KEGG PATHWAY: map04530

PATHWAY: map04530

Entry

map04530                    Pathway

Name

Tight junction

Description

Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.

Class

Cellular Processes; Cellular community - eukaryotes

Pathway map

map04530

Tight junction

Other DBs

GO:

0005923

Reference

PMID:27353478

Authors

Zihni C, Mills C, Matter K, Balda MS

Title

Tight junctions: from simple barriers to multifunctional molecular gates.

Journal

Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80

Reference

PMID:22169974

Authors

Martin-Belmonte F, Perez-Moreno M

Title

Epithelial cell polarity, stem cells and cancer.

Journal

Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169

Reference

PMID:17525755

Authors

Weber C, Fraemohs L, Dejana E

Title

The role of junctional adhesion molecules in vascular inflammation.

Journal

Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096

Reference

PMID:15820555

Authors

Miyoshi J, Takai Y

Title

Molecular perspective on tight-junction assembly and epithelial polarity.

Journal

Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008

Reference

PMID:16650994

Authors

Mertens AE, Pegtel DM, Collard JG

Title

Tiam1 takes PARt in cell polarity.

Journal

Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001

Reference

PMID:16771626

Authors

Shin K, Fogg VC, Margolis B

Title

Tight junctions and cell polarity.

Journal

Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219

Reference

PMID:17182900

Authors

Kooistra MR, Dube N, Bos JL

Title

Rap1: a key regulator in cell-cell junction formation.

Journal

J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306

Reference

PMID:17950242

Authors

Gonzalez-Mariscal L, Tapia R, Chamorro D

Title

Crosstalk of tight junction components with signaling pathways.

Journal

Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018

Reference

PMID:18005931

Authors

Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D

Title

Polarity complex proteins.

Journal

Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029

Reference

PMID:18946474

Authors

Iden S, Collard JG

Title

Crosstalk between small GTPases and polarity proteins in cell polarization.

Journal

Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521

Reference

PMID:20094051

Authors

Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ

Title

PKC and the control of localized signal dynamics.

Journal

Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847

Reference

PMID:20134025

Authors

Terry S, Nie M, Matter K, Balda MS

Title

Rho signaling and tight junction functions.

Journal

Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009

Reference

PMID:21283798

Authors

Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS

Title

Bves modulates tight junction associated signaling.

Journal

PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563

Reference

PMID:21781017

Authors

Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P

Title

Regulation of small GTPases at epithelial cell-cell junctions.

Journal

Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101

Reference

PMID:22896795

Authors

Lickert H, Van Campenhout CA

Title

Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.

Journal

Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792

Reference

PMID:22928510

Authors

Spadaro D, Tapia R, Pulimeno P, Citi S

Title

The control of gene expression and cell proliferation by the epithelial apical junctional complex.

Journal

Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083

Reference

PMID:24548561

Authors

Moleirinho S, Guerrant W, Kissil JL

Title

The Angiomotins--from discovery to function.

Journal

FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006

Reference

PMID:24651541

Authors

Rodriguez-Boulan E, Macara IG

Title

Organization and execution of the epithelial polarity programme.

Journal

Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775

Reference

PMID:25152334

Authors

Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G

Title

Tight junctions and the regulation of gene expression.

Journal

Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009

Reference

PMID:25469537

Authors

Mack NA, Georgiou M

Title

The interdependence of the Rho GTPases and apicobasal cell polarity.

Journal

Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768

Reference

PMID:25483301

Authors

Citi S, Guerrera D, Spadaro D, Shah J

Title

Epithelial junctions and Rho family GTPases: the zonular signalosome.

Journal

Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760

Reference

PMID:25757376

Authors

Zihni C, Terry SJ

Title

RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.

Journal

Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020

Reference

PMID:22892070

Authors

Nakano A, Takashima S

Title

LKB1 and AMP-activated protein kinase: regulators of cell polarity.

Journal

Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x

Reference

PMID:12042308

Authors

Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B

Title

Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.

Journal

J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200

Reference

PMID:18094055

Authors

Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T

Title

The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.

Journal

Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551

Reference

PMID:23885123

Authors

Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA

Title

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.

Journal

Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298

Related
pathway

map04520

Adherens junction

map04810

Regulation of actin cytoskeleton

KO pathway

ko04530

All links

Chemical substance (1)   
   KEGG COMPOUND (1)   
Gene (657247)   
   KEGG ORTHOLOGY (106)   
   RefGene (657141)   
Literature (26)   
   PubMed (26)   
All databases (657274)   

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