Entry
Name
Drug metabolism - other enzymes
Class
Metabolism; Xenobiotics biodegradation and metabolism
BRITE hierarchy
Pathway map
map00983 Drug metabolism - other enzymes
Ortholog table
Reference
Authors
Kato R, Kamatari T (eds).
Title
[Drug Metabolism] (In Japanese)
Journal
Tokyo Kagaku Dojin (2000)
Reference
Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
Journal
Reference
Authors
Gearry RB, Barclay ML.
Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
Journal
Reference
Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
Journal
Reference
Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
Journal
Reference
Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
Journal
Reference
Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
Journal
Reference
Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
Journal
Reference
Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
Journal
Reference
Authors
Wang P, Pradhan K, Zhong XB, Ma X
Title
Isoniazid metabolism and hepatotoxicity.
Journal
Reference
Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
Journal
Reference
Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
Journal
Reference
Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
Title
Mechanisms of catalase activity of heme peroxidases.
Journal
Reference
Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
Journal
Reference
Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
Journal
Reference
Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
Journal
Reference
Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
Journal
Reference
Authors
Argyrou A, Vetting MW, Blanchard JS
Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
Journal
KO pathway