KEGG   PATHWAY: aml05202
Entry
aml05202                    Pathway                                
Name
Transcriptional misregulation in cancer - Ailuropoda melanoleuca (giant panda)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
aml05202  Transcriptional misregulation in cancer
aml05202

Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100484679  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
100472252  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X2 [KO:K05090] [EC:2.7.10.1]
100472895  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
100473502  uncharacterized protein LOC100473502 [KO:K05427]
109488324  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
100473242  interleukin-3 [KO:K04736]
100478720  RUNX1T1; protein CBFA2T1 isoform X4 [KO:K10053]
100477725  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
100478424  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
100477344  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
100482935  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
100469640  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
100468132  PER2; period circadian protein homolog 2 isoform X3 [KO:K02633]
100476314  SPI1; transcription factor PU.1 isoform X3 [KO:K09438]
100467208  CD14; monocyte differentiation antigen CD14 [KO:K04391]
100475340  integrin alpha-M [KO:K06461]
100471819  FCGR1A; high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
100466345  JUP; junction plakoglobin [KO:K10056]
100475070  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
100463678  RARA; retinoic acid receptor alpha isoform X3 [KO:K08527]
100482271  CCNA2; cyclin-A2 [KO:K06627]
100475180  CCNA1; cyclin-A1 [KO:K06627]
100471463  CEBPE; CCAAT/enhancer-binding protein epsilon [KO:K10051]
100468997  BCL2A1; bcl-2-related protein A1 [KO:K02162]
100476757  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
100464396  MYC; myc proto-oncogene protein [KO:K04377]
100466694  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
100479681  TCF3; transcription factor E2-alpha isoform X3 [KO:K09063]
100474783  PBX1; pre-B-cell leukemia transcription factor 1 [KO:K09355]
100464171  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
100479305  ETV7; transcription factor ETV7 isoform X1 [KO:K03211]
100478095  ETV6; transcription factor ETV6 isoform X1 [KO:K03211]
105234922  M1-specific T cell receptor alpha chain isoform X1 [KO:K10784]
105234312  neutrophil elastase-like [KO:K01327] [EC:3.4.21.37]
100464420  granzyme B [KO:K01353] [EC:3.4.21.79]
100484220  KMT2A; histone-lysine N-methyltransferase 2A [KO:K09186] [EC:2.1.1.354]
100482315  AFF1; AF4/FMR2 family member 1 isoform X1 [KO:K15184]
100479557  CDK9; cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
100477426  CCNT1; cyclin-T1 [KO:K15188]
100483604  CCNT2; cyclin-T2 isoform X1 [KO:K15188]
100473573  MLLT1; protein ENL isoform X1 [KO:K15187]
100478831  MLLT3; protein AF-9 isoform X1 [KO:K15187]
100464435  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific [KO:K11427] [EC:2.1.1.360]
100481333  LMO2; rhombotin-2 isoform X1 [KO:K15612]
100482077  PBX3; pre-B-cell leukemia transcription factor 3 isoform X1 [KO:K15610]
100481039  RUNX2; runt-related transcription factor 2 isoform X1 [KO:K09278]
100479813  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
100471716  KLF3; Krueppel-like factor 3 [KO:K15605]
100464632  MEF2C; myocyte-specific enhancer factor 2C isoform X3 [KO:K04454]
105234293  HOXA9; homeobox protein Hox-A9 [KO:K21950]
100475292  HOXA10; homeobox protein Hox-A10 [KO:K17443]
100467502  JMJD1C; probable JmjC domain-containing histone demethylation protein 2C isoform X1 [KO:K11449] [EC:1.14.11.-]
105239968  HMGA2; high mobility group protein HMGI-C isoform X1 [KO:K09283]
100476598  KDM6A; lysine-specific demethylase 6A isoform X4 [KO:K11447] [EC:1.14.11.68]
100480979  SUPT3H; transcription initiation protein SPT3 homolog isoform X1 [KO:K11313]
100481824  PROM1; prominin-1 isoform X1 [KO:K06532]
100483963  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
100473920  BMP2K; BMP-2-inducible protein kinase [KO:K08854] [EC:2.7.11.1]
100471374  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100467824  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
105241354  CDK14; cyclin-dependent kinase 14 isoform X1 [KO:K08821] [EC:2.7.11.22]
100465236  MEIS1; homeobox protein Meis1 isoform X2 [KO:K15613]
100469395  HOXA11; homeobox protein Hox-A11 [KO:K21951]
