KEGG   PATHWAY: hsa00030Help
Entry
hsa00030                    Pathway                                

Name
Pentose phosphate pathway - Homo sapiens (human)
Description
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Pentose phosphate pathway
hsa00030

All organismsOrtholog table
Module
Pentose phosphate pathway (Pentose phosphate cycle) [PATH:hsa00030]
PRPP biosynthesis, ribose 5P => PRPP [PATH:hsa00030]
Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:hsa00030]
Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:hsa00030]
Disease
H00196  
Phosphoribosylpyrophosphate synthetase I superactivity
H00668  
Anemia due to disorders of glutathione metabolism
H00946  
Arts syndrome
H01111  
Cortisone reductase deficiency (CRD)
H01135  
Ribose 5-phosphate isomerase (RPI) deficiency
H01189  
Transaldolase (TALDO) deficiency
H01375  
Glucose 6-phosphate dehydrogenase deficiency
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
2821  
GPI; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
2539  
G6PD; glucose-6-phosphate dehydrogenase [KO:K00036] [EC:1.1.1.49]
25796  
PGLS; 6-phosphogluconolactonase [KO:K01057] [EC:3.1.1.31]
9563  
H6PD; hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) [KO:K13937] [EC:3.1.1.31 1.1.1.47]
5226  
PGD; phosphogluconate dehydrogenase [KO:K00033] [EC:1.1.1.44]
6120  
RPE; ribulose-5-phosphate-3-epimerase [KO:K01783] [EC:5.1.3.1]
729020  
RPEL1; ribulose-5-phosphate-3-epimerase-like 1 [KO:K01783] [EC:5.1.3.1]
7086  
TKT; transketolase [KO:K00615] [EC:2.2.1.1]
84076  
TKTL2; transketolase-like 2 [KO:K00615] [EC:2.2.1.1]
8277  
TKTL1; transketolase-like 1 [KO:K00615] [EC:2.2.1.1]
6888  
TALDO1; transaldolase 1 [KO:K00616] [EC:2.2.1.2]
22934  
RPIA; ribose 5-phosphate isomerase A [KO:K01807] [EC:5.3.1.6]
51071  
DERA; deoxyribose-phosphate aldolase (putative) [KO:K01619] [EC:4.1.2.4]
64080  
RBKS; ribokinase [KO:K00852] [EC:2.7.1.15]
5236  
PGM1; phosphoglucomutase 1 [KO:K01835] [EC:5.4.2.2]
55276  
PGM2; phosphoglucomutase 2 [KO:K15779] [EC:5.4.2.7 5.4.2.2]
221823  
PRPS1L1; phosphoribosyl pyrophosphate synthetase 1-like 1 [KO:K00948] [EC:2.7.6.1]
5634  
PRPS2; phosphoribosyl pyrophosphate synthetase 2 [KO:K00948] [EC:2.7.6.1]
5631  
PRPS1; phosphoribosyl pyrophosphate synthetase 1 [KO:K00948] [EC:2.7.6.1]
9104  
RGN; regucalcin [KO:K01053] [EC:3.1.1.17]
230  
ALDOC; aldolase C, fructose-bisphosphate [KO:K01623] [EC:4.1.2.13]
226  
ALDOA; aldolase A, fructose-bisphosphate [KO:K01623] [EC:4.1.2.13]
229  
ALDOB; aldolase B, fructose-bisphosphate [KO:K01623] [EC:4.1.2.13]
2203  
FBP1; fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
8789  
FBP2; fructose-1,6-bisphosphatase 2 [KO:K03841] [EC:3.1.3.11]
5213  
PFKM; phosphofructokinase, muscle [KO:K00850] [EC:2.7.1.11]
5214  
PFKP; phosphofructokinase, platelet [KO:K00850] [EC:2.7.1.11]
5211  
PFKL; phosphofructokinase, liver [KO:K00850] [EC:2.7.1.11]
Compound
C00022  
Pyruvate
C00031  
D-Glucose
C00117  
D-Ribose 5-phosphate
C00118  
D-Glyceraldehyde 3-phosphate
C00119  
5-Phospho-alpha-D-ribose 1-diphosphate
C00121  
D-Ribose
C00197  
3-Phospho-D-glycerate
C00198  
D-Glucono-1,5-lactone
C00199  
D-Ribulose 5-phosphate
C00204  
2-Dehydro-3-deoxy-D-gluconate
C00221  
beta-D-Glucose
C00231  
D-Xylulose 5-phosphate
C00257  
D-Gluconic acid
C00258  
D-Glycerate
C00279  
D-Erythrose 4-phosphate
C00345  
6-Phospho-D-gluconate
C00577  
D-Glyceraldehyde
C00620  
alpha-D-Ribose 1-phosphate
C00631  
2-Phospho-D-glycerate
C00668  
alpha-D-Glucose 6-phosphate
C00672  
2-Deoxy-D-ribose 1-phosphate
C00673  
2-Deoxy-D-ribose 5-phosphate
C01151  
D-Ribose 1,5-bisphosphate
C01172  
beta-D-Glucose 6-phosphate
C01218  
6-Phospho-2-dehydro-D-gluconate
C01236  
D-Glucono-1,5-lactone 6-phosphate
C01801  
Deoxyribose
C03752  
2-Amino-2-deoxy-D-gluconate
C04442  
2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05345  
beta-D-Fructose 6-phosphate
C05378  
beta-D-Fructose 1,6-bisphosphate
C05382  
Sedoheptulose 7-phosphate
C06019  
D-arabino-Hex-3-ulose 6-phosphate
C06473  
2-Keto-D-gluconic acid
C20589  
6-Phospho-D-glucosaminate
Reference
(map 3)
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
(map 4)
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Reference
  Authors
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  Title
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  Journal
J Bacteriol 185:2793-801 (2003)
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate  pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
Reference
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
Reference
  Authors
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  Title
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  Journal
FEBS J 280:1126-38 (2013)
Reference
  Authors
Reher M, Schonheit P
  Title
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  Journal
FEBS Lett 580:1198-204 (2006)
Reference
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
KO pathway
 

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