KEGG   PATHWAY: aml05166Help
Entry
aml05166                    Pathway                                

Name
HTLV-I infection - Ailuropoda melanoleuca (giant panda)
Description
Human T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, SRF, and NFAT.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
HTLV-I infection
aml05166

All organismsOrtholog table
Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
transforming growth factor beta-2-like; K13376 transforming growth factor beta-2 [KO:K13376]
transforming growth factor beta-3-like; K13377 transforming growth factor beta-3 [KO:K13377]
SLC2A1; solute carrier family 2 (facilitated glucose transporter), member 1 [KO:K07299]
NRP1; neuropilin 1 [KO:K06724]
vascular cell adhesion protein 1-like; K06527 vascular cell adhesion molecule 1 [KO:K06527]
t-cell surface glycoprotein CD3 delta chain-like; K06450 T-cell surface glycoprotein CD3 delta chain [KO:K06450]
t-cell surface glycoprotein CD3 epsilon chain-like; K06451 T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
t-cell surface glycoprotein CD3 gamma chain-like; K06452 T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
intercellular adhesion molecule 1-like; K06490 intercellular adhesion molecule 1 [KO:K06490]
ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1 [KO:K05718]
integrin beta-2-like; K06464 integrin beta 2 [KO:K06464]
TLN1; talin 1 [KO:K06271]
TLN2; talin 2 [KO:K06271]
myc proto-oncogene protein-like; K04377 Myc proto-oncogene protein [KO:K04377]
transformation/transcription domain-associated protein-like; K08874 transformation/transcription domain-associated protein [KO:K08874]
histone acetyltransferase KAT5-like; K11304 histone acetyltransferase HTATIP [EC:2.3.1.48] [KO:K11304] [EC:2.3.1.48]
g1/S-specific cyclin-D2-like; K10151 cyclin D2 [KO:K10151]
RANBP3L; RAN binding protein 3-like [KO:K15304]
GTP-binding nuclear protein Ran-like; K07936 GTP-binding nuclear protein Ran [KO:K07936]
GTP-binding nuclear protein Ran-like; K07936 GTP-binding nuclear protein Ran [KO:K07936]
GTP-binding nuclear protein Ran-like; K07936 GTP-binding nuclear protein Ran [KO:K07936]
exportin-1-like; K14290 exportin-1 [KO:K14290]
class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
AIME-152; class I histocompatibility antigen, Aime-152 [KO:K06751]
class I histocompatibility antigen; K06751 major histocompatibility complex, class I [KO:K06751]
calreticulin-like; K08057 calreticulin [KO:K08057]
PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like; K04348 serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16] [KO:K04348] [EC:3.1.3.16]
serine/threonine-protein phosphatase 2B catalytic subunit beta isoform-like; K04348 serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16] [KO:K04348] [EC:3.1.3.16]
calcineurin subunit B type 2-like; K06268 serine/threonine-protein phosphatase 2B regulatory subunit [KO:K06268]
calcineurin subunit B type 1-like; K06268 serine/threonine-protein phosphatase 2B regulatory subunit [KO:K06268]
NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 [KO:K04446]
NFATC2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 [KO:K17332]
NFATC3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 [KO:K17333]
nuclear factor of activated T-cells; K17334 nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
calnexin-like; K08054 calnexin [KO:K08054]
interleukin-2 receptor subunit beta-like; K05069 interleukin 2 receptor beta [KO:K05069]
cytokine receptor common subunit gamma-like; K05070 interleukin 2 receptor gamma [KO:K05070]
JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
tyrosine-protein kinase JAK3-like; K11218 Janus kinase 3 [EC:2.7.10.2] [KO:K11218] [EC:2.7.10.2]
signal transducer and activator of transcription 5A-like; K11223 signal transducer and activator of transcription 5A [KO:K11223]
signal transducer and activator of transcription 5B-like; K11224 signal transducer and activator of transcription 5B [KO:K11224]
GTPase HRas-like; K02833 GTPase HRas [KO:K02833]
GTPase KRas-like; K07827 GTPase KRas [KO:K07827]
GTPase NRas-like; K07828 GTPase NRas [KO:K07828]
