLLLLGADANRAKEGTSLICQVCEKASSPNLVELLLSGSREQDVRKALTISIGK
GNSQTISLLLRRLALDLANNSICLGGFCIGKIEPSWLSPLFPDKASNSRKETNIGSTLAR
MVLRYQMKSAVEEGTATGSDRNFSEEVINEWTFIPESYVDSVFGQIDDLDSEGSEGSFLV
KKKSNSISVGEFYRDPALQRCSPNLQRHSNSLGPIFDHEDLLKQKRKILSSDDSLRSSKL
PSHMRHSESISSLASEREYITSLDLSANELRDIDALSQKCCISGHLEHLEKLELHQNALT
SFPQQLCDTLKCLTHLDLHSNKFTSFPSYLLKMNCITNLDISRNDIGPSVVLDPVVKCAT
LKQFNLSYNQLSSVPENLGDAVEKLEQLILEGNKISGICSPLSLKELKILNLSKNHISSL
SEDFLEACPKVESFNARMNFLAAMPFLPSSMTSVKLSQNRFTCVPEAILNLPHLRSLDMS
SNVIQDLPSPAHWKSSNLRELLFSHNQISILDLSEKAYAWSRVEKLHLSHNKLKEIPPEI
GCLENLTSLDVSCNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHVGCKAKDIIRFLQQ
RLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIRGKK
KKDLILNVWDFAGREEFYSAHPHFMTQRSLYLAVYDLSKGQAEVDAMKPWLFNIKARASS
SPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTI
INESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPTEFPVIDRKRLLQLVKENQLQL
DENELPHAVHFLNESGVLLHFQDPALQLSNLYFVEPKWLCKVMAQILTVKVEGCPKYPKG
IISRRDVEKFLSKKKKFPKNYMHQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPH
CENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSP
EAYCLVGSEVLENHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEG
ETLLKKWALYSFNDGEEHQKILLDDLIKKAEEGDLLVNPHQPRLTIPISQIAPDLILADL
PRNIMLNSDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVL
CHLHHPSLISLLAAGIRPRMLVMXXXXXXXXXXXXXXXXLTRTLQHRIALHVADGLRYLH
SNMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARG
NVIYNQQADVYSFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYACTPWPP
VENLIKRCLKENPQERPTSAQVFDILNSAELICLMRHISIPKNFIVECMVATNHNSKNVG
IWLGCGHIDKGQLSFLDLNTERYTSEEVTDSRILCLALVYLPVEKESWIVAGTQSGMLLV
INTEDEKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLAGTADGNLAIFEDKTVKCEGAA
PLKILNIGNVSTPLMCLSESTNSIEKNIMWGGCGTKIFSFSDDLTIQKLIETSTNQLFSY
AAFSDSNIIAVVVDSALYIAKKNSPFVEVWDKKTEKLCELIDCVHFLKEELVKVKKESKH
TMYYSGRVKTLCLQKNTALWIGTGGGYVLLLDLSTRRIIRIIHNFCDSVRVMMTTQLGNL
KNAMLVLGYTQKSTEGTQHQKELQSCLSIWDINLPHEVQNLEKHIEMRKELAEKMRRISV
E
NT seq 7566 nt   +upstreamnt  +downstreamnt
atggccagtggcagctgtcaggggtgcgaggataaggacgaggaaactttgaagaagttg
atagtcaggctgaacaatgtccaggaaggaaaacagatagagacactggtccaaattctg
gaagatatgctggtgttcacctacgctgaccacgcctccaaattatttcaaggcaaaaat
gtccacgtgccactgctgatcgtcttggactcgtacatgagagtcgctagtgtgcagcag
gttggttggtcacttctatgcaaattaatagaaatctgcccagatacaatgcaaagctta
atgggaccagaagatattggacatgattgggaagtccttggggttcaccaactgattatt
aaaatgctcactgttcataatgccagtgtaaacttgtcaacaattggactgaaggcttta
gatctccttctaacttcaggtaaaatcactttgctgatattggatgaagaaagcgatatt
