KEGG   PATHWAY: asd03440
Entry
asd03440                    Pathway                                
Name
Homologous recombination - Hoyosella subflava
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
asd03440  Homologous recombination
asd03440

Other DBs
GO: 0000724
Organism
Hoyosella subflava [GN:asd]
Gene
AS9A_1059  Single-stranded DNA-binding protein [KO:K03111]
AS9A_4530  Single-stranded DNA-binding protein [KO:K03111]
AS9A_0003  recF; DNA replication and repair protein recF [KO:K03629]
AS9A_1208  recO; DNA repair protein recO [KO:K03584]
AS9A_0222  recR; Recombination protein R [KO:K06187]
AS9A_1702  Protein recA [KO:K03553]
AS9A_1477  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
AS9A_1815  ruvA; Holliday junction ATP-dependent DNA helicase ruvA [KO:K03550]
AS9A_1816  ruvB; Holliday junction ATP-dependent DNA helicase ruvB [KO:K03551] [EC:5.6.2.4]
AS9A_1814  ruvC; Crossover junction endodeoxyribonuclease ruvC [KO:K01159] [EC:3.1.21.10]
AS9A_3163  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
AS9A_2963  recB; Exodeoxyribonuclease V, beta subunit [KO:K03582] [EC:3.1.11.5]
AS9A_2962  recC; Exodeoxyribonuclease V gamma chain [KO:K03583] [EC:3.1.11.5]
AS9A_2965  putative exodeoxyribonuclease V alpha chain [KO:K03581] [EC:3.1.11.5]
AS9A_1376  dnaE; Putative DNA polymerase III alpha subunit [KO:K02337] [EC:2.7.7.7]
AS9A_0002  dnaN; DNA polymerase III beta subunit [KO:K02338] [EC:2.7.7.7]
AS9A_4201  Transcriptional regulator, MerR family [KO:K02338] [EC:2.7.7.7]
AS9A_0217  DNA polymerase III, subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
AS9A_1145  DNA-directed DNA polymerase III delta subunit [KO:K02340] [EC:2.7.7.7]
AS9A_0296  DNA-directed DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
AS9A_1285  dnaQ; Putative DNA polymerase III epsilon subunit [KO:K02342] [EC:2.7.7.7]
AS9A_1865  DNA replication factor Y [KO:K04066] [EC:5.6.2.4]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

  All links  
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG GENES (22)   
All databases (23)   

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