KEGG   PATHWAY: aga04141Help
aga04141                    Pathway                                

Protein processing in endoplasmic reticulum - Anopheles gambiae (mosquito)
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
Protein processing in endoplasmic reticulum

All organismsOrtholog table
p97-Ufd1-Npl4 complex [PATH:aga04141]
COPII complex [PATH:aga04141]
Other DBs
Anopheles gambiae (mosquito) [GN:aga]
AGAP009182-PA; K10956 protein transport protein SEC61 subunit alpha [KO:K10956]
AGAP011504-PA; K09481 protein transport protein SEC61 subunit beta [KO:K09481]
AGAP009788-PA; K12275 translocation protein SEC62 [KO:K12275]
AGAP007361-PA; K09540 translocation protein SEC63 [KO:K09540]
AGAP010174-PA; K12666 oligosaccharyltransferase complex subunit alpha (ribophorin I) [KO:K12666]
AGAP007638-PA; K12667 oligosaccharyltransferase complex subunit delta (ribophorin II) [KO:K12667]
AGAP008491-PA; K12668 oligosaccharyltransferase complex subunit epsilon [KO:K12668]
AGAP010010-PA; K12669 oligosaccharyltransferase complex subunit gamma [KO:K12669]
AGAP006383-PA; K12670 oligosaccharyltransferase complex subunit beta [KO:K12670]
AGAP000434-PA; K07151 dolichyl-diphosphooligosaccharide--protein glycosyltransferase [EC:] [KO:K07151] [EC:]
AGAP002396-PA; K07151 dolichyl-diphosphooligosaccharide--protein glycosyltransferase [EC:] [KO:K07151] [EC:]
AGAP003488-PA; K14001 nucleotide exchange factor SIL1 [KO:K14001]
AGAP001827-PA; K09486 hypoxia up-regulated 1 [KO:K09486]
AGAP004192-PA; K09490 heat shock 70kDa protein 5 [KO:K09490]
AGAP008327-PA; K09517 DnaJ homolog subfamily B member 11 [KO:K09517]
AGAP000261-PA; K09521 DnaJ homolog subfamily C member 1 [KO:K09521]
AGAP002752-PA; K09523 DnaJ homolog subfamily C member 3 [KO:K09523]
AGAP001424-PA; K09487 heat shock protein 90kDa beta [KO:K09487]
AGAP000862-PA; K05546 alpha 1,3-glucosidase [EC:] [KO:K05546] [EC:]
AGAP004609-PA; K08288 protein kinase C substrate 80K-H [KO:K08288]
AGAP005032-PA; K08054 calnexin [KO:K08054]
AGAP007393-PA; K08056 protein disulfide isomerase family A, member 3 [EC:] [KO:K08056] [EC:]
AGAP004212-PA; K08057 calreticulin [KO:K08057]
AGAP003884-PB; K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:] [KO:K01230] [EC:]
AGAP000558-PB; K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:] [KO:K01230] [EC:]
AGAP004407-PA; K10082 lectin, mannose-binding 2 [KO:K10082]
AGAP005404-PA; K10080 lectin, mannose-binding 1 [KO:K10080]
AGAP009942-PA; K14003 prolactin regulatory element-binding protein [KO:K14003]
AGAP004098-PA; K07953 GTP-binding protein SAR1 [EC:3.6.5.-] [KO:K07953] [EC:3.6.5.-]
AGAP003183-PA; K14004 protein transport protein SEC13 [KO:K14004]
AGAP011551-PA; K14005 protein transport protein SEC31 [KO:K14005]
AGAP001759-PA; K14006 protein transport protein SEC23 [KO:K14006]
AGAP005263-PA; K14007 protein transport protein SEC24 [KO:K14007]
AGAP003560-PA; K11718 UDP-glucose:glycoprotein glucosyltransferase [EC:2.4.1.-] [KO:K11718] [EC:2.4.1.-]