100473503  SIX1; homeobox protein SIX1 [KO:K15614]
100479044  SIX4; LOW QUALITY PROTEIN: homeobox protein SIX4 [KO:K15615]
100468043  EYA1; eyes absent homolog 1 isoform X1 [KO:K15616] [EC:3.1.3.48]
100470950  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
100476658  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
100472702  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
100470244  FUT8; alpha-(1,6)-fucosyltransferase isoform X2 [KO:K00717] [EC:2.4.1.68]
100464754  TLX3; T-cell leukemia homeobox protein 3 [KO:K15607]
100482063  TLX1; LOW QUALITY PROTEIN: T-cell leukemia homeobox protein 1 [KO:K09340]
100471593  BCL11B; LOW QUALITY PROTEIN: B-cell lymphoma/leukemia 11B [KO:K22046]
100473247  LDB1; LIM domain-binding protein 1 isoform X1 [KO:K15617]
100473448  LYL1; protein lyl-1 [KO:K15604]
100463548  HHEX; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
105235480  PTCRA; pre T-cell antigen receptor alpha [KO:K06056]
100465027  REL; proto-oncogene c-Rel isoform X2 [KO:K09254]
100471517  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100477152  baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
100477406  baculoviral IAP repeat-containing protein 2 [KO:K16060]
100464979  TRAF1; TNF receptor-associated factor 1 isoform X1 [KO:K03172]
100469922  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100483382  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
100476345  CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160]
100480054  BCL6; B-cell lymphoma 6 protein isoform X1 [KO:K15618]
100478908  MAF; transcription factor Maf [KO:K09035]
100474212  ITGB7; integrin beta-7 [KO:K06590]
100482078  NSD2; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD2 [KO:K11424] [EC:2.1.1.357]
100470602  histone H3.3A [KO:K11253]
100482800  histone H3.1 [KO:K11253]
100471070  histone H3 [KO:K11253]
100482789  histone H3.1 [KO:K11253]
100480024  histone H3.1 [KO:K11253]
100464611  uncharacterized protein LOC100464611 [KO:K11253]
100476918  histone H3.3A [KO:K11253]
100471714  LOW QUALITY PROTEIN: histone H3 [KO:K11253]
109490817  histone H3.1 [KO:K11253]
100468125  LOW QUALITY PROTEIN: histone H3.1 [KO:K11253]
117802187  histone H3.1 [KO:K11253]
117802188  histone H3.1 [KO:K11253]
117802189  histone H3.1 [KO:K11253]
117802192  histone H3.1 [KO:K11253]
117803471  histone H3.3A-like [KO:K11253]
100481668  PAX5; paired box protein Pax-5 isoform X1 [KO:K09383]
100480115  paired box protein Pax-8 [KO:K09293]
100482938  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
100479839  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
100475696  RXRB; retinoic acid receptor RXR-beta isoform X2 [KO:K08525]
100475450  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
100472890  PRCC; proline-rich protein PRCC [KO:K13105]
100470680  TFE3; transcription factor E3 isoform X1 [KO:K09105]
100484923  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100477592  TMPRSS2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
100477604  ERG; transcriptional regulator ERG isoform X1 [KO:K09435]
100481924  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
100471928  PLAT; tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
100478420  LOW QUALITY PROTEIN: stromelysin-1 [KO:K01394] [EC:3.4.24.17]
100477912  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
100475429  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
100473701  ZEB1; zinc finger E-box-binding homeobox 1 [KO:K09299]
100475938  IL1R2; interleukin-1 receptor type 2 isoform X2 [KO:K04387]
100473505  SPINT1; kunitz-type protease inhibitor 1 [KO:K15619]
100484119  ETV1; ETS translocation variant 1 isoform X1 [KO:K09431]
100466245  ETV4; ETS translocation variant 4 isoform X1 [KO:K15592]
100469232  ETV5; ETS translocation variant 5 [KO:K15593]
100471851  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
100471598  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
100470124  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
100478848  MYCN; LOW QUALITY PROTEIN: N-myc proto-oncogene protein [KO:K09109]
100468226  MAX; protein max isoform X2 [KO:K04453]
100479481  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
100464496  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100468516  TP53; cellular tumor antigen p53 [KO:K04451]
100464971  BMI1; polycomb complex protein BMI-1 isoform X1 [KO:K11459]
100474983  SP1; transcription factor Sp1 [KO:K04684]
100482510  ZBTB17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
