KEGG   PATHWAY: aor00030Help
aor00030                    Pathway                                

Pentose phosphate pathway - Aspergillus oryzae
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
aor00030  Pentose phosphate pathway

Ortholog table
aor_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:aor00030]
aor_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:aor00030]
Other DBs
BSID: 85459
GO: 0006098
Aspergillus oryzae [GN:aor]
AO090011000659  unnamed protein product; glucose-6-phosphate isomerase [KO:K01810] [EC:]
AO090005000789  unnamed protein product; 6-phosphogluconolactonase - like protein [KO:K01057] [EC:]
AO090003000121  unnamed protein product; 6-phosphogluconate dehydrogenase [KO:K00033] [EC:]
AO090001000547  unnamed protein product; 6-phosphogluconate dehydrogenase [KO:K00033] [EC:]
AO090012000303  unnamed protein product; D-ribulose-5-phosphate 3-epimerase [KO:K01783] [EC:]
AO090012000526  unnamed protein product; transketolase [KO:K00615] [EC:]
AO090020000520  unnamed protein product; transaldolase [KO:K00616] [EC:]
AO090023000209  unnamed protein product; ribose 5-phosphate isomerase [KO:K01807] [EC:]
AO090026000544  unnamed protein product; ribose 5-phosphate isomerase RpiB [KO:K01808] [EC:]
AO090012000711  unnamed protein product; phosphoketolase [KO:K01621] [EC:]
AO090003000625  unnamed protein product; phosphoketolase [KO:K01621] [EC:]
AO090138000062  unnamed protein product; deoxyribose-phosphate aldolase [KO:K01619] [EC:]
AO090038000092  unnamed protein product; ribokinase [KO:K00852] [EC:]
AO090102000368  unnamed protein product; sugar kinases, ribokinase family [KO:K00852] [EC:]
AO090003000746  unnamed protein product; phosphoglucomutase [KO:K01835] [EC:]
AO090011000487  unnamed protein product; phosphoglucomutase/phosphomannomutase [KO:K01835] [EC:]
AO090003001133  unnamed protein product; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:]
AO090005000432  unnamed protein product; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:]
AO090012000798  unnamed protein product; ribose-phosphate pyrophosphokinase [KO:K00948] [EC:]
AO090003001003  unnamed protein product; gluconate kinase [KO:K00851] [EC:]
AO090003000725  unnamed protein product; fructose 1,6-bisphosphate aldolase [KO:K01624] [EC:]
AO090010000514  unnamed protein product; fructose/tagatose bisphosphate aldolase [KO:K01624] [EC:]
AO090701000462  unnamed protein product; fructose/tagatose bisphosphate aldolase [KO:K01624] [EC:]
AO090003001089  unnamed protein product; fructose-1,6-bisphosphatase [KO:K03841] [EC:]
AO090010000444  unnamed protein product; pyrophosphate-dependent phosphofructo-1-kinase [KO:K00850] [EC:]
AO090003001390  unnamed protein product; pyrophosphate-dependent phosphofructo-1-kinase [KO:K00850] [EC:]
C00022  Pyruvate
C00031  D-Glucose
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
(map 3)
Nishizuka Y (ed).
[Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1980)
(map 4)
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
[Cellular Functions and Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1997)
Michal G.
Biochemical Pathways
Wiley (1999)
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
J Bacteriol 185:2793-801 (2003)
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
J Bacteriol 188:4698-704 (2006)
Kato N, Yurimoto H, Thauer RK
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
Biosci Biotechnol Biochem 70:10-21 (2006)
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
FEBS J 280:1126-38 (2013)
Reher M, Schonheit P
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
FEBS Lett 580:1198-204 (2006)
Reher M, Fuhrer T, Bott M, Schonheit P
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
J Bacteriol 192:964-74 (2010)
KO pathway

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