AGAP012463-PA; K10085 ER degradation enhancer, mannosidase alpha-like 2 [KO:K10085]
AGAP008749-PA; K10086 ER degradation enhancer, mannosidase alpha-like 3 [KO:K10086]
AGAP012407-PA; K09580 protein disulfide-isomerase A1 [EC:] [KO:K09580] [EC:]
AGAP001919-PA; K09584 protein disulfide-isomerase A6 [EC:] [KO:K09584] [EC:]
AGAP000395-PA; K09586 endoplasmic reticulum protein 29 [KO:K09586]
AGAP000044-PA; K13984 thioredoxin domain-containing protein 5 [KO:K13984]
AGAP002816-PA; K10950 ERO1-like protein alpha [EC:1.8.4.-] [KO:K10950] [EC:1.8.4.-]
AGAP009546-PA; K14008 endoplasmic reticulum lectin 1 [KO:K14008]
AGAP001721-PA; K13249 translocon-associated protein subunit alpha [KO:K13249]
AGAP005861-PB; K13250 translocon-associated protein subunit beta [KO:K13250]
AGAP008761-PA; K13251 translocon-associated protein subunit gamma [KO:K13251]
AGAP010557-PA; K14009 B-cell receptor-associated protein 31 [KO:K14009]
AGAP010386-PA; K14010 translocating chain-associated membrane protein 1 [KO:K14010]
AGAP009288-PA; K11519 Derlin-1 [KO:K11519]
AGAP000832-PA; K13989 Derlin-2/3 [KO:K13989]
AGAP006391-PA; K14011 UBX domain-containing protein 6 [KO:K14011]
AGAP005122-PA; K14012 UBX domain-containing protein 1 [KO:K14012]
AGAP013220-PA; K14014 small VCP/p97-interacting protein [KO:K14014]
AGAP005630-PA; K13525 transitional endoplasmic reticulum ATPase [KO:K13525]
AGAP001986-PA; K14015 nuclear protein localization protein 4 homolog [KO:K14015]
AGAP001307-PA; K14016 ubiquitin fusion degradation protein 1 [KO:K14016]
AGAP004582-PA; K03283 heat shock 70kDa protein 1/8 [KO:K03283]
AGAP004944-PA; K03283 heat shock 70kDa protein 1/8 [KO:K03283]
AGAP012891-PA; K03283 heat shock 70kDa protein 1/8 [KO:K03283]
AGAP002076-PA; K03283 heat shock 70kDa protein 1/8 [KO:K03283]
AGAP005981-PA; K09502 DnaJ homolog subfamily A member 1 [KO:K09502]
AGAP001810-PA; K09518 DnaJ homolog subfamily B member 12 [KO:K09518]
AGAP001859-PB; K09518 DnaJ homolog subfamily B member 12 [KO:K09518]
AGAP007620-PA; K09525 DnaJ homolog subfamily C member 5 [KO:K09525]
HSP83_ANOGA; AGAP006958-PA [KO:K04079]
AGAP006961-PA; K04079 molecular chaperone HtpG [KO:K04079]
AGAP006959-PA; K04079 molecular chaperone HtpG [KO:K04079]
AGAP010331-PA; K09485 heat shock protein 110kDa [KO:K09485]
AGAP010983-PA; K09556 BCL2-associated athanogene 2 [KO:K09556]
AGAP008392-PA; K09562 hsp70-interacting protein [KO:K09562]
AGAP007162-PB; K09542 crystallin, alpha B [KO:K09542]
AGAP007001-PA; K13719 ubiquitin thioesterase OTU1 [EC:3.1.2.-] [KO:K13719] [EC:3.1.2.-]
AGAP008620-PA; K14018 phospholipase A-2-activating protein [KO:K14018]
AGAP000733-PA; K10839 UV excision repair protein RAD23 [KO:K10839]
AGAP004294-PA; K04523 ubiquilin [KO:K04523]
AGAP007390-PA; K01456 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase [EC:] [KO:K01456] [EC:]
AGAP007870-PA; K10597 ubiquitin conjugation factor E4 B [EC:] [KO:K10597] [EC:]
AGAP010925-PA; K16194 eukaryotic translation initiation factor 2-alpha kinase 1 [EC:] [KO:K16194] [EC:]