100478241  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100472417  MEN1; menin isoform X1 [KO:K14970]
100466147  EWSR1; RNA-binding protein EWS isoform X1 [KO:K13209]
100469052  FLI1; Friend leukemia integration 1 transcription factor isoform X2 [KO:K09436]
100473254  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
100481765  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
100482939  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
105239315  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
105240817  FEV; LOW QUALITY PROTEIN: protein FEV [KO:K09437]
100480351  ATF1; cyclic AMP-dependent transcription factor ATF-1 isoform X1 [KO:K09053]
100468247  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X3 [KO:K15589]
100480638  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100471143  MITF; microphthalmia-associated transcription factor isoform X3 [KO:K09455]
100479572  WT1; Wilms tumor protein isoform X1 [KO:K09234]
100473486  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100478292  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
100465333  BAIAP3; BAI1-associated protein 3 isoform X1 [KO:K15621]
100466543  TSPAN7; tetraspanin-7 [KO:K06571]
100473366  MLF1; myeloid leukemia factor 1 isoform X2 [KO:K15622]
100475453  NR4A3; nuclear receptor subfamily 4 group A member 3 isoform X1 [KO:K08559]
100466750  TAF15; TATA-binding protein-associated factor 2N isoform X1 [KO:K14651]
100475993  FUS; RNA-binding protein FUS [KO:K13098]
100479063  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
100477151  IL6; interleukin-6 precursor [KO:K05405]
117803984  interleukin-6-like [KO:K05405]
100468820  NFKBIZ; NF-kappa-B inhibitor zeta [KO:K14242]
100467906  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100480158  RELA; transcription factor p65 isoform X1 [KO:K04735]
100472054  CXCL8; interleukin-8 [KO:K10030]
100468866  PAX3; paired box protein Pax-3 [KO:K09381]
100475347  PAX7; paired box protein Pax-7 isoform X2 [KO:K09381]
100471182  FOXO1; LOW QUALITY PROTEIN: forkhead box protein O1 [KO:K07201]
100483462  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
100480722  SS18; protein SSXT isoform X3 [KO:K15623]
100472933  SS18L1; calcium-responsive transactivator isoform X3 [KO:K15623]
100479982  protein SSX2-like [KO:K15625]
100480376  NUPR1; nuclear protein 1 [KO:K15626]
100469729  ASPSCR1; LOW QUALITY PROTEIN: tether containing UBX domain for GLUT4 [KO:K15627]
100480742  MET; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
100477654  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
100482871  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
100470600  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100471095  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100472241  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
100479738  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
100464732  POLK; DNA polymerase kappa isoform X2 [KO:K03511] [EC:2.7.7.7]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
PMID:12511414
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
DOI:10.1182/blood-2002-08-2577
Reference
PMID:11313274
  Authors
Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C
  Title
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
  Journal
Blood 97:2798-807 (2001)
DOI:10.1182/blood.V97.9.2798
Reference
PMID:12670461
  Authors
Zuzel M, Cawley JC.
  Title
The biology of hairy cells.
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Best Pract Res Clin Haematol 16:1-13 (2003)
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PMID:14998494
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Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM
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Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
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Cancer Cell 5:191-9 (2004)
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PMID:20974671
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Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD
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The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
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Blood 117:211-20 (2011)
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PMID:19059936
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MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.
