KEGG   PATHWAY: dme04310Help
dme04310                    Pathway                                

Wnt signaling pathway - Drosophila melanogaster (fruit fly)
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Environmental Information Processing; Signal transduction
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Wnt signaling pathway

All organismsOrtholog table
SCF-BTRC complex [PATH:dme04310]
Wnt signaling [PATH:dme04310]
Other DBs
Drosophila melanogaster (fruit fly) [GN:dme]
por; porcupine, isoform B [KO:K00181] [EC:]
wg; wingless [KO:K03209]
Wnt5; Wnt oncogene analog 5, isoform B [KO:K00444]
Wnt6; Wnt oncogene analog 6, isoform C [KO:K00445]
wntD; wnt inhibitor of dorsal [KO:K00714]
Wnt10; Wnt oncogene analog 10 [KO:K01357]
Notum; notum [KO:K19882] [EC:]
shf; shifted, isoform A [KO:K01691]
dally; division abnormally delayed, isoform B [KO:K02306]
fz; frizzled, isoform A [KO:K02432]
fz4; frizzled 4, isoform A [KO:K02354]
fz2; frizzled 2, isoform C [KO:K02375]
fz3; frizzled 3, isoform C [KO:K04690]
arr; arrow [KO:K03068]
dco; discs overgrown, isoform D [KO:K08960] [EC:]
dsh; dishevelled [KO:K02353]
CkIIalpha; casein kinase IIalpha, isoform D [KO:K03097] [EC:]
Ssl; suppressor of Stellate-like [KO:K03115]
CkIIbeta2; casein kinase II beta2 subunit [KO:K03115]
CkIIbeta; casein kinase II beta subunit, isoform E [KO:K03115]
Ste:CG33242 [KO:K03115]
Ste:CG33239 [KO:K03115]
Ste:CG33241 [KO:K03115]
Ste:CG33236 [KO:K03115]
Ste:CG33237 [KO:K03115]
Ste:CG33240 [KO:K03115]
Ste:CG33244 [KO:K03115]
Ste:CG33245 [KO:K03115]
Ste:CG33247 [KO:K03115]
Ste12DOR; stellate 12D orphon [KO:K03115]
Ste:CG33243 [KO:K03115]
Ste:CG33238 [KO:K03115]
Ste:CG33246 [KO:K03115]
SteXh:CG42398 [KO:K03115]
CG40635; uncharacterized protein [KO:K03115]
nkd; naked cuticle, isoform A [KO:K03213]
sgg; shaggy, isoform B [KO:K03083] [EC:]
gskt; gasket [KO:K03083] [EC:]
arm; armadillo, isoform F [KO:K02105]
Axn; axin, isoform A [KO:K02157]
Apc2; adenomatous polyposis coli 2, isoform B [KO:K02085]
Apc; APC-like, isoform B [KO:K02085]
CkIalpha; casein kinase ialpha, isoform D [KO:K08957] [EC:]
CG12147; uncharacterized protein [KO:K08957] [EC:]
CG2577 [KO:K08957] [EC:]
CG7094 [KO:K08957] [EC:]
pan; pangolin, isoform R [KO:K04491]
CtBP; C-terminal binding protein, isoform E [KO:K04496]
gro; groucho, isoform E [KO:K04497]
nej; nejire, isoform C [KO:K04498] [EC:]
pont; pontin [KO:K04499]
Med; medea, isoform A [KO:K04501]
Tak1; TGF-beta activated kinase 1, isoform A [KO:K04427] [EC:]
Takl2; Tak1-like 2 [KO:K04427] [EC:]
Takl1; Tak1-like 1 [KO:K04427] [EC:]
nmo; nemo, isoform H [KO:K04468] [EC:]
Myc; Myc, isoform B [KO:K04377]
Jra; Jun-related antigen, isoform A [KO:K04448]
CycD; cyclin D, isoform D [KO:K10151]
Psn; presenilin, isoform E [KO:K04505] [EC:3.4.23.-]
Pka-C1; protein kinase, cAMP-dependent, catalytic subunit 1, isoform D [KO:K04345] [EC:]
Pka-C2; protein kinase, cAMP-dependent, catalytic subunit 2, isoform B [KO:K04345] [EC:]
sina; seven in absentia, isoform C [KO:K04506] [EC:]
sinah; sina homologue [KO:K04506] [EC:]
CG3226 [KO:K04507]
SkpA; SKP1-related A, isoform H [KO:K03094]
SkpF; SKP1-related F [KO:K03094]
SkpB; SKP1-related B [KO:K03094]
SkpE; SKP1-related E [KO:K03094]
SkpC; SKP1-related C [KO:K03094]
SkpD; SKP1-related D [KO:K03094]
CG15800; uncharacterized protein [KO:K03094]
CG43089; uncharacterized protein, isoform B [KO:K03094]
ebi; ebi [KO:K04508]
slmb; supernumerary limbs, isoform C [KO:K03362]
Cul1; cullin 1, isoform D [KO:K03347]
CG11261; uncharacterized protein [KO:K03347]
Roc1a; regulator of cullins 1a, isoform D [KO:K03868]
Roc1b; regulator of cullins 1b [KO:K03868]
dlp; dally-like, isoform A [KO:K08110]
Vang; Van gogh, isoform B [KO:K04510]
pk; prickle, isoform C [KO:K04511]
esn; espinas, isoform B [KO:K04511]
DAAM; dishevelled associated activator of morphogenesis, isoform D [KO:K04512]
Rho1; Rho1, isoform A [KO:K04513]
Rac1; Rac1, isoform B [KO:K04392]
RhoL; Rho-like, isoform A [KO:K04392]
Mtl; Mig-2-like, isoform B [KO:K04392]
Rac2; Rac2, isoform B [KO:K04392]
bsk; basket, isoform F [KO:K04440] [EC:]
Plc21C; phospholipase C at 21C, isoform D [KO:K05858] [EC:]
norpA; no receptor potential A, isoform D [KO:K05858] [EC:]
CaMKII; Calcium/calmodulin-dependent protein kinase II, isoform I [KO:K04515] [EC:]
CanA1; calcineurin A1, isoform D [KO:K04348] [EC:]
Pp2B-14D; protein phosphatase 2B at 14D, isoform C [KO:K04348] [EC:]
CanA-14F; calcineurin A at 14F, isoform C [KO:K04348] [EC:]
CanB2; calcineurin B2, isoform B [KO:K06268]
CanB; calcineurin B, isoform B [KO:K06268]
inaC; inactivation no afterpotential C [KO:K02677] [EC:]
Pkc53E; protein C kinase 53E, isoform B [KO:K02677] [EC:]
Calcium cation
Hatsell S, Rowlands T, Hiremath M, Cowin P.
Beta-catenin and Tcfs in mammary development and cancer.
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
Yang Y.
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
Kalderon D.
Similarities between the Hedgehog and Wnt signaling pathways.
Trends Cell Biol 12:523-31 (2002)
Nusse R.
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Development 130:5297-305 (2003)
Jope RS, Johnson GV.
The glamour and gloom of glycogen synthase kinase-3.
Trends Biochem Sci 29:95-102 (2004)
Veeman MT, Axelrod JD, Moon RT.
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Dev Cell 5:367-77 (2003)
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Nat Cell Biol 3:628-36 (2001)
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
The way Wnt works: Components and mechanism.
Growth Factors 31:1-31 (2013)
Carethers JM
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Gastroenterology 137:33-6 (2009)
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
J Biol Chem 283:33053-8 (2008)
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