KEGG   PATHWAY: aga04141Help
Entry
aga04141                    Pathway                                

Name
Protein processing in endoplasmic reticulum - Anopheles gambiae (mosquito)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
aga04141  Protein processing in endoplasmic reticulum
aga04141

Ortholog table
Module
aga_M00400  p97-Ufd1-Npl4 complex [PATH:aga04141]
aga_M00404  COPII complex [PATH:aga04141]
Other DBs
BSID: 167383
GO: 0030433 0034976
Organism
Anopheles gambiae (mosquito) [GN:aga]
Gene
AgaP_AGAP009182  AGAP009182-PA [KO:K10956]
AgaP_AGAP011504  AGAP011504-PA [KO:K09481]
AgaP_AGAP009788  AGAP009788-PA [KO:K12275]
AgaP_AGAP007361  AGAP007361-PA [KO:K09540]
AgaP_AGAP010174  AGAP010174-PA [KO:K12666]
AgaP_AGAP007638  AGAP007638-PA [KO:K12667]
AgaP_AGAP008491  AGAP008491-PA [KO:K12668]
AgaP_AGAP010010  AGAP010010-PA [KO:K12669]
AgaP_AGAP006383  AGAP006383-PA [KO:K12670]
AgaP_AGAP000434  AGAP000434-PA [KO:K07151] [EC:2.4.99.18]
AgaP_AGAP002396  AGAP002396-PA [KO:K07151] [EC:2.4.99.18]
AgaP_AGAP003488  AGAP003488-PA [KO:K14001]
AgaP_AGAP001827  AGAP001827-PA [KO:K09486]
AgaP_AGAP004192  AGAP004192-PA [KO:K09490]
AgaP_AGAP008327  AGAP008327-PA [KO:K09517]
AgaP_AGAP000261  AGAP000261-PA [KO:K09521]
AgaP_AGAP002752  AGAP002752-PA [KO:K09523]
AgaP_AGAP001424  AGAP001424-PA [KO:K09487]
AgaP_AGAP000862  AGAP000862-PA [KO:K05546] [EC:3.2.1.84]
AgaP_AGAP004609  AGAP004609-PA [KO:K08288]
AgaP_AGAP005032  AGAP005032-PA [KO:K08054]
AgaP_AGAP007393  AGAP007393-PA [KO:K08056] [EC:5.3.4.1]
AgaP_AGAP004212  AGAP004212-PA [KO:K08057]
AgaP_AGAP003884  AGAP003884-PB [KO:K01230] [EC:3.2.1.113]
AgaP_AGAP000558  AGAP000558-PB [KO:K01230] [EC:3.2.1.113]
AgaP_AGAP004407  AGAP004407-PA [KO:K10082]
AgaP_AGAP005404  AGAP005404-PA [KO:K10080]
AgaP_AGAP009942  AGAP009942-PA [KO:K14003]
AgaP_AGAP004098  AGAP004098-PB [KO:K07953] [EC:3.6.5.-]
AgaP_AGAP003183  AGAP003183-PA [KO:K14004]
AgaP_AGAP011551  AGAP011551-PA [KO:K14005]
AgaP_AGAP001759  AGAP001759-PA [KO:K14006]
AgaP_AGAP005263  AGAP005263-PA [KO:K14007]
AgaP_AGAP003560  AGAP003560-PA [KO:K11718] [EC:2.4.1.-]
AgaP_AGAP012463  AGAP012463-PA [KO:K10085]
AgaP_AGAP008749  AGAP008749-PA [KO:K10086]
AgaP_AGAP012407  AGAP012407-PA [KO:K09580] [EC:5.3.4.1]
AgaP_AGAP001919  AGAP001919-PA [KO:K09584] [EC:5.3.4.1]
AgaP_AGAP000395  AGAP000395-PA [KO:K09586]
AgaP_AGAP000044  AGAP000044-PA [KO:K13984]
AgaP_AGAP002816  AGAP002816-PA [KO:K10950] [EC:1.8.4.-]
AgaP_AGAP009546  AGAP009546-PA [KO:K14008]
AgaP_AGAP001721  AGAP001721-PA [KO:K13249]
AgaP_AGAP005861  AGAP005861-PA [KO:K13250]
AgaP_AGAP008761  AGAP008761-PA [KO:K13251]
AgaP_AGAP010557  AGAP010557-PA [KO:K14009]
AgaP_AGAP010386  AGAP010386-PA [KO:K14010]
AgaP_AGAP009288  AGAP009288-PA [KO:K11519]
AgaP_AGAP000832  AGAP000832-PA [KO:K13989]
AgaP_AGAP006391  AGAP006391-PA [KO:K14011]
AgaP_AGAP005122  AGAP005122-PA [KO:K14012]
AgaP_AGAP013220  AGAP013220-PA [KO:K14014]
AgaP_AGAP005630  AGAP005630-PA [KO:K13525]