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Haematologica 94:78-86 (2009)
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PMID:10350329
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Iida S, Rao PH, Ueda R, Chaganti RS, Dalla-Favera R
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Chromosomal rearrangement of the PAX-5 locus in lymphoplasmacytic lymphoma with t(9;14)(p13;q32).
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Leuk Lymphoma 34:25-33 (1999)
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PMID:10784387
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The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma.
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Leuk Lymphoma 36:435-45 (2000)
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PMID:19233641
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Prensner JR, Chinnaiyan AM
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Oncogenic gene fusions in epithelial carcinomas.
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Curr Opin Genet Dev 19:82-91 (2009)
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PMID:19406209
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Brenner JC, Chinnaiyan AM
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Translocations in epithelial cancers.
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Biochim Biophys Acta 1796:201-15 (2009)
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PMID:16946003
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Reddi HV, McIver B, Grebe SK, Eberhardt NL
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The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
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Endocrinology 148:932-5 (2007)
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PMID:19422821
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Medendorp K, van Groningen JJ, Vreede L, Hetterschijt L, Brugmans L, van den Hurk WH, van Kessel AG
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The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.
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Exp Cell Res 315:2399-409 (2009)
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Kumar-Sinha C, Tomlins SA, Chinnaiyan AM
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Recurrent gene fusions in prostate cancer.
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Nat Rev Cancer 8:497-511 (2008)
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Yu J, Yu J, Mani RS, Cao Q, Brenner CJ, Cao X, Wang X, Wu L, Li J, Hu M, Gong Y, Cheng H, Laxman B, Vellaichamy A, Shankar S, Li Y, Dhanasekaran SM, Morey R, Barrette T, Lonigro RJ, Tomlins SA, Varambally S, Qin ZS, Chinnaiyan AM
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An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
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Cancer Cell 17:443-54 (2010)
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Leshem O, Madar S, Kogan-Sakin I, Kamer I, Goldstein I, Brosh R, Cohen Y, Jacob-Hirsch J, Ehrlich M, Ben-Sasson S, Goldfinger N, Loewenthal R, Gazit E, Rotter V, Berger R
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TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
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PLoS One 6:e21650 (2011)
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PMID:17505060
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Cai C, Hsieh CL, Omwancha J, Zheng Z, Chen SY, Baert JL, Shemshedini L
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ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
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Mol Endocrinol 21:1835-46 (2007)
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PMID:18172298
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Helgeson BE, Tomlins SA, Shah N, Laxman B, Cao Q, Prensner JR, Cao X, Singla N, Montie JE, Varambally S, Mehra R, Chinnaiyan AM
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Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
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Cancer Res 68:73-80 (2008)
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PMID:21849159
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Westermark UK, Wilhelm M, Frenzel A, Henriksson MA
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The MYCN oncogene and differentiation in neuroblastoma.
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Semin Cancer Biol 21:256-66 (2011)
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PMID:20153925
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Bell E, Chen L, Liu T, Marshall GM, Lunec J, Tweddle DA
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MYCN oncoprotein targets and their therapeutic potential.
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Cancer Lett 293:144-57 (2010)
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PMID:15644444
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Slack A, Chen Z, Tonelli R, Pule M, Hunt L, Pession A, Shohet JM
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The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
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Proc Natl Acad Sci U S A 102:731-6 (2005)
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PMID:20190806
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Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T
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Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
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Oncogene 29:2681-90 (2010)
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PMID:20145147
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Chen L, Iraci N, Gherardi S, Gamble LD, Wood KM, Perini G, Lunec J, Tweddle DA
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p53 is a direct transcriptional target of MYCN in neuroblastoma.
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Cancer Res 70:1377-88 (2010)
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PMID:17327229
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Beierle EA, Trujillo A, Nagaram A, Kurenova EV, Finch R, Ma X, Vella J, Cance WG, Golubovskaya VM
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N-MYC regulates focal adhesion kinase expression in human neuroblastoma.
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J Biol Chem 282:12503-16 (2007)
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A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.
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Cancer Res 71:404-12 (2011)
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Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation.
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Nat Clin Pract Endocrinol Metab 2:562-70 (2006)
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Wu X, Hua X
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Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.
