KEGG   PATHWAY: aml05166Help
Entry
aml05166                    Pathway                                

Name
HTLV-I infection - Ailuropoda melanoleuca (giant panda)
Description
Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, SRF, and NFAT.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
HTLV-I infection
aml05166

All organismsOrtholog table
Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
TGFB2; transforming growth factor, beta 2 [KO:K13376]
TGFB3; transforming growth factor, beta 3 [KO:K13377]
SLC2A1; solute carrier family 2 (facilitated glucose transporter), member 1 [KO:K07299]
NRP1; neuropilin 1 [KO:K06724]
VCAM1; vascular cell adhesion molecule 1 [KO:K06527]
CD3D; CD3d molecule, delta (CD3-TCR complex) [KO:K06450]
CD3E; CD3e molecule, epsilon (CD3-TCR complex) [KO:K06451]
CD3G; CD3g molecule, gamma (CD3-TCR complex) [KO:K06452]
ICAM1; intercellular adhesion molecule 1 [KO:K06490]
ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1 [KO:K05718]
ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) [KO:K06464]
TLN1; talin 1 [KO:K06271]
TLN2; talin 2 [KO:K06271]
MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
TRRAP; transformation/transcription domain-associated protein [KO:K08874]
KAT5; K(lysine) acetyltransferase 5 [KO:K11304] [EC:2.3.1.48]
CCND2; cyclin D2 [KO:K10151]
RANBP3L; RAN binding protein 3-like [KO:K15304]
RAN; RAN, member RAS oncogene family [KO:K07936]
XPO1; exportin 1 [KO:K14290]
class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
AIME-152; class I histocompatibility antigen, Aime-152 [KO:K06751]
H-2 class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
CALR; calreticulin [KO:K08057]
PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
PPP3R2; protein phosphatase 3, regulatory subunit B, beta [KO:K06268]
PPP3R1; protein phosphatase 3, regulatory subunit B, alpha [KO:K06268]
NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 [KO:K04446]
NFATC2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 [KO:K17332]
NFATC3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 [KO:K17333]
NFATC4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 [KO:K17334]
CANX; calnexin [KO:K08054]
IL2RB; interleukin 2 receptor, beta [KO:K05069]
IL2RG; interleukin 2 receptor, gamma [KO:K05070]
JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
HRAS; Harvey rat sarcoma viral oncogene homolog [KO:K02833]
KRAS; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
MRAS; muscle RAS oncogene homolog [KO:K07831]
VDAC1; voltage-dependent anion channel 1 [KO:K05862]
SLC25A4; solute carrier family 25 (mitochondrial carrier [KO:K05863]
SLC25A31; solute carrier family 25 (mitochondrial carrier [KO:K05863]
SLC25A6; solute carrier family 25 (mitochondrial carrier [KO:K05863]
SLC25A5; solute carrier family 25 (mitochondrial carrier [KO:K05863]
VDAC2; voltage-dependent anion channel 2 [KO:K15040]
VDAC3; voltage-dependent anion channel 3 [KO:K15041]
TSPO; translocator protein (18kDa) [KO:K05770]
VAC14; Vac14 homolog (S. cerevisiae) [KO:K15305]
BUB1B; BUB1 mitotic checkpoint serine/threonine kinase B [KO:K06637] [EC:2.7.11.1]
BUB3; BUB3 mitotic checkpoint protein [KO:K02180]
CDC20; cell division cycle 20 [KO:K03363]
ANAPC1; anaphase promoting complex subunit 1 [KO:K03348]
ANAPC2; anaphase promoting complex subunit 2 [KO:K03349]
CDC27; cell division cycle 27 [KO:K03350]
ANAPC4; anaphase promoting complex subunit 4 [KO:K03351]
ANAPC5; anaphase promoting complex subunit 5 [KO:K03352]
CDC16; cell division cycle 16 [KO:K03353]
ANAPC7; anaphase promoting complex subunit 7 [KO:K03354]
CDC23; cell division cycle 23 [KO:K03355]
ANAPC10; anaphase promoting complex subunit 10 [KO:K03357]
ANAPC11; anaphase promoting complex subunit 11 [KO:K03358]
CDC26; cell division cycle 26 [KO:K03359]
PTTG1; pituitary tumor-transforming 1 [KO:K06635]
CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1) [KO:K06625]