ttcttgttaatttttgatgccatgagcactttttctgccaacgacgaagtccagaaactt
ggatgcaaagctttacatgtgctgtttgagagagtttcagaggagcaactgactgaattt
gttgagaataaagattatatgatactgctaaatgcatttaaaaaatttaaagatgaagag
gaaattgcactttatgtactgcactgtttatattccctagcaactccttgcaataatatt
gaagtcctcatgagtggcaatgtcaggtgttataatattgtggtagaagccatgaaagca
ttccctatcaatgaaaaaattcaagaagtgagttgccggttgctccataggcttacatta
ggtaacttttttaacatcctggtattaaatgaggtacatgagtttgtggtgaaagctgtg
cagcggtactcagagaatgcagcattgcaaattgcagcgctcagctgtttagctctcctc
actgagaccattttcttaaatcaagacttagaggaaaagaatgagaatcaggagaatgat
gatgaagaagaagataaattgttttggctagaagcctgttacaaggcattaacatggcat
agaaagaacaagcatgtgcaggaggccgcatgctgggccctaaacaatctccttatgtac
caaaacagtttacacgagaagattggagatgaagatggccagttcccagctcatagggaa
gtgatgctctccatgctgatgcattcttcatcaaaagaagtcttccaggcatcagcaaat
gcactgtcaactctgctggaacaaaatgttaatttcagaaaaatcctgttgtcaaaagga
atatacctgaacgtgttggagttaatgcagaagcatatacattctcctgaagtggctgaa
agtggctgtaaaatgctaaatcatctttttgaaggaagtaacacttccctggatacaatg
gcagcagtggcccccaaaataataacagttatgaagagtcatgagacatcattatcagtg
cagctagaggcccttcgagctattttacattttatagttccaggtatgccaggagaatcc
aaggaagatactgaatatcaacataagctaaatatggttaccgaacagtgtttcaggaat
gatattcacaaactggtcctagtatctttgaacaggttcattggaaatcctgggattcag
aaatgtggattaaaagtaatttcttctatagcacgttttcctgatgcattagcggtgtta
tctctggaaggtgctattgattcagtgcttcaaacactgcagatgtatccacatgaccaa
gaaattcagtgtctgggtttaagtcttataggatgcttgattacaaagaagaatctattt
ataggaactgggcgtctgctggcgaaaattctggtttccagtttacaacgatttaaggat
atggctgaaatacagattaaaggatttcagacaatcttgacaatgctggaattgtcagag
tctttttccaagctgctggtgcattattactttgattcaataatattccatcagatgtct
tccagtctcatggaacataaagatcaacagtttctaaacctttgttgcaagtgttttgca
aaattagctatggatgatgagttaaaaagtgtgatgctagagagagcatgtgatcagaat
aatagcatcatggtcgaatgcttacttctgttgggtgcggacgccaatcgagcaaaggag
ggaacttctttaatttgtcaggtatgtgaaaaagcaagcagccccaacttggtggaactg
ttacttagtgggtctcgtgaacaagatgtacggaaagcactgacgataagcattgggaaa
ggcaacagccaaaccatcagtttactcttaagaagacttgccttggatctggccaataac
agcatttgccttggaggattttgtataggaaaaattgaaccttcttggcttagtccttta
tttccagataaggcatctaattcaagaaaagaaacaaatataggatccaccctagcaaga
atggtgctcagatatcagatgaaaagtgctgtggaagaaggaacagccacaggcagcgat
aggaatttttctgaagaagtaattaatgaatggaccttcattcctgagtcttatgtggac
agtgtctttggtcaaattgatgacctggatagtgaaggaagtgaaggctcatttcttgtg
aaaaagaaatcaaattcaattagcgtaggagaattttacagagatcctgccttgcagcgt
tgctcaccaaatttgcaaaggcattccaattcattgggacccattttcgatcatgaagat
ttactgaagcaaaaaagaaaaatattgtcctcagatgattcactcaggtcatcaaaactt
ccatcccatatgaggcattcagaaagcatttcttccctggcttctgagagagaatatatt