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Curr Mol Med 8:805-15 (2008)
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PMID:19564705
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Unusual clinical and pathological presentation of a neuroendocrine tumor in a patient with multiple endocrine neoplasia type 1.
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Endocr J 56:887-95 (2009)
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In search of tumor suppressing functions of menin.
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Mol Cell Endocrinol 265-266:34-41 (2007)
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PMID:15826838
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Fusion oncogenes in tumor development.
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Semin Cancer Biol 15:236-43 (2005)
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PMID:12527902
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Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.
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Oncogene 22:1-9 (2003)
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PMID:18648544
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Cironi L, Riggi N, Provero P, Wolf N, Suva ML, Suva D, Kindler V, Stamenkovic I
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IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.
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PLoS One 3:e2634 (2008)
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The Biology of Ewing sarcoma.
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Cancer Lett 254:1-10 (2007)
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Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.
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Int J Clin Exp Pathol 3:338-47 (2010)
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Ordonez JL, Osuna D, Herrero D, de Alava E, Madoz-Gurpide J
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Advances in Ewing's sarcoma research: where are we now and what lies ahead?
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Cancer Res 69:7140-50 (2009)
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PMID:12527906
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Identification of target genes for EWS/ATF-1 chimeric transcription factor.
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Oncogene 22:41-9 (2003)
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PMID:15826834
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The EWS-WT1 gene fusion in desmoplastic small round cell tumor.
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Semin Cancer Biol 15:197-205 (2005)
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PMID:18855877
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Filion C, Motoi T, Olshen AB, Lae M, Emnett RJ, Gutmann DH, Perry A, Ladanyi M, Labelle Y
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The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene.
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J Pathol 217:83-93 (2009)
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PMID:18330902
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Kim S, Lee HJ, Jun HJ, Kim J
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The hTAF II 68-TEC fusion protein functions as a strong transcriptional activator.
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Int J Cancer 122:2446-53 (2008)
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PMID:10537274
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Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
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Cancer Res 59:5064-7 (1999)
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PMID:15688424
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Goransson M, Elias E, Stahlberg A, Olofsson A, Andersson C, Aman P
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Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression.
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Int J Cancer 115:556-60 (2005)
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PMID:18850010
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Goransson M, Andersson MK, Forni C, Stahlberg A, Andersson C, Olofsson A, Mantovani R, Aman P
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The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.
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Oncogene 28:270-8 (2009)
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PMID:20863376
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Willems SM, Schrage YM, Bruijn IH, Szuhai K, Hogendoorn PC, Bovee JV
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Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
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Mol Cancer 9:257 (2010)
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PMID:18457914
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Linardic CM
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PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
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Cancer Lett 270:10-8 (2008)
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Reference
PMID:11863357
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Barber TD, Barber MC, Tomescu O, Barr FG, Ruben S, Friedman TB
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Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
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Genomics 79:278-84 (2002)
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Reference
PMID:17101797
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Ishida M, Miyamoto M, Naitoh S, Tatsuda D, Hasegawa T, Nemoto T, Yokozeki H, Nishioka K, Matsukage A, Ohki M, Ohta T
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The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
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Mol Cell Biol 27:1348-55 (2007)
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PMID:19472090
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Jun HJ, Lee J, Lim do H, Park JO, Ahn G, Seo SW, Sung KS, Lim do H, Yoo KH, Choi YL
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Expression of MET in alveolar soft part sarcoma.
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Med Oncol 27:459-65 (2010)
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Reference
PMID:21779514
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Rivlin N, Brosh R, Oren M, Rotter V
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
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Genes Cancer 2:466-74 (2011)
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Reference
PMID:21765642
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Suzuki K, Matsubara H
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Recent advances in p53 research and cancer treatment.
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J Biomed Biotechnol 2011:978312 (2011)
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Related
pathway
aml04115  p53 signaling pathway
aml05211  Renal cell carcinoma
aml05215  Prostate cancer
aml05216  Thyroid cancer
aml05221  Acute myeloid leukemia
KO pathway
ko05202   

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   KEGG GENES (183)   
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