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aje04145                    Pathway                                

Phagosome - Histoplasma capsulatum
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Cellular Processes; Transport and catabolism
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All organismsOrtholog table
Sec61 complex [PATH:aje04145]
Other DBs
Histoplasma capsulatum [GN:aje]
hypothetical protein; K08488 syntaxin 7 [KO:K08488]
actin; K05692 actin beta/gamma 1 [KO:K05692]
protein transport protein sec22; K08517 vesicle transport protein SEC22 [KO:K08517]
GTP-binding protein ypt5; K07889 Ras-related protein Rab-5C [KO:K07889]
similar to phosphatidylinositol 3-kinase; K00914 phosphatidylinositol 3-kinase [EC:] [KO:K00914] [EC:]
hypothetical protein; K12182 hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
vacuolar ATP synthase catalytic subunit A; K02145 V-type H+-transporting ATPase subunit A [EC:] [KO:K02145] [EC:]
vacuolar ATP synthase subunit B; K02147 V-type H+-transporting ATPase subunit B [KO:K02147]
hypothetical protein; K02148 V-type H+-transporting ATPase subunit C [KO:K02148]
vacuolar ATP synthase subunit D; K02149 V-type H+-transporting ATPase subunit D [KO:K02149]
vacuolar ATP synthase subunit E; K02150 V-type H+-transporting ATPase subunit E [KO:K02150]
hypothetical protein; K02151 V-type H+-transporting ATPase subunit F [KO:K02151]
hypothetical protein; K02152 V-type H+-transporting ATPase subunit G [KO:K02152]
vacuolar ATP synthase 98 kDa subunit; K02154 V-type H+-transporting ATPase subunit a [KO:K02154]
vacuolar ATP synthase subunit d; K02146 V-type H+-transporting ATPase subunit d [KO:K02146]
hypothetical protein; K02144 V-type H+-transporting ATPase subunit H [KO:K02144]
vacuolar membrane ATPase C; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
vacuolar ATP synthase 16 kDa proteolipid subunit 2; K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit [KO:K02155]
GTP-binding protein YPT7; K07897 Ras-related protein Rab-7A [KO:K07897]
dynein heavy chain; K10413 dynein heavy chain 1, cytosolic [KO:K10413]
dynein heavy chain; K10413 dynein heavy chain 1, cytosolic [KO:K10413]
similar to cytoplasmic dynein intermediate chain; K10415 dynein intermediate chain, cytosolic [KO:K10415]
hypothetical protein; K10416 dynein light intermediate chain 1, cytosolic [KO:K10416]
tubulin subunit alpha-2; K07374 tubulin alpha [KO:K07374]
tubulin alpha chain; K07374 tubulin alpha [KO:K07374]
tubulin beta chain; K07375 tubulin beta [KO:K07375]
hypothetical protein; K00921 1-phosphatidylinositol-3-phosphate 5-kinase [EC:] [KO:K00921] [EC:]
hypothetical protein; K10089 cation-dependent mannose-6-phosphate receptor [KO:K10089]
protein transport protein SEC61 alpha subunit; K10956 protein transport protein SEC61 subunit alpha [KO:K10956]
hypothetical protein; K09481 protein transport protein SEC61 subunit beta [KO:K09481]
hypothetical protein; K07342 protein transport protein SEC61 subunit gamma and related proteins [KO:K07342]
similar to calnexin; K08054 calnexin [KO:K08054]
similar to NADPH oxidase; K08008 NADPH oxidase [KO:K08008]
similar to NADPH oxidase isoform 2; K08008 NADPH oxidase [KO:K08008]
protein rho2; K04392 Ras-related C3 botulinum toxin substrate 1 [KO:K04392]
1-Phosphatidyl-1D-myo-inositol 3-phosphate
Stuart LM, Ezekowitz RA
Phagocytosis: elegant complexity.
Immunity 22:539-50 (2005)
Tjelle TE, Lovdal T, Berg T
Phagosome dynamics and function.
Bioessays 22:255-63 (2000)
Dupuy AG, Caron E
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
J Cell Sci 121:1773-83 (2008)
Brumell JH, Grinstein S
Salmonella redirects phagosomal maturation.
Curr Opin Microbiol 7:78-84 (2004)
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
LAMP proteins are required for fusion of lysosomes with phagosomes.
EMBO J 26:313-24 (2007)
Luzio JP, Pryor PR, Bright NA
Lysosomes: fusion and function.
Nat Rev Mol Cell Biol 8:622-32 (2007)
Sumimoto H
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
FEBS J 275:3249-77 (2008)
KO pathway

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