KEGG   PATHWAY: dme04310Help
Entry
dme04310                    Pathway                                

Name
Wnt signaling pathway - Drosophila melanogaster (fruit fly)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Wnt signaling pathway
dme04310

All organismsOrtholog table
Module
SCF-BTRC complex [PATH:dme04310]
Other DBs
BSID: 
GO: 
Organism
Drosophila melanogaster (fruit fly) [GN:dme]
Gene
por; porcupine [KO:K00181]
wg; wingless [KO:K03209]
Wnt5; Wnt oncogene analog 5 [KO:K00444]
Wnt6; Wnt oncogene analog 6 [KO:K00445]
wntD; wnt inhibitor of Dorsal [KO:K00714]
Wnt10; Wnt oncogene analog 10 [KO:K01357]
shf; shifted [KO:K01691]
dally; division abnormally delayed [KO:K02306]
fz; frizzled [KO:K02432]
fz4; frizzled 4 [KO:K02354]
fz2; frizzled 2 [KO:K02375]
fz3; frizzled 3 [KO:K04690]
arr; arrow [KO:K03068]
dco; discs overgrown [KO:K08960] [EC:2.7.11.1]
dsh; dishevelled [KO:K02353]
CkIIalpha; casein kinase IIalpha [KO:K03097] [EC:2.7.11.1]
Ssl; Suppressor of Stellate-like [KO:K03115]
CkIIbeta2; Casein kinase II beta2 subunit [KO:K03115]
CkIIbeta; Casein kinase II beta subunit [KO:K03115]
Ste:CG33242; CG33242 gene product from transcript CG33242-RB [KO:K03115]
Ste:CG33239; CG33239 gene product from transcript CG33239-RB [KO:K03115]
Ste:CG33241; CG33241 gene product from transcript CG33241-RB [KO:K03115]
Ste:CG33236; CG33236 gene product from transcript CG33236-RB [KO:K03115]
Ste:CG33237; CG33237 gene product from transcript CG33237-RB [KO:K03115]
Ste:CG33240; CG33240 gene product from transcript CG33240-RB [KO:K03115]
Ste:CG33244; CG33244 gene product from transcript CG33244-RB [KO:K03115]
Ste:CG33245; CG33245 gene product from transcript CG33245-RB [KO:K03115]
Ste:CG33247; CG33247 gene product from transcript CG33247-RB [KO:K03115]
Ste12DOR; Stellate 12D orphon [KO:K03115]
Ste:CG33243; CG33243 gene product from transcript CG33243-RB [KO:K03115]
Ste:CG33238; CG33238 gene product from transcript CG33238-RB [KO:K03115]
Ste:CG33246; CG33246 gene product from transcript CG33246-RB [KO:K03115]
SteXh:CG42398; CG42398 gene product from transcript CG42398-RA [KO:K03115]
CG40635 gene product from transcript CG40635-RB; K03115 casein kinase II subunit beta [KO:K03115]
nkd; naked cuticle [KO:K03213]
sgg; shaggy [KO:K03083] [EC:2.7.11.26]
gskt; gasket [KO:K03083] [EC:2.7.11.26]
arm; armadillo [KO:K02105]
Axn; Axin [KO:K02157]
Apc2; Adenomatous polyposis coli tumor suppressor homolog 2 [KO:K02085]
Apc; APC-like [KO:K02085]
CkIalpha; Casein kinase Ialpha [KO:K08957] [EC:2.7.11.1]
pan; pangolin [KO:K04491]
CtBP; C-terminal Binding Protein [KO:K04496]
gro; groucho [KO:K04497]
nej; nejire [KO:K04498] [EC:2.3.1.48]
pont; pontin [KO:K04499]
Med; Medea [KO:K04501]
Tak1; TGF-beta activated kinase 1 [KO:K04427] [EC:2.7.11.25]
Takl2; Tak1-like 2 [KO:K04427] [EC:2.7.11.25]
nmo; nemo [KO:K04468] [EC:2.7.11.24]
dm; diminutive [KO:K04377]
CycD; Cyclin D [KO:K10151]
Psn; Presenilin [KO:K04505] [EC:3.4.23.-]
Pka-C1; cAMP-dependent protein kinase 1 [KO:K04345] [EC:2.7.11.11]
Pka-C3; cAMP-dependent protein kinase 3 [KO:K04345] [EC:2.7.11.11]
Pka-C2; cAMP-dependent protein kinase 2 [KO:K04345] [EC:2.7.11.11]
sina; seven in absentia [KO:K04506] [EC:6.3.2.19]
sinah; sina homologue [KO:K04506] [EC:6.3.2.19]
CG3226 gene product from transcript CG3226-RA; K04507 calcyclin binding protein [KO:K04507]
skpA; CG16983 gene product from transcript CG16983-RD [KO:K03094]
skpF; CG12227 gene product from transcript CG12227-RA [KO:K03094]
skpB; CG8881 gene product from transcript CG8881-RA [KO:K03094]
skpE; CG11942 gene product from transcript CG11942-RA [KO:K03094]
skpC; CG11941 gene product from transcript CG11941-RA [KO:K03094]
skpD; CG12700 gene product from transcript CG12700-RA [KO:K03094]
CG15800 gene product from transcript CG15800-RA; K03094 S-phase kinase-associated protein 1 [KO:K03094]
ebi; CG4063 gene product from transcript CG4063-RA [KO:K04508]
slmb; supernumerary limbs [KO:K03362]
Cul1; Cullin 1 [KO:K03347]
Roc1a; CG16982 gene product from transcript CG16982-RC [KO:K03868]
Roc1b; CG16988 gene product from transcript CG16988-RA [KO:K03868]
Vang; Van Gogh [KO:K04510]
pk; prickle [KO:K04511]
DAAM; Dishevelled Associated Activator of Morphogenesis [KO:K04512]
Rho1; CG8416 gene product from transcript CG8416-RB [KO:K04513]
Rac1; CG2248 gene product from transcript CG2248-RB [KO:K04392]
Mtl; Mig-2-like [KO:K04392]
bsk; basket [KO:K04440] [EC:2.7.11.24]
Plc21C; Phospholipase C at 21C [KO:K05858] [EC:3.1.4.11]
norpA; no receptor potential A [KO:K05858] [EC:3.1.4.11]
CaMKII; Calcium/calmodulin-dependent protein kinase II [KO:K04515] [EC:2.7.11.17]
CanA1; Calcineurin A1 [KO:K04348] [EC:3.1.3.16]
Pp2B-14D; Protein phosphatase 2B at 14D [KO:K04348] [EC:3.1.3.16]
CanA-14F; Calcineurin A at 14F [KO:K04348] [EC:3.1.3.16]
CanB2; Calcineurin B2 [KO:K06268]
CanB; Calcineurin B [KO:K06268]
inaC; inactivation no afterpotential C [KO:K02677] [EC:2.7.11.13]
Pkc53E; Protein C kinase 53E [KO:K02677] [EC:2.7.11.13]
Compound
C00076  
Calcium cation
Reference
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
Reference
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
Reference
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
Reference
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
Reference
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
Reference
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
Reference
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
Reference
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
Reference
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
Reference
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates  Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
KO pathway
 

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