KEGG PATHWAY: map04514

PATHWAY: map04514

Entry

map04514                    Pathway

Name

Cell adhesion molecules

Description

Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.

Class

Environmental Information Processing; Signaling molecules and interaction

Pathway map

map04514

Cell adhesion molecules

Other DBs

GO:

0050839

Reference

PMID:14690046

Authors

Barclay AN.

Title

Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.

Journal

Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2

Reference

PMID:11910893

Authors

Sharpe AH, Freeman GJ.

Title

The B7-CD28 superfamily.

Journal

Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727

Reference

PMID:9597126

Authors

Grewal IS, Flavell RA.

Title

CD40 and CD154 in cell-mediated immunity.

Journal

Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111

Reference

PMID:16034094

Authors

Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.

Title

CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.

Journal

J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558

Reference

PMID:12234363

Authors

Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.

Title

Cell adhesion and polarity during immune interactions.

Journal

Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x

Reference

PMID:15071551

Authors

Dejana E.

Title

Endothelial cell-cell junctions: happy together.

Journal

Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357

Reference

PMID:14519386

Authors

Bazzoni G.

Title

The JAM family of junctional adhesion molecules.

Journal

Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2

Reference

PMID:10798271

Authors

Becker BF, Heindl B, Kupatt C, Zahler S.

Title

Endothelial function and hemostasis.

Journal

Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320

Reference

PMID:9150551

Authors

Elangbam CS, Qualls CW Jr, Dahlgren RR.

Title

Cell adhesion molecules--update.

Journal

Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113

Reference

PMID:12810109

Authors

Muller WA.

Title

Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.

Journal

Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0

Reference

PMID:14519398

Authors

Yamagata M, Sanes JR, Weiner JA.

Title

Synaptic adhesion molecules.

Journal

Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8

Reference

PMID:15882774

Authors

Ethell IM, Pasquale EB.

Title

Molecular mechanisms of dendritic spine development and remodeling.

Journal

Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003

Reference

PMID:11050419

Authors

Benson DL, Schnapp LM, Shapiro L, Huntley GW.

Title

Making memories stick: cell-adhesion molecules in synaptic plasticity.

Journal

Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9

Reference

PMID:11860281

Authors

Rosdahl JA, Mourton TL, Brady-Kalnay SM.

Title

Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.

Journal

Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071

Reference

PMID:10964748

Authors

Dunican DJ, Doherty P.

Title

The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.

Journal

Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225

Reference

PMID:12367625

Authors

Girault JA, Peles E.

Title

Development of nodes of Ranvier.

Journal

Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7

Reference

PMID:10664064

Authors

Arroyo EJ, Scherer SS.

Title

On the molecular architecture of myelinated fibers.

Journal

Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001

Reference

PMID:14556710

Authors

Salzer JL.

Title

Polarized domains of myelinated axons.

Journal

Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7

Reference

PMID:15561584

Authors

Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.

Title

Roles and modes of action of nectins in cell-cell adhesion.

Journal

Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002

Reference

PMID:15551862

Authors

Nakanishi H, Takai Y.

Title

Roles of nectins in cell adhesion, migration and polarization.

Journal

Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116

Reference

PMID:15115723

Authors

Siu MK, Cheng CY.

Title

Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.

Journal

Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225

Reference

PMID:15056568

Authors

Lee NP, Cheng CY.

Title

Adaptors, junction dynamics, and spermatogenesis.

Journal

Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268

Reference

PMID:15728677

Authors

Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.

Title

Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.

Journal

Development 132:1525-37 (2005)
DOI:10.1242/dev.01697

Reference

PMID:12500939

Authors

Marthiens V, Gavard J, Lambert M, Mege RM.

Title

Cadherin-based cell adhesion in neuromuscular development.

Journal

Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9

Reference

PMID:15923648

Authors

Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.

Title

Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.

Journal

J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397

Related
pathway

map04520

Adherens junction

map04530

Tight junction

map04610

Complement and coagulation cascades

map04660

T cell receptor signaling pathway

map04670

Leukocyte transendothelial migration

KO pathway

ko04514

All links

Gene (28431)   
   KEGG ORTHOLOGY (109)   
   RefGene (28322)   
Literature (25)   
   PubMed (25)   
All databases (28456)   

Download RDF

DBGET integrated database retrieval system