ras-related protein R-Ras-like; K07829 Ras-related protein R-Ras [KO:K07829]
ras-related protein R-Ras2-like; K07830 Ras-related protein R-Ras2 [KO:K07830]
ras-related protein M-Ras-like; K07831 Ras-related protein M-Ras [KO:K07831]
voltage-dependent anion-selective channel protein 1-like; K05862 voltage-dependent anion channel protein 1 [KO:K05862]
ADP/ATP translocase 1-like; K05863 solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 [KO:K05863]
ADP/ATP translocase 4-like; K05863 solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 [KO:K05863]
ADP/ATP translocase 3-like; K05863 solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 [KO:K05863]
ADP/ATP translocase 2-like; K05863 solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 [KO:K05863]
voltage-dependent anion-selective channel protein 2-like; K15040 voltage-dependent anion channel protein 2 [KO:K15040]
voltage-dependent anion-selective channel protein 3-like; K15041 voltage-dependent anion channel protein 3 [KO:K15041]
translocator protein-like; K05770 benzodiazapine receptor [KO:K05770]
VAC14; Vac14 homolog (S. cerevisiae) [KO:K15305]
BUB1B; budding uninhibited by benzimidazoles 1 homolog beta (yeast) [KO:K06637] [EC:2.7.11.1]
mitotic checkpoint protein BUB3-like; K02180 cell cycle arrest protein BUB3 [KO:K02180]
cell division cycle protein 20 homolog; K03363 cell division cycle 20, cofactor of APC complex [KO:K03363]
ANAPC1; anaphase promoting complex subunit 1 [KO:K03348]
ANAPC2; anaphase promoting complex subunit 2 [KO:K03349]
cell division cycle protein 27 homolog; K03350 anaphase-promoting complex subunit 3 [KO:K03350]
ANAPC4; anaphase promoting complex subunit 4 [KO:K03351]
ANAPC5; anaphase promoting complex subunit 5 [KO:K03352]
cell division cycle protein 16 homolog; K03353 anaphase-promoting complex subunit 6 [KO:K03353]
ANAPC7; anaphase promoting complex subunit 7 [KO:K03354]
cell division cycle protein 23 homolog; K03355 anaphase-promoting complex subunit 8 [KO:K03355]
anaphase-promoting complex subunit 10-like; K03357 anaphase-promoting complex subunit 10 [KO:K03357]
anaphase-promoting complex subunit 11-like; K03358 anaphase-promoting complex subunit 11 [KO:K03358]
anaphase-promoting complex subunit CDC26-like; K03359 anaphase-promoting complex subunit 12 [KO:K03359]
securin-like; K06635 securin [KO:K06635]
cyclin-dependent kinase inhibitor 1-like; K06625 cyclin-dependent kinase inhibitor 1A [KO:K06625]
proliferating cell nuclear antigen-like; K04802 proliferating cell nuclear antigen [KO:K04802]
DNA polymerase delta catalytic subunit-like; K02327 DNA polymerase delta subunit 1 [EC:2.7.7.7] [KO:K02327] [EC:2.7.7.7]
DNA polymerase delta subunit 2-like; K02328 DNA polymerase delta subunit 2 [KO:K02328]
POLD3; polymerase (DNA-directed), delta 3, accessory subunit [KO:K03504]
DNA polymerase delta subunit 4-like; K03505 DNA polymerase delta subunit 4 [KO:K03505]
POLE; polymerase (DNA directed), epsilon, catalytic subunit [KO:K02324] [EC:2.7.7.7]
DNA polymerase epsilon subunit 2-like; K02325 DNA polymerase epsilon subunit 2 [EC:2.7.7.7] [KO:K02325] [EC:2.7.7.7]
DNA polymerase epsilon subunit 3-like; K02326 DNA polymerase epsilon subunit 3 [EC:2.7.7.7] [KO:K02326] [EC:2.7.7.7]
uncharacterized LOC100477978; K03506 DNA polymerase epsilon subunit 4 [EC:2.7.7.7] [KO:K03506] [EC:2.7.7.7]
g1/S-specific cyclin-D1-like; K04503 cyclin D1 [KO:K04503]
g1/S-specific cyclin-D3-like; K10152 cyclin D3 [KO:K10152]
cell division protein kinase 4-like; K02089 cyclin-dependent kinase 4 [EC:2.7.11.22] [KO:K02089] [EC:2.7.11.22]
RB1; retinoblastoma 1 [KO:K06618]
transcription factor E2F2-like; K09389 transcription factor E2F2 [KO:K09389]
transcription factor E2F3-like; K06620 transcription factor E2F3 [KO:K06620]
uncharacterized LOC100472171; K06621 cyclin-dependent kinase inhibitor 2A [KO:K06621]
cyclin-dependent kinase 4 inhibitor B-like; K04685 cyclin-dependent kinase inhibitor 2B [KO:K04685]
proto-oncogene Wnt-1-like; K03209 wingless-type MMTV integration site family, member 1 [KO:K03209]
