KEGG PATHWAY: map00908

PATHWAY: map00908

Entry

map00908                    Pathway

Name

Zeatin biosynthesis

Description

Zeatin is a member of the cytokinin family, a class of phytohormones involved in various processes of growth and development in plants. Most abundant cytokinins are adenine-type, where the N6 position of adenine is substituted with an isoprenoid, such as in zeatin, or an aromatic side chain, such as in kinetin. Zeatin can be synthesized in two different pathways: the tRNA pathway and the AMP pathway. In the tRNA pathway zeatin is a recycled product of isopentenylated tRNAs. In the AMP pathway zeatin is synthesized from an isopentenyl donor, dimethylallyl diphosphate (DMAPP), and AMP, ADP, or ATP by isopentenyltransferases. After synthesis cytokinins can be glucosylated.

Class

Metabolism; Metabolism of terpenoids and polyketides

Pathway map

map00908

Zeatin biosynthesis

Other DBs

GO:

0009691

Reference

PMID:14726522

Authors

Kasahara H, Takei K, Ueda N, Hishiyama S, Yamaya T, Kamiya Y, Yamaguchi S, Sakakibara H.

Title

Distinct isoprenoid origins of cis- and trans-zeatin biosyntheses in Arabidopsis.

Journal

J Biol Chem 279:14049-54 (2004)
DOI:10.1074/jbc.M314195200

Reference

PMID:11313355

Authors

Takei K, Sakakibara H, Sugiyama T.

Title

Identification of genes encoding adenylate isopentenyltransferase, a cytokinin biosynthesis enzyme, in Arabidopsis thaliana.

Journal

J Biol Chem 276:26405-10 (2001)
DOI:10.1074/jbc.M102130200

Reference

PMID:11479373

Authors

Kakimoto T.

Title

Identification of plant cytokinin biosynthetic enzymes as dimethylallyl diphosphate:ATP/ADP isopentenyltransferases.

Journal

Plant Cell Physiol 42:677-85 (2001)
DOI:10.1093/pcp/pce112

Reference

PMID:15280363

Authors

Takei K, Yamaya T, Sakakibara H.

Title

Arabidopsis CYP735A1 and CYP735A2 encode cytokinin hydroxylases that catalyze the biosynthesis of trans-Zeatin.

Journal

J Biol Chem 279:41866-72 (2004)
DOI:10.1074/jbc.M406337200

Reference

PMID:15342621

Authors

Hou B, Lim EK, Higgins GS, Bowles DJ.

Title

N-glucosylation of cytokinins by glycosyltransferases of Arabidopsis thaliana.

Journal

J Biol Chem 279:47822-32 (2004)
DOI:10.1074/jbc.M409569200

Reference

PMID:9874810

Authors

Martin RC, Mok MC, Mok DW

Title

Isolation of a cytokinin gene, ZOG1, encoding zeatin O-glucosyltransferase from Phaseolus lunatus.

Journal

Proc Natl Acad Sci U S A 96:284-9 (1999)
DOI:10.1073/pnas.96.1.284

Reference

PMID:10364407

Authors

Martin RC, Mok MC, Mok DW

Title

A gene encoding the cytokinin enzyme zeatin O-xylosyltransferase of Phaseolus vulgaris.

Journal

Plant Physiol 120:553-8 (1999)
DOI:10.1104/pp.120.2.553

Reference

PMID:12644686

Authors

Veach YK, Martin RC, Mok DW, Malbeck J, Vankova R, Mok MC

Title

O-glucosylation of cis-zeatin in maize. Characterization of genes, enzymes, and endogenous cytokinins.

Journal

Plant Physiol 131:1374-80 (2003)
DOI:10.1104/pp.017210

Reference

PMID:14555694

Authors

Werner T, Motyka V, Laucou V, Smets R, Van Onckelen H, Schmulling T

Title

Cytokinin-deficient transgenic Arabidopsis plants show multiple developmental alterations indicating opposite functions of cytokinins in the regulation of shoot and root meristem activity.

Journal

Plant Cell 15:2532-50 (2003)
DOI:10.1105/tpc.014928

Reference

PMID:17062755

Authors

Miyawaki K, Tarkowski P, Matsumoto-Kitano M, Kato T, Sato S, Tarkowska D, Tabata S, Sandberg G, Kakimoto T

Title

Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis.

Journal

Proc Natl Acad Sci U S A 103:16598-603 (2006)
DOI:10.1073/pnas.0603522103

Related
pathway

map00900

Terpenoid backbone biosynthesis

KO pathway

ko00908

All links

Chemical substance (39)   
   KEGG COMPOUND (39)   
Chemical reaction (44)   
   KEGG ENZYME (10)   
   KEGG REACTION (34)   
Gene (18064)   
   KEGG ORTHOLOGY (10)   
   RefGene (18054)   
Literature (10)   
   PubMed (10)   
All databases (18157)   

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