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Entry
map00600                    Pathway                                

Name
Sphingolipid metabolism
Class
Metabolism; Lipid metabolism
BRITE hierarchy
Pathway map
Sphingolipid metabolism
map00600

All organismsOrtholog table
Module
M00066  
Lactosylceramide biosynthesis [PATH:map00600]
M00067  
Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:map00600]
M00094  
Ceramide biosynthesis [PATH:map00600]
M00099  
Sphingosine biosynthesis [PATH:map00600]
M00100  
Sphingosine degradation [PATH:map00600]
Disease
H00125  
Fabry disease
H00126  
Gaucher disease
H00127  
Metachromatic leukodystrophy (MLD)
H00135  
Krabbe disease
H00137  
Niemann-Pick disease (NPD), type A/ B
H00138  
Farber lipogranulomatosis
H00142  
Sialidosis
H00265  
Hereditary sensory and autonomic neuropathy (HSAN)
H00276  
Galactosialidosis
H00281  
GM1 gangliosidosis
H00423  
Defects in the degradation of sulfatide
H00424  
Defects in the degradation of sphingomyelin
H00426  
Defects in the degradation of ganglioside
H00810  
Progressive myoclonic epilepsy (PME/ EPM)
Other DBs
Reference
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
KO pathway
 

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