protein Wnt-2-like; K00182 wingless-type MMTV integration site family, member 2 [KO:K00182]
WNT2B; wingless-type MMTV integration site family, member 2B [KO:K00182]
proto-oncogene Wnt-3-like; K00312 wingless-type MMTV integration site family, member 3 [KO:K00312]
protein Wnt-3a-like; K00312 wingless-type MMTV integration site family, member 3 [KO:K00312]
protein Wnt-4-like; K00408 wingless-type MMTV integration site family, member 4 [KO:K00408]
protein Wnt-5a-like; K00444 wingless-type MMTV integration site family, member 5 [KO:K00444]
protein Wnt-5b-like; K00444 wingless-type MMTV integration site family, member 5 [KO:K00444]
protein Wnt-6-like; K00445 wingless-type MMTV integration site family, member 6 [KO:K00445]
protein Wnt-7a-like; K00572 wingless-type MMTV integration site family, member 7 [KO:K00572]
WNT7B; wingless-type MMTV integration site family, member 7B [KO:K00572]
protein Wnt-8b-like; K00714 wingless-type MMTV integration site family, member 8 [KO:K00714]
protein Wnt-8a-like; K00714 wingless-type MMTV integration site family, member 8 [KO:K00714]
protein Wnt-9b-like; K01064 wingless-type MMTV integration site family, member 9 [KO:K01064]
protein Wnt-9a-like; K01064 wingless-type MMTV integration site family, member 9 [KO:K01064]
protein Wnt-10a-like; K01357 wingless-type MMTV integration site family, member 10 [KO:K01357]
protein Wnt-10b-like; K01357 wingless-type MMTV integration site family, member 10 [KO:K01357]
WNT11; wingless-type MMTV integration site family, member 11 [KO:K01384]
protein Wnt-16-like; K01558 wingless-type MMTV integration site family, member 16 [KO:K01558]
frizzled-7-like; K02432 frizzled 1/7 [KO:K02432]
FZD1; frizzled family receptor 1 [KO:K02432]
FZD3; frizzled family receptor 3 [KO:K02329]
FZD4; frizzled family receptor 4 [KO:K02354]
frizzled-5-like; K02375 frizzled 5/8 [KO:K02375]
frizzled-6-like; K02376 frizzled 6 [KO:K02376]
frizzled-10-like; K02842 frizzled 9/10 [KO:K02842]
segment polarity protein dishevelled homolog DVL-3-like; K02353 segment polarity protein dishevelled [KO:K02353]
segment polarity protein dishevelled homolog DVL-1-like; K02353 segment polarity protein dishevelled [KO:K02353]
segment polarity protein dishevelled homolog DVL-2-like; K02353 segment polarity protein dishevelled [KO:K02353]
GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
catenin beta-1-like; K02105 catenin beta 1 [KO:K02105]
APC; adenomatous polyposis coli [KO:K02085]
adenomatous polyposis coli protein 2-like; K02085 adenomatosis polyposis coli protein [KO:K02085]
DLG1; discs, large homolog 1 (Drosophila) [KO:K12076]
platelet-derived growth factor subunit A-like; K04359 platelet-derived growth factor subunit A [KO:K04359]
platelet-derived growth factor subunit B-like; K17386 platelet-derived growth factor subunit B [KO:K17386]
PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
beta-type platelet-derived growth factor receptor-like; K05089 platelet-derived growth factor receptor beta [EC:2.7.10.1] [KO:K05089] [EC:2.7.10.1]
phosphatidylinositol 3-kinase regulatory subunit beta-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
phosphatidylinositol 3-kinase regulatory subunit alpha-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
phosphoinositide 3-kinase regulatory subunit 5-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
phosphatidylinositol 3-kinase regulatory subunit gamma-like; K02649 phosphoinositide-3-kinase, regulatory subunit [KO:K02649]
phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
phosphatidylinositol-4; K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153] [KO:K00922] [EC:2.7.1.153]
AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [KO:K04456] [EC:2.7.11.1]
RAC-alpha serine/threonine-protein kinase-like; K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] [KO:K04456] [EC:2.7.11.1]
tumor necrosis factor-like; K03156 tumor necrosis factor superfamily, member 2 [KO:K03156]
tumor necrosis factor receptor superfamily member 1A-like; K03158 tumor necrosis factor receptor superfamily member 1A [KO:K03158]
MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase [KO:K04416] [EC:2.7.11.25]
dual specificity mitogen-activated protein kinase kinase 4-like; K04430 mitogen-activated protein kinase kinase 4 [EC:2.7.12.2] [KO:K04430] [EC:2.7.12.2]
transcription factor AP-1-like; K04448 transcription factor AP-1 [KO:K04448]
IL1R1; interleukin 1 receptor, type I [KO:K04386]
interleukin-1 receptor type 2-like; K04387 interleukin 1 receptor type II [KO:K04387]
uncharacterized LOC100478379; K10784 T cell receptor alpha chain V region [KO:K10784]
t-cell receptor beta chain T17T-22-like; K10785 T-cell receptor beta chain V region [KO:K10785]
mitogen-activated protein kinase kinase kinase 3-like; K04421 mitogen-activated protein kinase kinase kinase 3 [EC:2.7.11.25] [KO:K04421] [EC:2.7.11.25]
CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO:K07210]
NF-kappa-B inhibitor alpha-like; K04734 NF-kappa-B inhibitor alpha [KO:K04734]
NFKB; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
transcription factor p65-like; K04735 transcription factor p65 [KO:K04735]
tumor necrosis factor receptor superfamily member 3-like; K03159 lymphotoxin beta receptor TNFR superfamily member 3 [KO:K03159]
tumor necrosis factor receptor superfamily member 5-like; K03160 tumor necrosis factor receptor superfamily member 5 [KO:K03160]
tumor necrosis factor receptor superfamily member 13C-like; K05151 tumor necrosis factor receptor superfamily member 13C [KO:K05151]
MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
transcription factor RelB-like; K09253 transcription factor RelB [KO:K09253]
NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) [KO:K04469]
IL2; interleukin 2 [KO:K05429]
uncharacterized LOC100466247; K05068 interleukin 2 receptor alpha [KO:K05068]
IL15; interleukin 15 [KO:K05433]
IL6; interleukin 6 (interferon, beta 2) [KO:K05405]
uncharacterized LOC100473502; K05427 granulocyte-macrophage colony-stimulating factor [KO:K05427]
lymphotoxin-alpha-like; K05468 lymphotoxin alpha (TNF superfamily, member 1) [KO:K05468]
bcl-2-like protein 1-like; K04570 BCL2-like 1 (apoptosis regulator Bcl-X) [KO:K04570]
XIAP; X-linked inhibitor of apoptosis [KO:K04725]
tristetraproline-like; K15308 tristetraprolin [KO:K15308]
nuclear transcription factor Y subunit beta-like; K08065 nuclear transcription Y subunit beta [KO:K08065]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
SLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
DLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
HLA class II histocompatibility antigen; K06752 major histocompatibility complex, class II [KO:K06752]
ETS domain-containing protein Elk-4-like; K04376 ETS domain-containing protein Elk-4 [KO:K04376]
ETS domain-containing protein Elk-1-like; K04375 ETS domain-containing protein Elk-1 [KO:K04375]
transcription factor PU.1-like; K09438 transcription factor PU.1 [KO:K09438]
ETS1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) [KO:K02678]
ETS2; v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) [KO:K02678]
TATA box-binding protein-like protein 1-like; K03120 transcription initiation factor TFIID TATA-box-binding protein [KO:K03120]
TATA-box-binding protein-like; K03120 transcription initiation factor TFIID TATA-box-binding protein [KO:K03120]
proto-oncogene c-Fos-like; K04379 proto-oncogene protein c-fos [KO:K04379]
EGR1; early growth response 1 [KO:K09203]
early growth response protein 2-like; K12496 early growth response protein 2 [KO:K12496]
fos-related antigen 1-like; K04502 fos-like antigen 1 [KO:K04502]
adenylate cyclase type 1-like; K08041 adenylate cyclase 1 [EC:4.6.1.1] [KO:K08041] [EC:4.6.1.1]
ADCY2; adenylate cyclase 2 (brain) [KO:K08042] [EC:4.6.1.1]
ADCY8; adenylate cyclase 8 (brain) [KO:K08043] [EC:4.6.1.1]
ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
adenylate cyclase type 7-like; K08047 adenylate cyclase 7 [EC:4.6.1.1] [KO:K08047] [EC:4.6.1.1]
ADCY8; adenylate cyclase 8 (brain) [KO:K08048] [EC:4.6.1.1]
ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
serine/threonine-protein kinase PRKX-like; K04345 protein kinase A [EC:2.7.11.11] [KO:K04345] [EC:2.7.11.11]