AgaP_AGAP001986  AGAP001986-PA [KO:K14015]
AgaP_AGAP001307  AGAP001307-PA [KO:K14016]
AgaP_AGAP004944  AGAP004944-PA [KO:K03283]
AgaP_AGAP002076  AGAP002076-PA [KO:K03283]
AgaP_AGAP004581  AGAP004581-PA [KO:K03283]
AgaP_AGAP004583  AGAP004583-PA [KO:K03283]
AgaP_AGAP005981  AGAP005981-PA [KO:K09502]
AgaP_AGAP000008  AGAP000008-PA [KO:K09502]
AgaP_AGAP001810  AGAP001810-PA [KO:K09518]
AgaP_AGAP001859  AGAP001859-PA [KO:K09518]
AgaP_AGAP007620  AGAP007620-PA [KO:K09525]
AgaP_AGAP006958  HSP83_ANOGA; AGAP006958-PA [KO:K04079]
AgaP_AGAP006961  AGAP006961-PA [KO:K04079]
AgaP_AGAP006959  AGAP006959-PA [KO:K04079]
AgaP_AGAP010331  AGAP010331-PA [KO:K09485]
AgaP_AGAP010983  AGAP010983-PA [KO:K09556]
AgaP_AGAP008392  AGAP008392-PA [KO:K09562]
AgaP_AGAP007162  AGAP007162-PB [KO:K09542]
AgaP_AGAP005547  AGAP005547-PA [KO:K09542]
AgaP_AGAP005548  AGAP005548-PA [KO:K09542]
AgaP_AGAP007161  AGAP007161-PA [KO:K09542]
AgaP_AGAP007158  AGAP007158-PA [KO:K09542]
AgaP_AGAP007159  AGAP007159-PA [KO:K09542]
AgaP_AGAP007001  AGAP007001-PA [KO:K13719] [EC:3.1.2.-]
AgaP_AGAP008620  AGAP008620-PA [KO:K14018]
AgaP_AGAP000733  AGAP000733-PA [KO:K10839]
AgaP_AGAP004294  AGAP004294-PA [KO:K04523]
AgaP_AGAP007390  AGAP007390-PA [KO:K01456] [EC:3.5.1.52]
AgaP_AGAP007870  AGAP007870-PA [KO:K10597] [EC:2.3.2.27]
AgaP_AGAP010925  AGAP010925-PA [KO:K16194] [EC:2.7.11.1]
AgaP_AGAP013266  AGAP013266-PA [KO:K08860] [EC:2.7.11.1]
AgaP_AGAP012368  AGAP012368-PA [KO:K16196] [EC:2.7.11.1]
AgaP_AGAP011190  AGAP011190-PA [KO:K03237]
AgaP_AGAP008832  AGAP008832-PA [KO:K09054]
AgaP_AGAP004409  AGAP004409-PA [KO:K14020]
AgaP_AGAP012203  AGAP012203-PA [KO:K08653] [EC:3.4.21.112]
AgaP_AGAP011819  AGAP011819-PA [KO:K07765] [EC:3.4.24.85]
AgaP_AGAP010623  AGAP010623-PA [KO:K09027]
AgaP_AGAP004176  AGAP004176-PA [KO:K08852] [EC:3.1.26.- 2.7.11.1]
AgaP_AGAP000747  AGAP000747-PB [KO:K04426] [EC:2.7.11.25]
AgaP_AGAP001867  AGAP001867-PA [KO:K04431] [EC:2.7.12.2]
AgaP_AGAP009461  AGAP009461-PA [KO:K04440] [EC:2.7.11.24]
AgaP_AGAP009460  AGAP009460-PA [KO:K04440] [EC:2.7.11.24]
AgaP_AGAP007204  AGAP007204-PA [KO:K10661] [EC:2.3.2.27]
AgaP_AGAP005954  AGAP005954-PA [KO:K04554] [EC:2.3.2.23]
AgaP_AGAP002251  AGAP002251-PA [KO:K10575] [EC:2.3.2.23]
AgaP_AGAP002169  AGAP002169-PA [KO:K04555] [EC:2.3.2.23]
AgaP_AGAP003179  AGAP003179-PA [KO:K10601] [EC:2.3.2.27]
AgaP_AGAP006041  AGAP006041-PA [KO:K10666] [EC:2.3.2.27]
AgaP_AGAP000615  AGAP000615-PA [KO:K14026]
AgaP_AGAP007538  AGAP007538-PA [KO:K10636] [EC:2.3.2.27]
AgaP_AGAP008918  AGAP008918-PA [KO:K09561] [EC:2.3.2.27]
AgaP_AGAP000145  AGAP000145-PA [KO:K06689] [EC:2.3.2.23]
AgaP_AGAP006580  AGAP006580-PA [KO:K04556] [EC:2.3.2.31]
AgaP_AGAP005202  AGAP005202-PA [KO:K03868] [EC:2.3.2.32]
AgaP_AGAP008007  AGAP008007-PA [KO:K03347]
AgaP_AGAP008719  AGAP008719-PA [KO:K03094]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
KO pathway
ko04141   

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