acatcattagacctttcagcaaatgaactaagagatattgatgccctgagccagaaatgc
tgtataagtggtcatttggagcatcttgaaaaactggagcttcaccagaatgcactcacg
agctttccacaacaactatgtgatactctgaagtgtttgacacatttggacttgcacagt
aataaatttacatcatttccctcctacttgttgaaaatgaactgtattaccaaccttgac
atctctcgaaatgacattggaccctcagtagttctggatcctgtggtgaagtgtgcaacc
ttgaaacagtttaacctgtcatataatcagctgtcttctgttcctgagaaccttggcgat
gcggtggagaaactggaacagctcattttagaaggaaataaaatatcaggaatatgctcc
ccactgagcctgaaggaactgaaaattttaaaccttagtaaaaaccacatttcatctcta
tcagaggactttcttgaggcttgtcctaaagtggagagtttcaatgccagaatgaatttt
cttgctgctatgccttttttgccttcttctatgacaagtgtaaaattatctcaaaacaga
ttcacatgtgttccagaagcaattttaaatcttccacacttgcggtccttagatatgagc
agcaatgttattcaggatctgccaagtcctgcccactggaaatcttcgaacttaagggaa
ctcctgtttagtcataatcagatcagcatcttggacttgagtgaaaaagcatatgcatgg
tctagagtagagaaactacatctttctcataataaactgaaggagattcctcctgagatt
ggctgtcttgaaaatctgacatctcttgatgttagttgcaacttggaactgagatccttt
cccaatgaaatgggaaaattaagcaaaatatgggatcttcctttggatgaactgcgtctt
aattttgattttaaacatgtaggatgtaaagccaaagacatcataaggtttcttcaacaa
cggttaaagaaggctgtgccctataaccgaatgaaacttatgattgtgggaaacactggg
agtggtaaaaccaccttattgcagcaattaatgaaaacaaagaaatcagatcttgggatg
caaagtgccacagttggcatagacgtgaaagactggcctatccaaataaggggcaaaaag
aagaaagatctcattctaaatgtatgggattttgcaggtcgtgaggaattctatagtgct
catccccactttatgacccaacgatcactataccttgctgtctatgacctcagcaaaggt
caggctgaagttgatgctatgaaaccttggctcttcaatataaaggctcgtgcttcttct
tcccctgtgattcttgttggcacacatttggatgtttctgatgagaagcagcgcaaagcc
tgcataagtaaaattaccaaggaactcttaaacaagcgaggctttcctgcaatacgtgat
taccactttgtgaatgccactgaggaatctgatgctttggcaaaacttcggaaaaccatc
ataaatgaaagccttaatttcaagatccgagatcagcctgttgttgggcagctgattcca
gactgctatgtagaacttgagaaaatcattttatcagagcgtaaaaatgtgccaactgaa
tttcctgtaattgaccggaaacgattattacaactcgtgaaagaaaatcaactgcaatta
gatgaaaatgagcttcctcatgcagttcactttctaaatgaatcaggggtccttcttcat
tttcaagacccagcacttcagttaagtaacttatattttgtggaacccaagtggctgtgt
aaagtcatggcacagattttgacagtgaaagtggaaggctgtccaaaatatcctaaagga
attatctcacgtagagatgtggaaaaatttctttcaaagaaaaagaaatttccaaagaac
tacatgcaccaatactttaaactcctagaaaaattccaaattgccttgccaataggagaa
gaatatttgctggttccaagcagtttgtctgaccacaggcctgtgatagagcttccccac
tgcgagaactccgagattatcattcgattatatgaaatgccttattttccaatgggattt
tggtcgagattaatcaatcgattacttgaaatttcaccttacatgctttcaggcagagaa
cgagcacttcgcccaaacagaatgtattggcgacaaggcatctacttgaattggtctcct
gaagcttactgtctggtgggatctgaagtcttagaaaatcacccagagagtttcttaaaa
attacagttccttcttgtagaaaaggctgtattcttttgggtcaagttgtggaccacatt
gattctctcatggaagaatggtttcctgggttattagagattgatatttgtggtgaagga
