KEGG   PATHWAY: aje04145Help
Entry
aje04145                    Pathway                                

Name
Phagosome - Histoplasma capsulatum
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Phagosome
aje04145

All organismsOrtholog table
Module
Sec61 complex [PATH:aje04145]
Other DBs
BSID: 
GO: 
Organism
Histoplasma capsulatum [GN:aje]
Gene
hypothetical protein [KO:K08488]
actin [KO:K05692]
protein transport protein sec22 [KO:K08517]
GTP-binding protein ypt5 [KO:K07889]
GTP-binding protein YPT52 [KO:K07889]
similar to phosphatidylinositol 3-kinase [KO:K00914] [EC:2.7.1.137]
hypothetical protein [KO:K12182]
vacuolar ATP synthase catalytic subunit A [KO:K02145] [EC:3.6.3.14]
vacuolar ATP synthase subunit B [KO:K02147]
hypothetical protein [KO:K02148]
vacuolar ATP synthase subunit D [KO:K02149]
vacuolar ATP synthase subunit E [KO:K02150]
hypothetical protein [KO:K02151]
hypothetical protein [KO:K02152]
vacuolar ATP synthase 98 kDa subunit [KO:K02154]
vacuolar ATP synthase subunit d [KO:K02146]
hypothetical protein [KO:K02144]
vacuolar membrane ATPase C [KO:K02155]
vacuolar ATP synthase 16 kDa proteolipid subunit 2 [KO:K02155]
GTP-binding protein YPT7 [KO:K07897]
dynein heavy chain [KO:K10413]
dynein heavy chain [KO:K10413]
similar to cytoplasmic dynein intermediate chain [KO:K10415]
hypothetical protein [KO:K10416]
tubulin subunit alpha-2 [KO:K07374]
tubulin alpha chain [KO:K07374]
tubulin beta chain [KO:K07375]
hypothetical protein [KO:K00921] [EC:2.7.1.150]
hypothetical protein [KO:K10089]
protein transport protein SEC61 alpha subunit [KO:K10956]
hypothetical protein [KO:K09481]
hypothetical protein [KO:K07342]
similar to calnexin [KO:K08054]
similar to NADPH oxidase [KO:K08008]
similar to NADPH oxidase isoform 2 [KO:K08008]
protein rho2 [KO:K04392]
Compound
C04549  
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
Reference
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
Reference
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
Reference
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
Reference
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
Reference
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
KO pathway
 

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