KEGG   PATHWAY: map04520Help
Entry
map04520                    Pathway                                

Name
Adherens junction
Description
Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion.
Class
Cellular Processes; Cell communication
BRITE hierarchy
Pathway map
Adherens junction
map04520

All organismsOrtholog table
Disease
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H00626  
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Leprechaunism
H00759  
Waardenburg syndrome (WS)
H00800  
Loeys-Dietz syndrome (LDS)
H00801  
Familial thoracic aortic aneurysm and dissection (TAAD)
H00942  
Rabson-Mendenhall syndrome
H00947  
Pilomatricoma
H01023  
Juvenile polyposis syndrome
H01207  
Trigonocephaly
H01228  
Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN)
H01255  
Juvenile-onset dystonia
H01274  
Growth delay due to insulin-like growth factor I resistance
Other DBs
GO: 
Reference
  Authors
Nelson WJ, Nusse R.
  Title
Convergence of Wnt, beta-catenin, and cadherin pathways.
  Journal
Science 303:1483-7 (2004)
Reference
  Authors
Potter E, Bergwitz C, Brabant G.
  Title
The cadherin-catenin system: implications for growth and differentiation of endocrine tissues.
  Journal
Endocr Rev 20:207-39 (1999)
Reference
  Authors
Beavon IR.
  Title
The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation.
  Journal
Eur J Cancer 36:1607-20 (2000)
Reference
  Authors
Reynolds AB, Roczniak-Ferguson A.
  Title
Emerging roles for p120-catenin in cell adhesion and cancer.
  Journal
Oncogene 23:7947-56 (2004)
Reference
  Authors
Angst BD, Marcozzi C, Magee AI.
  Title
The cadherin superfamily: diversity in form and function.
  Journal
J Cell Sci 114:629-41 (2001)
Reference
  Authors
Lilien J, Balsamo J, Arregui C, Xu G.
  Title
Turn-off, drop-out: functional state switching of cadherins.
  Journal
Dev Dyn 224:18-29 (2002)
Reference
  Authors
Piedra J, Miravet S, Castano J, Palmer HG, Heisterkamp N, Garcia de Herreros A, Dunach M.
  Title
p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
  Journal
Mol Cell Biol 23:2287-97 (2003)
Reference
  Authors
Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, Ben-Ze'ev A.
  Title
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK.
  Journal
J Cell Biol 163:847-57 (2003)
Reference
  Authors
Ciruna B, Rossant J.
  Title
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak.
  Journal
Dev Cell 1:37-49 (2001)
Reference
  Authors
Peinado H, Quintanilla M, Cano A.
  Title
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
  Journal
J Biol Chem 278:21113-23 (2003)
Reference
  Authors
Labbe E, Letamendia A, Attisano L.
  Title
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways.
  Journal
Proc Natl Acad Sci U S A 97:8358-63 (2000)
Reference
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
Reference
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
KO pathway
 

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