cAMP-dependent protein kinase catalytic subunit alpha-like; K04345 protein kinase A [EC:2.7.11.11] [KO:K04345] [EC:2.7.11.11]
cAMP-dependent protein kinase catalytic subunit beta-like; K04345 protein kinase A [EC:2.7.11.11] [KO:K04345] [EC:2.7.11.11]
cyclic AMP-responsive element-binding protein 1-like; K05870 cyclic AMP-responsive element-binding protein 1 [KO:K05870]
cAMP-responsive element modulator-like; K09052 cAMP response element modulator [KO:K09052]
cyclic AMP-dependent transcription factor ATF-1-like; K09053 activating transcription factor 1 [KO:K09053]
ATF2; activating transcription factor 2 [KO:K04450]
cyclic AMP-dependent transcription factor ATF-3-like; K09032 activating transcription factor 3 [KO:K09032]
cyclic AMP-dependent transcription factor ATF-4-like; K04374 cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
CRTC1; CREB regulated transcription coactivator 1 [KO:K15309]
CREB-regulated transcription coactivator 2-like; K16333 CREB-regulated transcription coactivator 2 [KO:K16333]
CRTC2; CREB regulated transcription coactivator 2 [KO:K16333]
CRTC3; CREB regulated transcription coactivator 3 [KO:K16334]
CREB-binding protein-like; K04498 E1A/CREB-binding protein [EC:2.3.1.48] [KO:K04498] [EC:2.3.1.48]
EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
KAT2B; K(lysine) acetyltransferase 2B [KO:K06062] [EC:2.3.1.48]
histone acetyltransferase KAT2A-like; K06062 histone acetyltransferase [EC:2.3.1.48] [KO:K06062] [EC:2.3.1.48]
transcription factor E2-alpha-like; K09063 transcription factor E2-alpha [KO:K09063]
DNA polymerase beta-like; K02330 DNA polymerase beta [EC:2.7.7.7 4.2.99.-] [KO:K02330] [EC:4.2.99.- 2.7.7.7]
cyclin-dependent kinase 4 inhibitor C-like; K06622 cyclin-dependent kinase inhibitor 2C [KO:K06622]
LCK; lymphocyte-specific protein tyrosine kinase [KO:K05856] [EC:2.7.10.2]
transcriptional activator Myb-like; K09420 myb proto-oncogene protein [KO:K09420]
MYBL1; v-myb myeloblastosis viral oncogene homolog (avian)-like 1 [KO:K09421]
myb-related protein B-like; K09421 myb-related protein [KO:K09421]
TGF-beta receptor type-1-like; K04674 TGF-beta receptor type-1 [EC:2.7.11.30] [KO:K04674] [EC:2.7.11.30]
TGFBR2; transforming growth factor, beta receptor II (70/80kDa) [KO:K04388] [EC:2.7.11.30]
mothers against decapentaplegic homolog 3-like; K04500 mothers against decapentaplegic homolog 2/3 [KO:K04500]
SMAD2; SMAD family member 2 [KO:K04500]
mothers against decapentaplegic homolog 4-like; K04501 mothers against decapentaplegic homolog 4 [KO:K04501]
ATM; ataxia telangiectasia mutated [KO:K04728] [EC:2.7.11.1]
ATR; ataxia telangiectasia and Rad3 related [KO:K06640] [EC:2.7.11.1]
CHEK1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
CHEK2; checkpoint kinase 2 [KO:K06641] [EC:2.7.11.1]
cellular tumor antigen p53-like; K04451 tumor protein p53 [KO:K04451]
apoptosis regulator BAX-like; K02159 apoptosis regulator BAX [KO:K02159]
tumor protein p53-inducible nuclear protein 1-like; K15310 tumor protein p53-inducible nuclear protein 1 [KO:K15310]
homeobox protein MSX-2-like; K09341 homeobox protein MSX [KO:K09341]
homeobox protein MSX-1-like; K09341 homeobox protein MSX [KO:K09341]
homeobox protein MSX-3-like; K09341 homeobox protein MSX [KO:K09341]
Compound
C00027  
Hydrogen peroxide
C00076  
Calcium cation
C00238  
Potassium cation
C00575  
3',5'-Cyclic AMP
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
C18994  
Accessory protein p12I
C18995  
P13 protein
C18996  
Accessory protein p30II
C19313  
HTLV-1 basic zipper factor
Reference
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
Reference
  Authors
Gatza ML, Watt JC, Marriott SJ
  Title
Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades.
  Journal
Oncogene 22:5141-9 (2003)
Reference
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
Reference
  Authors
Boxus M, Willems L
  Title
Mechanisms of HTLV-1 persistence and transformation.
  Journal
Br J Cancer 101:1497-501 (2009)
Reference
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
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