KEGG   PATHWAY: ang04146
Entry
ang04146                    Pathway                                
Name
Peroxisome - Aspergillus niger (black aspergilli)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
ang04146  Peroxisome
ang04146

Other DBs
GO: 0005777
Organism
Aspergillus niger (black aspergilli) [GN:ang]
Gene
An07g10240  uncharacterized protein [KO:K13335]
An17g01440  uncharacterized protein [KO:K13336]
An02g06680  uncharacterized protein [KO:K13337]
An16g04880  uncharacterized protein [KO:K13338]
An16g02010  uncharacterized protein [KO:K13339]
An01g13690  uncharacterized protein [KO:K13341]
An16g07480  uncharacterized protein [KO:K13342]
An16g04020  uncharacterized protein [KO:K13343]
An16g07610  uncharacterized protein [KO:K13344]
An04g08740  uncharacterized protein [KO:K13345]
An13g00800  uncharacterized protein [KO:K13346]
An18g04150  uncharacterized protein [KO:K06664]
An12g01340  uncharacterized protein [KO:K13348]
An09g02510  uncharacterized protein [KO:K13348]
An16g08040  uncharacterized protein [KO:K13350]
An09g06780  uncharacterized protein [KO:K13354]
An16g07490  uncharacterized protein [KO:K12261] [EC:4.1.2.63]
An09g06420  uncharacterized protein [KO:K01796] [EC:5.1.99.4]
An13g01600  uncharacterized protein [KO:K00477] [EC:1.14.11.18]
An05g01410  uncharacterized protein [KO:K00232] [EC:1.3.3.6]
An04g00740  uncharacterized protein [KO:K08764] [EC:2.3.1.176]
An08g05400  uncharacterized protein [KO:K07513] [EC:2.3.1.16]
An13g00590  uncharacterized protein [KO:K07513] [EC:2.3.1.16]
An02g03320  uncharacterized protein [KO:K07513] [EC:2.3.1.16]
An04g05720  uncharacterized protein [KO:K07513] [EC:2.3.1.16]
An15g02860  uncharacterized protein [KO:K13237] [EC:1.3.1.124]
An09g02050  uncharacterized protein [KO:K12663] [EC:5.3.3.21]
An01g03680  uncharacterized protein [KO:K15628] [EC:7.6.2.4]
An08g05780  uncharacterized protein [KO:K15628] [EC:7.6.2.4]
An09g06740  uncharacterized protein [KO:K01897] [EC:6.2.1.3]
An16g05150  uncharacterized protein [KO:K01897] [EC:6.2.1.3]
An07g00290  uncharacterized protein [KO:K13239] [EC:5.3.3.8]
An15g01280  uncharacterized protein [KO:K13239] [EC:5.3.3.8]
An16g02290  uncharacterized protein [KO:K13239] [EC:5.3.3.8]
An09g05670  uncharacterized protein [KO:K03426] [EC:3.6.1.22]
An08g04990  uncharacterized protein [KO:K00624] [EC:2.3.1.7]
An18g01590  uncharacterized protein [KO:K00624] [EC:2.3.1.7]
An08g10170  uncharacterized protein [KO:K13356] [EC:1.2.1.84]
An09g01260  uncharacterized protein [KO:K13356] [EC:1.2.1.84]
An14g04760  uncharacterized protein [KO:K13356] [EC:1.2.1.84]
An04g02190  uncharacterized protein [KO:K00869] [EC:2.7.1.36]
An08g01000  uncharacterized protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
An06g02340  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
An14g05380  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
An01g02430  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
An02g12430  icdA; precursor of mitochondrial isocitrate dehydrogenase icdA-Aspergillus niger [KO:K00031] [EC:1.1.1.42]
An07g05010  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
An07g05900  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
An08g01300  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
An12g05570  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
An16g03950  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
An04g09820  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
An02g08980  uncharacterized protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
An02g04640  uncharacterized protein [KO:K01640] [EC:4.1.3.4]
An01g14530  uncharacterized protein [KO:K11517] [EC:1.1.3.15]
An12g10140  uncharacterized protein [KO:K11517] [EC:1.1.3.15]
An08g08920  uncharacterized protein [KO:K03781] [EC:1.11.1.6]
An01g01550  uncharacterized protein [KO:K03781] [EC:1.11.1.6]
An01g01820  catR; catalase R catR-Aspergillus niger [KO:K03781] [EC:1.11.1.6]
An03g05660  uncharacterized protein [KO:K03781] [EC:1.11.1.6]
An09g03130  uncharacterized protein [KO:K03781] [EC:1.11.1.6]
An12g10720  uncharacterized protein [KO:K03781] [EC:1.11.1.6]
An02g02750  uncharacterized protein [KO:K03781] [EC:1.11.1.6]
An14g07200  uncharacterized protein [KO:K03781] [EC:1.11.1.6]
An14g00690  uncharacterized protein [KO:K03781] [EC:1.11.1.6]
An06g01660  uncharacterized protein [KO:K11187] [EC:1.11.1.24]
An07g03770  uncharacterized protein [KO:K04565] [EC:1.15.1.1]
An07g09250  uncharacterized protein [KO:K04564] [EC:1.15.1.1]
An01g12530  uncharacterized protein [KO:K04564] [EC:1.15.1.1]
An04g04870  uncharacterized protein [KO:K04564] [EC:1.15.1.1]
An01g14420  uncharacterized protein [KO:K08726] [EC:3.3.2.10 3.1.3.76]
An04g05440  uncharacterized protein [KO:K00106] [EC:1.17.1.4 1.17.3.2]
An03g01530  uncharacterized protein [KO:K00106] [EC:1.17.1.4 1.17.3.2]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
ang00071  Fatty acid degradation
ang00230  Purine metabolism
ang00564  Glycerophospholipid metabolism
ang00565  Ether lipid metabolism
ang00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (73)   
   KEGG GENES (73)   
All databases (74)   

Download RDF
DBGET integrated database retrieval system