PCNA; proliferating cell nuclear antigen [KO:K04802]
POLD1; polymerase (DNA directed), delta 1, catalytic subunit [KO:K02327] [EC:2.7.7.7]
POLD2; polymerase (DNA directed), delta 2, accessory subunit [KO:K02328]
POLD3; polymerase (DNA-directed), delta 3, accessory subunit [KO:K03504]
POLD4; polymerase (DNA-directed), delta 4, accessory subunit [KO:K03505]
POLE; polymerase (DNA directed), epsilon, catalytic subunit [KO:K02324] [EC:2.7.7.7]
POLE2; polymerase (DNA directed), epsilon 2, accessory subunit [KO:K02325] [EC:2.7.7.7]
POLE3; polymerase (DNA directed), epsilon 3, accessory subunit [KO:K02326] [EC:2.7.7.7]
POLE4; polymerase (DNA-directed), epsilon 4, accessory subunit [KO:K03506] [EC:2.7.7.7]
CCND1; cyclin D1 [KO:K04503]
CCND3; cyclin D3 [KO:K10152]
CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
RB1; retinoblastoma 1 [KO:K06618]
E2F2; E2F transcription factor 2 [KO:K09389]
E2F3; E2F transcription factor 3 [KO:K06620]
cyclin-dependent kinase 4 inhibitor B-like; K06621 cyclin-dependent kinase inhibitor 2A [KO:K06621]
CDKN2B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) [KO:K04685]
WNT1; wingless-type MMTV integration site family, member 1 [KO:K03209]
WNT2; wingless-type MMTV integration site family member 2 [KO:K00182]
WNT2B; wingless-type MMTV integration site family, member 2B [KO:K00182]
WNT3; wingless-type MMTV integration site family, member 3 [KO:K00312]
WNT3A; wingless-type MMTV integration site family, member 3A [KO:K00312]
WNT4; wingless-type MMTV integration site family, member 4 [KO:K00408]
WNT5A; wingless-type MMTV integration site family, member 5A [KO:K00444]
WNT5B; wingless-type MMTV integration site family, member 5B [KO:K00444]
WNT6; wingless-type MMTV integration site family, member 6 [KO:K00445]
WNT7A; wingless-type MMTV integration site family, member 7A [KO:K00572]
WNT7B; wingless-type MMTV integration site family, member 7B [KO:K00572]
WNT8B; wingless-type MMTV integration site family, member 8B [KO:K00714]
WNT8A; wingless-type MMTV integration site family, member 8A [KO:K00714]
WNT9B; wingless-type MMTV integration site family, member 9B [KO:K01064]
WNT9A; wingless-type MMTV integration site family, member 9A [KO:K01064]
WNT10A; wingless-type MMTV integration site family, member 10A [KO:K01357]
WNT10B; wingless-type MMTV integration site family, member 10B [KO:K01357]
WNT11; wingless-type MMTV integration site family, member 11 [KO:K01384]
WNT16; wingless-type MMTV integration site family, member 16 [KO:K01558]
FZD1; frizzled class receptor 1 [KO:K02432]
FZD3; frizzled class receptor 3 [KO:K02329]
FZD4; frizzled class receptor 4 [KO:K02354]
FZD5; frizzled class receptor 5 [KO:K02375]
FZD6; frizzled class receptor 6 [KO:K02376]
FZD10; frizzled class receptor 10 [KO:K02842]
DVL3; dishevelled segment polarity protein 3 [KO:K02353]
DVL1; dishevelled segment polarity protein 1 [KO:K02353]
DVL2; dishevelled segment polarity protein 2 [KO:K02353]
GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
CTNNB1; catenin (cadherin-associated protein), beta 1, 88kDa [KO:K02105]
APC; adenomatous polyposis coli [KO:K02085]
APC2; adenomatosis polyposis coli 2 [KO:K02085]
DLG1; discs, large homolog 1 (Drosophila) [KO:K12076]
PDGFA; platelet-derived growth factor alpha polypeptide [KO:K04359]
PDGFB; platelet-derived growth factor beta polypeptide [KO:K17386]
PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
PDGFRB; platelet-derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta) [KO:K02649]
PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha) [KO:K02649]
PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5 [KO:K02649]
PIK3R3; phosphoinositide-3-kinase, regulatory subunit 3 (gamma) [KO:K02649]
PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma [KO:K00922] [EC:2.7.1.153]
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
AKT3; v-akt murine thymoma viral oncogene homolog 3 [KO:K04456] [EC:2.7.11.1]
AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
TNF; tumor necrosis factor [KO:K03156]
TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A [KO:K03158]
MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase [KO:K04416] [EC:2.7.11.25]
MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
JUN; jun proto-oncogene [KO:K04448]
IL1R1; interleukin 1 receptor, type I [KO:K04386]
IL1R2; interleukin 1 receptor, type II [KO:K04387]
MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO:K07210]
NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [KO:K04734]
NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A [KO:K04735]
LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3) [KO:K03159]
CD40; CD40 molecule, TNF receptor superfamily member 5 [KO:K03160]
TNFRSF13C; tumor necrosis factor receptor superfamily, member 13C [KO:K05151]
MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
RELB; v-rel avian reticuloendotheliosis viral oncogene homolog B [KO:K09253]
NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) [KO:K04469]
IL2; interleukin 2 [KO:K05429]
IL2RA; interleukin 2 receptor, alpha [KO:K05068]
IL15; interleukin 15 [KO:K05433]
IL6; interleukin 6 [KO:K05405]
CSF2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427]
LTA; lymphotoxin alpha [KO:K05468]
BCL2L1; BCL2-like 1 [KO:K04570]
XIAP; X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase [KO:K04725]
ZFP36; ZFP36 ring finger protein [KO:K15308]
NFYB; nuclear transcription factor Y, beta [KO:K08065]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
SLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
DLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
ELK4; ELK4, ETS-domain protein (SRF accessory protein 1) [KO:K04376]
ELK1; ELK1, member of ETS oncogene family [KO:K04375]
SPI1; Spi-1 proto-oncogene [KO:K09438]
ETS1; v-ets avian erythroblastosis virus E26 oncogene homolog 1 [KO:K02678]
ETS2; v-ets avian erythroblastosis virus E26 oncogene homolog 2 [KO:K02678]
TBPL1; TBP-like 1 [KO:K03120]
TBP; TATA box binding protein [KO:K03120]
FOS; FBJ murine osteosarcoma viral oncogene homolog [KO:K04379]
EGR1; early growth response 1 [KO:K09203]
EGR2; early growth response 2 [KO:K12496]
FOSL1; FOS-like antigen 1 [KO:K04502]
ADCY1; adenylate cyclase 1 (brain) [KO:K08041] [EC:4.6.1.1]
ADCY2; adenylate cyclase 2 (brain) [KO:K08042] [EC:4.6.1.1]
ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
ADCY8; adenylate cyclase 8 (brain) [KO:K08048] [EC:4.6.1.1]
ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
PRKX; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
PRKACA; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
PRKACB; protein kinase, cAMP-dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
CREB1; cAMP responsive element binding protein 1 [KO:K05870]
CREM; cAMP responsive element modulator [KO:K09052]
ATF1; activating transcription factor 1 [KO:K09053]
ATF2; activating transcription factor 2 [KO:K04450]
ATF3; activating transcription factor 3 [KO:K09032]
ATF4; activating transcription factor 4 [KO:K04374]
CRTC1; CREB regulated transcription coactivator 1 [KO:K15309]
CREB-regulated transcription coactivator 2-like; K16333 CREB-regulated transcription coactivator 2 [KO:K16333]
CRTC2; CREB regulated transcription coactivator 2 [KO:K16333]
CRTC3; CREB regulated transcription coactivator 3 [KO:K16334]
CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
KAT2B; K(lysine) acetyltransferase 2B [KO:K06062] [EC:2.3.1.48]
KAT2A; K(lysine) acetyltransferase 2A [KO:K06062] [EC:2.3.1.48]
TCF3; transcription factor 3 [KO:K09063]
POLB; polymerase (DNA directed), beta [KO:K02330] [EC:4.2.99.- 2.7.7.7]
CDKN2C; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) [KO:K06622]
LCK; LCK proto-oncogene, Src family tyrosine kinase [KO:K05856] [EC:2.7.10.2]
MYB; v-myb avian myeloblastosis viral oncogene homolog [KO:K09420]
MYBL1; v-myb avian myeloblastosis viral oncogene homolog-like 1 [KO:K09421]
