KEGG   PATHWAY: aga04141Help
Entry
aga04141                    Pathway                                

Name
Protein processing in endoplasmic reticulum - Anopheles gambiae (mosquito)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
Protein processing in endoplasmic reticulum
aga04141

All organismsOrtholog table
Module
p97-Ufd1-Npl4 complex [PATH:aga04141]
COPII complex [PATH:aga04141]
Other DBs
Organism
Anopheles gambiae (mosquito) [GN:aga]
Gene
AGAP009182-PA [KO:K10956]
AGAP011504-PA [KO:K09481]
AGAP009788-PA [KO:K12275]
AGAP007361-PA [KO:K09540]
AGAP010174-PA [KO:K12666]
AGAP007638-PA [KO:K12667]
AGAP008491-PA [KO:K12668]
AGAP010010-PA [KO:K12669]
AGAP006383-PA [KO:K12670]
AGAP000434-PA [KO:K07151] [EC:2.4.99.18]
AGAP002396-PA [KO:K07151] [EC:2.4.99.18]
AGAP003488-PA [KO:K14001]
AGAP001827-PA [KO:K09486]
AGAP004192-PA [KO:K09490]
AGAP008327-PA [KO:K09517]
AGAP000261-PA [KO:K09521]
AGAP002752-PA [KO:K09523]
AGAP001424-PA [KO:K09487]
AGAP000862-PA [KO:K05546] [EC:3.2.1.84]
AGAP004609-PA [KO:K08288]
AGAP005032-PA [KO:K08054]
AGAP007393-PA [KO:K08056] [EC:5.3.4.1]
AGAP004212-PA [KO:K08057]
AGAP003884-PB [KO:K01230] [EC:3.2.1.113]
AGAP000558-PB [KO:K01230] [EC:3.2.1.113]
AGAP004407-PA [KO:K10082]
AGAP005404-PA [KO:K10080]
AGAP009942-PA [KO:K14003]
AGAP004098-PA [KO:K07953] [EC:3.6.5.-]
AGAP003183-PA [KO:K14004]
AGAP011551-PA [KO:K14005]
AGAP001759-PA [KO:K14006]
AGAP005263-PA [KO:K14007]
AGAP003560-PA [KO:K11718] [EC:2.4.1.-]
AGAP012463-PA [KO:K10085]
AGAP008749-PA [KO:K10086]
AGAP012407-PA [KO:K09580] [EC:5.3.4.1]
AGAP001919-PA [KO:K09584] [EC:5.3.4.1]
AGAP000395-PA [KO:K09586]
AGAP000044-PA [KO:K13984]
AGAP002816-PA [KO:K10950] [EC:1.8.4.-]
AGAP009546-PA [KO:K14008]
AGAP001721-PA [KO:K13249]
AGAP005861-PB [KO:K13250]
AGAP008761-PA [KO:K13251]
AGAP010557-PA [KO:K14009]
AGAP010386-PA [KO:K14010]
AGAP009288-PA [KO:K11519]
AGAP000832-PA [KO:K13989]
AGAP006391-PA [KO:K14011]
AGAP005122-PA [KO:K14012]
AGAP013220-PA [KO:K14014]
AGAP005630-PA [KO:K13525]
AGAP001986-PA [KO:K14015]
AGAP001307-PA [KO:K14016]
AGAP004582-PA [KO:K03283]
AGAP004944-PA [KO:K03283]
AGAP012891-PA [KO:K03283]
AGAP002076-PA [KO:K03283]
AGAP004581-PA [KO:K03283]
AGAP004583-PA [KO:K03283]
AGAP005981-PA [KO:K09502]
AGAP000008-PA [KO:K09502]
AGAP001810-PA [KO:K09518]
AGAP001859-PB [KO:K09518]
AGAP007620-PA [KO:K09525]
HSP83_ANOGA; AGAP006958-PA [KO:K04079]
AGAP006961-PA [KO:K04079]
AGAP006959-PA [KO:K04079]
AGAP010331-PA [KO:K09485]
AGAP010983-PA [KO:K09556]
AGAP008392-PA [KO:K09562]
AGAP007162-PB [KO:K09542]
AGAP005547-PA [KO:K09542]
AGAP005548-PA [KO:K09542]
AGAP007161-PA [KO:K09542]
AGAP007158-PA [KO:K09542]
AGAP007159-PA [KO:K09542]
AGAP007001-PA [KO:K13719] [EC:3.1.2.-]
AGAP008620-PA [KO:K14018]
AGAP000733-PA [KO:K10839]
AGAP004294-PA [KO:K04523]
AGAP007390-PA [KO:K01456] [EC:3.5.1.52]
AGAP007870-PA [KO:K10597] [EC:2.3.2.27]
AGAP010925-PA [KO:K16194] [EC:2.7.11.1]
AGAP013266-PA [KO:K08860] [EC:2.7.11.1]
AGAP012368-PA [KO:K16196] [EC:2.7.11.1]
AGAP011190-PA [KO:K03237]
AGAP008832-PA [KO:K09054]
AGAP004409-PA [KO:K14020]
AGAP012203-PA [KO:K08653] [EC:3.4.21.112]
AGAP011819-PA [KO:K07765] [EC:3.4.24.85]
AGAP010623-PA [KO:K09027]
AGAP004176-PA [KO:K08852] [EC:3.1.26.- 2.7.11.1]
AGAP000747-PB [KO:K04426] [EC:2.7.11.25]
AGAP001867-PA [KO:K04431] [EC:2.7.12.2]
AGAP009461-PA [KO:K04440] [EC:2.7.11.24]
AGAP009460-PA [KO:K04440] [EC:2.7.11.24]
AGAP007204-PA [KO:K10661] [EC:2.3.2.27]
AGAP005954-PA [KO:K04554] [EC:2.3.2.23]
AGAP002251-PA [KO:K10575] [EC:2.3.2.23]
AGAP002169-PA [KO:K04555] [EC:2.3.2.23]
AGAP003179-PA [KO:K10601] [EC:2.3.2.27]
AGAP006041-PA [KO:K10666] [EC:2.3.2.27]
AGAP000615-PA [KO:K14026]
AGAP007538-PA [KO:K10636] [EC:2.3.2.27]
AGAP008918-PA [KO:K09561] [EC:2.3.2.27]
AGAP000145-PA [KO:K06689] [EC:2.3.2.23]
AGAP006580-PA [KO:K04556] [EC:2.3.2.27]
AGAP005202-PB [KO:K03868]
AGAP008007-PA [KO:K03347]
AGAP008719-PA [KO:K03094]
Compound
C00076  
Calcium cation
G00009  
 
G00010  
 
G00011  
 
G00012  
 
G10694  
 
Reference
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
Reference
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
Reference
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
Reference
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
Reference
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
KO pathway
 

DBGET integrated database retrieval system