KEGG   PATHWAY: afe03440
Entry
afe03440                    Pathway                                
Name
Homologous recombination - Acidithiobacillus ferrooxidans ATCC 53993
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
afe03440  Homologous recombination
afe03440

Other DBs
GO: 0000724
Organism
Acidithiobacillus ferrooxidans ATCC 53993 [GN:afe]
Gene
Lferr_0636  phosphoesterase RecJ domain protein [KO:K07462] [EC:3.1.-.-]
Lferr_2466  single-strand binding protein [KO:K03111]
Lferr_1280  single-strand binding protein [KO:K03111]
Lferr_0140  single-strand binding protein [KO:K03111]
Lferr_0003  DNA replication and repair protein RecF [KO:K03629]
Lferr_1123  DNA repair protein RecO [KO:K03584]
Lferr_1593  recombination protein RecR [KO:K06187]
Lferr_1050  recA protein [KO:K03553]
Lferr_2692  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
Lferr_0062  Holliday junction DNA helicase RuvA [KO:K03550]
Lferr_0063  Holliday junction DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
Lferr_0061  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
Lferr_0722  ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
Lferr_2795  putative transcriptional regulator [KO:K03655] [EC:5.6.2.4]
Lferr_0965  putative transcriptional regulator [KO:K03655] [EC:5.6.2.4]
Lferr_2547  exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
Lferr_2546  exodeoxyribonuclease V, gamma subunit [KO:K03583] [EC:3.1.11.5]
Lferr_2548  exodeoxyribonuclease V, alpha subunit [KO:K03581] [EC:3.1.11.5]
Lferr_1177  DNA polymerase III, alpha subunit [KO:K02337] [EC:2.7.7.7]
Lferr_0002  DNA polymerase III, beta subunit [KO:K02338] [EC:2.7.7.7]
Lferr_1591  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
Lferr_0617  DNA polymerase III, delta subunit [KO:K02340] [EC:2.7.7.7]
Lferr_1589  DNA-directed DNA polymerase [KO:K02341] [EC:2.7.7.7]
Lferr_0564  DNA polymerase III, epsilon subunit [KO:K02342] [EC:2.7.7.7]
Lferr_1858  DNA polymerase III chi subunit HolC [KO:K02339] [EC:2.7.7.7]
Lferr_0743  primosomal protein N' [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG GENES (26)   
All databases (27)   

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