MYBL2; v-myb avian myeloblastosis viral oncogene homolog-like 2 [KO:K09421]
TGFBR1; transforming growth factor, beta receptor 1 [KO:K04674] [EC:2.7.11.30]
TGFBR2; transforming growth factor, beta receptor II (70/80kDa) [KO:K04388] [EC:2.7.11.30]
SMAD3; SMAD family member 3 [KO:K04500]
SMAD2; SMAD family member 2 [KO:K04500]
SMAD4; SMAD family member 4 [KO:K04501]
ATM; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
ATR; ATR serine/threonine kinase [KO:K06640] [EC:2.7.11.1]
CHEK1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
CHEK2; checkpoint kinase 2 [KO:K06641] [EC:2.7.11.1]
TP53; tumor protein p53 [KO:K04451]
BAX; BCL2-associated X protein [KO:K02159]
TP53INP1; tumor protein p53 inducible nuclear protein 1 [KO:K15310]
MSX2; msh homeobox 2 [KO:K09341]
MSX1; msh homeobox 1 [KO:K09341]
homeobox protein MSX-3-like; K09341 homeobox protein MSX [KO:K09341]
 
 
 
 
Compound
C00027  
Hydrogen peroxide
C00076  
Calcium cation
C00238  
Potassium cation
C00575  
3',5'-Cyclic AMP
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C18994  
Accessory protein p12I
C18995  
P13 protein
C18996  
Accessory protein p30II
C19313  
HTLV-1 basic zipper factor
Reference
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
Reference
  Authors
Gatza ML, Watt JC, Marriott SJ
  Title
Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades.
  Journal
Oncogene 22:5141-9 (2003)
Reference
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
Reference
  Authors
Boxus M, Willems L
  Title
Mechanisms of HTLV-1 persistence and transformation.
  Journal
Br J Cancer 101:1497-501 (2009)
Reference
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
Reference
  Authors
Yasunaga J, Matsuoka M
  Title
[HTLV-I and leukemogenesis].
  Journal
Uirusu 56:241-9 (2006)
Reference
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
Reference
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
Reference
  Authors
Peloponese JM Jr, Jeang KT
  Title
Role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by the human T-cell leukemia virus type 1 tax oncoprotein.
  Journal
J Biol Chem 281:8927-38 (2006)
Reference
  Authors
Marriott SJ, Semmes OJ
  Title
Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response.
  Journal
Oncogene 24:5986-95 (2005)
Reference
  Authors
Jeang KT
  Title
Functional activities of the human T-cell leukemia virus type I Tax oncoprotein:  cellular signaling through NF-kappa B.
  Journal
Cytokine Growth Factor Rev 12:207-17 (2001)
Reference
  Authors
Bouzar AB, Willems L
  Title
How HTLV-1 may subvert miRNAs for persistence and transformation.
  Journal
Retrovirology 5:101 (2008)
Reference
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
Reference
  Authors
Manel N, Battini JL, Taylor N, Sitbon M
  Title
HTLV-1 tropism and envelope receptor.
  Journal
Oncogene 24:6016-25 (2005)
Reference
  Authors
Sun SC, Ballard DW
  Title
Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases.
  Journal
Oncogene 18:6948-58 (1999)
Reference
  Authors
Taylor GP, Matsuoka M
  Title
Natural history of adult T-cell leukemia/lymphoma and approaches to therapy.
  Journal
Oncogene 24:6047-57 (2005)
Reference
  Authors
Franchini G, Fukumoto R, Fullen JR
  Title
T-cell control by human T-cell leukemia/lymphoma virus type 1.
  Journal
Int J Hematol 78:280-96 (2003)
Reference
  Authors
Baydoun HH, Bellon M, Nicot C
  Title
HTLV-1 Yin and Yang: Rex and p30 master regulators of viral mRNA trafficking.
  Journal
AIDS Rev 10:195-204 (2008)
Reference
PMID:9325311
  Authors
Jin DY, Teramoto H, Giam CZ, Chun RF, Gutkind JS, Jeang KT
  Title
A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha.
  Journal
J Biol Chem 272:25816-23 (1997)
Reference
  Authors
Pise-Masison CA, Brady JN
  Title
Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function.
  Journal
Front Biosci 10:919-30 (2005)
KO pathway
 

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