KEGG PATHWAY: map04666

PATHWAY: map04666

Entry

map04666                    Pathway

Name

Fc gamma R-mediated phagocytosis

Description

Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.

Class

Organismal Systems; Immune system

Pathway map

map04666

Fc gamma R-mediated phagocytosis

Other DBs

GO:

0006909

Reference

PMID:12488490

Authors

Garcia-Garcia E, Rosales C

Title

Signal transduction during Fc receptor-mediated phagocytosis.

Journal

J Leukoc Biol 72:1092-108 (2002)
DOI:10.1189/jlb.72.6.1092

Reference

PMID:11708889

Authors

Cox D, Greenberg S

Title

Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.

Journal

Semin Immunol 13:339-45 (2001)
DOI:10.1006/smim.2001.0330

Reference

PMID:15466916

Authors

Swanson JA, Hoppe AD

Title

The coordination of signaling during Fc receptor-mediated phagocytosis.

Journal

J Leukoc Biol 76:1093-103 (2004)
DOI:10.1189/jlb.0804439

Reference

PMID:11244038

Authors

Ravetch JV, Bolland S

Title

IgG Fc receptors.

Journal

Annu Rev Immunol 19:275-90 (2001)
DOI:10.1146/annurev.immunol.19.1.275

Reference

PMID:18322649

Authors

Groves E, Dart AE, Covarelli V, Caron E

Title

Molecular mechanisms of phagocytic uptake in mammalian cells.

Journal

Cell Mol Life Sci 65:1957-76 (2008)
DOI:10.1007/s00018-008-7578-4

Reference

PMID:10376013

Authors

Kwiatkowska K, Sobota A

Title

Signaling pathways in phagocytosis.

Journal

Bioessays 21:422-31 (1999)
DOI:10.1002/(SICI)1521-1878(199905)21:5<422::AID-BIES9>3.0.CO;2-#

Reference

PMID:10577498

Authors

Greenberg S

Title

Modular components of phagocytosis.

Journal

J Leukoc Biol 66:712-7 (1999)
DOI:10.1002/jlb.66.5.712

Reference

PMID:10224668

Authors

Lennartz MR

Title

Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.

Journal

Int J Biochem Cell Biol 31:415-30 (1999)
DOI:10.1016/S1357-2725(98)00108-3

Reference

PMID:11228151

Authors

May RC, Machesky LM

Title

Phagocytosis and the actin cytoskeleton.

Journal

J Cell Sci 114:1061-77 (2001)

Reference

PMID:17050193

Authors

Joshi T, Butchar JP, Tridandapani S

Title

Fcgamma receptor signaling in phagocytes.

Journal

Int J Hematol 84:210-6 (2006)
DOI:10.1532/IJH97.06140

Reference

PMID:17308335

Authors

Lee WL, Cosio G, Ireton K, Grinstein S

Title

Role of CrkII in Fcgamma receptor-mediated phagocytosis.

Journal

J Biol Chem 282:11135-43 (2007)
DOI:10.1074/jbc.M700823200

Reference

PMID:11304556

Authors

Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H

Title

PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.

Journal

J Exp Med 193:955-66 (2001)
DOI:10.1084/jem.193.8.955

Reference

PMID:15485887

Authors

Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S

Title

The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.

Journal

J Biol Chem 279:54416-25 (2004)
DOI:10.1074/jbc.M408188200

Reference

PMID:9545263

Authors

Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM

Title

FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.

Journal

J Biol Chem 273:9393-402 (1998)
DOI:10.1074/jbc.273.16.9393

Reference

PMID:12821647

Authors

Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG

Title

Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.

Journal

J Cell Biol 161:1151-61 (2003)
DOI:10.1083/jcb.200212158

Reference

PMID:9417101

Authors

Dana R, Leto TL, Malech HL, Levy R

Title

Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.

Journal

J Biol Chem 273:441-5 (1998)
DOI:10.1074/jbc.273.1.441

Reference

PMID:10601359

Authors

Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A

Title

Dynamin 2 is required for phagocytosis in macrophages.

Journal

J Exp Med 190:1849-56 (1999)
DOI:10.1084/jem.190.12.1849

Reference

PMID:10755615

Authors

Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A

Title

Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.

Journal

Immunity 12:285-92 (2000)
DOI:10.1016/S1074-7613(00)80181-8

Reference

PMID:10586078

Authors

Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA

Title

Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.

Journal

J Immunol 163:6785-93 (1999)

Reference

PMID:9581795

Authors

Sanchez-Mejorada G, Rosales C

Title

Signal transduction by immunoglobulin Fc receptors.

Journal

J Leukoc Biol 63:521-33 (1998)
DOI:10.1002/jlb.63.5.521

Reference

Authors

Rosales C (ed).

Title

Molecular Mechanisms of Phagocytosis

Journal

Springer (2005)

Related
pathway

map04020

Calcium signaling pathway

map04142

Lysosome

map04144

Endocytosis

map04810

Regulation of actin cytoskeleton

KO pathway

ko04666

All links

Chemical substance (8)   
   KEGG COMPOUND (8)   
Gene (140802)   
   KEGG ORTHOLOGY (64)   
   RefGene (140738)   
Literature (20)   
   PubMed (20)   
All databases (140830)   

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