AGAP013266-PA; K08860 eukaryotic translation initiation factor 2-alpha kinase 3 [EC:] [KO:K08860] [EC:]
AGAP012368-PA; K16196 eukaryotic translation initiation factor 2-alpha kinase 4 [EC:] [KO:K16196] [EC:]
AGAP011190-PA; K03237 translation initiation factor 2 subunit 1 [KO:K03237]
AGAP008832-PA; K09054 cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
AGAP004409-PA; K14020 wolfamin [KO:K14020]
AGAP012203-PA; K08653 membrane-bound transcription factor site-1 protease [EC:] [KO:K08653] [EC:]
AGAP011819-PA; K07765 S2P endopeptidase [EC:] [KO:K07765] [EC:]
AGAP010623-PA; K09027 X box-binding protein 1 [KO:K09027]
AGAP004176-PA; K08852 serine/threonine-protein kinase/endoribonuclease IRE1 [EC: 3.1.26.-] [KO:K08852] [EC:3.1.26.-]
AGAP000747-PB; K04426 mitogen-activated protein kinase kinase kinase 5 [EC:] [KO:K04426] [EC:]
AGAP001867-PA; K04431 mitogen-activated protein kinase kinase 7 [EC:] [KO:K04431] [EC:]
AGAP009461-PA; K04440 c-Jun N-terminal kinase [EC:] [KO:K04440] [EC:]
AGAP009460-PA; K04440 c-Jun N-terminal kinase [EC:] [KO:K04440] [EC:]
AGAP007204-PA; K10661 E3 ubiquitin-protein ligase MARCH6 [EC:] [KO:K10661] [EC:]
AGAP005954-PA; K04554 ubiquitin-conjugating enzyme E2 J2 [EC:] [KO:K04554] [EC:]
AGAP002251-PA; K10575 ubiquitin-conjugating enzyme E2 G1 [EC:] [KO:K10575] [EC:]
AGAP002169-PA; K04555 ubiquitin-conjugating enzyme E2 G2 [EC:] [KO:K04555] [EC:]
AGAP003179-PA; K10601 E3 ubiquitin-protein ligase synoviolin [EC:] [KO:K10601] [EC:]
AGAP006041-PA; K10666 E3 ubiquitin-protein ligase RNF5 [EC:] [KO:K10666] [EC:]
AGAP000615-PA; K14026 SEL1 protein [KO:K14026]
AGAP007538-PA; K10636 autocrine motility factor receptor [EC:] [KO:K10636] [EC:]
AGAP008918-PA; K09561 STIP1 homology and U-box containing protein 1 [EC:] [KO:K09561] [EC:]
AGAP000145-PA; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:] [KO:K06689] [EC:]
AGAP008941-PA; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:] [KO:K06689] [EC:]
AGAP007952-PA; K06689 ubiquitin-conjugating enzyme E2 D/E [EC:] [KO:K06689] [EC:]
AGAP006580-PA; K04556 parkin [EC:] [KO:K04556] [EC:]
AGAP005202-PB; K03868 RING-box protein 1 [KO:K03868]
AGAP008007-PA; K03347 cullin 1 [KO:K03347]
AGAP008719-PA; K03094 S-phase kinase-associated protein 1 [KO:K03094]
Calcium cation
Naidoo N
ER and aging-Protein folding and the ER stress response.
Ageing Res Rev 8:150-9 (2009)
Malhotra JD, Kaufman RJ
The endoplasmic reticulum and the unfolded protein response.
Semin Cell Dev Biol 18:716-31 (2007)
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
Protein quality control in the ER: the recognition of misfolded proteins.
Semin Cell Dev Biol 21:500-11 (2010)
Stolz A, Wolf DH
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
Biochim Biophys Acta 1803:694-705 (2010)
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
J Proteome Res 9:1763-71 (2010)
KO pathway

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