gaaactctgttgaagaaatgggcattatatagtttcaatgatggtgaagaacatcaaaaa
atcttacttgatgacttgataaagaaagcagaagaaggagacctcctagtaaatccacat
caaccaaggctcaccattccaatatctcagattgctcctgacttgattttggctgacctg
cctagaaatattatgttgaatagtgacgaattggaatttgaacaagctccagagtttctc
ttaggtgatggcagttttggttcagtttatcgagcagcctatgaaggagaagaagtggct
gtgaagatttttaataaacatacatcacttagactcttaagacaagagctggtggtgctt
tgccacctccaccatcccagcttaatatctttgctggcagctggaattcgtcctcgaatg
ttggtgatggannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnctc
acaagaaccttgcagcacaggattgcactgcatgtggctgatggtttgagatacctccac
tcgaacatgattatataccgtgacttgaagccccacaacgtgctgcttttcaccctgtat
cccaatgctgccatcattgcaaagattgctgactatgggattgcccagtactgttgcaga
atggggataaaaacatcagagggcacaccagggtttcgtgcacctgaagttgctagagga
aatgttatttataaccaacaggctgatgtttattcatttggtttactactctatgacatt
ttgacaactggaggtagaatagcagagggtttgaagtttccaaatgagtttgatgaatta
gcaatacaaggaaaattacctgatccagttaaagaatacgcttgtaccccatggcctccg
gttgagaacttaattaaaagatgtttgaaagaaaatcctcaagaaagacctacttctgcc
caggtctttgacattttgaattcagctgagttaatctgtctgatgagacatatatcaata
cctaaaaactttattgttgaatgcatggttgctacaaatcataacagcaagaatgtaggc
atctggctgggttgtggacacatcgacaaaggacagctctcatttcttgatttaaatact
gaaagatacacttctgaggaagttactgatagtagaatactgtgcctagccttggtgtat
ctgcctgttgaaaaggaaagctggattgtggctgggacacagtctgggatgcttctagtc
atcaatactgaagatgagaaaaagagacatacccttgaaaagatgactgattcagttact
tgcttgtattgcaattctttttccaagcaaagcaagcaaaaaaattttctcttggcggga
actgctgatggcaacttagcaatttttgaagataaaactgttaagtgtgaaggagctgct
cctttgaagatactcaatataggaaatgtcagcactccgctgatgtgtttgagtgaatcc
acgaattcaattgaaaaaaacattatgtggggaggatgtggcacaaaaattttctcattt
tctgatgatttgactattcagaaattgattgagaccagcacaaatcagctgttttcttat
gcagctttcagtgattccaacatcatagcagtggtggtagactcggctctctacattgct
aagaaaaatagcccgtttgtggaagtgtgggataagaaaactgaaaagctctgtgaacta
atagactgtgtgcactttttaaaggaggaattggtaaaagtgaagaaggaatcaaaacac
actatgtactattctgggagagtgaaaactctctgcctccagaagaacactgccctctgg
attggaactggaggaggctatgttttactgcttgatctttcaactcgtcgaatcatacgt
ataattcacaatttttgtgattctgttagagtcatgatgacaacacagttaggcaatctt
aaaaatgccatgctggttttggggtatacccagaaaagtactgaaggtacccaacatcaa
aaagagttacagtcttgcttgtctatttgggacatcaatcttccacatgaagtgcaaaat
ttggaaaaacatattgaaatgagaaaagaattagctgaaaaaatgagaagaatatccgtt
gaataa

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (37)   
   KEGG ORTHOLOGY (1)   
   RefGene (33)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (35)   
   Pfam (35)   
All databases (83)   

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