KEGG   PATHWAY: aga04141Help
aga04141                    Pathway                                

Protein processing in endoplasmic reticulum - Anopheles gambiae (mosquito)
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
Protein processing in endoplasmic reticulum

All organismsOrtholog table
p97-Ufd1-Npl4 complex [PATH:aga04141]
COPII complex [PATH:aga04141]
Other DBs
Anopheles gambiae (mosquito) [GN:aga]
AGAP009182-PA [KO:K10956]
AGAP011504-PA [KO:K09481]
AGAP009788-PA [KO:K12275]
AGAP007361-PA [KO:K09540]
AGAP010174-PA [KO:K12666]
AGAP007638-PA [KO:K12667]
AGAP008491-PA [KO:K12668]
AGAP010010-PA [KO:K12669]
AGAP006383-PA [KO:K12670]
AGAP000434-PA [KO:K07151] [EC:]
AGAP002396-PA [KO:K07151] [EC:]
AGAP003488-PA [KO:K14001]
AGAP001827-PA [KO:K09486]
AGAP004192-PA [KO:K09490]
AGAP008327-PA [KO:K09517]
AGAP000261-PA [KO:K09521]
AGAP002752-PA [KO:K09523]
AGAP001424-PA [KO:K09487]
AGAP000862-PA [KO:K05546] [EC:]
AGAP004609-PA [KO:K08288]
AGAP005032-PA [KO:K08054]
AGAP007393-PA [KO:K08056] [EC:]
AGAP004212-PA [KO:K08057]
AGAP003884-PB [KO:K01230] [EC:]
AGAP000558-PB [KO:K01230] [EC:]
AGAP004407-PA [KO:K10082]
AGAP005404-PA [KO:K10080]
AGAP009942-PA [KO:K14003]
AGAP004098-PA [KO:K07953] [EC:3.6.5.-]
AGAP003183-PA [KO:K14004]
AGAP011551-PA [KO:K14005]
AGAP001759-PA [KO:K14006]
AGAP005263-PA [KO:K14007]
AGAP003560-PA [KO:K11718] [EC:2.4.1.-]
AGAP012463-PA [KO:K10085]
AGAP008749-PA [KO:K10086]
AGAP012407-PA [KO:K09580] [EC:]
AGAP001919-PA [KO:K09584] [EC:]
AGAP000395-PA [KO:K09586]
AGAP000044-PA [KO:K13984]
AGAP002816-PA [KO:K10950] [EC:1.8.4.-]
AGAP009546-PA [KO:K14008]
AGAP001721-PA [KO:K13249]
AGAP005861-PB [KO:K13250]
AGAP008761-PA [KO:K13251]
AGAP010557-PA [KO:K14009]
AGAP010386-PA [KO:K14010]
AGAP009288-PA [KO:K11519]
AGAP000832-PA [KO:K13989]
AGAP006391-PA [KO:K14011]
AGAP005122-PA [KO:K14012]
AGAP013220-PA [KO:K14014]
AGAP005630-PA [KO:K13525]
AGAP001986-PA [KO:K14015]
AGAP001307-PA [KO:K14016]
AGAP004582-PA [KO:K03283]
AGAP004944-PA [KO:K03283]
AGAP012891-PA [KO:K03283]
AGAP002076-PA [KO:K03283]
AGAP004581-PA [KO:K03283]
AGAP004583-PA [KO:K03283]
AGAP005981-PA [KO:K09502]
AGAP000008-PA [KO:K09502]
AGAP001810-PA [KO:K09518]
AGAP001859-PB [KO:K09518]
AGAP007620-PA [KO:K09525]
HSP83_ANOGA; AGAP006958-PA [KO:K04079]
AGAP006961-PA [KO:K04079]
AGAP006959-PA [KO:K04079]
AGAP010331-PA [KO:K09485]
AGAP010983-PA [KO:K09556]
AGAP008392-PA [KO:K09562]
AGAP007162-PB [KO:K09542]
AGAP005547-PA [KO:K09542]
AGAP005548-PA [KO:K09542]
AGAP007161-PA [KO:K09542]
AGAP007158-PA [KO:K09542]
AGAP007159-PA [KO:K09542]
AGAP007001-PA [KO:K13719] [EC:3.1.2.-]
AGAP008620-PA [KO:K14018]
AGAP000733-PA [KO:K10839]
AGAP004294-PA [KO:K04523]
AGAP007390-PA [KO:K01456] [EC:]
AGAP007870-PA [KO:K10597] [EC:]
AGAP010925-PA [KO:K16194] [EC:]
AGAP013266-PA [KO:K08860] [EC:]
AGAP012368-PA [KO:K16196] [EC:]
AGAP011190-PA [KO:K03237]
AGAP008832-PA [KO:K09054]
AGAP004409-PA [KO:K14020]
AGAP012203-PA [KO:K08653] [EC:]
AGAP011819-PA [KO:K07765] [EC:]
AGAP010623-PA [KO:K09027]
AGAP004176-PA [KO:K08852] [EC:3.1.26.-]
AGAP000747-PB [KO:K04426] [EC:]
AGAP001867-PA [KO:K04431] [EC:]
AGAP009461-PA [KO:K04440] [EC:]
AGAP009460-PA [KO:K04440] [EC:]
AGAP007204-PA [KO:K10661] [EC:]
AGAP005954-PA [KO:K04554] [EC:]
AGAP002251-PA [KO:K10575] [EC:]
AGAP002169-PA [KO:K04555] [EC:]
AGAP003179-PA [KO:K10601] [EC:]
AGAP006041-PA [KO:K10666] [EC:]
AGAP000615-PA [KO:K14026]
AGAP007538-PA [KO:K10636] [EC:]
AGAP008918-PA [KO:K09561] [EC:]
AGAP000145-PA [KO:K06689] [EC:]
AGAP006580-PA [KO:K04556] [EC:]
AGAP005202-PB [KO:K03868]
AGAP008007-PA [KO:K03347]
AGAP008719-PA [KO:K03094]
Calcium cation
Naidoo N
ER and aging-Protein folding and the ER stress response.
Ageing Res Rev 8:150-9 (2009)
Malhotra JD, Kaufman RJ
The endoplasmic reticulum and the unfolded protein response.
Semin Cell Dev Biol 18:716-31 (2007)
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
Protein quality control in the ER: the recognition of misfolded proteins.
Semin Cell Dev Biol 21:500-11 (2010)
Stolz A, Wolf DH
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
Biochim Biophys Acta 1803:694-705 (2010)
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
J Proteome Res 9:1763-71 (2010)
KO pathway

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