KEGG   PATHWAY: aml00564
Entry
aml00564                    Pathway                                
Name
Glycerophospholipid metabolism - Ailuropoda melanoleuca (giant panda)
Class
Metabolism; Lipid metabolism
Pathway map
aml00564  Glycerophospholipid metabolism
aml00564

Module
aml_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:aml00564]
aml_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:aml00564]
aml_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:aml00564]
Other DBs
GO: 0006650
Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100473892  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
100470374  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
100482626  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
100468728  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
100478256  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X5 [KO:K00629] [EC:2.3.1.15]
100463623  GPAT3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
100483093  GPAT4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
100476518  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
100469184  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
100476840  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
100465163  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1 [KO:K13523] [EC:2.3.1.51 2.3.1.-]
100467346  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
100476509  LCLAT1; lysocardiolipin acyltransferase 1 isoform X2 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
100483522  MBOAT2; lysophospholipid acyltransferase 2 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
100484290  MBOAT1; lysophospholipid acyltransferase 1 isoform X2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
100472094  GNPAT; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
100484618  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
100475075  PLPP2; phospholipid phosphatase 2 isoform X2 [KO:K01080] [EC:3.1.3.4]
100479871  PLPP1; phospholipid phosphatase 1 isoform X2 [KO:K01080] [EC:3.1.3.4]
100481127  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
100465923  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
100480077  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
100466187  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
100473006  PLPP5; phospholipid phosphatase 5 isoform X12 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
100481980  PLPP4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
100481233  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
100473609  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
100467810  DGKA; diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
100463647  DGKD; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
100483868  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
100483027  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
100471116  DGKZ; diacylglycerol kinase zeta isoform X4 [KO:K00901] [EC:2.7.1.107]
100465305  DGKI; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
100482826  DGKH; diacylglycerol kinase eta isoform X3 [KO:K00901] [EC:2.7.1.107]
105237007  DGKK; diacylglycerol kinase kappa [KO:K00901] [EC:2.7.1.107]
100484386  CHPT1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
100473311  CEPT1; choline/ethanolaminephosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
100477588  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
100484111  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
100468263  PLD3; 5'-3' exonuclease PLD3 isoform X1 [KO:K16860] [EC:3.1.4.4]
100466285  PLD4; LOW QUALITY PROTEIN: 5'-3' exonuclease PLD4 [KO:K16860] [EC:3.1.4.4]
100469078  LCAT; phosphatidylcholine-sterol acyltransferase isoform X2 [KO:K00650] [EC:2.3.1.43]
100484745  PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100478212  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100463545  group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100463798  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100464051  PLA2G2C; putative inactive group IIC secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
100471349  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100479059  PLA2G3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
100475358  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100480927  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
100473488  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
117796269  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100470490  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
100482619  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
100469987  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
100470240  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
100470998  cytosolic phospholipase A2 beta isoform X2 [KO:K16342] [EC:3.1.1.4]
100472577  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X4 [KO:K16343] [EC:3.1.1.4]
100471208  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
100476627  PLAAT3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100467983  phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100464874  LPCAT2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
100480167  LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
100471481  LPCAT4; lysophospholipid acyltransferase LPCAT4 isoform X1 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
100472770  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
100478269  LYPLA1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
100477335  PLA2G15; phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
100476783  LYPLA2; acyl-protein thioesterase 2 isoform X2 [KO:K06130] [EC:3.1.1.5]
100465087  PNPLA6; patatin-like phospholipase domain-containing protein 6 isoform X1 [KO:K14676] [EC:3.1.1.5]
100467869  PNPLA7; LOW QUALITY PROTEIN: patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
100464203  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
105240673  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
100482126  ACHE; acetylcholinesterase isoform X1 [KO:K01049] [EC:3.1.1.7]
100472870  CHKA; choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
100482241  CHKB; choline/ethanolamine kinase isoform X2 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
100484341  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase isoform X1 [KO:K06124] [EC:3.1.3.75]
100465781  PCYT1B; choline-phosphate cytidylyltransferase B isoform X2 [KO:K00968] [EC:2.7.7.15]
100473355  PCYT1A; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
100469400  SELENOI; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
100463892  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
100469833  ETNK2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
100470488  PCYT2; ethanolamine-phosphate cytidylyltransferase isoform X1 [KO:K00967] [EC:2.7.7.14]
100467475  ETNPPL; ethanolamine-phosphate phospho-lyase isoform X1 [KO:K14286] [EC:4.2.3.2]
100471478  PEMT; phosphatidylethanolamine N-methyltransferase isoform X1 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
100483815  CDS1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
100475824  CDS2; phosphatidate cytidylyltransferase 2 isoform X1 [KO:K00981] [EC:2.7.7.41]
100483166  PLA1A; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
100468000  PTDSS1; phosphatidylserine synthase 1 isoform X1 [KO:K08729] [EC:2.7.8.-]
100475601  PTDSS2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
100468150  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X3 [KO:K01613] [EC:4.1.1.65]
100480076  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial isoform X1 [KO:K00995] [EC:2.7.8.5]
100467607  CRLS1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
100469042  tafazzin [KO:K13511] [EC:2.3.1.-]
100476631  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
100475176  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
100464529  MBOAT7; lysophospholipid acyltransferase 7 isoform X1 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
aml00010  Glycolysis / Gluconeogenesis
aml00260  Glycine, serine and threonine metabolism
aml00561  Glycerolipid metabolism
aml00562  Inositol phosphate metabolism
aml00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
aml00565  Ether lipid metabolism
aml00620  Pyruvate metabolism
KO pathway
ko00564   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (97)   
   KEGG GENES (97)   
All databases (98)   

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